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Short Communication: The Interaction of HIV Set Point Viral Load and Subtype on Disease Progression

HIV-1 subtype and viral load set point have been implicated as strong predictors of HIV-1 disease progression; however, the relationship between these two variables has not been investigated. We used data from the Rakai Community Cohort Study to investigate whether the association between viral load... Full description

Journal Title: AIDS research and human retroviruses 2019-01-01, Vol.35 (1), p.49-51
Main Author: McPhee, Emily
Other Authors: Grabowski, M. Kate , Gray, Ronald H. , Ndyanabo, Anthony , Ssekasanvu, Joseph , Kigozi, Godfrey , Makumbi, Fredrick , Serwadda, David , Quinn, Thomas C. , Laeyendecker, Oliver
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Mary Ann Liebert, Inc., publishers
ID: ISSN: 0889-2229
Link: https://www.ncbi.nlm.nih.gov/pubmed/30520309
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6343197
title: Short Communication: The Interaction of HIV Set Point Viral Load and Subtype on Disease Progression
format: Article
creator:
  • McPhee, Emily
  • Grabowski, M. Kate
  • Gray, Ronald H.
  • Ndyanabo, Anthony
  • Ssekasanvu, Joseph
  • Kigozi, Godfrey
  • Makumbi, Fredrick
  • Serwadda, David
  • Quinn, Thomas C.
  • Laeyendecker, Oliver
subjects:
  • Adolescent
  • Adult
  • AIDS/HIV
  • Cohort Studies
  • Disease Progression
  • Female
  • Genotype
  • HIV Infections - pathology
  • HIV Infections - virology
  • HIV subtype
  • HIV-1 - classification
  • HIV-1 - genetics
  • HIV-1 - isolation & purification
  • Humans
  • Male
  • Middle Aged
  • Models, Statistical
  • Pathogenesis
  • Survival Analysis
  • Time Factors
  • Uganda
  • Viral Load
  • Young Adult
ispartof: AIDS research and human retroviruses, 2019-01-01, Vol.35 (1), p.49-51
description: HIV-1 subtype and viral load set point have been implicated as strong predictors of HIV-1 disease progression; however, the relationship between these two variables has not been investigated. We used data from the Rakai Community Cohort Study to investigate whether the association between viral load set point and disease progression is modified by HIV subtype. Time to AIDS or AIDS-related death was estimated by Kaplan–Meier survival analysis stratified by subtype and viral set point, and Cox proportional hazards regression with an interaction term between viral load set point and HIV subtype. The interaction term did not indicate effect measure modification between viral load set point and progression to AIDS by HIV-1 subtype [adjusted hazard ratio (aHR), 0.99; 95% confidence interval (CI) 0.61–1.61; p  = .968]. Stratifed analysis by subtype was also not indicative of a difference in relationship between viral load set point and time to AIDS with overlapping 95% CIs between subtypes A and D (subtype A aHR: 2.40, 95% CI 1.45–3.99, subtype D aHR: 1.96, 95% CI 1.60–2.40). These results indicate that the higher mortality in subtype D-infected individuals is independent of viral load set point.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0889-2229
fulltext: fulltext
issn:
  • 0889-2229
  • 1931-8405
url: Link


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descriptionHIV-1 subtype and viral load set point have been implicated as strong predictors of HIV-1 disease progression; however, the relationship between these two variables has not been investigated. We used data from the Rakai Community Cohort Study to investigate whether the association between viral load set point and disease progression is modified by HIV subtype. Time to AIDS or AIDS-related death was estimated by Kaplan–Meier survival analysis stratified by subtype and viral set point, and Cox proportional hazards regression with an interaction term between viral load set point and HIV subtype. The interaction term did not indicate effect measure modification between viral load set point and progression to AIDS by HIV-1 subtype [adjusted hazard ratio (aHR), 0.99; 95% confidence interval (CI) 0.61–1.61; p  = .968]. Stratifed analysis by subtype was also not indicative of a difference in relationship between viral load set point and time to AIDS with overlapping 95% CIs between subtypes A and D (subtype A aHR: 2.40, 95% CI 1.45–3.99, subtype D aHR: 1.96, 95% CI 1.60–2.40). These results indicate that the higher mortality in subtype D-infected individuals is independent of viral load set point.
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subjectAdolescent ; Adult ; AIDS/HIV ; Cohort Studies ; Disease Progression ; Female ; Genotype ; HIV Infections - pathology ; HIV Infections - virology ; HIV subtype ; HIV-1 - classification ; HIV-1 - genetics ; HIV-1 - isolation & purification ; Humans ; Male ; Middle Aged ; Models, Statistical ; Pathogenesis ; Survival Analysis ; Time Factors ; Uganda ; Viral Load ; Young Adult
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abstractHIV-1 subtype and viral load set point have been implicated as strong predictors of HIV-1 disease progression; however, the relationship between these two variables has not been investigated. We used data from the Rakai Community Cohort Study to investigate whether the association between viral load set point and disease progression is modified by HIV subtype. Time to AIDS or AIDS-related death was estimated by Kaplan–Meier survival analysis stratified by subtype and viral set point, and Cox proportional hazards regression with an interaction term between viral load set point and HIV subtype. The interaction term did not indicate effect measure modification between viral load set point and progression to AIDS by HIV-1 subtype [adjusted hazard ratio (aHR), 0.99; 95% confidence interval (CI) 0.61–1.61; p  = .968]. Stratifed analysis by subtype was also not indicative of a difference in relationship between viral load set point and time to AIDS with overlapping 95% CIs between subtypes A and D (subtype A aHR: 2.40, 95% CI 1.45–3.99, subtype D aHR: 1.96, 95% CI 1.60–2.40). These results indicate that the higher mortality in subtype D-infected individuals is independent of viral load set point.
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