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Spatial Representations of Granule Cells and Mossy Cells of the Dentate Gyrus

Granule cells in the dentate gyrus of the hippocampus are thought to be essential to memory function by decorrelating overlapping input patterns (pattern separation). A second excitatory cell type in the dentate gyrus, the mossy cell, forms an intricate circuit with granule cells, CA3c pyramidal cel... Full description

Journal Title: Neuron (Cambridge Mass.), 2017-02-08, Vol.93 (3), p.677-690.e5
Main Author: GoodSmith, Douglas
Other Authors: Chen, Xiaojing , Wang, Cheng , Kim, Sang Hoon , Song, Hongjun , Burgalossi, Andrea , Christian, Kimberly M , Knierim, James J
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 0896-6273
Link: https://www.ncbi.nlm.nih.gov/pubmed/28132828
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title: Spatial Representations of Granule Cells and Mossy Cells of the Dentate Gyrus
format: Article
creator:
  • GoodSmith, Douglas
  • Chen, Xiaojing
  • Wang, Cheng
  • Kim, Sang Hoon
  • Song, Hongjun
  • Burgalossi, Andrea
  • Christian, Kimberly M
  • Knierim, James J
subjects:
  • Action Potentials - physiology
  • Animals
  • Article
  • Brain Mapping
  • CA3 Region, Hippocampal - cytology
  • CA3 Region, Hippocampal - physiology
  • Decision Trees
  • dentate gyrus
  • Dentate Gyrus - cytology
  • Dentate Gyrus - physiology
  • Exploratory Behavior - physiology
  • granule cell
  • hilus
  • Interneurons - cytology
  • Interneurons - physiology
  • Laboratories
  • Medical colleges
  • Memory
  • Models, Neurological
  • mossy cell
  • Mossy Fibers, Hippocampal - physiology
  • nervous system
  • Neurons - cytology
  • Neurons - physiology
  • Neurosciences
  • pattern separation
  • Pyramidal Cells - cytology
  • Pyramidal Cells - physiology
  • Rats
  • Rats, Long-Evans
  • Rodents
  • Spatial Processing - physiology
ispartof: Neuron (Cambridge, Mass.), 2017-02-08, Vol.93 (3), p.677-690.e5
description: Granule cells in the dentate gyrus of the hippocampus are thought to be essential to memory function by decorrelating overlapping input patterns (pattern separation). A second excitatory cell type in the dentate gyrus, the mossy cell, forms an intricate circuit with granule cells, CA3c pyramidal cells, and local interneurons, but the influence of mossy cells on dentate function is often overlooked. Multiple tetrode recordings, supported by juxtacellular recording techniques, showed that granule cells fired very sparsely, whereas mossy cells in the hilus fired promiscuously in multiple locations and in multiple environments. The activity patterns of these cell types thus represent different environments through distinct computational mechanisms: sparse coding in granule cells and changes in firing field locations in mossy cells. •A decision tree classifier identified putative granule and mossy cells from tetrodes•Granule cells are rarely active and typically have single firing fields•Juxtacellularly identified mossy cells have multiple firing fields•Granule cells and mossy cells differentially encode distinct environments Using tetrode and juxtacellular recordings, GoodSmith et al. demonstrate distinct spatial firing and remapping properties of excitatory cell types within the dentate gyrus and CA3c and assess how these cells may support pattern separation in the dentate-CA3 circuit.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0896-6273
fulltext: fulltext
issn:
  • 0896-6273
  • 1097-4199
url: Link


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descriptionGranule cells in the dentate gyrus of the hippocampus are thought to be essential to memory function by decorrelating overlapping input patterns (pattern separation). A second excitatory cell type in the dentate gyrus, the mossy cell, forms an intricate circuit with granule cells, CA3c pyramidal cells, and local interneurons, but the influence of mossy cells on dentate function is often overlooked. Multiple tetrode recordings, supported by juxtacellular recording techniques, showed that granule cells fired very sparsely, whereas mossy cells in the hilus fired promiscuously in multiple locations and in multiple environments. The activity patterns of these cell types thus represent different environments through distinct computational mechanisms: sparse coding in granule cells and changes in firing field locations in mossy cells. •A decision tree classifier identified putative granule and mossy cells from tetrodes•Granule cells are rarely active and typically have single firing fields•Juxtacellularly identified mossy cells have multiple firing fields•Granule cells and mossy cells differentially encode distinct environments Using tetrode and juxtacellular recordings, GoodSmith et al. demonstrate distinct spatial firing and remapping properties of excitatory cell types within the dentate gyrus and CA3c and assess how these cells may support pattern separation in the dentate-CA3 circuit.
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subjectAction Potentials - physiology ; Animals ; Article ; Brain Mapping ; CA3 Region, Hippocampal - cytology ; CA3 Region, Hippocampal - physiology ; Decision Trees ; dentate gyrus ; Dentate Gyrus - cytology ; Dentate Gyrus - physiology ; Exploratory Behavior - physiology ; granule cell ; hilus ; Interneurons - cytology ; Interneurons - physiology ; Laboratories ; Medical colleges ; Memory ; Models, Neurological ; mossy cell ; Mossy Fibers, Hippocampal - physiology ; nervous system ; Neurons - cytology ; Neurons - physiology ; Neurosciences ; pattern separation ; Pyramidal Cells - cytology ; Pyramidal Cells - physiology ; Rats ; Rats, Long-Evans ; Rodents ; Spatial Processing - physiology
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abstractGranule cells in the dentate gyrus of the hippocampus are thought to be essential to memory function by decorrelating overlapping input patterns (pattern separation). A second excitatory cell type in the dentate gyrus, the mossy cell, forms an intricate circuit with granule cells, CA3c pyramidal cells, and local interneurons, but the influence of mossy cells on dentate function is often overlooked. Multiple tetrode recordings, supported by juxtacellular recording techniques, showed that granule cells fired very sparsely, whereas mossy cells in the hilus fired promiscuously in multiple locations and in multiple environments. The activity patterns of these cell types thus represent different environments through distinct computational mechanisms: sparse coding in granule cells and changes in firing field locations in mossy cells. •A decision tree classifier identified putative granule and mossy cells from tetrodes•Granule cells are rarely active and typically have single firing fields•Juxtacellularly identified mossy cells have multiple firing fields•Granule cells and mossy cells differentially encode distinct environments Using tetrode and juxtacellular recordings, GoodSmith et al. demonstrate distinct spatial firing and remapping properties of excitatory cell types within the dentate gyrus and CA3c and assess how these cells may support pattern separation in the dentate-CA3 circuit.
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