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VLDL Triglyceride Kinetics in Lean, Overweight, and Obese Men and Women

Context: High-plasma very low-density lipoprotein (VLDL) triglyceride (TG) concentration and alterations in VLDL-TG metabolism are associated with cardiometabolic disease. Objective: This study sought to evaluate the interrelationships among factors purported to regulate VLDL-TG metabolism in a larg... Full description

Journal Title: The journal of clinical endocrinology and metabolism 2016-11, Vol.101 (11), p.4151-4160
Main Author: Mittendorfer, Bettina
Other Authors: Yoshino, Mihoko , Patterson, Bruce W , Klein, Samuel
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States: Endocrine Society
ID: ISSN: 0021-972X
Link: https://www.ncbi.nlm.nih.gov/pubmed/27588438
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5095238
title: VLDL Triglyceride Kinetics in Lean, Overweight, and Obese Men and Women
format: Article
creator:
  • Mittendorfer, Bettina
  • Yoshino, Mihoko
  • Patterson, Bruce W
  • Klein, Samuel
subjects:
  • Abridged Index Medicus
  • Adipose Tissue - diagnostic imaging
  • Adolescent
  • Adult
  • Apolipoprotein B-100 - metabolism
  • Body Mass Index
  • Female
  • Humans
  • Kinetics
  • Lipoproteins, VLDL - blood
  • Male
  • Middle Aged
  • Obesity - blood
  • Original
  • Original Articles
  • Overweight - blood
  • Triglycerides - blood
  • Young Adult
ispartof: The journal of clinical endocrinology and metabolism, 2016-11, Vol.101 (11), p.4151-4160
description: Context: High-plasma very low-density lipoprotein (VLDL) triglyceride (TG) concentration and alterations in VLDL-TG metabolism are associated with cardiometabolic disease. Objective: This study sought to evaluate the interrelationships among factors purported to regulate VLDL-TG metabolism in a large cohort of men and women with a wide range in body adiposity and fat distribution but without diabetes. Subjects and Design: We assessed body composition and fat distribution, plasma insulin concentration, free fatty acid availability, and basal VLDL-TG and VLDL-apoB-100 (VLDL particle number) kinetics in 233 lean, overweight, and obese men and women. Results: We found that: 1) plasma VLDL-TG concentration is determined primarily by VLDL-TG secretion rate (SR) in men and by VLDL-TG clearance rate in women; 2) there is a dissociation between VLDL-TG and VLDL-apoB-100 SRs, and VLDL-apoB-100 SR only explains ∼30% of the variance in VLDL-TG SR; 3) ∼50% of people with obesity have high plasma VLDL-TG concentration due to both an increased VLDL-TG SR and a decreased rate of VLDL-TG plasma clearance, and they have lower plasma high-density lipoprotein-cholesterol concentration and more intra-abdominal and liver fat than those with normal VLDL-TG concentration; and 4) fat-free mass, liver fat content and the rate of free fatty acid release into plasma are independent predictors (with a sex × race interaction) of VLDL-TG SR. Conclusions: The regulation of plasma VLDL-TG concentration is complex and influenced by multiple metabolic factors. Many people with obesity have normal plasma VLDL-TG concentrations and kinetics, whereas those with high plasma VLDL-TG concentrations have increased VLDL-TG SR and other markers of cardiometabolic disease risk. Fat-free mass, intra-hepatic triglyceride content and fatty acid rate of appearance in plasma were identified as statistically independent predictors (with a sex by race interaction) of VLDL-TG secretion rate.
language: eng
source:
identifier: ISSN: 0021-972X
fulltext: no_fulltext
issn:
  • 0021-972X
  • 1945-7197
url: Link


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creatorMittendorfer, Bettina ; Yoshino, Mihoko ; Patterson, Bruce W ; Klein, Samuel
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descriptionContext: High-plasma very low-density lipoprotein (VLDL) triglyceride (TG) concentration and alterations in VLDL-TG metabolism are associated with cardiometabolic disease. Objective: This study sought to evaluate the interrelationships among factors purported to regulate VLDL-TG metabolism in a large cohort of men and women with a wide range in body adiposity and fat distribution but without diabetes. Subjects and Design: We assessed body composition and fat distribution, plasma insulin concentration, free fatty acid availability, and basal VLDL-TG and VLDL-apoB-100 (VLDL particle number) kinetics in 233 lean, overweight, and obese men and women. Results: We found that: 1) plasma VLDL-TG concentration is determined primarily by VLDL-TG secretion rate (SR) in men and by VLDL-TG clearance rate in women; 2) there is a dissociation between VLDL-TG and VLDL-apoB-100 SRs, and VLDL-apoB-100 SR only explains ∼30% of the variance in VLDL-TG SR; 3) ∼50% of people with obesity have high plasma VLDL-TG concentration due to both an increased VLDL-TG SR and a decreased rate of VLDL-TG plasma clearance, and they have lower plasma high-density lipoprotein-cholesterol concentration and more intra-abdominal and liver fat than those with normal VLDL-TG concentration; and 4) fat-free mass, liver fat content and the rate of free fatty acid release into plasma are independent predictors (with a sex × race interaction) of VLDL-TG SR. Conclusions: The regulation of plasma VLDL-TG concentration is complex and influenced by multiple metabolic factors. Many people with obesity have normal plasma VLDL-TG concentrations and kinetics, whereas those with high plasma VLDL-TG concentrations have increased VLDL-TG SR and other markers of cardiometabolic disease risk. Fat-free mass, intra-hepatic triglyceride content and fatty acid rate of appearance in plasma were identified as statistically independent predictors (with a sex by race interaction) of VLDL-TG secretion rate.
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ispartofThe journal of clinical endocrinology and metabolism, 2016-11, Vol.101 (11), p.4151-4160
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descriptionContext: High-plasma very low-density lipoprotein (VLDL) triglyceride (TG) concentration and alterations in VLDL-TG metabolism are associated with cardiometabolic disease. Objective: This study sought to evaluate the interrelationships among factors purported to regulate VLDL-TG metabolism in a large cohort of men and women with a wide range in body adiposity and fat distribution but without diabetes. Subjects and Design: We assessed body composition and fat distribution, plasma insulin concentration, free fatty acid availability, and basal VLDL-TG and VLDL-apoB-100 (VLDL particle number) kinetics in 233 lean, overweight, and obese men and women. Results: We found that: 1) plasma VLDL-TG concentration is determined primarily by VLDL-TG secretion rate (SR) in men and by VLDL-TG clearance rate in women; 2) there is a dissociation between VLDL-TG and VLDL-apoB-100 SRs, and VLDL-apoB-100 SR only explains ∼30% of the variance in VLDL-TG SR; 3) ∼50% of people with obesity have high plasma VLDL-TG concentration due to both an increased VLDL-TG SR and a decreased rate of VLDL-TG plasma clearance, and they have lower plasma high-density lipoprotein-cholesterol concentration and more intra-abdominal and liver fat than those with normal VLDL-TG concentration; and 4) fat-free mass, liver fat content and the rate of free fatty acid release into plasma are independent predictors (with a sex × race interaction) of VLDL-TG SR. Conclusions: The regulation of plasma VLDL-TG concentration is complex and influenced by multiple metabolic factors. Many people with obesity have normal plasma VLDL-TG concentrations and kinetics, whereas those with high plasma VLDL-TG concentrations have increased VLDL-TG SR and other markers of cardiometabolic disease risk. Fat-free mass, intra-hepatic triglyceride content and fatty acid rate of appearance in plasma were identified as statistically independent predictors (with a sex by race interaction) of VLDL-TG secretion rate.
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4Apolipoprotein B-100 - metabolism
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authorMittendorfer, Bettina ; Yoshino, Mihoko ; Patterson, Bruce W ; Klein, Samuel
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notesThis work was supported by National Institutes of Health grants DK 37948, AT 0110, AR 49869, HD 57796, DK 94483, DK 56341 (Washington University School of Medicine Nutrition and Obesity Research Center), DK 020579 (Washington University School of Medicine Diabetes Research Center), GM 103422 (Washington University School of Medicine Biomedical Mass Spectrometry Resource), UL1 TR000448 (Washington University School of Medicine Clinical Translational Science Award), T32 DK07296, and DK007120 (Diabetes Research Postdoctoral Training Program) and grants from the International Life Sciences Foundation, the American Heart Association (0365436Z and 0510015Z), and the Pershing Square Foundation.
abstractContext: High-plasma very low-density lipoprotein (VLDL) triglyceride (TG) concentration and alterations in VLDL-TG metabolism are associated with cardiometabolic disease. Objective: This study sought to evaluate the interrelationships among factors purported to regulate VLDL-TG metabolism in a large cohort of men and women with a wide range in body adiposity and fat distribution but without diabetes. Subjects and Design: We assessed body composition and fat distribution, plasma insulin concentration, free fatty acid availability, and basal VLDL-TG and VLDL-apoB-100 (VLDL particle number) kinetics in 233 lean, overweight, and obese men and women. Results: We found that: 1) plasma VLDL-TG concentration is determined primarily by VLDL-TG secretion rate (SR) in men and by VLDL-TG clearance rate in women; 2) there is a dissociation between VLDL-TG and VLDL-apoB-100 SRs, and VLDL-apoB-100 SR only explains ∼30% of the variance in VLDL-TG SR; 3) ∼50% of people with obesity have high plasma VLDL-TG concentration due to both an increased VLDL-TG SR and a decreased rate of VLDL-TG plasma clearance, and they have lower plasma high-density lipoprotein-cholesterol concentration and more intra-abdominal and liver fat than those with normal VLDL-TG concentration; and 4) fat-free mass, liver fat content and the rate of free fatty acid release into plasma are independent predictors (with a sex × race interaction) of VLDL-TG SR. Conclusions: The regulation of plasma VLDL-TG concentration is complex and influenced by multiple metabolic factors. Many people with obesity have normal plasma VLDL-TG concentrations and kinetics, whereas those with high plasma VLDL-TG concentrations have increased VLDL-TG SR and other markers of cardiometabolic disease risk. Fat-free mass, intra-hepatic triglyceride content and fatty acid rate of appearance in plasma were identified as statistically independent predictors (with a sex by race interaction) of VLDL-TG secretion rate.
copUnited States
pubEndocrine Society
pmid27588438
doi10.1210/jc.2016-1500
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