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Short Communication: False Recent Ratio of the Limiting-Antigen Avidity Assay and Viral Load Testing Algorithm Among Cameroonians with Long-Term HIV Infection

Current serological assays that are used for cross-sectional HIV incidence estimation have been shown to misclassify individuals with chronic infection. Limited information exists on the performance of cross-sectional incidence assays in Central Africa. HIV-positive individuals from Cameroon who wer... Full description

Journal Title: AIDS research and human retroviruses 2017, Vol.33 (11), p.1114-1116
Main Author: Lynch, Briana A.
Other Authors: Patel, Eshan U. , Courtney, Colleen R. , Nanfack, Aubin J. , Bimela, Jude , Wang, Xiaohong , Eid, Issa , Quinn, Thomas C. , Laeyendecker, Oliver , Nyambi, Phillipe N. , Duerr, Ralf , Redd, Andrew D.
Format: Electronic Article Electronic Article
Language: English
Subjects:
HIV
Quelle: Alma/SFX Local Collection
Publisher: United States: Mary Ann Liebert, Inc
ID: ISSN: 0889-2229
Link: https://www.ncbi.nlm.nih.gov/pubmed/28670965
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5665419
title: Short Communication: False Recent Ratio of the Limiting-Antigen Avidity Assay and Viral Load Testing Algorithm Among Cameroonians with Long-Term HIV Infection
format: Article
creator:
  • Lynch, Briana A.
  • Patel, Eshan U.
  • Courtney, Colleen R.
  • Nanfack, Aubin J.
  • Bimela, Jude
  • Wang, Xiaohong
  • Eid, Issa
  • Quinn, Thomas C.
  • Laeyendecker, Oliver
  • Nyambi, Phillipe N.
  • Duerr, Ralf
  • Redd, Andrew D.
subjects:
  • Adult
  • Aged
  • AIDS/HIV
  • Algorithms
  • Antigens
  • Antiretroviral drugs
  • Assaying
  • Avidity
  • Cameroon
  • Cameroon - epidemiology
  • Chronic infection
  • Confidence intervals
  • Constraining
  • Cross sections
  • cross-sectional incidence
  • Cross-Sectional Studies
  • Diagnostic Errors
  • Diagnostic Tests, Routine - methods
  • Epidemiology
  • Female
  • HIV
  • HIV Infections - diagnosis
  • HIV Infections - epidemiology
  • HIV Infections - virology
  • Human immunodeficiency virus
  • Humans
  • Immunoassay - methods
  • Incidence
  • Infections
  • Male
  • Middle Aged
  • Oligonucleotides
  • Optical density
  • Viral Load - methods
ispartof: AIDS research and human retroviruses, 2017, Vol.33 (11), p.1114-1116
description: Current serological assays that are used for cross-sectional HIV incidence estimation have been shown to misclassify individuals with chronic infection. Limited information exists on the performance of cross-sectional incidence assays in Central Africa. HIV-positive individuals from Cameroon who were infected for at least 1 or 2 years were evaluated to determine the false recent ratio (FRR) of a two-assay algorithm, which includes the Limiting Antigen Avidity (LAg-Avidity) assay (normalized optical density units, ODn 1000 copies/ml). The subject-level FRR was 5.3% (95% confidence interval [CI], 2.1–10.5) for individuals infected for ≥1 year and 3.9% (95% CI, 0.8–11.0) for individuals infected for ≥2 years. These data suggest that the LAg-Avidity plus viral load incidence algorithm may overestimate HIV incidence rates in Central Africa.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0889-2229
fulltext: fulltext
issn:
  • 0889-2229
  • 1931-8405
url: Link


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titleShort Communication: False Recent Ratio of the Limiting-Antigen Avidity Assay and Viral Load Testing Algorithm Among Cameroonians with Long-Term HIV Infection
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creatorLynch, Briana A. ; Patel, Eshan U. ; Courtney, Colleen R. ; Nanfack, Aubin J. ; Bimela, Jude ; Wang, Xiaohong ; Eid, Issa ; Quinn, Thomas C. ; Laeyendecker, Oliver ; Nyambi, Phillipe N. ; Duerr, Ralf ; Redd, Andrew D.
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descriptionCurrent serological assays that are used for cross-sectional HIV incidence estimation have been shown to misclassify individuals with chronic infection. Limited information exists on the performance of cross-sectional incidence assays in Central Africa. HIV-positive individuals from Cameroon who were infected for at least 1 or 2 years were evaluated to determine the false recent ratio (FRR) of a two-assay algorithm, which includes the Limiting Antigen Avidity (LAg-Avidity) assay (normalized optical density units, ODn <1.5) and HIV viral load (>1000 copies/ml). The subject-level FRR was 5.3% (95% confidence interval [CI], 2.1–10.5) for individuals infected for ≥1 year and 3.9% (95% CI, 0.8–11.0) for individuals infected for ≥2 years. These data suggest that the LAg-Avidity plus viral load incidence algorithm may overestimate HIV incidence rates in Central Africa.
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subjectAdult ; Aged ; AIDS/HIV ; Algorithms ; Antigens ; Antiretroviral drugs ; Assaying ; Avidity ; Cameroon ; Cameroon - epidemiology ; Chronic infection ; Confidence intervals ; Constraining ; Cross sections ; cross-sectional incidence ; Cross-Sectional Studies ; Diagnostic Errors ; Diagnostic Tests, Routine - methods ; Epidemiology ; Female ; HIV ; HIV Infections - diagnosis ; HIV Infections - epidemiology ; HIV Infections - virology ; Human immunodeficiency virus ; Humans ; Immunoassay - methods ; Incidence ; Infections ; Male ; Middle Aged ; Oligonucleotides ; Optical density ; Viral Load - methods
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descriptionCurrent serological assays that are used for cross-sectional HIV incidence estimation have been shown to misclassify individuals with chronic infection. Limited information exists on the performance of cross-sectional incidence assays in Central Africa. HIV-positive individuals from Cameroon who were infected for at least 1 or 2 years were evaluated to determine the false recent ratio (FRR) of a two-assay algorithm, which includes the Limiting Antigen Avidity (LAg-Avidity) assay (normalized optical density units, ODn <1.5) and HIV viral load (>1000 copies/ml). The subject-level FRR was 5.3% (95% confidence interval [CI], 2.1–10.5) for individuals infected for ≥1 year and 3.9% (95% CI, 0.8–11.0) for individuals infected for ≥2 years. These data suggest that the LAg-Avidity plus viral load incidence algorithm may overestimate HIV incidence rates in Central Africa.
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titleShort Communication: False Recent Ratio of the Limiting-Antigen Avidity Assay and Viral Load Testing Algorithm Among Cameroonians with Long-Term HIV Infection
authorLynch, Briana A. ; Patel, Eshan U. ; Courtney, Colleen R. ; Nanfack, Aubin J. ; Bimela, Jude ; Wang, Xiaohong ; Eid, Issa ; Quinn, Thomas C. ; Laeyendecker, Oliver ; Nyambi, Phillipe N. ; Duerr, Ralf ; Redd, Andrew D.
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atitleShort Communication: False Recent Ratio of the Limiting-Antigen Avidity Assay and Viral Load Testing Algorithm Among Cameroonians with Long-Term HIV Infection
jtitleAIDS research and human retroviruses
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date2017-11-01
risdate2017
volume33
issue11
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pages1114-1116
issn0889-2229
eissn1931-8405
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abstractCurrent serological assays that are used for cross-sectional HIV incidence estimation have been shown to misclassify individuals with chronic infection. Limited information exists on the performance of cross-sectional incidence assays in Central Africa. HIV-positive individuals from Cameroon who were infected for at least 1 or 2 years were evaluated to determine the false recent ratio (FRR) of a two-assay algorithm, which includes the Limiting Antigen Avidity (LAg-Avidity) assay (normalized optical density units, ODn <1.5) and HIV viral load (>1000 copies/ml). The subject-level FRR was 5.3% (95% confidence interval [CI], 2.1–10.5) for individuals infected for ≥1 year and 3.9% (95% CI, 0.8–11.0) for individuals infected for ≥2 years. These data suggest that the LAg-Avidity plus viral load incidence algorithm may overestimate HIV incidence rates in Central Africa.
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pmid28670965
doi10.1089/aid.2017.0084
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