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Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases

The term "aging-related tau astrogliopathy" (ARTAG) describes pathological accumulation of abnormally phosphorylated tau protein in astrocytes. We evaluated the correlates of ARTAG types (i.e., subpial, subependymal, white and gray matter, and perivascular) in different neuroanatomical regions. Clin... Full description

Journal Title: Journal of neuropathology and experimental neurology 2017-04-01, Vol.76 (4), p.270-288
Main Author: Kovacs, Gabor G
Other Authors: Robinson, John L , Xie, Sharon X , Lee, Edward B , Grossman, Murray , Wolk, David A , Irwin, David J , Weintraub, Dan , Kim, Christopher F , Schuck, Theresa , Yousef, Ahmed , Wagner, Stephanie T , Suh, Eunran , Van Deerlin, Vivianna M , Lee, Virginia M.-Y , Trojanowski, John Q
Format: Electronic Article Electronic Article
Language: English
Subjects:
Tau
Publisher: England: by American Association of Neuropathologists, Inc
ID: ISSN: 0022-3069
Link: https://www.ncbi.nlm.nih.gov/pubmed/28340083
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6251691
title: Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases
format: Article
creator:
  • Kovacs, Gabor G
  • Robinson, John L
  • Xie, Sharon X
  • Lee, Edward B
  • Grossman, Murray
  • Wolk, David A
  • Irwin, David J
  • Weintraub, Dan
  • Kim, Christopher F
  • Schuck, Theresa
  • Yousef, Ahmed
  • Wagner, Stephanie T
  • Suh, Eunran
  • Van Deerlin, Vivianna M
  • Lee, Virginia M.-Y
  • Trojanowski, John Q
subjects:
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging - pathology
  • Aging-related tau astrogliopathy
  • Alzheimer disease
  • Alzheimer Disease - pathology
  • Apolipoproteins E - biosynthesis
  • Apolipoproteins E - genetics
  • ARTAG
  • Astrocytes - pathology
  • Atrophy
  • Brain - pathology
  • Chronic traumatic encephalopathy
  • Dementia
  • Female
  • Frontotemporal Lobar Degeneration - genetics
  • Frontotemporal Lobar Degeneration - pathology
  • Humans
  • Longitudinal Studies
  • Male
  • mental disorders
  • Neurodegenerative Diseases - pathology
  • Neuroglia - pathology
  • Original
  • Original Articles
  • Sex Factors
  • Tau
  • tau Proteins - biosynthesis
  • tau Proteins - genetics
  • Tauopathies - pathology
  • Tauopathy
ispartof: Journal of neuropathology and experimental neurology, 2017-04-01, Vol.76 (4), p.270-288
description: The term "aging-related tau astrogliopathy" (ARTAG) describes pathological accumulation of abnormally phosphorylated tau protein in astrocytes. We evaluated the correlates of ARTAG types (i.e., subpial, subependymal, white and gray matter, and perivascular) in different neuroanatomical regions. Clinical, neuropathological, and genetic (eg, APOE ε4 allele, MAPT H1/H2 haplotype) data from 628 postmortem brains from subjects were investigated; most of the patients had been longitudinally followed at the University of Pennsylvania. We found that (i) the amygdala is a hotspot for all ARTAG types; (ii) age at death, male sex, and presence of primary frontotemporal lobar degeneration (FTLD) tauopathy are significantly associated with ARTAG; (iii) age at death, greater degree of brain atrophy, ventricular enlargement, and Alzheimer disease (AD)-related variables are associated with subpial, white matter, and perivascular ARTAG types; (iv) AD-related variables are associated particularly with lobar white matter ARTAG; and (v) gray matter ARTAG in primary FTLD-tauopathies appears in areas without neuronal tau pathology. We provide a reference map of ARTAG types and propose at least 5 constellations of ARTAG. Furthermore, we propose a conceptual link between primary FTLD-tauopathy and ARTAG-related astrocytic tau pathologies. Our observations serve as a basis for etiological stratification and definition of progression patterns of ARTAG.
language: eng
source:
identifier: ISSN: 0022-3069
fulltext: no_fulltext
issn:
  • 0022-3069
  • 1554-6578
url: Link


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titleEvaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases
creatorKovacs, Gabor G ; Robinson, John L ; Xie, Sharon X ; Lee, Edward B ; Grossman, Murray ; Wolk, David A ; Irwin, David J ; Weintraub, Dan ; Kim, Christopher F ; Schuck, Theresa ; Yousef, Ahmed ; Wagner, Stephanie T ; Suh, Eunran ; Van Deerlin, Vivianna M ; Lee, Virginia M.-Y ; Trojanowski, John Q
creatorcontribKovacs, Gabor G ; Robinson, John L ; Xie, Sharon X ; Lee, Edward B ; Grossman, Murray ; Wolk, David A ; Irwin, David J ; Weintraub, Dan ; Kim, Christopher F ; Schuck, Theresa ; Yousef, Ahmed ; Wagner, Stephanie T ; Suh, Eunran ; Van Deerlin, Vivianna M ; Lee, Virginia M.-Y ; Trojanowski, John Q
descriptionThe term "aging-related tau astrogliopathy" (ARTAG) describes pathological accumulation of abnormally phosphorylated tau protein in astrocytes. We evaluated the correlates of ARTAG types (i.e., subpial, subependymal, white and gray matter, and perivascular) in different neuroanatomical regions. Clinical, neuropathological, and genetic (eg, APOE ε4 allele, MAPT H1/H2 haplotype) data from 628 postmortem brains from subjects were investigated; most of the patients had been longitudinally followed at the University of Pennsylvania. We found that (i) the amygdala is a hotspot for all ARTAG types; (ii) age at death, male sex, and presence of primary frontotemporal lobar degeneration (FTLD) tauopathy are significantly associated with ARTAG; (iii) age at death, greater degree of brain atrophy, ventricular enlargement, and Alzheimer disease (AD)-related variables are associated with subpial, white matter, and perivascular ARTAG types; (iv) AD-related variables are associated particularly with lobar white matter ARTAG; and (v) gray matter ARTAG in primary FTLD-tauopathies appears in areas without neuronal tau pathology. We provide a reference map of ARTAG types and propose at least 5 constellations of ARTAG. Furthermore, we propose a conceptual link between primary FTLD-tauopathy and ARTAG-related astrocytic tau pathologies. Our observations serve as a basis for etiological stratification and definition of progression patterns of ARTAG.
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subjectAge Factors ; Aged ; Aged, 80 and over ; Aging - pathology ; Aging-related tau astrogliopathy ; Alzheimer disease ; Alzheimer Disease - pathology ; Apolipoproteins E - biosynthesis ; Apolipoproteins E - genetics ; ARTAG ; Astrocytes - pathology ; Atrophy ; Brain - pathology ; Chronic traumatic encephalopathy ; Dementia ; Female ; Frontotemporal Lobar Degeneration - genetics ; Frontotemporal Lobar Degeneration - pathology ; Humans ; Longitudinal Studies ; Male ; mental disorders ; Neurodegenerative Diseases - pathology ; Neuroglia - pathology ; Original ; Original Articles ; Sex Factors ; Tau ; tau Proteins - biosynthesis ; tau Proteins - genetics ; Tauopathies - pathology ; Tauopathy
ispartofJournal of neuropathology and experimental neurology, 2017-04-01, Vol.76 (4), p.270-288
rights
02017 by American Association of Neuropathologists, Inc.
12017 American Association of Neuropathologists, Inc. All rights reserved.
22017 American Association of Neuropathologists, Inc. All rights reserved. 2017
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1Robinson, John L
2Xie, Sharon X
3Lee, Edward B
4Grossman, Murray
5Wolk, David A
6Irwin, David J
7Weintraub, Dan
8Kim, Christopher F
9Schuck, Theresa
10Yousef, Ahmed
11Wagner, Stephanie T
12Suh, Eunran
13Van Deerlin, Vivianna M
14Lee, Virginia M.-Y
15Trojanowski, John Q
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0Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases
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descriptionThe term "aging-related tau astrogliopathy" (ARTAG) describes pathological accumulation of abnormally phosphorylated tau protein in astrocytes. We evaluated the correlates of ARTAG types (i.e., subpial, subependymal, white and gray matter, and perivascular) in different neuroanatomical regions. Clinical, neuropathological, and genetic (eg, APOE ε4 allele, MAPT H1/H2 haplotype) data from 628 postmortem brains from subjects were investigated; most of the patients had been longitudinally followed at the University of Pennsylvania. We found that (i) the amygdala is a hotspot for all ARTAG types; (ii) age at death, male sex, and presence of primary frontotemporal lobar degeneration (FTLD) tauopathy are significantly associated with ARTAG; (iii) age at death, greater degree of brain atrophy, ventricular enlargement, and Alzheimer disease (AD)-related variables are associated with subpial, white matter, and perivascular ARTAG types; (iv) AD-related variables are associated particularly with lobar white matter ARTAG; and (v) gray matter ARTAG in primary FTLD-tauopathies appears in areas without neuronal tau pathology. We provide a reference map of ARTAG types and propose at least 5 constellations of ARTAG. Furthermore, we propose a conceptual link between primary FTLD-tauopathy and ARTAG-related astrocytic tau pathologies. Our observations serve as a basis for etiological stratification and definition of progression patterns of ARTAG.
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3Aging - pathology
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5Alzheimer disease
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titleEvaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases
authorKovacs, Gabor G ; Robinson, John L ; Xie, Sharon X ; Lee, Edward B ; Grossman, Murray ; Wolk, David A ; Irwin, David J ; Weintraub, Dan ; Kim, Christopher F ; Schuck, Theresa ; Yousef, Ahmed ; Wagner, Stephanie T ; Suh, Eunran ; Van Deerlin, Vivianna M ; Lee, Virginia M.-Y ; Trojanowski, John Q
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8Kim, Christopher F
9Schuck, Theresa
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7Weintraub, Dan
8Kim, Christopher F
9Schuck, Theresa
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notes
0Supplementary Data can be found at http://www.jnen.oxfordjournals.org.
1The authors have no duality or conflicts of interest to declare.
2This work was supported by grants from the National Institute on Aging of the National Institutes of Health (P30-AG10124, PO1-AG17586, NS088341, and NS094003).
abstractThe term "aging-related tau astrogliopathy" (ARTAG) describes pathological accumulation of abnormally phosphorylated tau protein in astrocytes. We evaluated the correlates of ARTAG types (i.e., subpial, subependymal, white and gray matter, and perivascular) in different neuroanatomical regions. Clinical, neuropathological, and genetic (eg, APOE ε4 allele, MAPT H1/H2 haplotype) data from 628 postmortem brains from subjects were investigated; most of the patients had been longitudinally followed at the University of Pennsylvania. We found that (i) the amygdala is a hotspot for all ARTAG types; (ii) age at death, male sex, and presence of primary frontotemporal lobar degeneration (FTLD) tauopathy are significantly associated with ARTAG; (iii) age at death, greater degree of brain atrophy, ventricular enlargement, and Alzheimer disease (AD)-related variables are associated with subpial, white matter, and perivascular ARTAG types; (iv) AD-related variables are associated particularly with lobar white matter ARTAG; and (v) gray matter ARTAG in primary FTLD-tauopathies appears in areas without neuronal tau pathology. We provide a reference map of ARTAG types and propose at least 5 constellations of ARTAG. Furthermore, we propose a conceptual link between primary FTLD-tauopathy and ARTAG-related astrocytic tau pathologies. Our observations serve as a basis for etiological stratification and definition of progression patterns of ARTAG.
copEngland
pubby American Association of Neuropathologists, Inc
pmid28340083
doi10.1093/jnen/nlx007
oafree_for_read