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Cap Inflammation Leads to Higher Plaque Cap Strain and Lower Cap Stress: An MRI-PET/CT-Based FSI Modeling Approach

Abstract Plaque rupture may be triggered by extreme stress/strain conditions. Inflammation is also implicated and can be imaged using novel imaging techniques. The impact of cap inflammation on plaque stress/strain and flow shear stress were investigated. A patient-specific MRI-PET/CT-based modeling... Full description

Journal Title: Journal of biomechanics 2016, Vol.50, p.121-129
Main Author: Tang, Dalin
Other Authors: Yang, Chun , Huang, Sarayu , Mani, Venkatesh , Zheng, Jie , Woodard, Pamela K , Robson, Philip , Teng, Zhongzhao , Dweck, Marc , Fayad, Zahi A
Format: Electronic Article Electronic Article
Language: English
Subjects:
Age
NMR
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Ltd
ID: ISSN: 0021-9290
Link: https://www.ncbi.nlm.nih.gov/pubmed/27847118
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5191978
title: Cap Inflammation Leads to Higher Plaque Cap Strain and Lower Cap Stress: An MRI-PET/CT-Based FSI Modeling Approach
format: Article
creator:
  • Tang, Dalin
  • Yang, Chun
  • Huang, Sarayu
  • Mani, Venkatesh
  • Zheng, Jie
  • Woodard, Pamela K
  • Robson, Philip
  • Teng, Zhongzhao
  • Dweck, Marc
  • Fayad, Zahi A
subjects:
  • Age
  • Aged
  • Aorta
  • Arteries
  • Arteriosclerosis
  • Arteritis - diagnostic imaging
  • Arteritis - pathology
  • Atherosclerosis
  • Biomechanical Phenomena
  • Biomedical engineering
  • Blood
  • Blood flow
  • Blood pressure
  • Body weight
  • Calcification (ectopic)
  • Cardiovascular disease
  • Cardiovascular diseases
  • Carotid arteries
  • Carotid Arteries - diagnostic imaging
  • Carotid Arteries - pathology
  • Carotid artery
  • Carotid Artery Diseases - diagnostic imaging
  • Carotid Artery Diseases - pathology
  • Computational neuroscience
  • Computed tomography
  • Computer applications
  • Computer programs
  • Coronary artery
  • Coronary artery disease
  • Data acquisition
  • Fluid flow
  • Geometry
  • Heart diseases
  • Humans
  • Hypertension
  • Hypotheses
  • Inflammation
  • Magnetic Resonance Imaging
  • Male
  • Medical colleges
  • Medical imaging
  • Medical research
  • Medicine, Experimental
  • Models
  • Models, Cardiovascular
  • Neuroimaging
  • NMR
  • Nuclear magnetic resonance
  • Patients
  • PET imaging
  • Physical Medicine and Rehabilitation
  • Plaque rupture
  • Plaque, Atherosclerotic - diagnostic imaging
  • Plaque, Atherosclerotic - pathology
  • Positron emission tomography
  • Positron Emission Tomography Computed Tomography
  • Regional Blood Flow
  • Resonance
  • Risk assessment
  • Risk factors
  • Rupture
  • Shear stress
  • Software
  • Stress
  • Stress-strain relationships
  • Stroke
  • Tomography
  • Velocity
  • Vulnerable plaque
  • Yield strength
ispartof: Journal of biomechanics, 2016, Vol.50, p.121-129
description: Abstract Plaque rupture may be triggered by extreme stress/strain conditions. Inflammation is also implicated and can be imaged using novel imaging techniques. The impact of cap inflammation on plaque stress/strain and flow shear stress were investigated. A patient-specific MRI-PET/CT-based modeling approach was used to develop 3D fluid-structure interaction models and investigate the impact of inflammation on plaque stress/strain conditions for better plaque assessment. 18FDG-PET/CT and MRI data were acquired from 4 male patients (average age: 66) to assess plaque characteristics and inflammation. Material stiffness for the fibrous cap was adjusted lower to reflect cap weakening causing by inflammation. Setting stiffness ratio (SR) to be 1.0 (fibrous tissue) for baseline, results for SR=0.5, 0.25, and 0.1 were obtained. Thin cap and hypertension were also considered. Combining results from the 4 patients, mean cap stress from 729 cap nodes was lowered by 25.2% as SR went from 1.0 to 0.1. Mean cap strain value for SR=0.1 was 0.313, 114% higher than that from SR=1.0 model. The thin cap SR=0.1 model had 40% mean cap stress decrease and 81% cap strain increase compared with SR=1.0 model. The hypertension SR=0.1 model had 19.5% cap stress decrease and 98.6% cap strain increase compared with SR=1.0 model. Differences of flow shear stress with 4 different SR values were limited (
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0021-9290
fulltext: fulltext
issn:
  • 0021-9290
  • 1873-2380
url: Link


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titleCap Inflammation Leads to Higher Plaque Cap Strain and Lower Cap Stress: An MRI-PET/CT-Based FSI Modeling Approach
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creatorTang, Dalin ; Yang, Chun ; Huang, Sarayu ; Mani, Venkatesh ; Zheng, Jie ; Woodard, Pamela K ; Robson, Philip ; Teng, Zhongzhao ; Dweck, Marc ; Fayad, Zahi A
creatorcontribTang, Dalin ; Yang, Chun ; Huang, Sarayu ; Mani, Venkatesh ; Zheng, Jie ; Woodard, Pamela K ; Robson, Philip ; Teng, Zhongzhao ; Dweck, Marc ; Fayad, Zahi A
descriptionAbstract Plaque rupture may be triggered by extreme stress/strain conditions. Inflammation is also implicated and can be imaged using novel imaging techniques. The impact of cap inflammation on plaque stress/strain and flow shear stress were investigated. A patient-specific MRI-PET/CT-based modeling approach was used to develop 3D fluid-structure interaction models and investigate the impact of inflammation on plaque stress/strain conditions for better plaque assessment. 18FDG-PET/CT and MRI data were acquired from 4 male patients (average age: 66) to assess plaque characteristics and inflammation. Material stiffness for the fibrous cap was adjusted lower to reflect cap weakening causing by inflammation. Setting stiffness ratio (SR) to be 1.0 (fibrous tissue) for baseline, results for SR=0.5, 0.25, and 0.1 were obtained. Thin cap and hypertension were also considered. Combining results from the 4 patients, mean cap stress from 729 cap nodes was lowered by 25.2% as SR went from 1.0 to 0.1. Mean cap strain value for SR=0.1 was 0.313, 114% higher than that from SR=1.0 model. The thin cap SR=0.1 model had 40% mean cap stress decrease and 81% cap strain increase compared with SR=1.0 model. The hypertension SR=0.1 model had 19.5% cap stress decrease and 98.6% cap strain increase compared with SR=1.0 model. Differences of flow shear stress with 4 different SR values were limited (<10%). Cap inflammation may lead to large cap strain conditions when combined with thin cap and hypertension. Inflammation also led to lower cap stress. This shows the influence of inflammation on stress/strain calculations which are closely related to plaque assessment.
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1EISSN: 1873-2380
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3PMID: 27847118
languageeng
publisherUnited States: Elsevier Ltd
subjectAge ; Aged ; Aorta ; Arteries ; Arteriosclerosis ; Arteritis - diagnostic imaging ; Arteritis - pathology ; Atherosclerosis ; Biomechanical Phenomena ; Biomedical engineering ; Blood ; Blood flow ; Blood pressure ; Body weight ; Calcification (ectopic) ; Cardiovascular disease ; Cardiovascular diseases ; Carotid arteries ; Carotid Arteries - diagnostic imaging ; Carotid Arteries - pathology ; Carotid artery ; Carotid Artery Diseases - diagnostic imaging ; Carotid Artery Diseases - pathology ; Computational neuroscience ; Computed tomography ; Computer applications ; Computer programs ; Coronary artery ; Coronary artery disease ; Data acquisition ; Fluid flow ; Geometry ; Heart diseases ; Humans ; Hypertension ; Hypotheses ; Inflammation ; Magnetic Resonance Imaging ; Male ; Medical colleges ; Medical imaging ; Medical research ; Medicine, Experimental ; Models ; Models, Cardiovascular ; Neuroimaging ; NMR ; Nuclear magnetic resonance ; Patients ; PET imaging ; Physical Medicine and Rehabilitation ; Plaque rupture ; Plaque, Atherosclerotic - diagnostic imaging ; Plaque, Atherosclerotic - pathology ; Positron emission tomography ; Positron Emission Tomography Computed Tomography ; Regional Blood Flow ; Resonance ; Risk assessment ; Risk factors ; Rupture ; Shear stress ; Software ; Stress ; Stress-strain relationships ; Stroke ; Tomography ; Velocity ; Vulnerable plaque ; Yield strength
ispartofJournal of biomechanics, 2016, Vol.50, p.121-129
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0Tang, Dalin
1Yang, Chun
2Huang, Sarayu
3Mani, Venkatesh
4Zheng, Jie
5Woodard, Pamela K
6Robson, Philip
7Teng, Zhongzhao
8Dweck, Marc
9Fayad, Zahi A
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0Cap Inflammation Leads to Higher Plaque Cap Strain and Lower Cap Stress: An MRI-PET/CT-Based FSI Modeling Approach
1Journal of biomechanics
addtitleJ Biomech
descriptionAbstract Plaque rupture may be triggered by extreme stress/strain conditions. Inflammation is also implicated and can be imaged using novel imaging techniques. The impact of cap inflammation on plaque stress/strain and flow shear stress were investigated. A patient-specific MRI-PET/CT-based modeling approach was used to develop 3D fluid-structure interaction models and investigate the impact of inflammation on plaque stress/strain conditions for better plaque assessment. 18FDG-PET/CT and MRI data were acquired from 4 male patients (average age: 66) to assess plaque characteristics and inflammation. Material stiffness for the fibrous cap was adjusted lower to reflect cap weakening causing by inflammation. Setting stiffness ratio (SR) to be 1.0 (fibrous tissue) for baseline, results for SR=0.5, 0.25, and 0.1 were obtained. Thin cap and hypertension were also considered. Combining results from the 4 patients, mean cap stress from 729 cap nodes was lowered by 25.2% as SR went from 1.0 to 0.1. Mean cap strain value for SR=0.1 was 0.313, 114% higher than that from SR=1.0 model. The thin cap SR=0.1 model had 40% mean cap stress decrease and 81% cap strain increase compared with SR=1.0 model. The hypertension SR=0.1 model had 19.5% cap stress decrease and 98.6% cap strain increase compared with SR=1.0 model. Differences of flow shear stress with 4 different SR values were limited (<10%). Cap inflammation may lead to large cap strain conditions when combined with thin cap and hypertension. Inflammation also led to lower cap stress. This shows the influence of inflammation on stress/strain calculations which are closely related to plaque assessment.
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0Age
1Aged
2Aorta
3Arteries
4Arteriosclerosis
5Arteritis - diagnostic imaging
6Arteritis - pathology
7Atherosclerosis
8Biomechanical Phenomena
9Biomedical engineering
10Blood
11Blood flow
12Blood pressure
13Body weight
14Calcification (ectopic)
15Cardiovascular disease
16Cardiovascular diseases
17Carotid arteries
18Carotid Arteries - diagnostic imaging
19Carotid Arteries - pathology
20Carotid artery
21Carotid Artery Diseases - diagnostic imaging
22Carotid Artery Diseases - pathology
23Computational neuroscience
24Computed tomography
25Computer applications
26Computer programs
27Coronary artery
28Coronary artery disease
29Data acquisition
30Fluid flow
31Geometry
32Heart diseases
33Humans
34Hypertension
35Hypotheses
36Inflammation
37Magnetic Resonance Imaging
38Male
39Medical colleges
40Medical imaging
41Medical research
42Medicine, Experimental
43Models
44Models, Cardiovascular
45Neuroimaging
46NMR
47Nuclear magnetic resonance
48Patients
49PET imaging
50Physical Medicine and Rehabilitation
51Plaque rupture
52Plaque, Atherosclerotic - diagnostic imaging
53Plaque, Atherosclerotic - pathology
54Positron emission tomography
55Positron Emission Tomography Computed Tomography
56Regional Blood Flow
57Resonance
58Risk assessment
59Risk factors
60Rupture
61Shear stress
62Software
63Stress
64Stress-strain relationships
65Stroke
66Tomography
67Velocity
68Vulnerable plaque
69Yield strength
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3Mani, Venkatesh
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5Woodard, Pamela K
6Robson, Philip
7Teng, Zhongzhao
8Dweck, Marc
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titleCap Inflammation Leads to Higher Plaque Cap Strain and Lower Cap Stress: An MRI-PET/CT-Based FSI Modeling Approach
authorTang, Dalin ; Yang, Chun ; Huang, Sarayu ; Mani, Venkatesh ; Zheng, Jie ; Woodard, Pamela K ; Robson, Philip ; Teng, Zhongzhao ; Dweck, Marc ; Fayad, Zahi A
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2Aorta
3Arteries
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5Arteritis - diagnostic imaging
6Arteritis - pathology
7Atherosclerosis
8Biomechanical Phenomena
9Biomedical engineering
10Blood
11Blood flow
12Blood pressure
13Body weight
14Calcification (ectopic)
15Cardiovascular disease
16Cardiovascular diseases
17Carotid arteries
18Carotid Arteries - diagnostic imaging
19Carotid Arteries - pathology
20Carotid artery
21Carotid Artery Diseases - diagnostic imaging
22Carotid Artery Diseases - pathology
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24Computed tomography
25Computer applications
26Computer programs
27Coronary artery
28Coronary artery disease
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30Fluid flow
31Geometry
32Heart diseases
33Humans
34Hypertension
35Hypotheses
36Inflammation
37Magnetic Resonance Imaging
38Male
39Medical colleges
40Medical imaging
41Medical research
42Medicine, Experimental
43Models
44Models, Cardiovascular
45Neuroimaging
46NMR
47Nuclear magnetic resonance
48Patients
49PET imaging
50Physical Medicine and Rehabilitation
51Plaque rupture
52Plaque, Atherosclerotic - diagnostic imaging
53Plaque, Atherosclerotic - pathology
54Positron emission tomography
55Positron Emission Tomography Computed Tomography
56Regional Blood Flow
57Resonance
58Risk assessment
59Risk factors
60Rupture
61Shear stress
62Software
63Stress
64Stress-strain relationships
65Stroke
66Tomography
67Velocity
68Vulnerable plaque
69Yield strength
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abstractAbstract Plaque rupture may be triggered by extreme stress/strain conditions. Inflammation is also implicated and can be imaged using novel imaging techniques. The impact of cap inflammation on plaque stress/strain and flow shear stress were investigated. A patient-specific MRI-PET/CT-based modeling approach was used to develop 3D fluid-structure interaction models and investigate the impact of inflammation on plaque stress/strain conditions for better plaque assessment. 18FDG-PET/CT and MRI data were acquired from 4 male patients (average age: 66) to assess plaque characteristics and inflammation. Material stiffness for the fibrous cap was adjusted lower to reflect cap weakening causing by inflammation. Setting stiffness ratio (SR) to be 1.0 (fibrous tissue) for baseline, results for SR=0.5, 0.25, and 0.1 were obtained. Thin cap and hypertension were also considered. Combining results from the 4 patients, mean cap stress from 729 cap nodes was lowered by 25.2% as SR went from 1.0 to 0.1. Mean cap strain value for SR=0.1 was 0.313, 114% higher than that from SR=1.0 model. The thin cap SR=0.1 model had 40% mean cap stress decrease and 81% cap strain increase compared with SR=1.0 model. The hypertension SR=0.1 model had 19.5% cap stress decrease and 98.6% cap strain increase compared with SR=1.0 model. Differences of flow shear stress with 4 different SR values were limited (<10%). Cap inflammation may lead to large cap strain conditions when combined with thin cap and hypertension. Inflammation also led to lower cap stress. This shows the influence of inflammation on stress/strain calculations which are closely related to plaque assessment.
copUnited States
pubElsevier Ltd
pmid27847118
doi10.1016/j.jbiomech.2016.11.011
orcididhttps://orcid.org/0000-0002-0432-2918