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Rationale and Design of Family-Based Approach in a Minority Community Integrating Systems–Biology for Promotion of Health (FAMILIA)

The 2020 American Heart Association Impact Goal aims to improve cardiovascular health of all Americans by 20% while reducing deaths from cardiovascular disease and stroke by 20%. A large step toward this goal would be to better understand and take advantage of the significant intersection between be... Full description

Journal Title: The American heart journal 2017-05, Vol.187, p.170-181
Main Author: Bansilal, Sameer
Other Authors: Vedanthan, Rajesh , Kovacic, Jason C , Soto, Ana Victoria , Latina, Jacqueline , Björkegren, Johan L.M , Jaslow, Risa , Santana, Maribel , Sartori, Samantha , Giannarelli, Chiara , Mani, Venkatesh , Hajjar, Roger , Schadt, Eric , Kasarskis, Andrew , Fayad, Zahi A , Fuster, Valentin
Format: Electronic Article Electronic Article
Language: English
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Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 0002-8703
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6190598
title: Rationale and Design of Family-Based Approach in a Minority Community Integrating Systems–Biology for Promotion of Health (FAMILIA)
format: Article
creator:
  • Bansilal, Sameer
  • Vedanthan, Rajesh
  • Kovacic, Jason C
  • Soto, Ana Victoria
  • Latina, Jacqueline
  • Björkegren, Johan L.M
  • Jaslow, Risa
  • Santana, Maribel
  • Sartori, Samantha
  • Giannarelli, Chiara
  • Mani, Venkatesh
  • Hajjar, Roger
  • Schadt, Eric
  • Kasarskis, Andrew
  • Fayad, Zahi A
  • Fuster, Valentin
subjects:
  • Abridged Index Medicus
  • Adult
  • Article
  • Body Mass Index
  • Cardiovascular Diseases - ethnology
  • Cardiovascular Diseases - prevention & control
  • Child, Preschool
  • Counseling
  • Early Intervention (Education)
  • Exercise
  • Health Education
  • Health Knowledge, Attitudes, Practice
  • Health Promotion - methods
  • Healthy Diet
  • Humans
  • Medicin och hälsovetenskap
  • Minority Groups - education
  • New York
  • Pilot Projects
  • Stroke (Disease)
  • Surveys and Questionnaires
ispartof: The American heart journal, 2017-05, Vol.187, p.170-181
description: The 2020 American Heart Association Impact Goal aims to improve cardiovascular health of all Americans by 20% while reducing deaths from cardiovascular disease and stroke by 20%. A large step toward this goal would be to better understand and take advantage of the significant intersection between behavior and biology across the entire life-span. In the proposed FAMILIA studies, we aim to directly address this major knowledge and clinical health gap by implementing an integrated family-centric health promotion intervention and focusing on the intersection of environment and behavior, while understanding the genetic and biologic basis of cardiovascular disease. We plan to recruit 600 preschool children and their 600 parents or caregivers from 12-15 Head Start schools in Harlem, NY, and perform a 2:1 (2 intervention/1 control) cluster randomization of the schools. The preschool children will receive our intensive 37-hour educational program as the intervention for 4 months. For the adults, those in the “intervention” group will be randomly assigned to 1 of 2 intervention programs: an “individual-focused” or “peer-to-peer based.” The primary outcome in children will be a composite score of knowledge (K), attitudes (A), habits (H), related to body mass index Z score (B), exercise (E), and alimentation (A) (KAH-BEA), using questionnaires and anthropometric measurements. For adults, the primary outcome will be a composite score for behaviors/outcomes related to blood pressure, exercise, weight, alimentation (diet) and tobacco (smoking; Fuster-BEWAT score). Saliva will be collected from the children for SNP genotyping, and blood will be collected from adults for RNA sequencing to identify network models and predictors of primary prevention outcomes. The FAMILIA studies seek to demonstrate that targeting a younger age group (3-5 years) and using a family-based approach may be a critical strategy in promoting cardiovascular health across the life-span.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0002-8703
fulltext: fulltext
issn:
  • 0002-8703
  • 1097-6744
  • 1097-6744
url: Link


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titleRationale and Design of Family-Based Approach in a Minority Community Integrating Systems–Biology for Promotion of Health (FAMILIA)
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creatorBansilal, Sameer ; Vedanthan, Rajesh ; Kovacic, Jason C ; Soto, Ana Victoria ; Latina, Jacqueline ; Björkegren, Johan L.M ; Jaslow, Risa ; Santana, Maribel ; Sartori, Samantha ; Giannarelli, Chiara ; Mani, Venkatesh ; Hajjar, Roger ; Schadt, Eric ; Kasarskis, Andrew ; Fayad, Zahi A ; Fuster, Valentin
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descriptionThe 2020 American Heart Association Impact Goal aims to improve cardiovascular health of all Americans by 20% while reducing deaths from cardiovascular disease and stroke by 20%. A large step toward this goal would be to better understand and take advantage of the significant intersection between behavior and biology across the entire life-span. In the proposed FAMILIA studies, we aim to directly address this major knowledge and clinical health gap by implementing an integrated family-centric health promotion intervention and focusing on the intersection of environment and behavior, while understanding the genetic and biologic basis of cardiovascular disease. We plan to recruit 600 preschool children and their 600 parents or caregivers from 12-15 Head Start schools in Harlem, NY, and perform a 2:1 (2 intervention/1 control) cluster randomization of the schools. The preschool children will receive our intensive 37-hour educational program as the intervention for 4 months. For the adults, those in the “intervention” group will be randomly assigned to 1 of 2 intervention programs: an “individual-focused” or “peer-to-peer based.” The primary outcome in children will be a composite score of knowledge (K), attitudes (A), habits (H), related to body mass index Z score (B), exercise (E), and alimentation (A) (KAH-BEA), using questionnaires and anthropometric measurements. For adults, the primary outcome will be a composite score for behaviors/outcomes related to blood pressure, exercise, weight, alimentation (diet) and tobacco (smoking; Fuster-BEWAT score). Saliva will be collected from the children for SNP genotyping, and blood will be collected from adults for RNA sequencing to identify network models and predictors of primary prevention outcomes. The FAMILIA studies seek to demonstrate that targeting a younger age group (3-5 years) and using a family-based approach may be a critical strategy in promoting cardiovascular health across the life-span.
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subjectAbridged Index Medicus ; Adult ; Article ; Body Mass Index ; Cardiovascular Diseases - ethnology ; Cardiovascular Diseases - prevention & control ; Child, Preschool ; Counseling ; Early Intervention (Education) ; Exercise ; Health Education ; Health Knowledge, Attitudes, Practice ; Health Promotion - methods ; Healthy Diet ; Humans ; Medicin och hälsovetenskap ; Minority Groups - education ; New York ; Pilot Projects ; Stroke (Disease) ; Surveys and Questionnaires
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descriptionThe 2020 American Heart Association Impact Goal aims to improve cardiovascular health of all Americans by 20% while reducing deaths from cardiovascular disease and stroke by 20%. A large step toward this goal would be to better understand and take advantage of the significant intersection between behavior and biology across the entire life-span. In the proposed FAMILIA studies, we aim to directly address this major knowledge and clinical health gap by implementing an integrated family-centric health promotion intervention and focusing on the intersection of environment and behavior, while understanding the genetic and biologic basis of cardiovascular disease. We plan to recruit 600 preschool children and their 600 parents or caregivers from 12-15 Head Start schools in Harlem, NY, and perform a 2:1 (2 intervention/1 control) cluster randomization of the schools. The preschool children will receive our intensive 37-hour educational program as the intervention for 4 months. For the adults, those in the “intervention” group will be randomly assigned to 1 of 2 intervention programs: an “individual-focused” or “peer-to-peer based.” The primary outcome in children will be a composite score of knowledge (K), attitudes (A), habits (H), related to body mass index Z score (B), exercise (E), and alimentation (A) (KAH-BEA), using questionnaires and anthropometric measurements. For adults, the primary outcome will be a composite score for behaviors/outcomes related to blood pressure, exercise, weight, alimentation (diet) and tobacco (smoking; Fuster-BEWAT score). Saliva will be collected from the children for SNP genotyping, and blood will be collected from adults for RNA sequencing to identify network models and predictors of primary prevention outcomes. The FAMILIA studies seek to demonstrate that targeting a younger age group (3-5 years) and using a family-based approach may be a critical strategy in promoting cardiovascular health across the life-span.
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titleRationale and Design of Family-Based Approach in a Minority Community Integrating Systems–Biology for Promotion of Health (FAMILIA)
authorBansilal, Sameer ; Vedanthan, Rajesh ; Kovacic, Jason C ; Soto, Ana Victoria ; Latina, Jacqueline ; Björkegren, Johan L.M ; Jaslow, Risa ; Santana, Maribel ; Sartori, Samantha ; Giannarelli, Chiara ; Mani, Venkatesh ; Hajjar, Roger ; Schadt, Eric ; Kasarskis, Andrew ; Fayad, Zahi A ; Fuster, Valentin
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notesReprint requests: Sameer Bansilal, MD, MS, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1030 New York, NY 10029.
abstractThe 2020 American Heart Association Impact Goal aims to improve cardiovascular health of all Americans by 20% while reducing deaths from cardiovascular disease and stroke by 20%. A large step toward this goal would be to better understand and take advantage of the significant intersection between behavior and biology across the entire life-span. In the proposed FAMILIA studies, we aim to directly address this major knowledge and clinical health gap by implementing an integrated family-centric health promotion intervention and focusing on the intersection of environment and behavior, while understanding the genetic and biologic basis of cardiovascular disease. We plan to recruit 600 preschool children and their 600 parents or caregivers from 12-15 Head Start schools in Harlem, NY, and perform a 2:1 (2 intervention/1 control) cluster randomization of the schools. The preschool children will receive our intensive 37-hour educational program as the intervention for 4 months. For the adults, those in the “intervention” group will be randomly assigned to 1 of 2 intervention programs: an “individual-focused” or “peer-to-peer based.” The primary outcome in children will be a composite score of knowledge (K), attitudes (A), habits (H), related to body mass index Z score (B), exercise (E), and alimentation (A) (KAH-BEA), using questionnaires and anthropometric measurements. For adults, the primary outcome will be a composite score for behaviors/outcomes related to blood pressure, exercise, weight, alimentation (diet) and tobacco (smoking; Fuster-BEWAT score). Saliva will be collected from the children for SNP genotyping, and blood will be collected from adults for RNA sequencing to identify network models and predictors of primary prevention outcomes. The FAMILIA studies seek to demonstrate that targeting a younger age group (3-5 years) and using a family-based approach may be a critical strategy in promoting cardiovascular health across the life-span.
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