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Association of Kidney Function and Early Kidney Injury With Incident Hypertension in HIV-Infected Women

Subclinical kidney disease is associated with developing hypertension in the general population, but data are lacking among HIV-infected people. We examined associations of kidney function and injury with incident hypertension in 823 HIV-infected and 267 HIV-uninfected women in the Women’s Interagen... Full description

Journal Title: Hypertension (Dallas Tex. 1979), 2017-02, Vol.69 (2), p.304-313
Main Author: Ascher, Simon B
Other Authors: Scherzer, Rebecca , Peralta, Carmen A , Tien, Phyllis C , Grunfeld, Carl , Estrella, Michelle M , Abraham, Alison , Gustafson, Deborah R , Nowicki, Marek , Sharma, Anjali , Cohen, Mardge H , Butch, Anthony W , Young, Mary A , Bennett, Michael R , Shlipak, Michael G
Format: Electronic Article Electronic Article
Language: English
Subjects:
HIV
Publisher: United States: American Heart Association, Inc
ID: ISSN: 0194-911X
Link: https://www.ncbi.nlm.nih.gov/pubmed/27993956
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5233560
title: Association of Kidney Function and Early Kidney Injury With Incident Hypertension in HIV-Infected Women
format: Article
creator:
  • Ascher, Simon B
  • Scherzer, Rebecca
  • Peralta, Carmen A
  • Tien, Phyllis C
  • Grunfeld, Carl
  • Estrella, Michelle M
  • Abraham, Alison
  • Gustafson, Deborah R
  • Nowicki, Marek
  • Sharma, Anjali
  • Cohen, Mardge H
  • Butch, Anthony W
  • Young, Mary A
  • Bennett, Michael R
  • Shlipak, Michael G
subjects:
  • Acute Kidney Injury - epidemiology
  • Acute Kidney Injury - etiology
  • Acute Kidney Injury - metabolism
  • Adult
  • albuminuria
  • Article
  • Biomarkers - urine
  • Female
  • glomerular filtration rate
  • Glomerular Filtration Rate - physiology
  • HIV
  • HIV Infections - complications
  • HIV Infections - epidemiology
  • Humans
  • hypertension
  • Hypertension - epidemiology
  • Hypertension - etiology
  • Hypertension - physiopathology
  • Incidence
  • Kidney
  • kidney disease
  • Prevalence
  • Retrospective Studies
  • United States - epidemiology
  • urine biomarker
ispartof: Hypertension (Dallas, Tex. 1979), 2017-02, Vol.69 (2), p.304-313
description: Subclinical kidney disease is associated with developing hypertension in the general population, but data are lacking among HIV-infected people. We examined associations of kidney function and injury with incident hypertension in 823 HIV-infected and 267 HIV-uninfected women in the Women’s Interagency HIV Study, a multicenter, prospective cohort of HIV-infected and uninfected women in the United States. Baseline kidney biomarkers included estimated glomerular filtration rate using cystatin C, urine albumin-to-creatinine ratio, and 7 urine biomarkers of tubular injuryα-1-microglobulin, interleukin-18, kidney injury molecule-1, neutrophil gelatinase–associated lipocalin, liver fatty acid–binding protein, N-acetyl-β-D-glucosaminidase, and α1-acid-glycoprotein. We used multivariable Poisson regression to evaluate associations of kidney biomarkers with incident hypertension, defined as 2 consecutive visits of antihypertensive medication use. During a median follow-up of 9.6 years, 288 HIV-infected women (35%) developed hypertension. Among the HIV-infected women, higher urine albumin-to-creatinine ratio was independently associated with incident hypertension (relative risk =1.13 per urine albumin-to-creatinine ratio doubling, 95% confidence interval, 1.07–1.20), as was lower estimated glomerular filtration rate (relative risk =1.10 per 10 mL/min/1.73 m lower estimated glomerular filtration rate; 95% confidence interval, 1.04–1.17). No tubular injury and dysfunction biomarkers were independently associated with incident hypertension in HIV-infected women. In contrast, among the HIV-uninfected women, urine albumin-to-creatinine ratio was not associated with incident hypertension, whereas higher urine interleukin-18, α1-acid-glycoprotein, and N-acetyl-β-D-glucosaminidase levels were significantly associated with incident hypertension. These findings suggest that early glomerular injury and kidney dysfunction may be involved in the pathogenesis of hypertension in HIV-infected people. The associations of tubular markers with hypertension in HIV-uninfected women should be validated in other studies.
language: eng
source:
identifier: ISSN: 0194-911X
fulltext: no_fulltext
issn:
  • 0194-911X
  • 1524-4563
url: Link


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titleAssociation of Kidney Function and Early Kidney Injury With Incident Hypertension in HIV-Infected Women
creatorAscher, Simon B ; Scherzer, Rebecca ; Peralta, Carmen A ; Tien, Phyllis C ; Grunfeld, Carl ; Estrella, Michelle M ; Abraham, Alison ; Gustafson, Deborah R ; Nowicki, Marek ; Sharma, Anjali ; Cohen, Mardge H ; Butch, Anthony W ; Young, Mary A ; Bennett, Michael R ; Shlipak, Michael G
creatorcontribAscher, Simon B ; Scherzer, Rebecca ; Peralta, Carmen A ; Tien, Phyllis C ; Grunfeld, Carl ; Estrella, Michelle M ; Abraham, Alison ; Gustafson, Deborah R ; Nowicki, Marek ; Sharma, Anjali ; Cohen, Mardge H ; Butch, Anthony W ; Young, Mary A ; Bennett, Michael R ; Shlipak, Michael G
descriptionSubclinical kidney disease is associated with developing hypertension in the general population, but data are lacking among HIV-infected people. We examined associations of kidney function and injury with incident hypertension in 823 HIV-infected and 267 HIV-uninfected women in the Women’s Interagency HIV Study, a multicenter, prospective cohort of HIV-infected and uninfected women in the United States. Baseline kidney biomarkers included estimated glomerular filtration rate using cystatin C, urine albumin-to-creatinine ratio, and 7 urine biomarkers of tubular injuryα-1-microglobulin, interleukin-18, kidney injury molecule-1, neutrophil gelatinase–associated lipocalin, liver fatty acid–binding protein, N-acetyl-β-D-glucosaminidase, and α1-acid-glycoprotein. We used multivariable Poisson regression to evaluate associations of kidney biomarkers with incident hypertension, defined as 2 consecutive visits of antihypertensive medication use. During a median follow-up of 9.6 years, 288 HIV-infected women (35%) developed hypertension. Among the HIV-infected women, higher urine albumin-to-creatinine ratio was independently associated with incident hypertension (relative risk =1.13 per urine albumin-to-creatinine ratio doubling, 95% confidence interval, 1.07–1.20), as was lower estimated glomerular filtration rate (relative risk =1.10 per 10 mL/min/1.73 m lower estimated glomerular filtration rate; 95% confidence interval, 1.04–1.17). No tubular injury and dysfunction biomarkers were independently associated with incident hypertension in HIV-infected women. In contrast, among the HIV-uninfected women, urine albumin-to-creatinine ratio was not associated with incident hypertension, whereas higher urine interleukin-18, α1-acid-glycoprotein, and N-acetyl-β-D-glucosaminidase levels were significantly associated with incident hypertension. These findings suggest that early glomerular injury and kidney dysfunction may be involved in the pathogenesis of hypertension in HIV-infected people. The associations of tubular markers with hypertension in HIV-uninfected women should be validated in other studies.
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subjectAcute Kidney Injury - epidemiology ; Acute Kidney Injury - etiology ; Acute Kidney Injury - metabolism ; Adult ; albuminuria ; Article ; Biomarkers - urine ; Female ; glomerular filtration rate ; Glomerular Filtration Rate - physiology ; HIV ; HIV Infections - complications ; HIV Infections - epidemiology ; Humans ; hypertension ; Hypertension - epidemiology ; Hypertension - etiology ; Hypertension - physiopathology ; Incidence ; Kidney ; kidney disease ; Prevalence ; Retrospective Studies ; United States - epidemiology ; urine biomarker
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9Sharma, Anjali
10Cohen, Mardge H
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descriptionSubclinical kidney disease is associated with developing hypertension in the general population, but data are lacking among HIV-infected people. We examined associations of kidney function and injury with incident hypertension in 823 HIV-infected and 267 HIV-uninfected women in the Women’s Interagency HIV Study, a multicenter, prospective cohort of HIV-infected and uninfected women in the United States. Baseline kidney biomarkers included estimated glomerular filtration rate using cystatin C, urine albumin-to-creatinine ratio, and 7 urine biomarkers of tubular injuryα-1-microglobulin, interleukin-18, kidney injury molecule-1, neutrophil gelatinase–associated lipocalin, liver fatty acid–binding protein, N-acetyl-β-D-glucosaminidase, and α1-acid-glycoprotein. We used multivariable Poisson regression to evaluate associations of kidney biomarkers with incident hypertension, defined as 2 consecutive visits of antihypertensive medication use. During a median follow-up of 9.6 years, 288 HIV-infected women (35%) developed hypertension. Among the HIV-infected women, higher urine albumin-to-creatinine ratio was independently associated with incident hypertension (relative risk =1.13 per urine albumin-to-creatinine ratio doubling, 95% confidence interval, 1.07–1.20), as was lower estimated glomerular filtration rate (relative risk =1.10 per 10 mL/min/1.73 m lower estimated glomerular filtration rate; 95% confidence interval, 1.04–1.17). No tubular injury and dysfunction biomarkers were independently associated with incident hypertension in HIV-infected women. In contrast, among the HIV-uninfected women, urine albumin-to-creatinine ratio was not associated with incident hypertension, whereas higher urine interleukin-18, α1-acid-glycoprotein, and N-acetyl-β-D-glucosaminidase levels were significantly associated with incident hypertension. These findings suggest that early glomerular injury and kidney dysfunction may be involved in the pathogenesis of hypertension in HIV-infected people. The associations of tubular markers with hypertension in HIV-uninfected women should be validated in other studies.
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titleAssociation of Kidney Function and Early Kidney Injury With Incident Hypertension in HIV-Infected Women
authorAscher, Simon B ; Scherzer, Rebecca ; Peralta, Carmen A ; Tien, Phyllis C ; Grunfeld, Carl ; Estrella, Michelle M ; Abraham, Alison ; Gustafson, Deborah R ; Nowicki, Marek ; Sharma, Anjali ; Cohen, Mardge H ; Butch, Anthony W ; Young, Mary A ; Bennett, Michael R ; Shlipak, Michael G
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abstractSubclinical kidney disease is associated with developing hypertension in the general population, but data are lacking among HIV-infected people. We examined associations of kidney function and injury with incident hypertension in 823 HIV-infected and 267 HIV-uninfected women in the Women’s Interagency HIV Study, a multicenter, prospective cohort of HIV-infected and uninfected women in the United States. Baseline kidney biomarkers included estimated glomerular filtration rate using cystatin C, urine albumin-to-creatinine ratio, and 7 urine biomarkers of tubular injuryα-1-microglobulin, interleukin-18, kidney injury molecule-1, neutrophil gelatinase–associated lipocalin, liver fatty acid–binding protein, N-acetyl-β-D-glucosaminidase, and α1-acid-glycoprotein. We used multivariable Poisson regression to evaluate associations of kidney biomarkers with incident hypertension, defined as 2 consecutive visits of antihypertensive medication use. During a median follow-up of 9.6 years, 288 HIV-infected women (35%) developed hypertension. Among the HIV-infected women, higher urine albumin-to-creatinine ratio was independently associated with incident hypertension (relative risk =1.13 per urine albumin-to-creatinine ratio doubling, 95% confidence interval, 1.07–1.20), as was lower estimated glomerular filtration rate (relative risk =1.10 per 10 mL/min/1.73 m lower estimated glomerular filtration rate; 95% confidence interval, 1.04–1.17). No tubular injury and dysfunction biomarkers were independently associated with incident hypertension in HIV-infected women. In contrast, among the HIV-uninfected women, urine albumin-to-creatinine ratio was not associated with incident hypertension, whereas higher urine interleukin-18, α1-acid-glycoprotein, and N-acetyl-β-D-glucosaminidase levels were significantly associated with incident hypertension. These findings suggest that early glomerular injury and kidney dysfunction may be involved in the pathogenesis of hypertension in HIV-infected people. The associations of tubular markers with hypertension in HIV-uninfected women should be validated in other studies.
copUnited States
pubAmerican Heart Association, Inc
pmid27993956
doi10.1161/HYPERTENSIONAHA.116.08258
oafree_for_read