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Subclinical Thyroid Dysfunction and the Risk of Cognitive Decline: a Meta-Analysis of Prospective Cohort Studies

Context: Although both overt hyper- and hypothyroidism are known to lead to cognitive impairment, data on the association between subclinical thyroid dysfunction and cognitive function are conflicting. Objective: This study sought to determine the risk of dementia and cognitive decline associated wi... Full description

Journal Title: The Journal of Clinical Endocrinology & Metabolism 2016, Vol.101 (12), p.4945-4954
Main Author: Rieben, Carole
Other Authors: Segna, Daniel , da Costa, Bruno R , Collet, Tinh-Hai , Chaker, Layal , Aubert, Carole E , Baumgartner, Christine , Almeida, Osvaldo P , Hogervorst, Eef , Trompet, Stella , Masaki, Kamal , Mooijaart, Simon P , Gussekloo, Jacobijn , Peeters, Robin P , Bauer, Douglas C , Aujesky, Drahomir , Rodondi, Nicolas
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States: Endocrine Society
ID: ISSN: 0021-972X
Link: https://www.ncbi.nlm.nih.gov/pubmed/27689250
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title: Subclinical Thyroid Dysfunction and the Risk of Cognitive Decline: a Meta-Analysis of Prospective Cohort Studies
format: Article
creator:
  • Rieben, Carole
  • Segna, Daniel
  • da Costa, Bruno R
  • Collet, Tinh-Hai
  • Chaker, Layal
  • Aubert, Carole E
  • Baumgartner, Christine
  • Almeida, Osvaldo P
  • Hogervorst, Eef
  • Trompet, Stella
  • Masaki, Kamal
  • Mooijaart, Simon P
  • Gussekloo, Jacobijn
  • Peeters, Robin P
  • Bauer, Douglas C
  • Aujesky, Drahomir
  • Rodondi, Nicolas
subjects:
  • Abridged Index Medicus
  • Cognitive Dysfunction - epidemiology
  • Cognitive Dysfunction - etiology
  • Dementia - epidemiology
  • Dementia - etiology
  • endocrine system
  • endocrine system diseases
  • hormone antagonists
  • hormone substitutes
  • hormones
  • Humans
  • Hyperthyroidism - complications
  • Hyperthyroidism - epidemiology
  • Hypothyroidism - complications
  • Hypothyroidism - epidemiology
  • Original
ispartof: The Journal of Clinical Endocrinology & Metabolism, 2016, Vol.101 (12), p.4945-4954
description: Context: Although both overt hyper- and hypothyroidism are known to lead to cognitive impairment, data on the association between subclinical thyroid dysfunction and cognitive function are conflicting. Objective: This study sought to determine the risk of dementia and cognitive decline associated with subclinical thyroid dysfunction among prospective cohorts. Data Sources: We searched in MEDLINE and EMBASE from inception until November 2014. Study Selection: Two physicians identified prospective cohorts that assessed thyroid function and cognitive outcomes (dementia; Mini-Mental State Examination [MMSE]). Data Extraction: Data were extracted by one reviewer following standardized protocols and verified by a second reviewer. The primary outcome was dementia and decline in cognitive function was the secondary outcome. Data Synthesis: Eleven prospective cohorts followed 16,805 participants during a median followup of 44.4 months. Five studies analyzed the risk of dementia in subclinical hyperthyroidism (SHyper) (n = 6410), six in subclinical hypothyroidism (SHypo) (n = 7401). Five studies analyzed MMSE decline in SHyper (n = 7895), seven in SHypo (n = 8960). In random-effects models, the pooled adjusted risk ratio for dementia in SHyper was 1.67 (95% confidence interval, 1.04; 2.69) and 1.14 (95% confidence interval, 0.84; 1.55) in SHypo vs euthyroidism, both without evidence of significant heterogeneity (I2 = 0.0%). The pooled mean MMSE decline from baseline to followup (mean 32 mo) did not significantly differ between SHyper or SHypo vs euthyroidism. Conclusions: SHyper might be associated with an elevated risk for dementia, whereas SHypo is not, and both conditions are not associated with faster decline in MMSE over time. Available data are limited, and additional large, high-quality studies are needed. This meta-analysis determined the risk of dementia and cognitive decline associated with subclinical thyroid dysfunction and found a possible association for subclinical hyperthyroidism and dementia.
language: eng
source:
identifier: ISSN: 0021-972X
fulltext: no_fulltext
issn:
  • 0021-972X
  • 1945-7197
url: Link


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titleSubclinical Thyroid Dysfunction and the Risk of Cognitive Decline: a Meta-Analysis of Prospective Cohort Studies
creatorRieben, Carole ; Segna, Daniel ; da Costa, Bruno R ; Collet, Tinh-Hai ; Chaker, Layal ; Aubert, Carole E ; Baumgartner, Christine ; Almeida, Osvaldo P ; Hogervorst, Eef ; Trompet, Stella ; Masaki, Kamal ; Mooijaart, Simon P ; Gussekloo, Jacobijn ; Peeters, Robin P ; Bauer, Douglas C ; Aujesky, Drahomir ; Rodondi, Nicolas
creatorcontribRieben, Carole ; Segna, Daniel ; da Costa, Bruno R ; Collet, Tinh-Hai ; Chaker, Layal ; Aubert, Carole E ; Baumgartner, Christine ; Almeida, Osvaldo P ; Hogervorst, Eef ; Trompet, Stella ; Masaki, Kamal ; Mooijaart, Simon P ; Gussekloo, Jacobijn ; Peeters, Robin P ; Bauer, Douglas C ; Aujesky, Drahomir ; Rodondi, Nicolas
descriptionContext: Although both overt hyper- and hypothyroidism are known to lead to cognitive impairment, data on the association between subclinical thyroid dysfunction and cognitive function are conflicting. Objective: This study sought to determine the risk of dementia and cognitive decline associated with subclinical thyroid dysfunction among prospective cohorts. Data Sources: We searched in MEDLINE and EMBASE from inception until November 2014. Study Selection: Two physicians identified prospective cohorts that assessed thyroid function and cognitive outcomes (dementia; Mini-Mental State Examination [MMSE]). Data Extraction: Data were extracted by one reviewer following standardized protocols and verified by a second reviewer. The primary outcome was dementia and decline in cognitive function was the secondary outcome. Data Synthesis: Eleven prospective cohorts followed 16,805 participants during a median followup of 44.4 months. Five studies analyzed the risk of dementia in subclinical hyperthyroidism (SHyper) (n = 6410), six in subclinical hypothyroidism (SHypo) (n = 7401). Five studies analyzed MMSE decline in SHyper (n = 7895), seven in SHypo (n = 8960). In random-effects models, the pooled adjusted risk ratio for dementia in SHyper was 1.67 (95% confidence interval, 1.04; 2.69) and 1.14 (95% confidence interval, 0.84; 1.55) in SHypo vs euthyroidism, both without evidence of significant heterogeneity (I2 = 0.0%). The pooled mean MMSE decline from baseline to followup (mean 32 mo) did not significantly differ between SHyper or SHypo vs euthyroidism. Conclusions: SHyper might be associated with an elevated risk for dementia, whereas SHypo is not, and both conditions are not associated with faster decline in MMSE over time. Available data are limited, and additional large, high-quality studies are needed. This meta-analysis determined the risk of dementia and cognitive decline associated with subclinical thyroid dysfunction and found a possible association for subclinical hyperthyroidism and dementia.
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subjectAbridged Index Medicus ; Cognitive Dysfunction - epidemiology ; Cognitive Dysfunction - etiology ; Dementia - epidemiology ; Dementia - etiology ; endocrine system ; endocrine system diseases ; hormone antagonists ; hormone substitutes ; hormones ; Humans ; Hyperthyroidism - complications ; Hyperthyroidism - epidemiology ; Hypothyroidism - complications ; Hypothyroidism - epidemiology ; Original
ispartofThe Journal of Clinical Endocrinology & Metabolism, 2016, Vol.101 (12), p.4945-4954
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7Almeida, Osvaldo P
8Hogervorst, Eef
9Trompet, Stella
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11Mooijaart, Simon P
12Gussekloo, Jacobijn
13Peeters, Robin P
14Bauer, Douglas C
15Aujesky, Drahomir
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descriptionContext: Although both overt hyper- and hypothyroidism are known to lead to cognitive impairment, data on the association between subclinical thyroid dysfunction and cognitive function are conflicting. Objective: This study sought to determine the risk of dementia and cognitive decline associated with subclinical thyroid dysfunction among prospective cohorts. Data Sources: We searched in MEDLINE and EMBASE from inception until November 2014. Study Selection: Two physicians identified prospective cohorts that assessed thyroid function and cognitive outcomes (dementia; Mini-Mental State Examination [MMSE]). Data Extraction: Data were extracted by one reviewer following standardized protocols and verified by a second reviewer. The primary outcome was dementia and decline in cognitive function was the secondary outcome. Data Synthesis: Eleven prospective cohorts followed 16,805 participants during a median followup of 44.4 months. Five studies analyzed the risk of dementia in subclinical hyperthyroidism (SHyper) (n = 6410), six in subclinical hypothyroidism (SHypo) (n = 7401). Five studies analyzed MMSE decline in SHyper (n = 7895), seven in SHypo (n = 8960). In random-effects models, the pooled adjusted risk ratio for dementia in SHyper was 1.67 (95% confidence interval, 1.04; 2.69) and 1.14 (95% confidence interval, 0.84; 1.55) in SHypo vs euthyroidism, both without evidence of significant heterogeneity (I2 = 0.0%). The pooled mean MMSE decline from baseline to followup (mean 32 mo) did not significantly differ between SHyper or SHypo vs euthyroidism. Conclusions: SHyper might be associated with an elevated risk for dementia, whereas SHypo is not, and both conditions are not associated with faster decline in MMSE over time. Available data are limited, and additional large, high-quality studies are needed. This meta-analysis determined the risk of dementia and cognitive decline associated with subclinical thyroid dysfunction and found a possible association for subclinical hyperthyroidism and dementia.
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7hormone antagonists
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13Hypothyroidism - complications
14Hypothyroidism - epidemiology
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7Almeida, Osvaldo P
8Hogervorst, Eef
9Trompet, Stella
10Masaki, Kamal
11Mooijaart, Simon P
12Gussekloo, Jacobijn
13Peeters, Robin P
14Bauer, Douglas C
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titleSubclinical Thyroid Dysfunction and the Risk of Cognitive Decline: a Meta-Analysis of Prospective Cohort Studies
authorRieben, Carole ; Segna, Daniel ; da Costa, Bruno R ; Collet, Tinh-Hai ; Chaker, Layal ; Aubert, Carole E ; Baumgartner, Christine ; Almeida, Osvaldo P ; Hogervorst, Eef ; Trompet, Stella ; Masaki, Kamal ; Mooijaart, Simon P ; Gussekloo, Jacobijn ; Peeters, Robin P ; Bauer, Douglas C ; Aujesky, Drahomir ; Rodondi, Nicolas
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1Cognitive Dysfunction - epidemiology
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5endocrine system
6endocrine system diseases
7hormone antagonists
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1Segna, Daniel
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7Almeida, Osvaldo P
8Hogervorst, Eef
9Trompet, Stella
10Masaki, Kamal
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13Peeters, Robin P
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7Almeida, Osvaldo P
8Hogervorst, Eef
9Trompet, Stella
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notesN.R.'s work is supported by a grant from the Swiss National Science Foundation (SNSF 320030-150025). T.-H.C.'s research is supported by grants from the Swiss National Science Foundation (PBLAP3-145870, P3SMP3-155318).
abstractContext: Although both overt hyper- and hypothyroidism are known to lead to cognitive impairment, data on the association between subclinical thyroid dysfunction and cognitive function are conflicting. Objective: This study sought to determine the risk of dementia and cognitive decline associated with subclinical thyroid dysfunction among prospective cohorts. Data Sources: We searched in MEDLINE and EMBASE from inception until November 2014. Study Selection: Two physicians identified prospective cohorts that assessed thyroid function and cognitive outcomes (dementia; Mini-Mental State Examination [MMSE]). Data Extraction: Data were extracted by one reviewer following standardized protocols and verified by a second reviewer. The primary outcome was dementia and decline in cognitive function was the secondary outcome. Data Synthesis: Eleven prospective cohorts followed 16,805 participants during a median followup of 44.4 months. Five studies analyzed the risk of dementia in subclinical hyperthyroidism (SHyper) (n = 6410), six in subclinical hypothyroidism (SHypo) (n = 7401). Five studies analyzed MMSE decline in SHyper (n = 7895), seven in SHypo (n = 8960). In random-effects models, the pooled adjusted risk ratio for dementia in SHyper was 1.67 (95% confidence interval, 1.04; 2.69) and 1.14 (95% confidence interval, 0.84; 1.55) in SHypo vs euthyroidism, both without evidence of significant heterogeneity (I2 = 0.0%). The pooled mean MMSE decline from baseline to followup (mean 32 mo) did not significantly differ between SHyper or SHypo vs euthyroidism. Conclusions: SHyper might be associated with an elevated risk for dementia, whereas SHypo is not, and both conditions are not associated with faster decline in MMSE over time. Available data are limited, and additional large, high-quality studies are needed. This meta-analysis determined the risk of dementia and cognitive decline associated with subclinical thyroid dysfunction and found a possible association for subclinical hyperthyroidism and dementia.
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pmid27689250
doi10.1210/jc.2016-2129
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