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Influenza vaccine effectiveness in older adults compared with younger adults over five seasons

There have been inconsistent reports of decreased vaccine effectiveness (VE) against influenza viruses among older adults (aged ≥ 65 years) compared with younger adults in the United States. A direct comparison of VE over multiple seasons is needed to assess the consistency of these observations. We... Full description

Journal Title: Vaccine 2018-02-28, Vol.36 (10), p.1272-1278
Main Author: Russell, Kate
Other Authors: Chung, Jessie R , Monto, Arnold S , Martin, Emily T , Belongia, Edward A , McLean, Huong Q , Gaglani, Manjusha , Murthy, Kempapura , Zimmerman, Richard K , Nowalk, Mary Patricia , Jackson, Michael L , Jackson, Lisa A , Flannery, Brendan
Format: Electronic Article Electronic Article
Language: English
Subjects:
Age
Quelle: Alma/SFX Local Collection
Publisher: Netherlands: Elsevier Ltd
ID: ISSN: 0264-410X
Link: https://www.ncbi.nlm.nih.gov/pubmed/29402578
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5812289
title: Influenza vaccine effectiveness in older adults compared with younger adults over five seasons
format: Article
creator:
  • Russell, Kate
  • Chung, Jessie R
  • Monto, Arnold S
  • Martin, Emily T
  • Belongia, Edward A
  • McLean, Huong Q
  • Gaglani, Manjusha
  • Murthy, Kempapura
  • Zimmerman, Richard K
  • Nowalk, Mary Patricia
  • Jackson, Michael L
  • Jackson, Lisa A
  • Flannery, Brendan
subjects:
  • Adolescent
  • Adult
  • Adults
  • Age
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Article
  • Confidence intervals
  • Cough
  • Female
  • Human
  • Humans
  • Immunization
  • Influenza
  • Influenza A
  • Influenza A Virus, H1N1 Subtype - immunology
  • Influenza A Virus, H3N2 Subtype - immunology
  • Influenza vaccine effectiveness
  • Influenza vaccines
  • Influenza Vaccines - administration & dosage
  • Influenza Vaccines - immunology
  • Influenza, Human - epidemiology
  • Influenza, Human - prevention & control
  • Influenza, Human - virology
  • Male
  • Medical records
  • Middle Aged
  • Odds Ratio
  • Older adults
  • Older people
  • Outcome Assessment (Health Care)
  • Patients
  • Polymerase chain reaction
  • Public Health Surveillance
  • Respiratory diseases
  • Reverse transcription
  • Seasons
  • Statistical analysis
  • United States - epidemiology
  • Vaccination
  • Vaccine efficacy
  • Vaccines
  • Viruses
  • Young Adult
ispartof: Vaccine, 2018-02-28, Vol.36 (10), p.1272-1278
description: There have been inconsistent reports of decreased vaccine effectiveness (VE) against influenza viruses among older adults (aged ≥ 65 years) compared with younger adults in the United States. A direct comparison of VE over multiple seasons is needed to assess the consistency of these observations. We performed a pooled analysis of VE over 5 seasons among adults aged ≥ 18 years who were systematically enrolled in the U.S. Flu VE Network. Outpatients with medically-attended acute respiratory illness (cough with illness onset ≤ 7 days prior to enrollment) were tested for influenza by reverse transcription polymerase chain reaction. We compared differences in VE and vaccine failures among older adult age group (65–74, ≥75, and ≥ 65 years) to adults aged 18–49 years by influenza type and subtype using interaction terms to test for statistical significance and stratified by prior season vaccination status. Analysis included 20,022 adults aged ≥ 18 years enrolled during the 2011–12 through 2015–16 influenza seasons; 4,785 (24%) tested positive for influenza. VE among patients aged ≥ 65 years was not significantly lower than VE among patients aged 18–49 years against any subtype with no significant interaction of age and vaccination. VE against A(H3N2) viruses was 14% (95% confidence interval [CI] −14% to 36%) for adults ≥ 65 years and 21% (CI 9–32%) for adults 18–49 years. VE against A(H1N1)pdm09 was 49% (95% CI 22–66%) for adults ≥ 65 years and 48% (95% CI 41–54%) for adults 18–49 years and against B viruses was 62% (95% CI 44–74%) for adults ≥ 65 years and 55% (95% CI 45–63%) for adults 18–49 years. There was no significant interaction of age and vaccination for separate strata of prior vaccination status. Over 5 seasons, influenza vaccination provided similar levels of protection among older and younger adults, with lower levels of protection against influenza A(H3N2) in all ages.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0264-410X
fulltext: fulltext
issn:
  • 0264-410X
  • 1873-2518
url: Link


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titleInfluenza vaccine effectiveness in older adults compared with younger adults over five seasons
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creatorRussell, Kate ; Chung, Jessie R ; Monto, Arnold S ; Martin, Emily T ; Belongia, Edward A ; McLean, Huong Q ; Gaglani, Manjusha ; Murthy, Kempapura ; Zimmerman, Richard K ; Nowalk, Mary Patricia ; Jackson, Michael L ; Jackson, Lisa A ; Flannery, Brendan
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descriptionThere have been inconsistent reports of decreased vaccine effectiveness (VE) against influenza viruses among older adults (aged ≥ 65 years) compared with younger adults in the United States. A direct comparison of VE over multiple seasons is needed to assess the consistency of these observations. We performed a pooled analysis of VE over 5 seasons among adults aged ≥ 18 years who were systematically enrolled in the U.S. Flu VE Network. Outpatients with medically-attended acute respiratory illness (cough with illness onset ≤ 7 days prior to enrollment) were tested for influenza by reverse transcription polymerase chain reaction. We compared differences in VE and vaccine failures among older adult age group (65–74, ≥75, and ≥ 65 years) to adults aged 18–49 years by influenza type and subtype using interaction terms to test for statistical significance and stratified by prior season vaccination status. Analysis included 20,022 adults aged ≥ 18 years enrolled during the 2011–12 through 2015–16 influenza seasons; 4,785 (24%) tested positive for influenza. VE among patients aged ≥ 65 years was not significantly lower than VE among patients aged 18–49 years against any subtype with no significant interaction of age and vaccination. VE against A(H3N2) viruses was 14% (95% confidence interval [CI] −14% to 36%) for adults ≥ 65 years and 21% (CI 9–32%) for adults 18–49 years. VE against A(H1N1)pdm09 was 49% (95% CI 22–66%) for adults ≥ 65 years and 48% (95% CI 41–54%) for adults 18–49 years and against B viruses was 62% (95% CI 44–74%) for adults ≥ 65 years and 55% (95% CI 45–63%) for adults 18–49 years. There was no significant interaction of age and vaccination for separate strata of prior vaccination status. Over 5 seasons, influenza vaccination provided similar levels of protection among older and younger adults, with lower levels of protection against influenza A(H3N2) in all ages.
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subjectAdolescent ; Adult ; Adults ; Age ; Age Factors ; Aged ; Aged, 80 and over ; Article ; Confidence intervals ; Cough ; Female ; Human ; Humans ; Immunization ; Influenza ; Influenza A ; Influenza A Virus, H1N1 Subtype - immunology ; Influenza A Virus, H3N2 Subtype - immunology ; Influenza vaccine effectiveness ; Influenza vaccines ; Influenza Vaccines - administration & dosage ; Influenza Vaccines - immunology ; Influenza, Human - epidemiology ; Influenza, Human - prevention & control ; Influenza, Human - virology ; Male ; Medical records ; Middle Aged ; Odds Ratio ; Older adults ; Older people ; Outcome Assessment (Health Care) ; Patients ; Polymerase chain reaction ; Public Health Surveillance ; Respiratory diseases ; Reverse transcription ; Seasons ; Statistical analysis ; United States - epidemiology ; Vaccination ; Vaccine efficacy ; Vaccines ; Viruses ; Young Adult
ispartofVaccine, 2018-02-28, Vol.36 (10), p.1272-1278
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9Nowalk, Mary Patricia
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descriptionThere have been inconsistent reports of decreased vaccine effectiveness (VE) against influenza viruses among older adults (aged ≥ 65 years) compared with younger adults in the United States. A direct comparison of VE over multiple seasons is needed to assess the consistency of these observations. We performed a pooled analysis of VE over 5 seasons among adults aged ≥ 18 years who were systematically enrolled in the U.S. Flu VE Network. Outpatients with medically-attended acute respiratory illness (cough with illness onset ≤ 7 days prior to enrollment) were tested for influenza by reverse transcription polymerase chain reaction. We compared differences in VE and vaccine failures among older adult age group (65–74, ≥75, and ≥ 65 years) to adults aged 18–49 years by influenza type and subtype using interaction terms to test for statistical significance and stratified by prior season vaccination status. Analysis included 20,022 adults aged ≥ 18 years enrolled during the 2011–12 through 2015–16 influenza seasons; 4,785 (24%) tested positive for influenza. VE among patients aged ≥ 65 years was not significantly lower than VE among patients aged 18–49 years against any subtype with no significant interaction of age and vaccination. VE against A(H3N2) viruses was 14% (95% confidence interval [CI] −14% to 36%) for adults ≥ 65 years and 21% (CI 9–32%) for adults 18–49 years. VE against A(H1N1)pdm09 was 49% (95% CI 22–66%) for adults ≥ 65 years and 48% (95% CI 41–54%) for adults 18–49 years and against B viruses was 62% (95% CI 44–74%) for adults ≥ 65 years and 55% (95% CI 45–63%) for adults 18–49 years. There was no significant interaction of age and vaccination for separate strata of prior vaccination status. Over 5 seasons, influenza vaccination provided similar levels of protection among older and younger adults, with lower levels of protection against influenza A(H3N2) in all ages.
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20Influenza Vaccines - administration & dosage
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28Odds Ratio
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authorRussell, Kate ; Chung, Jessie R ; Monto, Arnold S ; Martin, Emily T ; Belongia, Edward A ; McLean, Huong Q ; Gaglani, Manjusha ; Murthy, Kempapura ; Zimmerman, Richard K ; Nowalk, Mary Patricia ; Jackson, Michael L ; Jackson, Lisa A ; Flannery, Brendan
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abstractThere have been inconsistent reports of decreased vaccine effectiveness (VE) against influenza viruses among older adults (aged ≥ 65 years) compared with younger adults in the United States. A direct comparison of VE over multiple seasons is needed to assess the consistency of these observations. We performed a pooled analysis of VE over 5 seasons among adults aged ≥ 18 years who were systematically enrolled in the U.S. Flu VE Network. Outpatients with medically-attended acute respiratory illness (cough with illness onset ≤ 7 days prior to enrollment) were tested for influenza by reverse transcription polymerase chain reaction. We compared differences in VE and vaccine failures among older adult age group (65–74, ≥75, and ≥ 65 years) to adults aged 18–49 years by influenza type and subtype using interaction terms to test for statistical significance and stratified by prior season vaccination status. Analysis included 20,022 adults aged ≥ 18 years enrolled during the 2011–12 through 2015–16 influenza seasons; 4,785 (24%) tested positive for influenza. VE among patients aged ≥ 65 years was not significantly lower than VE among patients aged 18–49 years against any subtype with no significant interaction of age and vaccination. VE against A(H3N2) viruses was 14% (95% confidence interval [CI] −14% to 36%) for adults ≥ 65 years and 21% (CI 9–32%) for adults 18–49 years. VE against A(H1N1)pdm09 was 49% (95% CI 22–66%) for adults ≥ 65 years and 48% (95% CI 41–54%) for adults 18–49 years and against B viruses was 62% (95% CI 44–74%) for adults ≥ 65 years and 55% (95% CI 45–63%) for adults 18–49 years. There was no significant interaction of age and vaccination for separate strata of prior vaccination status. Over 5 seasons, influenza vaccination provided similar levels of protection among older and younger adults, with lower levels of protection against influenza A(H3N2) in all ages.
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pmid29402578
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