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A Metabolomic Signature of Acute Caloric Restriction

Abstract Context The experimental paradigm of acute caloric restriction (CR) followed by refeeding (RF) can be used to study the homeostatic mechanisms that regulate energy homeostasis, which are relevant to understanding the adaptive response to weight loss. Objective Metabolomics, the measurement... Full description

Journal Title: The journal of clinical endocrinology and metabolism 2017, Vol.102 (12), p.4486-4495
Main Author: Collet, Tinh-Hai
Other Authors: Sonoyama, Takuhiro , Henning, Elana , Keogh, Julia M , Ingram, Brian , Kelway, Sarah , Guo, Lining , Farooqi, I Sadaf
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Washington, DC: Endocrine Society
ID: ISSN: 0021-972X
Link: https://www.ncbi.nlm.nih.gov/pubmed/29029202
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5718701
title: A Metabolomic Signature of Acute Caloric Restriction
format: Article
creator:
  • Collet, Tinh-Hai
  • Sonoyama, Takuhiro
  • Henning, Elana
  • Keogh, Julia M
  • Ingram, Brian
  • Kelway, Sarah
  • Guo, Lining
  • Farooqi, I Sadaf
subjects:
  • Adipocyte Biology
  • Adult
  • Amino Acids
  • Amino Acids - metabolism
  • Antioxidants
  • Antioxidants - metabolism
  • blood
  • Body weight loss
  • Caloric Restriction
  • Cannabinoids
  • Carbohydrate Metabolism
  • Carbohydrate Metabolism - physiology
  • Carbohydrates
  • Chain branching
  • Chromatography
  • Chromatography, High Pressure Liquid
  • Clinical Research Articles
  • Clinical s
  • Degradation products
  • Dehydroepi
  • Dehydroepiandrosterone
  • Dehydroepiandrosterone sulfate
  • Dehydroepiandrosterone Sulfate - metabolism
  • Diet
  • Dietary restrictions
  • em Mass Spectrometry
  • Endocannabinoids
  • Endocannabinoids - metabolism
  • Energy balance
  • Energy Metabolism
  • Energy Metabolism - physiology
  • Energy requirements
  • Fatty Acids
  • Fatty Acids - metabolism
  • Food intake
  • High performance liquid chromatography
  • High Pressure Liquid
  • Homeostasis
  • Humans
  • Lipid Metabolism
  • Lipid Metabolism - physiology
  • Lipids
  • Lipolysis
  • Liquid chromatography
  • Male
  • Mass spectrometry
  • Mass spectroscopy
  • Metabolic response
  • metabolism
  • Metabolites
  • Metabolomics
  • Metabolomics - methods
  • methods
  • Obesity
  • Oxidation
  • Oxidation-Reduction
  • physiology
  • Reduction
  • rosterone Sulfate
  • Steroid hormones
  • Steroids
  • Steroids - blood
  • Sulfates
  • Tandem Mass Spectrometry
  • Weight Loss
  • Weight Loss - physiology
  • Weight loss measurement
ispartof: The journal of clinical endocrinology and metabolism, 2017, Vol.102 (12), p.4486-4495
description: Abstract Context The experimental paradigm of acute caloric restriction (CR) followed by refeeding (RF) can be used to study the homeostatic mechanisms that regulate energy homeostasis, which are relevant to understanding the adaptive response to weight loss. Objective Metabolomics, the measurement of hundreds of small molecule metabolites, their precursors, derivatives, and degradation products, has emerged as a useful tool for the study of physiology and disease and was used here to study the metabolic response to acute CR. Participants, Design, and Setting We used four ultra high-performance liquid chromatography-tandem mass spectrometry methods to characterize changes in carbohydrates, lipids, amino acids, and steroids in eight normal weight men at baseline, after 48 hours of CR (10% of energy requirements) and after 48 hours of ad libitum RF in a tightly controlled environment. Results We identified a distinct metabolomic signature associated with acute CR characterized by the expected switch from carbohydrate to fat utilization with increased lipolysis and β-fatty acid oxidation. We found an increase in ω-fatty acid oxidation and levels of endocannabinoids, which are known to promote food intake. These changes were reversed with RF. Several plasmalogen phosphatidylethanolamines (endogenous antioxidants) significantly decreased with CR (all P ≤ 0.0007). Additionally, acute CR was associated with an increase in the branched chain amino acids (all P ≤ 1.4 × 10−7) and dehydroepiandrosterone sulfate (P = 0.0006). Conclusions We identified a distinct metabolomic signature associated with acute CR. Further studies are needed to characterize the mechanisms that mediate these changes and their potential contribution to the adaptive response to dietary restriction. We conducted a metabolomic analysis of 770 small molecules in eight healthy lean men and identified a distinct metabolomic signature associated with acute caloric restriction.
language: eng
source:
identifier: ISSN: 0021-972X
fulltext: no_fulltext
issn:
  • 0021-972X
  • 1945-7197
url: Link


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descriptionAbstract Context The experimental paradigm of acute caloric restriction (CR) followed by refeeding (RF) can be used to study the homeostatic mechanisms that regulate energy homeostasis, which are relevant to understanding the adaptive response to weight loss. Objective Metabolomics, the measurement of hundreds of small molecule metabolites, their precursors, derivatives, and degradation products, has emerged as a useful tool for the study of physiology and disease and was used here to study the metabolic response to acute CR. Participants, Design, and Setting We used four ultra high-performance liquid chromatography-tandem mass spectrometry methods to characterize changes in carbohydrates, lipids, amino acids, and steroids in eight normal weight men at baseline, after 48 hours of CR (10% of energy requirements) and after 48 hours of ad libitum RF in a tightly controlled environment. Results We identified a distinct metabolomic signature associated with acute CR characterized by the expected switch from carbohydrate to fat utilization with increased lipolysis and β-fatty acid oxidation. We found an increase in ω-fatty acid oxidation and levels of endocannabinoids, which are known to promote food intake. These changes were reversed with RF. Several plasmalogen phosphatidylethanolamines (endogenous antioxidants) significantly decreased with CR (all P ≤ 0.0007). Additionally, acute CR was associated with an increase in the branched chain amino acids (all P ≤ 1.4 × 10−7) and dehydroepiandrosterone sulfate (P = 0.0006). Conclusions We identified a distinct metabolomic signature associated with acute CR. Further studies are needed to characterize the mechanisms that mediate these changes and their potential contribution to the adaptive response to dietary restriction. We conducted a metabolomic analysis of 770 small molecules in eight healthy lean men and identified a distinct metabolomic signature associated with acute caloric restriction.
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subjectAdipocyte Biology ; Adult ; Amino Acids ; Amino Acids - metabolism ; Antioxidants ; Antioxidants - metabolism ; blood ; Body weight loss ; Caloric Restriction ; Cannabinoids ; Carbohydrate Metabolism ; Carbohydrate Metabolism - physiology ; Carbohydrates ; Chain branching ; Chromatography ; Chromatography, High Pressure Liquid ; Clinical Research Articles ; Clinical s ; Degradation products ; Dehydroepi ; Dehydroepiandrosterone ; Dehydroepiandrosterone sulfate ; Dehydroepiandrosterone Sulfate - metabolism ; Diet ; Dietary restrictions ; em Mass Spectrometry ; Endocannabinoids ; Endocannabinoids - metabolism ; Energy balance ; Energy Metabolism ; Energy Metabolism - physiology ; Energy requirements ; Fatty Acids ; Fatty Acids - metabolism ; Food intake ; High performance liquid chromatography ; High Pressure Liquid ; Homeostasis ; Humans ; Lipid Metabolism ; Lipid Metabolism - physiology ; Lipids ; Lipolysis ; Liquid chromatography ; Male ; Mass spectrometry ; Mass spectroscopy ; Metabolic response ; metabolism ; Metabolites ; Metabolomics ; Metabolomics - methods ; methods ; Obesity ; Oxidation ; Oxidation-Reduction ; physiology ; Reduction ; rosterone Sulfate ; Steroid hormones ; Steroids ; Steroids - blood ; Sulfates ; Tandem Mass Spectrometry ; Weight Loss ; Weight Loss - physiology ; Weight loss measurement
ispartofThe journal of clinical endocrinology and metabolism, 2017, Vol.102 (12), p.4486-4495
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1Copyright © 2017 Endocrine Society
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2Henning, Elana
3Keogh, Julia M
4Ingram, Brian
5Kelway, Sarah
6Guo, Lining
7Farooqi, I Sadaf
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descriptionAbstract Context The experimental paradigm of acute caloric restriction (CR) followed by refeeding (RF) can be used to study the homeostatic mechanisms that regulate energy homeostasis, which are relevant to understanding the adaptive response to weight loss. Objective Metabolomics, the measurement of hundreds of small molecule metabolites, their precursors, derivatives, and degradation products, has emerged as a useful tool for the study of physiology and disease and was used here to study the metabolic response to acute CR. Participants, Design, and Setting We used four ultra high-performance liquid chromatography-tandem mass spectrometry methods to characterize changes in carbohydrates, lipids, amino acids, and steroids in eight normal weight men at baseline, after 48 hours of CR (10% of energy requirements) and after 48 hours of ad libitum RF in a tightly controlled environment. Results We identified a distinct metabolomic signature associated with acute CR characterized by the expected switch from carbohydrate to fat utilization with increased lipolysis and β-fatty acid oxidation. We found an increase in ω-fatty acid oxidation and levels of endocannabinoids, which are known to promote food intake. These changes were reversed with RF. Several plasmalogen phosphatidylethanolamines (endogenous antioxidants) significantly decreased with CR (all P ≤ 0.0007). Additionally, acute CR was associated with an increase in the branched chain amino acids (all P ≤ 1.4 × 10−7) and dehydroepiandrosterone sulfate (P = 0.0006). Conclusions We identified a distinct metabolomic signature associated with acute CR. Further studies are needed to characterize the mechanisms that mediate these changes and their potential contribution to the adaptive response to dietary restriction. We conducted a metabolomic analysis of 770 small molecules in eight healthy lean men and identified a distinct metabolomic signature associated with acute caloric restriction.
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0Adipocyte Biology
1Adult
2Amino Acids
3Amino Acids - metabolism
4Antioxidants
5Antioxidants - metabolism
6blood
7Body weight loss
8Caloric Restriction
9Cannabinoids
10Carbohydrate Metabolism
11Carbohydrate Metabolism - physiology
12Carbohydrates
13Chain branching
14Chromatography
15Chromatography, High Pressure Liquid
16Clinical Research Articles
17Clinical s
18Degradation products
19Dehydroepi
20Dehydroepiandrosterone
21Dehydroepiandrosterone sulfate
22Dehydroepiandrosterone Sulfate - metabolism
23Diet
24Dietary restrictions
25em Mass Spectrometry
26Endocannabinoids
27Endocannabinoids - metabolism
28Energy balance
29Energy Metabolism
30Energy Metabolism - physiology
31Energy requirements
32Fatty Acids
33Fatty Acids - metabolism
34Food intake
35High performance liquid chromatography
36High Pressure Liquid
37Homeostasis
38Humans
39Lipid Metabolism
40Lipid Metabolism - physiology
41Lipids
42Lipolysis
43Liquid chromatography
44Male
45Mass spectrometry
46Mass spectroscopy
47Metabolic response
48metabolism
49Metabolites
50Metabolomics
51Metabolomics - methods
52methods
53Obesity
54Oxidation
55Oxidation-Reduction
56physiology
57Reduction
58rosterone Sulfate
59Steroid hormones
60Steroids
61Steroids - blood
62Sulfates
63Tandem Mass Spectrometry
64Weight Loss
65Weight Loss - physiology
66Weight loss measurement
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titleA Metabolomic Signature of Acute Caloric Restriction
authorCollet, Tinh-Hai ; Sonoyama, Takuhiro ; Henning, Elana ; Keogh, Julia M ; Ingram, Brian ; Kelway, Sarah ; Guo, Lining ; Farooqi, I Sadaf
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9Cannabinoids
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24Dietary restrictions
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29Energy Metabolism
30Energy Metabolism - physiology
31Energy requirements
32Fatty Acids
33Fatty Acids - metabolism
34Food intake
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36High Pressure Liquid
37Homeostasis
38Humans
39Lipid Metabolism
40Lipid Metabolism - physiology
41Lipids
42Lipolysis
43Liquid chromatography
44Male
45Mass spectrometry
46Mass spectroscopy
47Metabolic response
48metabolism
49Metabolites
50Metabolomics
51Metabolomics - methods
52methods
53Obesity
54Oxidation
55Oxidation-Reduction
56physiology
57Reduction
58rosterone Sulfate
59Steroid hormones
60Steroids
61Steroids - blood
62Sulfates
63Tandem Mass Spectrometry
64Weight Loss
65Weight Loss - physiology
66Weight loss measurement
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abstractAbstract Context The experimental paradigm of acute caloric restriction (CR) followed by refeeding (RF) can be used to study the homeostatic mechanisms that regulate energy homeostasis, which are relevant to understanding the adaptive response to weight loss. Objective Metabolomics, the measurement of hundreds of small molecule metabolites, their precursors, derivatives, and degradation products, has emerged as a useful tool for the study of physiology and disease and was used here to study the metabolic response to acute CR. Participants, Design, and Setting We used four ultra high-performance liquid chromatography-tandem mass spectrometry methods to characterize changes in carbohydrates, lipids, amino acids, and steroids in eight normal weight men at baseline, after 48 hours of CR (10% of energy requirements) and after 48 hours of ad libitum RF in a tightly controlled environment. Results We identified a distinct metabolomic signature associated with acute CR characterized by the expected switch from carbohydrate to fat utilization with increased lipolysis and β-fatty acid oxidation. We found an increase in ω-fatty acid oxidation and levels of endocannabinoids, which are known to promote food intake. These changes were reversed with RF. Several plasmalogen phosphatidylethanolamines (endogenous antioxidants) significantly decreased with CR (all P ≤ 0.0007). Additionally, acute CR was associated with an increase in the branched chain amino acids (all P ≤ 1.4 × 10−7) and dehydroepiandrosterone sulfate (P = 0.0006). Conclusions We identified a distinct metabolomic signature associated with acute CR. Further studies are needed to characterize the mechanisms that mediate these changes and their potential contribution to the adaptive response to dietary restriction. We conducted a metabolomic analysis of 770 small molecules in eight healthy lean men and identified a distinct metabolomic signature associated with acute caloric restriction.
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pmid29029202
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