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Elevated cytomegalovirus IgG antibody levels are associated with HIV-1 disease progression and immune activation

To assess the association between cytomegalovirus (CMV) IgG antibody levels, HIV disease progression, and immune activation markers. A prospective cohort study was conducted among women enrolled in a trial that was designed to determine the effect of acyclovir on HIV disease progression in Rakai, Ug... Full description

Journal Title: AIDS (London) 2017-03-27, Vol.31 (6), p.807-813
Main Author: Patel, Eshan U
Other Authors: Gianella, Sara , Newell, Kevin , Tobian, Aaron A R , Kirkpatrick, Allison R , Nalugoda, Fredrick , Grabowski, Mary K , Gray, Ronald H , Serwadda, David , Quinn, Thomas C , Redd, Andrew D , Reynolds, Steven J
Format: Electronic Article Electronic Article
Language: English
Subjects:
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Ug
Publisher: England: eScholarship, University of California
ID: ISSN: 0269-9370
Link: https://www.ncbi.nlm.nih.gov/pubmed/28121712
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5352830
title: Elevated cytomegalovirus IgG antibody levels are associated with HIV-1 disease progression and immune activation
format: Article
creator:
  • Patel, Eshan U
  • Gianella, Sara
  • Newell, Kevin
  • Tobian, Aaron A R
  • Kirkpatrick, Allison R
  • Nalugoda, Fredrick
  • Grabowski, Mary K
  • Gray, Ronald H
  • Serwadda, David
  • Quinn, Thomas C
  • Redd, Andrew D
  • Reynolds, Steven J
subjects:
  • a
  • Acyclovir
  • Acyclovir - therapeutic use
  • AIDS/HIV
  • Antibodies
  • Antibodies, Viral - blood
  • Antiviral Agents
  • Antiviral Agents - therapeutic use
  • Article
  • Biological Sciences
  • blood Antiviral Agents
  • blood Prospective Studies Ug
  • CD4 Lymphocyte Count
  • Clinical Research
  • complications
  • complications HIV
  • cytomegalovirus
  • Cytomegalovirus Infections
  • Cytomegalovirus Infections - complications
  • Cytomegalovirus Infections - drug therapy
  • Cytomegalovirus Infections - immunology
  • Disease Progression
  • drug therapy
  • epidemiology Viral Load
  • Female
  • Herpesviridae
  • HIV disease progression
  • HIV Infections
  • HIV Infections - complications
  • HIV-1 - isolation & purification
  • Humans
  • humoral immune response
  • immune activation
  • Immune System
  • Immunoglobulin G
  • Immunoglobulin G - blood
  • immunology Disease Progression Female HIV Infections
  • Infection
  • Infectious Diseases
  • inflammation
  • Inflammatory
  • isolation & purification Humans Immunoglobulin G
  • Lentivirus
  • Medical And Health Sciences
  • Prospective Studies
  • Psychology And Cognitive Sciences
  • Retroviridae
  • therapeutic use Antibodies
  • therapeutic use CD4 Lymphocyte Count Cytomegalovirus Infections
  • Ug
  • Uganda - epidemiology
  • Viral
  • Viral Load
  • Virology
  • virus diseases
ispartof: AIDS (London), 2017-03-27, Vol.31 (6), p.807-813
description: To assess the association between cytomegalovirus (CMV) IgG antibody levels, HIV disease progression, and immune activation markers. A prospective cohort study was conducted among women enrolled in a trial that was designed to determine the effect of acyclovir on HIV disease progression in Rakai, Uganda. The primary endpoints were progression to a CD4 T-cell count less than 250 cells/μl, nontraumatic death, or initiation of antiretroviral therapy (ART). CD4 T-cell counts, HIV viral load, C-reactive protein (CRP), and soluble CD14 levels were assessed biannually for 24 months. CMV IgG antibodies were measured at baseline among all women and annually among a subset of women who initiated ART. There were 300 HIV/CMV-coinfected participants who contributed a total of 426.4 person-years with a median follow-up time of 1.81 years. Compared with the lowest CMV IgG tertile group at baseline, the highest CMV IgG tertile group was associated with an increased risk to reach a primary endpoint independent of acyclovir use, age, CD4 T-cell count, and HIV viral load at baseline [adjusted hazard ratio = 1.59; (95% CI = 1.05-2.39); P = 0.027]. Among pre-ART visits (n = 1200), women in the highest baseline CMV IgG tertile had increasing annual rates of soluble CD14 and CRP levels, which was not observed for the low CMV IgG tertile group. Compared with pre-ART visits, CMV IgG antibody levels were higher post-ART initiation, and concurrent levels remained associated with soluble CD14 and CRP during suppressive ART (n = 88 person-visits). The magnitude of the immune response to CMV was associated with HIV disease progression and immune activation in sub-Saharan Africa.
language: eng
source:
identifier: ISSN: 0269-9370
fulltext: no_fulltext
issn:
  • 0269-9370
  • 1473-5571
url: Link


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titleElevated cytomegalovirus IgG antibody levels are associated with HIV-1 disease progression and immune activation
creatorPatel, Eshan U ; Gianella, Sara ; Newell, Kevin ; Tobian, Aaron A R ; Kirkpatrick, Allison R ; Nalugoda, Fredrick ; Grabowski, Mary K ; Gray, Ronald H ; Serwadda, David ; Quinn, Thomas C ; Redd, Andrew D ; Reynolds, Steven J
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descriptionTo assess the association between cytomegalovirus (CMV) IgG antibody levels, HIV disease progression, and immune activation markers. A prospective cohort study was conducted among women enrolled in a trial that was designed to determine the effect of acyclovir on HIV disease progression in Rakai, Uganda. The primary endpoints were progression to a CD4 T-cell count less than 250 cells/μl, nontraumatic death, or initiation of antiretroviral therapy (ART). CD4 T-cell counts, HIV viral load, C-reactive protein (CRP), and soluble CD14 levels were assessed biannually for 24 months. CMV IgG antibodies were measured at baseline among all women and annually among a subset of women who initiated ART. There were 300 HIV/CMV-coinfected participants who contributed a total of 426.4 person-years with a median follow-up time of 1.81 years. Compared with the lowest CMV IgG tertile group at baseline, the highest CMV IgG tertile group was associated with an increased risk to reach a primary endpoint independent of acyclovir use, age, CD4 T-cell count, and HIV viral load at baseline [adjusted hazard ratio = 1.59; (95% CI = 1.05-2.39); P = 0.027]. Among pre-ART visits (n = 1200), women in the highest baseline CMV IgG tertile had increasing annual rates of soluble CD14 and CRP levels, which was not observed for the low CMV IgG tertile group. Compared with pre-ART visits, CMV IgG antibody levels were higher post-ART initiation, and concurrent levels remained associated with soluble CD14 and CRP during suppressive ART (n = 88 person-visits). The magnitude of the immune response to CMV was associated with HIV disease progression and immune activation in sub-Saharan Africa.
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subjecta ; Acyclovir ; Acyclovir - therapeutic use ; AIDS/HIV ; Antibodies ; Antibodies, Viral - blood ; Antiviral Agents ; Antiviral Agents - therapeutic use ; Article ; Biological Sciences ; blood Antiviral Agents ; blood Prospective Studies Ug ; CD4 Lymphocyte Count ; Clinical Research ; complications ; complications HIV ; cytomegalovirus ; Cytomegalovirus Infections ; Cytomegalovirus Infections - complications ; Cytomegalovirus Infections - drug therapy ; Cytomegalovirus Infections - immunology ; Disease Progression ; drug therapy ; epidemiology Viral Load ; Female ; Herpesviridae ; HIV disease progression ; HIV Infections ; HIV Infections - complications ; HIV-1 - isolation & purification ; Humans ; humoral immune response ; immune activation ; Immune System ; Immunoglobulin G ; Immunoglobulin G - blood ; immunology Disease Progression Female HIV Infections ; Infection ; Infectious Diseases ; inflammation ; Inflammatory ; isolation & purification Humans Immunoglobulin G ; Lentivirus ; Medical And Health Sciences ; Prospective Studies ; Psychology And Cognitive Sciences ; Retroviridae ; therapeutic use Antibodies ; therapeutic use CD4 Lymphocyte Count Cytomegalovirus Infections ; Ug ; Uganda - epidemiology ; Viral ; Viral Load ; Virology ; virus diseases
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7Gray, Ronald H
8Serwadda, David
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descriptionTo assess the association between cytomegalovirus (CMV) IgG antibody levels, HIV disease progression, and immune activation markers. A prospective cohort study was conducted among women enrolled in a trial that was designed to determine the effect of acyclovir on HIV disease progression in Rakai, Uganda. The primary endpoints were progression to a CD4 T-cell count less than 250 cells/μl, nontraumatic death, or initiation of antiretroviral therapy (ART). CD4 T-cell counts, HIV viral load, C-reactive protein (CRP), and soluble CD14 levels were assessed biannually for 24 months. CMV IgG antibodies were measured at baseline among all women and annually among a subset of women who initiated ART. There were 300 HIV/CMV-coinfected participants who contributed a total of 426.4 person-years with a median follow-up time of 1.81 years. Compared with the lowest CMV IgG tertile group at baseline, the highest CMV IgG tertile group was associated with an increased risk to reach a primary endpoint independent of acyclovir use, age, CD4 T-cell count, and HIV viral load at baseline [adjusted hazard ratio = 1.59; (95% CI = 1.05-2.39); P = 0.027]. Among pre-ART visits (n = 1200), women in the highest baseline CMV IgG tertile had increasing annual rates of soluble CD14 and CRP levels, which was not observed for the low CMV IgG tertile group. Compared with pre-ART visits, CMV IgG antibody levels were higher post-ART initiation, and concurrent levels remained associated with soluble CD14 and CRP during suppressive ART (n = 88 person-visits). The magnitude of the immune response to CMV was associated with HIV disease progression and immune activation in sub-Saharan Africa.
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9Biological Sciences
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21Disease Progression
22drug therapy
23epidemiology Viral Load
24Female
25Herpesviridae
26HIV disease progression
27HIV Infections
28HIV Infections - complications
29HIV-1 - isolation & purification
30Humans
31humoral immune response
32immune activation
33Immune System
34Immunoglobulin G
35Immunoglobulin G - blood
36immunology Disease Progression Female HIV Infections
37Infection
38Infectious Diseases
39inflammation
40Inflammatory
41isolation & purification Humans Immunoglobulin G
42Lentivirus
43Medical And Health Sciences
44Prospective Studies
45Psychology And Cognitive Sciences
46Retroviridae
47therapeutic use Antibodies
48therapeutic use CD4 Lymphocyte Count Cytomegalovirus Infections
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50Uganda - epidemiology
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52Viral Load
53Virology
54virus diseases
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titleElevated cytomegalovirus IgG antibody levels are associated with HIV-1 disease progression and immune activation
authorPatel, Eshan U ; Gianella, Sara ; Newell, Kevin ; Tobian, Aaron A R ; Kirkpatrick, Allison R ; Nalugoda, Fredrick ; Grabowski, Mary K ; Gray, Ronald H ; Serwadda, David ; Quinn, Thomas C ; Redd, Andrew D ; Reynolds, Steven J
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39inflammation
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42Lentivirus
43Medical And Health Sciences
44Prospective Studies
45Psychology And Cognitive Sciences
46Retroviridae
47therapeutic use Antibodies
48therapeutic use CD4 Lymphocyte Count Cytomegalovirus Infections
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abstractTo assess the association between cytomegalovirus (CMV) IgG antibody levels, HIV disease progression, and immune activation markers. A prospective cohort study was conducted among women enrolled in a trial that was designed to determine the effect of acyclovir on HIV disease progression in Rakai, Uganda. The primary endpoints were progression to a CD4 T-cell count less than 250 cells/μl, nontraumatic death, or initiation of antiretroviral therapy (ART). CD4 T-cell counts, HIV viral load, C-reactive protein (CRP), and soluble CD14 levels were assessed biannually for 24 months. CMV IgG antibodies were measured at baseline among all women and annually among a subset of women who initiated ART. There were 300 HIV/CMV-coinfected participants who contributed a total of 426.4 person-years with a median follow-up time of 1.81 years. Compared with the lowest CMV IgG tertile group at baseline, the highest CMV IgG tertile group was associated with an increased risk to reach a primary endpoint independent of acyclovir use, age, CD4 T-cell count, and HIV viral load at baseline [adjusted hazard ratio = 1.59; (95% CI = 1.05-2.39); P = 0.027]. Among pre-ART visits (n = 1200), women in the highest baseline CMV IgG tertile had increasing annual rates of soluble CD14 and CRP levels, which was not observed for the low CMV IgG tertile group. Compared with pre-ART visits, CMV IgG antibody levels were higher post-ART initiation, and concurrent levels remained associated with soluble CD14 and CRP during suppressive ART (n = 88 person-visits). The magnitude of the immune response to CMV was associated with HIV disease progression and immune activation in sub-Saharan Africa.
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pubeScholarship, University of California
pmid28121712
doi10.1097/QAD.0000000000001412
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