schliessen

Filtern

 

Bibliotheken

Phosphodiesterase type-5 inhibitor use in type 2 diabetes is associated with a reduction in all-cause mortality

ObjectiveExperimental evidence has shown potential cardioprotective actions of phosphodiesterase type-5 inhibitors (PDE5is). We investigated whether PDE5i use in patients with type 2 diabetes, with high-attendant cardiovascular risk, was associated with altered mortality in a retrospective cohort st... Full description

Journal Title: Heart 2016-11, Vol.102 (21), p.1750-1756
Main Author: Anderson, Simon G
Other Authors: Hutchings, David C , Woodward, Mark , Rahimi, Kazem , Rutter, Martin K , Kirby, Mike , Hackett, Geoff , Trafford, Andrew W , Heald, Adrian H
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: British Medical Association
ID: ISSN: 1355-6037
Link: https://www.ncbi.nlm.nih.gov/pubmed/27465053
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5099221
title: Phosphodiesterase type-5 inhibitor use in type 2 diabetes is associated with a reduction in all-cause mortality
format: Article
creator:
  • Anderson, Simon G
  • Hutchings, David C
  • Woodward, Mark
  • Rahimi, Kazem
  • Rutter, Martin K
  • Kirby, Mike
  • Hackett, Geoff
  • Trafford, Andrew W
  • Heald, Adrian H
subjects:
  • 1506
  • Abridged Index Medicus
  • Adult
  • Aged
  • Aged, 80 and over
  • Cardiac Risk Factors
  • Cardiac Risk Factors and Prevention
  • Cardiovascular Diseases - diagnosis
  • Cardiovascular Diseases - mortality
  • Cause of Death
  • Chi-Square Distribution
  • Databases, Factual
  • Diabetes Mellitus, Type 2 - diagnosis
  • Diabetes Mellitus, Type 2 - mortality
  • Electronic Health Records
  • England - epidemiology
  • Erectile Dysfunction - diagnosis
  • Erectile Dysfunction - drug therapy
  • Erectile Dysfunction - mortality
  • General Practice
  • Humans
  • Kaplan-Meier Estimate
  • Linear Models
  • Logistic Models
  • Male
  • Medical records
  • Middle Aged
  • Multivariate Analysis
  • Myocardial Infarction - diagnosis
  • Myocardial Infarction - mortality
  • Patient outcomes
  • Phosphodiesterase 5 Inhibitors - therapeutic use
  • Phosphodiesterases
  • Prevention
  • Protective Factors
  • Retrospective Studies
  • Risk Assessment
  • Risk Factors
  • Time Factors
  • Treatment Outcome
  • Type 2 diabetes
  • Usage
ispartof: Heart, 2016-11, Vol.102 (21), p.1750-1756
description: ObjectiveExperimental evidence has shown potential cardioprotective actions of phosphodiesterase type-5 inhibitors (PDE5is). We investigated whether PDE5i use in patients with type 2 diabetes, with high-attendant cardiovascular risk, was associated with altered mortality in a retrospective cohort study.Research design and methodsBetween January 2007 and May 2015, 5956 men aged 40–89 years diagnosed with type 2 diabetes before 2007 were identified from anonymised electronic health records of 42 general practices in Cheshire, UK, and were followed for 7.5 years. HRs from multivariable survival (accelerated failure time, Weibull) models were used to describe the association between on-demand PDE5i use and all-cause mortality.SM110.1136/heartjnl-2015-309223.supp1Supplementary appendixResultsCompared with non-users, men who are prescribed PDE5is (n=1359) experienced lower percentage of deaths during follow-up (19.1% vs 23.8%) and lower risk of all-cause mortality (unadjusted HR=0.69 (95% CI: 0.64 to 0.79); p
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1355-6037
fulltext: fulltext
issn:
  • 1355-6037
  • 1468-201X
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.6511877
LOCALfalse
PrimoNMBib
record
control
sourceidgale_pubme
recordidTN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5099221
sourceformatXML
sourcesystemPC
galeidA480572647
sourcerecordidA480572647
originalsourceidFETCH-LOGICAL-1639t-19394bb5c027271a828bce67e171401a3d5e3c2f4316b1c0e632918ce7121d4d3
addsrcrecordideNqNUl1r1jAYLaK4Of0HIgVvvOmW77ZeCGP4BUO9UPAupMnTNS9t8pqkG--_N7X78B0DpYSGJ-ccznM4RfESo2OMqTgZQIW0cWNFEOYVRS0h9FFxiJloltHPx_lOOa8EovVB8SzGDUKItY14WhyQmgmOOD0s_LfBx-3gjYWYIKgIZdptoeKldYPtbPKhnPPQuj_zkpTGqg4SxNLGUsXotVUJTHll01CqMoCZdbLeLQw1jpVWC33yIanRpt3z4kmvxggvrv9HxY8P77-ffarOv378fHZ6XmFB21Thlras67hGpCY1Vg1pOg2iBlxjhrCihgPVpGcUiw5rBIKSFjcaakywYYYeFe9W3e3cTWA0uBTUKLfBTirspFdW7r84O8gLfyk5anOSOAt8WQX8FpyyAfa4xkGSJu-6lVe9RAjnA4JBn72ImgjCaS_yBlQ3CmvRCciCb64dBf9rzmnLyUYN46gc-DlK3BBRUy5onaGv70E3fg4u55VRAjWE0gbfoS7UCNK63udF9CIqT1mDeLbBFq3jB1D5MzBZ7R30Ns_3CK8eIMi_AWwF6OBjDNDfJoORXKopb6opl2rKtZp3umvut6SbLmbA23u62ia1dCkbsOO_1E9Wcjdt_s_Pb_xlATU
sourcetypeOpen Access Repository
isCDItrue
recordtypearticle
pqid1860823381
display
typearticle
titlePhosphodiesterase type-5 inhibitor use in type 2 diabetes is associated with a reduction in all-cause mortality
sourceAlma/SFX Local Collection
creatorAnderson, Simon G ; Hutchings, David C ; Woodward, Mark ; Rahimi, Kazem ; Rutter, Martin K ; Kirby, Mike ; Hackett, Geoff ; Trafford, Andrew W ; Heald, Adrian H
creatorcontribAnderson, Simon G ; Hutchings, David C ; Woodward, Mark ; Rahimi, Kazem ; Rutter, Martin K ; Kirby, Mike ; Hackett, Geoff ; Trafford, Andrew W ; Heald, Adrian H
descriptionObjectiveExperimental evidence has shown potential cardioprotective actions of phosphodiesterase type-5 inhibitors (PDE5is). We investigated whether PDE5i use in patients with type 2 diabetes, with high-attendant cardiovascular risk, was associated with altered mortality in a retrospective cohort study.Research design and methodsBetween January 2007 and May 2015, 5956 men aged 40–89 years diagnosed with type 2 diabetes before 2007 were identified from anonymised electronic health records of 42 general practices in Cheshire, UK, and were followed for 7.5 years. HRs from multivariable survival (accelerated failure time, Weibull) models were used to describe the association between on-demand PDE5i use and all-cause mortality.SM110.1136/heartjnl-2015-309223.supp1Supplementary appendixResultsCompared with non-users, men who are prescribed PDE5is (n=1359) experienced lower percentage of deaths during follow-up (19.1% vs 23.8%) and lower risk of all-cause mortality (unadjusted HR=0.69 (95% CI: 0.64 to 0.79); p<0.001)). The reduction in risk of mortality (HR=0.54 (0.36 to 0.80); p=0.002) remained after adjusting for age, estimated glomerular filtration rate, smoking status, prior cerebrovascular accident (CVA) hypertension, prior myocardial infarction (MI), systolic blood pressure, use of statin, metformin, aspirin and β-blocker medication. PDE5i users had lower rates of incident MI (incidence rate ratio (0.62 (0.49 to 0.80), p<0.0001) with lower mortality (25.7% vs 40.1% deaths; age-adjusted HR=0.60 (0.54 to 0.69); p=0.001) compared with non-users within this subgroup.ConclusionIn a population of men with type 2 diabetes, use of PDE5is was associated with lower risk of overall mortality and mortality in those with a history of acute MI.
identifier
0ISSN: 1355-6037
1EISSN: 1468-201X
2DOI: 10.1136/heartjnl-2015-309223
3PMID: 27465053
languageeng
publisherEngland: British Medical Association
subject1506 ; Abridged Index Medicus ; Adult ; Aged ; Aged, 80 and over ; Cardiac Risk Factors ; Cardiac Risk Factors and Prevention ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - mortality ; Cause of Death ; Chi-Square Distribution ; Databases, Factual ; Diabetes Mellitus, Type 2 - diagnosis ; Diabetes Mellitus, Type 2 - mortality ; Electronic Health Records ; England - epidemiology ; Erectile Dysfunction - diagnosis ; Erectile Dysfunction - drug therapy ; Erectile Dysfunction - mortality ; General Practice ; Humans ; Kaplan-Meier Estimate ; Linear Models ; Logistic Models ; Male ; Medical records ; Middle Aged ; Multivariate Analysis ; Myocardial Infarction - diagnosis ; Myocardial Infarction - mortality ; Patient outcomes ; Phosphodiesterase 5 Inhibitors - therapeutic use ; Phosphodiesterases ; Prevention ; Protective Factors ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome ; Type 2 diabetes ; Usage
ispartofHeart, 2016-11, Vol.102 (21), p.1750-1756
rights
0Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing
1Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.
2Copyright: 2016 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing
3Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ 2016
lds50peer_reviewed
oafree_for_read
citedbyFETCH-LOGICAL-1639t-19394bb5c027271a828bce67e171401a3d5e3c2f4316b1c0e632918ce7121d4d3
citesFETCH-LOGICAL-1639t-19394bb5c027271a828bce67e171401a3d5e3c2f4316b1c0e632918ce7121d4d3
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27465053$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Anderson, Simon G
1Hutchings, David C
2Woodward, Mark
3Rahimi, Kazem
4Rutter, Martin K
5Kirby, Mike
6Hackett, Geoff
7Trafford, Andrew W
8Heald, Adrian H
title
0Phosphodiesterase type-5 inhibitor use in type 2 diabetes is associated with a reduction in all-cause mortality
1Heart
addtitleHeart
descriptionObjectiveExperimental evidence has shown potential cardioprotective actions of phosphodiesterase type-5 inhibitors (PDE5is). We investigated whether PDE5i use in patients with type 2 diabetes, with high-attendant cardiovascular risk, was associated with altered mortality in a retrospective cohort study.Research design and methodsBetween January 2007 and May 2015, 5956 men aged 40–89 years diagnosed with type 2 diabetes before 2007 were identified from anonymised electronic health records of 42 general practices in Cheshire, UK, and were followed for 7.5 years. HRs from multivariable survival (accelerated failure time, Weibull) models were used to describe the association between on-demand PDE5i use and all-cause mortality.SM110.1136/heartjnl-2015-309223.supp1Supplementary appendixResultsCompared with non-users, men who are prescribed PDE5is (n=1359) experienced lower percentage of deaths during follow-up (19.1% vs 23.8%) and lower risk of all-cause mortality (unadjusted HR=0.69 (95% CI: 0.64 to 0.79); p<0.001)). The reduction in risk of mortality (HR=0.54 (0.36 to 0.80); p=0.002) remained after adjusting for age, estimated glomerular filtration rate, smoking status, prior cerebrovascular accident (CVA) hypertension, prior myocardial infarction (MI), systolic blood pressure, use of statin, metformin, aspirin and β-blocker medication. PDE5i users had lower rates of incident MI (incidence rate ratio (0.62 (0.49 to 0.80), p<0.0001) with lower mortality (25.7% vs 40.1% deaths; age-adjusted HR=0.60 (0.54 to 0.69); p=0.001) compared with non-users within this subgroup.ConclusionIn a population of men with type 2 diabetes, use of PDE5is was associated with lower risk of overall mortality and mortality in those with a history of acute MI.
subject
01506
1Abridged Index Medicus
2Adult
3Aged
4Aged, 80 and over
5Cardiac Risk Factors
6Cardiac Risk Factors and Prevention
7Cardiovascular Diseases - diagnosis
8Cardiovascular Diseases - mortality
9Cause of Death
10Chi-Square Distribution
11Databases, Factual
12Diabetes Mellitus, Type 2 - diagnosis
13Diabetes Mellitus, Type 2 - mortality
14Electronic Health Records
15England - epidemiology
16Erectile Dysfunction - diagnosis
17Erectile Dysfunction - drug therapy
18Erectile Dysfunction - mortality
19General Practice
20Humans
21Kaplan-Meier Estimate
22Linear Models
23Logistic Models
24Male
25Medical records
26Middle Aged
27Multivariate Analysis
28Myocardial Infarction - diagnosis
29Myocardial Infarction - mortality
30Patient outcomes
31Phosphodiesterase 5 Inhibitors - therapeutic use
32Phosphodiesterases
33Prevention
34Protective Factors
35Retrospective Studies
36Risk Assessment
37Risk Factors
38Time Factors
39Treatment Outcome
40Type 2 diabetes
41Usage
issn
01355-6037
11468-201X
fulltexttrue
rsrctypearticle
creationdate2016
recordtypearticle
recordideNqNUl1r1jAYLaK4Of0HIgVvvOmW77ZeCGP4BUO9UPAupMnTNS9t8pqkG--_N7X78B0DpYSGJ-ccznM4RfESo2OMqTgZQIW0cWNFEOYVRS0h9FFxiJloltHPx_lOOa8EovVB8SzGDUKItY14WhyQmgmOOD0s_LfBx-3gjYWYIKgIZdptoeKldYPtbPKhnPPQuj_zkpTGqg4SxNLGUsXotVUJTHll01CqMoCZdbLeLQw1jpVWC33yIanRpt3z4kmvxggvrv9HxY8P77-ffarOv378fHZ6XmFB21Thlras67hGpCY1Vg1pOg2iBlxjhrCihgPVpGcUiw5rBIKSFjcaakywYYYeFe9W3e3cTWA0uBTUKLfBTirspFdW7r84O8gLfyk5anOSOAt8WQX8FpyyAfa4xkGSJu-6lVe9RAjnA4JBn72ImgjCaS_yBlQ3CmvRCciCb64dBf9rzmnLyUYN46gc-DlK3BBRUy5onaGv70E3fg4u55VRAjWE0gbfoS7UCNK63udF9CIqT1mDeLbBFq3jB1D5MzBZ7R30Ns_3CK8eIMi_AWwF6OBjDNDfJoORXKopb6opl2rKtZp3umvut6SbLmbA23u62ia1dCkbsOO_1E9Wcjdt_s_Pb_xlATU
startdate201611
enddate201611
creator
0Anderson, Simon G
1Hutchings, David C
2Woodward, Mark
3Rahimi, Kazem
4Rutter, Martin K
5Kirby, Mike
6Hackett, Geoff
7Trafford, Andrew W
8Heald, Adrian H
general
0British Medical Association
1BMJ Publishing Group Ltd
2BMJ Publishing Group LTD
3BMJ Publishing Group
scope
09YT
1ACMMV
2CGR
3CUY
4CVF
5ECM
6EIF
7NPM
8AAYXX
9CITATION
10BKMMT
11BSHEE
123V.
137X7
147XB
1588E
1688I
178AF
188FI
198FJ
208FK
21ABUWG
22AZQEC
23BENPR
24BTHHO
25DWQXO
26FYUFA
27GHDGH
28GNUQQ
29HCIFZ
30K9.
31M0S
32M1P
33M2P
34PQEST
35PQQKQ
36PQUKI
37PRINS
38Q9U
397X8
40BOBZL
41CLFQK
425PM
sort
creationdate201611
titlePhosphodiesterase type-5 inhibitor use in type 2 diabetes is associated with a reduction in all-cause mortality
authorAnderson, Simon G ; Hutchings, David C ; Woodward, Mark ; Rahimi, Kazem ; Rutter, Martin K ; Kirby, Mike ; Hackett, Geoff ; Trafford, Andrew W ; Heald, Adrian H
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1639t-19394bb5c027271a828bce67e171401a3d5e3c2f4316b1c0e632918ce7121d4d3
rsrctypearticles
prefilterarticles
languageeng
creationdate2016
topic
01506
1Abridged Index Medicus
2Adult
3Aged
4Aged, 80 and over
5Cardiac Risk Factors
6Cardiac Risk Factors and Prevention
7Cardiovascular Diseases - diagnosis
8Cardiovascular Diseases - mortality
9Cause of Death
10Chi-Square Distribution
11Databases, Factual
12Diabetes Mellitus, Type 2 - diagnosis
13Diabetes Mellitus, Type 2 - mortality
14Electronic Health Records
15England - epidemiology
16Erectile Dysfunction - diagnosis
17Erectile Dysfunction - drug therapy
18Erectile Dysfunction - mortality
19General Practice
20Humans
21Kaplan-Meier Estimate
22Linear Models
23Logistic Models
24Male
25Medical records
26Middle Aged
27Multivariate Analysis
28Myocardial Infarction - diagnosis
29Myocardial Infarction - mortality
30Patient outcomes
31Phosphodiesterase 5 Inhibitors - therapeutic use
32Phosphodiesterases
33Prevention
34Protective Factors
35Retrospective Studies
36Risk Assessment
37Risk Factors
38Time Factors
39Treatment Outcome
40Type 2 diabetes
41Usage
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Anderson, Simon G
1Hutchings, David C
2Woodward, Mark
3Rahimi, Kazem
4Rutter, Martin K
5Kirby, Mike
6Hackett, Geoff
7Trafford, Andrew W
8Heald, Adrian H
collection
0BMJ Open Access Journals
1BMJ Journals:Open Access
2Medline
3MEDLINE
4MEDLINE (Ovid)
5MEDLINE
6MEDLINE
7PubMed
8CrossRef
9Gale General OneFile (A&I only)
10Academic OneFile (A&I only)
11ProQuest Central (Corporate)
12Health & Medical Collection
13ProQuest Central (purchase pre-March 2016)
14Medical Database (Alumni Edition)
15Science Database (Alumni Edition)
16STEM Database
17Hospital Premium Collection
18Hospital Premium Collection (Alumni Edition)
19ProQuest Central (Alumni) (purchase pre-March 2016)
20ProQuest Central (Alumni Edition)
21ProQuest Central Essentials
22ProQuest Central
23BMJ Journals
24ProQuest Central Korea
25Health Research Premium Collection
26Health Research Premium Collection (Alumni)
27ProQuest Central Student
28SciTech Premium Collection
29ProQuest Health & Medical Complete (Alumni)
30Health & Medical Collection (Alumni Edition)
31Medical Database
32Science Database
33ProQuest One Academic Eastern Edition
34ProQuest One Academic
35ProQuest One Academic UKI Edition
36ProQuest Central China
37ProQuest Central Basic
38MEDLINE - Academic
39OpenAIRE (Open Access)
40OpenAIRE
41PubMed Central (Full Participant titles)
jtitleHeart
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Anderson, Simon G
1Hutchings, David C
2Woodward, Mark
3Rahimi, Kazem
4Rutter, Martin K
5Kirby, Mike
6Hackett, Geoff
7Trafford, Andrew W
8Heald, Adrian H
formatjournal
genrearticle
ristypeJOUR
atitlePhosphodiesterase type-5 inhibitor use in type 2 diabetes is associated with a reduction in all-cause mortality
jtitleHeart
addtitleHeart
seriestitleOriginal article
date2016-11
risdate2016
volume102
issue21
spage1750
epage1756
pages1750-1756
issn1355-6037
eissn1468-201X
notesSGA and DCH contributed equally to this study.
abstractObjectiveExperimental evidence has shown potential cardioprotective actions of phosphodiesterase type-5 inhibitors (PDE5is). We investigated whether PDE5i use in patients with type 2 diabetes, with high-attendant cardiovascular risk, was associated with altered mortality in a retrospective cohort study.Research design and methodsBetween January 2007 and May 2015, 5956 men aged 40–89 years diagnosed with type 2 diabetes before 2007 were identified from anonymised electronic health records of 42 general practices in Cheshire, UK, and were followed for 7.5 years. HRs from multivariable survival (accelerated failure time, Weibull) models were used to describe the association between on-demand PDE5i use and all-cause mortality.SM110.1136/heartjnl-2015-309223.supp1Supplementary appendixResultsCompared with non-users, men who are prescribed PDE5is (n=1359) experienced lower percentage of deaths during follow-up (19.1% vs 23.8%) and lower risk of all-cause mortality (unadjusted HR=0.69 (95% CI: 0.64 to 0.79); p<0.001)). The reduction in risk of mortality (HR=0.54 (0.36 to 0.80); p=0.002) remained after adjusting for age, estimated glomerular filtration rate, smoking status, prior cerebrovascular accident (CVA) hypertension, prior myocardial infarction (MI), systolic blood pressure, use of statin, metformin, aspirin and β-blocker medication. PDE5i users had lower rates of incident MI (incidence rate ratio (0.62 (0.49 to 0.80), p<0.0001) with lower mortality (25.7% vs 40.1% deaths; age-adjusted HR=0.60 (0.54 to 0.69); p=0.001) compared with non-users within this subgroup.ConclusionIn a population of men with type 2 diabetes, use of PDE5is was associated with lower risk of overall mortality and mortality in those with a history of acute MI.
copEngland
pubBritish Medical Association
pmid27465053
doi10.1136/heartjnl-2015-309223
oafree_for_read