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Thymidine phosphorylase: A potential new target for treating cardiovascular disease

We recently found that thymidine phosphorylase (TYMP), also known as platelet-derived endothelial cell growth factor, plays an important role in platelet activation in vitro and thrombosis in vivo by participating in multiple signaling pathways. Platelets are a major source of TYMP. Since platelet-m... Full description

Journal Title: Trends in cardiovascular medicine 2018-04, Vol.28 (3), p.157-171
Main Author: Li, Wei
Other Authors: Yue, Hong
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 1050-1738
Link: https://www.ncbi.nlm.nih.gov/pubmed/29108898
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5856583
title: Thymidine phosphorylase: A potential new target for treating cardiovascular disease
format: Article
creator:
  • Li, Wei
  • Yue, Hong
subjects:
  • Angiogenesis
  • Animals
  • Article
  • Cancer
  • Cardiovascular Agents - adverse effects
  • Cardiovascular Agents - therapeutic use
  • Cardiovascular diseases
  • Cardiovascular Diseases - drug therapy
  • Cardiovascular Diseases - enzymology
  • Cardiovascular Diseases - genetics
  • Cell growth
  • Cerebral infarction
  • Disease
  • Drug Discovery - methods
  • Embolism
  • Endothelial cells
  • Enzyme Inhibitors - adverse effects
  • Enzyme Inhibitors - therapeutic use
  • Enzymes
  • Gene Expression Regulation, Enzymologic
  • Growth factors
  • Humans
  • Kinases
  • Mammals
  • Molecular modelling
  • Molecular Targeted Therapy - adverse effects
  • Molecular Targeted Therapy - methods
  • Mutation
  • Myocardial infarction
  • Phosphate esters
  • Phosphorylase
  • Platelet-derived endothelial cell growth factor
  • Platelets
  • Protein Conformation
  • Proteins
  • Stroke
  • Structure-Activity Relationship
  • Thrombosis
  • Thymidine
  • Thymidine phosphorylase
  • Thymidine Phosphorylase - antagonists & inhibitors
  • Thymidine Phosphorylase - chemistry
  • Thymidine Phosphorylase - genetics
  • Thymidine Phosphorylase - metabolism
  • Tumors
ispartof: Trends in cardiovascular medicine, 2018-04, Vol.28 (3), p.157-171
description: We recently found that thymidine phosphorylase (TYMP), also known as platelet-derived endothelial cell growth factor, plays an important role in platelet activation in vitro and thrombosis in vivo by participating in multiple signaling pathways. Platelets are a major source of TYMP. Since platelet-mediated clot formation is a key event in several fatal diseases, such as myocardial infarction, stroke and pulmonary embolism, understanding TYMP in depth may lead to uncovering novel mechanisms in the development of cardiovascular diseases. Targeting TYMP may become a novel therapeutic for cardiovascular disorders. In this review article, we summarize the discovery of TYMP and the potential molecular mechanisms of TYMP involved in the development of various diseases, especially cardiovascular diseases. We also offer insights regarding future studies exploring the role of TYMP in the development of cardiovascular disease as well as in therapy.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1050-1738
fulltext: fulltext
issn:
  • 1050-1738
  • 1873-2615
url: Link


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descriptionWe recently found that thymidine phosphorylase (TYMP), also known as platelet-derived endothelial cell growth factor, plays an important role in platelet activation in vitro and thrombosis in vivo by participating in multiple signaling pathways. Platelets are a major source of TYMP. Since platelet-mediated clot formation is a key event in several fatal diseases, such as myocardial infarction, stroke and pulmonary embolism, understanding TYMP in depth may lead to uncovering novel mechanisms in the development of cardiovascular diseases. Targeting TYMP may become a novel therapeutic for cardiovascular disorders. In this review article, we summarize the discovery of TYMP and the potential molecular mechanisms of TYMP involved in the development of various diseases, especially cardiovascular diseases. We also offer insights regarding future studies exploring the role of TYMP in the development of cardiovascular disease as well as in therapy.
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subjectAngiogenesis ; Animals ; Article ; Cancer ; Cardiovascular Agents - adverse effects ; Cardiovascular Agents - therapeutic use ; Cardiovascular diseases ; Cardiovascular Diseases - drug therapy ; Cardiovascular Diseases - enzymology ; Cardiovascular Diseases - genetics ; Cell growth ; Cerebral infarction ; Disease ; Drug Discovery - methods ; Embolism ; Endothelial cells ; Enzyme Inhibitors - adverse effects ; Enzyme Inhibitors - therapeutic use ; Enzymes ; Gene Expression Regulation, Enzymologic ; Growth factors ; Humans ; Kinases ; Mammals ; Molecular modelling ; Molecular Targeted Therapy - adverse effects ; Molecular Targeted Therapy - methods ; Mutation ; Myocardial infarction ; Phosphate esters ; Phosphorylase ; Platelet-derived endothelial cell growth factor ; Platelets ; Protein Conformation ; Proteins ; Stroke ; Structure-Activity Relationship ; Thrombosis ; Thymidine ; Thymidine phosphorylase ; Thymidine Phosphorylase - antagonists & inhibitors ; Thymidine Phosphorylase - chemistry ; Thymidine Phosphorylase - genetics ; Thymidine Phosphorylase - metabolism ; Tumors
ispartofTrends in cardiovascular medicine, 2018-04, Vol.28 (3), p.157-171
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descriptionWe recently found that thymidine phosphorylase (TYMP), also known as platelet-derived endothelial cell growth factor, plays an important role in platelet activation in vitro and thrombosis in vivo by participating in multiple signaling pathways. Platelets are a major source of TYMP. Since platelet-mediated clot formation is a key event in several fatal diseases, such as myocardial infarction, stroke and pulmonary embolism, understanding TYMP in depth may lead to uncovering novel mechanisms in the development of cardiovascular diseases. Targeting TYMP may become a novel therapeutic for cardiovascular disorders. In this review article, we summarize the discovery of TYMP and the potential molecular mechanisms of TYMP involved in the development of various diseases, especially cardiovascular diseases. We also offer insights regarding future studies exploring the role of TYMP in the development of cardiovascular disease as well as in therapy.
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abstractWe recently found that thymidine phosphorylase (TYMP), also known as platelet-derived endothelial cell growth factor, plays an important role in platelet activation in vitro and thrombosis in vivo by participating in multiple signaling pathways. Platelets are a major source of TYMP. Since platelet-mediated clot formation is a key event in several fatal diseases, such as myocardial infarction, stroke and pulmonary embolism, understanding TYMP in depth may lead to uncovering novel mechanisms in the development of cardiovascular diseases. Targeting TYMP may become a novel therapeutic for cardiovascular disorders. In this review article, we summarize the discovery of TYMP and the potential molecular mechanisms of TYMP involved in the development of various diseases, especially cardiovascular diseases. We also offer insights regarding future studies exploring the role of TYMP in the development of cardiovascular disease as well as in therapy.
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