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The QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation

To evaluate the impact of the QuinteT Recruitment Intervention (QRI) on recruitment in challenging randomized controlled trials (RCTs) that have applied the intervention. The QRI aims to understand recruitment difficulties and then implements “QRI actions” to address these as recruitment proceeds. A... Full description

Journal Title: Journal of Clinical Epidemiology 2019-02, Vol.106, p.108-120
Main Author: Rooshenas, Leila
Other Authors: Scott, Lauren J , Blazeby, Jane M , Rogers, Chris A , Tilling, Kate M , Husbands, Samantha , Conefrey, Carmel , Mills, Nicola , Stein, Robert C , Metcalfe, Chris , Carr, Andrew J , Beard, David J , Davis, Tim , Paramasivan, Sangeetha , Jepson, Marcus , Avery, Kerry , Elliott, Daisy , Wilson, Caroline , Donovan, Jenny L , Rogers, Chris A , Andrews, Robert , Blazeby, Jane M , Byrne, James , Donovan, Jenny L , Kelly, Jamie , Mazza, Graziella , Mahon, David , Noble, Hamish , Reeves, Barnaby C , Thompson, Janice L , Wordsworth, Sarah , Welbourn, Richard , Beard, David , Carr, Andrew , Cook, Jonathan , Cooper, Cushla , Dean, Benjamin , Gray, Alastair , Gwilym, Stephen , Judge, Andrew , Merritt, Naomi , Moser, Jane , Rees, Jonathan , Rombach, Ines , Savulescu, Julian , Tracey, Irene , Wartolowska, Karolina , Harrison, Eleanor , Tan, Wei , Mills, Nicola , Karantana, Alexia , Sprange, Kirsty , Duley, Lelia , Elliott, Daisy , Hollingworth, William , Montgomery, Alan A , Davis, Tim , Stein, Rob , Bartlett, John , Cameron, David , Campbell, Amy , Canney, Peter , Dunn, Janet , Earl, Helena , Falzon, Mary , Francis, Adele , Hall, Peter , Harmer, Victoria , Higgins, Helen , Hiller, Louise , Hughes-Davies, Luke , Hulme, Claire , Macpherson, Iain , Makris, Andreas , Marshall, Andrea , McCabe, Christopher , Morgan, Adrienne , Pinder, Sarah , Poole, Christopher , Provenzano, Elena , Rea, Daniel , Stallard, Nigel , Avery, Kerry N.L , Barham, C. Paul , Berrisford, Richard , Elliott, Jackie , Falk, Stephen J , Goldin, Rob , Hanna, George , Hollowood, Andrew A , Krysztopik, Richard , Metcalfe, Chris , Noble, Sian , Sanders, Grant , Streets, Christopher G , Titcomb, Dan R , Wheatley, Tim
Format: Electronic Article Electronic Article
Language: English
Subjects:
Non
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 0895-4356
Link: https://www.ncbi.nlm.nih.gov/pubmed/30339938
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6355457
title: The QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation
format: Article
creator:
  • Rooshenas, Leila
  • Scott, Lauren J
  • Blazeby, Jane M
  • Rogers, Chris A
  • Tilling, Kate M
  • Husbands, Samantha
  • Conefrey, Carmel
  • Mills, Nicola
  • Stein, Robert C
  • Metcalfe, Chris
  • Carr, Andrew J
  • Beard, David J
  • Davis, Tim
  • Paramasivan, Sangeetha
  • Jepson, Marcus
  • Avery, Kerry
  • Elliott, Daisy
  • Wilson, Caroline
  • Donovan, Jenny L
  • Rogers, Chris A
  • Andrews, Robert
  • Blazeby, Jane M
  • Byrne, James
  • Donovan, Jenny L
  • Kelly, Jamie
  • Mazza, Graziella
  • Mahon, David
  • Noble, Hamish
  • Reeves, Barnaby C
  • Thompson, Janice L
  • Wordsworth, Sarah
  • Welbourn, Richard
  • Beard, David
  • Carr, Andrew
  • Cook, Jonathan
  • Cooper, Cushla
  • Dean, Benjamin
  • Gray, Alastair
  • Gwilym, Stephen
  • Judge, Andrew
  • Merritt, Naomi
  • Moser, Jane
  • Rees, Jonathan
  • Rombach, Ines
  • Savulescu, Julian
  • Tracey, Irene
  • Wartolowska, Karolina
  • Harrison, Eleanor
  • Tan, Wei
  • Mills, Nicola
  • Karantana, Alexia
  • Sprange, Kirsty
  • Duley, Lelia
  • Elliott, Daisy
  • Hollingworth, William
  • Montgomery, Alan A
  • Davis, Tim
  • Stein, Rob
  • Bartlett, John
  • Cameron, David
  • Campbell, Amy
  • Canney, Peter
  • Dunn, Janet
  • Earl, Helena
  • Falzon, Mary
  • Francis, Adele
  • Hall, Peter
  • Harmer, Victoria
  • Higgins, Helen
  • Hiller, Louise
  • Hughes-Davies, Luke
  • Hulme, Claire
  • Macpherson, Iain
  • Makris, Andreas
  • Marshall, Andrea
  • McCabe, Christopher
  • Morgan, Adrienne
  • Pinder, Sarah
  • Poole, Christopher
  • Provenzano, Elena
  • Rea, Daniel
  • Stallard, Nigel
  • Avery, Kerry N.L
  • Barham, C. Paul
  • Berrisford, Richard
  • Elliott, Jackie
  • Falk, Stephen J
  • Goldin, Rob
  • Hanna, George
  • Hollowood, Andrew A
  • Krysztopik, Richard
  • Metcalfe, Chris
  • Noble, Sian
  • Sanders, Grant
  • Streets, Christopher G
  • Titcomb, Dan R
  • Wheatley, Tim
subjects:
  • Article
  • atira
  • Case studies
  • Centre for Surgical Research
  • Clinical Protocols
  • Clinical Trial
  • Clinical trials
  • Communication
  • core
  • Data collection
  • Evaluation
  • Feedback
  • Gov't
  • Humans
  • Intervention
  • Journal Article
  • keywords
  • Non
  • omized controlled trial
  • Patient Selection
  • Patients
  • pubmedpublicationtype
  • pure
  • Qualitative analysis
  • Qualitative research
  • Randomization
  • Randomized controlled trial
  • Randomized Controlled Trials as Topic - methods
  • Recruitment
  • Research Support
  • researchoutput
  • Studies
  • Training healthcare professionals
ispartof: Journal of Clinical Epidemiology, 2019-02, Vol.106, p.108-120
description: To evaluate the impact of the QuinteT Recruitment Intervention (QRI) on recruitment in challenging randomized controlled trials (RCTs) that have applied the intervention. The QRI aims to understand recruitment difficulties and then implements “QRI actions” to address these as recruitment proceeds. A mixed-methods study, comprising (1) before-and-after comparisons of recruitment rates and the numbers of patients approached and (2) qualitative case studies, including documentary analysis and interviews with RCT investigators. Five UK-based publicly funded RCTs were included in the evaluation. All recruited to target. Randomized controlled trial 2 and RCT 5 both received up-front prerecruitment training before the intervention was applied. Randomized controlled trial 2 did not encounter recruitment issues and recruited above target from its outset. Recruitment difficulties, particularly communication issues, were identified and addressed through QRI actions in RCTs 1, 3, 4, and 5. Randomization rates significantly improved after QRI action in RCTs 1, 3, and 4. Quintet Recruitment Intervention actions addressed issues with approaching eligible patients in RCTs 3 and 5, which both saw significant increases in the number of patients approached. Trial investigators reported that the QRI had unearthed issues they had been unaware of and reportedly changed their practices after QRI action. There is promising evidence to suggest that the QRI can support recruitment to difficult RCTs. This needs to be substantiated with future controlled evaluations.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0895-4356
fulltext: fulltext
issn:
  • 0895-4356
  • 1878-5921
url: Link


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titleThe QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation
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creatorRooshenas, Leila ; Scott, Lauren J ; Blazeby, Jane M ; Rogers, Chris A ; Tilling, Kate M ; Husbands, Samantha ; Conefrey, Carmel ; Mills, Nicola ; Stein, Robert C ; Metcalfe, Chris ; Carr, Andrew J ; Beard, David J ; Davis, Tim ; Paramasivan, Sangeetha ; Jepson, Marcus ; Avery, Kerry ; Elliott, Daisy ; Wilson, Caroline ; Donovan, Jenny L ; Rogers, Chris A ; Andrews, Robert ; Blazeby, Jane M ; Byrne, James ; Donovan, Jenny L ; Kelly, Jamie ; Mazza, Graziella ; Mahon, David ; Noble, Hamish ; Reeves, Barnaby C ; Thompson, Janice L ; Wordsworth, Sarah ; Welbourn, Richard ; Beard, David ; Carr, Andrew ; Cook, Jonathan ; Cooper, Cushla ; Dean, Benjamin ; Gray, Alastair ; Gwilym, Stephen ; Judge, Andrew ; Merritt, Naomi ; Moser, Jane ; Rees, Jonathan ; Rombach, Ines ; Savulescu, Julian ; Tracey, Irene ; Wartolowska, Karolina ; Harrison, Eleanor ; Tan, Wei ; Mills, Nicola ; Karantana, Alexia ; Sprange, Kirsty ; Duley, Lelia ; Elliott, Daisy ; Hollingworth, William ; Montgomery, Alan A ; Davis, Tim ; Stein, Rob ; Bartlett, John ; Cameron, David ; Campbell, Amy ; Canney, Peter ; Dunn, Janet ; Earl, Helena ; Falzon, Mary ; Francis, Adele ; Hall, Peter ; Harmer, Victoria ; Higgins, Helen ; Hiller, Louise ; Hughes-Davies, Luke ; Hulme, Claire ; Macpherson, Iain ; Makris, Andreas ; Marshall, Andrea ; McCabe, Christopher ; Morgan, Adrienne ; Pinder, Sarah ; Poole, Christopher ; Provenzano, Elena ; Rea, Daniel ; Stallard, Nigel ; Avery, Kerry N.L ; Barham, C. Paul ; Berrisford, Richard ; Elliott, Jackie ; Falk, Stephen J ; Goldin, Rob ; Hanna, George ; Hollowood, Andrew A ; Krysztopik, Richard ; Metcalfe, Chris ; Noble, Sian ; Sanders, Grant ; Streets, Christopher G ; Titcomb, Dan R ; Wheatley, Tim
creatorcontribRooshenas, Leila ; Scott, Lauren J ; Blazeby, Jane M ; Rogers, Chris A ; Tilling, Kate M ; Husbands, Samantha ; Conefrey, Carmel ; Mills, Nicola ; Stein, Robert C ; Metcalfe, Chris ; Carr, Andrew J ; Beard, David J ; Davis, Tim ; Paramasivan, Sangeetha ; Jepson, Marcus ; Avery, Kerry ; Elliott, Daisy ; Wilson, Caroline ; Donovan, Jenny L ; Rogers, Chris A ; Andrews, Robert ; Blazeby, Jane M ; Byrne, James ; Donovan, Jenny L ; Kelly, Jamie ; Mazza, Graziella ; Mahon, David ; Noble, Hamish ; Reeves, Barnaby C ; Thompson, Janice L ; Wordsworth, Sarah ; Welbourn, Richard ; Beard, David ; Carr, Andrew ; Cook, Jonathan ; Cooper, Cushla ; Dean, Benjamin ; Gray, Alastair ; Gwilym, Stephen ; Judge, Andrew ; Merritt, Naomi ; Moser, Jane ; Rees, Jonathan ; Rombach, Ines ; Savulescu, Julian ; Tracey, Irene ; Wartolowska, Karolina ; Harrison, Eleanor ; Tan, Wei ; Mills, Nicola ; Karantana, Alexia ; Sprange, Kirsty ; Duley, Lelia ; Elliott, Daisy ; Hollingworth, William ; Montgomery, Alan A ; Davis, Tim ; Stein, Rob ; Bartlett, John ; Cameron, David ; Campbell, Amy ; Canney, Peter ; Dunn, Janet ; Earl, Helena ; Falzon, Mary ; Francis, Adele ; Hall, Peter ; Harmer, Victoria ; Higgins, Helen ; Hiller, Louise ; Hughes-Davies, Luke ; Hulme, Claire ; Macpherson, Iain ; Makris, Andreas ; Marshall, Andrea ; McCabe, Christopher ; Morgan, Adrienne ; Pinder, Sarah ; Poole, Christopher ; Provenzano, Elena ; Rea, Daniel ; Stallard, Nigel ; Avery, Kerry N.L ; Barham, C. Paul ; Berrisford, Richard ; Elliott, Jackie ; Falk, Stephen J ; Goldin, Rob ; Hanna, George ; Hollowood, Andrew A ; Krysztopik, Richard ; Metcalfe, Chris ; Noble, Sian ; Sanders, Grant ; Streets, Christopher G ; Titcomb, Dan R ; Wheatley, Tim ; Optima prelim study group ; CSAW study group ; HAND-1 study group ; the Romio feasibility study group ; By-Band-Sleeve study group ; Romio feasibility study group
descriptionTo evaluate the impact of the QuinteT Recruitment Intervention (QRI) on recruitment in challenging randomized controlled trials (RCTs) that have applied the intervention. The QRI aims to understand recruitment difficulties and then implements “QRI actions” to address these as recruitment proceeds. A mixed-methods study, comprising (1) before-and-after comparisons of recruitment rates and the numbers of patients approached and (2) qualitative case studies, including documentary analysis and interviews with RCT investigators. Five UK-based publicly funded RCTs were included in the evaluation. All recruited to target. Randomized controlled trial 2 and RCT 5 both received up-front prerecruitment training before the intervention was applied. Randomized controlled trial 2 did not encounter recruitment issues and recruited above target from its outset. Recruitment difficulties, particularly communication issues, were identified and addressed through QRI actions in RCTs 1, 3, 4, and 5. Randomization rates significantly improved after QRI action in RCTs 1, 3, and 4. Quintet Recruitment Intervention actions addressed issues with approaching eligible patients in RCTs 3 and 5, which both saw significant increases in the number of patients approached. Trial investigators reported that the QRI had unearthed issues they had been unaware of and reportedly changed their practices after QRI action. There is promising evidence to suggest that the QRI can support recruitment to difficult RCTs. This needs to be substantiated with future controlled evaluations.
identifier
0ISSN: 0895-4356
1EISSN: 1878-5921
2DOI: 10.1016/j.jclinepi.2018.10.004
3PMID: 30339938
languageeng
publisherUnited States: Elsevier Inc
subjectArticle ; atira ; Case studies ; Centre for Surgical Research ; Clinical Protocols ; Clinical Trial ; Clinical trials ; Communication ; core ; Data collection ; Evaluation ; Feedback ; Gov't ; Humans ; Intervention ; Journal Article ; keywords ; Non ; omized controlled trial ; Patient Selection ; Patients ; pubmedpublicationtype ; pure ; Qualitative analysis ; Qualitative research ; Randomization ; Randomized controlled trial ; Randomized Controlled Trials as Topic - methods ; Recruitment ; Research Support ; researchoutput ; Studies ; Training healthcare professionals
ispartofJournal of Clinical Epidemiology, 2019-02, Vol.106, p.108-120
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1Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
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0Rooshenas, Leila
1Scott, Lauren J
2Blazeby, Jane M
3Rogers, Chris A
4Tilling, Kate M
5Husbands, Samantha
6Conefrey, Carmel
7Mills, Nicola
8Stein, Robert C
9Metcalfe, Chris
10Carr, Andrew J
11Beard, David J
12Davis, Tim
13Paramasivan, Sangeetha
14Jepson, Marcus
15Avery, Kerry
16Elliott, Daisy
17Wilson, Caroline
18Donovan, Jenny L
19Rogers, Chris A
20Andrews, Robert
21Blazeby, Jane M
22Byrne, James
23Donovan, Jenny L
24Kelly, Jamie
25Mazza, Graziella
26Mahon, David
27Noble, Hamish
28Reeves, Barnaby C
29Thompson, Janice L
30Wordsworth, Sarah
31Welbourn, Richard
32Beard, David
33Carr, Andrew
34Cook, Jonathan
35Cooper, Cushla
36Dean, Benjamin
37Gray, Alastair
38Gwilym, Stephen
39Judge, Andrew
40Merritt, Naomi
41Moser, Jane
42Rees, Jonathan
43Rombach, Ines
44Savulescu, Julian
45Tracey, Irene
46Wartolowska, Karolina
47Harrison, Eleanor
48Tan, Wei
49Mills, Nicola
50Karantana, Alexia
51Sprange, Kirsty
52Duley, Lelia
53Elliott, Daisy
54Hollingworth, William
55Montgomery, Alan A
56Davis, Tim
57Stein, Rob
58Bartlett, John
59Cameron, David
60Campbell, Amy
61Canney, Peter
62Dunn, Janet
63Earl, Helena
64Falzon, Mary
65Francis, Adele
66Hall, Peter
67Harmer, Victoria
68Higgins, Helen
69Hiller, Louise
70Hughes-Davies, Luke
71Hulme, Claire
72Macpherson, Iain
73Makris, Andreas
74Marshall, Andrea
75McCabe, Christopher
76Morgan, Adrienne
77Pinder, Sarah
78Poole, Christopher
79Provenzano, Elena
80Rea, Daniel
81Stallard, Nigel
82Avery, Kerry N.L
83Barham, C. Paul
84Berrisford, Richard
85Elliott, Jackie
86Falk, Stephen J
87Goldin, Rob
88Hanna, George
89Hollowood, Andrew A
90Krysztopik, Richard
91Metcalfe, Chris
92Noble, Sian
93Sanders, Grant
94Streets, Christopher G
95Titcomb, Dan R
96Wheatley, Tim
97Optima prelim study group
98CSAW study group
99HAND-1 study group
100the Romio feasibility study group
101By-Band-Sleeve study group
102Romio feasibility study group
title
0The QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation
1Journal of Clinical Epidemiology
addtitleJ Clin Epidemiol
descriptionTo evaluate the impact of the QuinteT Recruitment Intervention (QRI) on recruitment in challenging randomized controlled trials (RCTs) that have applied the intervention. The QRI aims to understand recruitment difficulties and then implements “QRI actions” to address these as recruitment proceeds. A mixed-methods study, comprising (1) before-and-after comparisons of recruitment rates and the numbers of patients approached and (2) qualitative case studies, including documentary analysis and interviews with RCT investigators. Five UK-based publicly funded RCTs were included in the evaluation. All recruited to target. Randomized controlled trial 2 and RCT 5 both received up-front prerecruitment training before the intervention was applied. Randomized controlled trial 2 did not encounter recruitment issues and recruited above target from its outset. Recruitment difficulties, particularly communication issues, were identified and addressed through QRI actions in RCTs 1, 3, 4, and 5. Randomization rates significantly improved after QRI action in RCTs 1, 3, and 4. Quintet Recruitment Intervention actions addressed issues with approaching eligible patients in RCTs 3 and 5, which both saw significant increases in the number of patients approached. Trial investigators reported that the QRI had unearthed issues they had been unaware of and reportedly changed their practices after QRI action. There is promising evidence to suggest that the QRI can support recruitment to difficult RCTs. This needs to be substantiated with future controlled evaluations.
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1atira
2Case studies
3Centre for Surgical Research
4Clinical Protocols
5Clinical Trial
6Clinical trials
7Communication
8core
9Data collection
10Evaluation
11Feedback
12Gov't
13Humans
14Intervention
15Journal Article
16keywords
17Non
18omized controlled trial
19Patient Selection
20Patients
21pubmedpublicationtype
22pure
23Qualitative analysis
24Qualitative research
25Randomization
26Randomized controlled trial
27Randomized Controlled Trials as Topic - methods
28Recruitment
29Research Support
30researchoutput
31Studies
32Training healthcare professionals
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8Stein, Robert C
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16Elliott, Daisy
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20Andrews, Robert
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26Mahon, David
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30Wordsworth, Sarah
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33Carr, Andrew
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37Gray, Alastair
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39Judge, Andrew
40Merritt, Naomi
41Moser, Jane
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44Savulescu, Julian
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47Harrison, Eleanor
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58Bartlett, John
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62Dunn, Janet
63Earl, Helena
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65Francis, Adele
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67Harmer, Victoria
68Higgins, Helen
69Hiller, Louise
70Hughes-Davies, Luke
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93Sanders, Grant
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creationdate201902
titleThe QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation
authorRooshenas, Leila ; Scott, Lauren J ; Blazeby, Jane M ; Rogers, Chris A ; Tilling, Kate M ; Husbands, Samantha ; Conefrey, Carmel ; Mills, Nicola ; Stein, Robert C ; Metcalfe, Chris ; Carr, Andrew J ; Beard, David J ; Davis, Tim ; Paramasivan, Sangeetha ; Jepson, Marcus ; Avery, Kerry ; Elliott, Daisy ; Wilson, Caroline ; Donovan, Jenny L ; Rogers, Chris A ; Andrews, Robert ; Blazeby, Jane M ; Byrne, James ; Donovan, Jenny L ; Kelly, Jamie ; Mazza, Graziella ; Mahon, David ; Noble, Hamish ; Reeves, Barnaby C ; Thompson, Janice L ; Wordsworth, Sarah ; Welbourn, Richard ; Beard, David ; Carr, Andrew ; Cook, Jonathan ; Cooper, Cushla ; Dean, Benjamin ; Gray, Alastair ; Gwilym, Stephen ; Judge, Andrew ; Merritt, Naomi ; Moser, Jane ; Rees, Jonathan ; Rombach, Ines ; Savulescu, Julian ; Tracey, Irene ; Wartolowska, Karolina ; Harrison, Eleanor ; Tan, Wei ; Mills, Nicola ; Karantana, Alexia ; Sprange, Kirsty ; Duley, Lelia ; Elliott, Daisy ; Hollingworth, William ; Montgomery, Alan A ; Davis, Tim ; Stein, Rob ; Bartlett, John ; Cameron, David ; Campbell, Amy ; Canney, Peter ; Dunn, Janet ; Earl, Helena ; Falzon, Mary ; Francis, Adele ; Hall, Peter ; Harmer, Victoria ; Higgins, Helen ; Hiller, Louise ; Hughes-Davies, Luke ; Hulme, Claire ; Macpherson, Iain ; Makris, Andreas ; Marshall, Andrea ; McCabe, Christopher ; Morgan, Adrienne ; Pinder, Sarah ; Poole, Christopher ; Provenzano, Elena ; Rea, Daniel ; Stallard, Nigel ; Avery, Kerry N.L ; Barham, C. Paul ; Berrisford, Richard ; Elliott, Jackie ; Falk, Stephen J ; Goldin, Rob ; Hanna, George ; Hollowood, Andrew A ; Krysztopik, Richard ; Metcalfe, Chris ; Noble, Sian ; Sanders, Grant ; Streets, Christopher G ; Titcomb, Dan R ; Wheatley, Tim
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languageeng
creationdate2019
topic
0Article
1atira
2Case studies
3Centre for Surgical Research
4Clinical Protocols
5Clinical Trial
6Clinical trials
7Communication
8core
9Data collection
10Evaluation
11Feedback
12Gov't
13Humans
14Intervention
15Journal Article
16keywords
17Non
18omized controlled trial
19Patient Selection
20Patients
21pubmedpublicationtype
22pure
23Qualitative analysis
24Qualitative research
25Randomization
26Randomized controlled trial
27Randomized Controlled Trials as Topic - methods
28Recruitment
29Research Support
30researchoutput
31Studies
32Training healthcare professionals
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Rooshenas, Leila
1Scott, Lauren J
2Blazeby, Jane M
3Rogers, Chris A
4Tilling, Kate M
5Husbands, Samantha
6Conefrey, Carmel
7Mills, Nicola
8Stein, Robert C
9Metcalfe, Chris
10Carr, Andrew J
11Beard, David J
12Davis, Tim
13Paramasivan, Sangeetha
14Jepson, Marcus
15Avery, Kerry
16Elliott, Daisy
17Wilson, Caroline
18Donovan, Jenny L
19Rogers, Chris A
20Andrews, Robert
21Blazeby, Jane M
22Byrne, James
23Donovan, Jenny L
24Kelly, Jamie
25Mazza, Graziella
26Mahon, David
27Noble, Hamish
28Reeves, Barnaby C
29Thompson, Janice L
30Wordsworth, Sarah
31Welbourn, Richard
32Beard, David
33Carr, Andrew
34Cook, Jonathan
35Cooper, Cushla
36Dean, Benjamin
37Gray, Alastair
38Gwilym, Stephen
39Judge, Andrew
40Merritt, Naomi
41Moser, Jane
42Rees, Jonathan
43Rombach, Ines
44Savulescu, Julian
45Tracey, Irene
46Wartolowska, Karolina
47Harrison, Eleanor
48Tan, Wei
49Mills, Nicola
50Karantana, Alexia
51Sprange, Kirsty
52Duley, Lelia
53Elliott, Daisy
54Hollingworth, William
55Montgomery, Alan A
56Davis, Tim
57Stein, Rob
58Bartlett, John
59Cameron, David
60Campbell, Amy
61Canney, Peter
62Dunn, Janet
63Earl, Helena
64Falzon, Mary
65Francis, Adele
66Hall, Peter
67Harmer, Victoria
68Higgins, Helen
69Hiller, Louise
70Hughes-Davies, Luke
71Hulme, Claire
72Macpherson, Iain
73Makris, Andreas
74Marshall, Andrea
75McCabe, Christopher
76Morgan, Adrienne
77Pinder, Sarah
78Poole, Christopher
79Provenzano, Elena
80Rea, Daniel
81Stallard, Nigel
82Avery, Kerry N.L
83Barham, C. Paul
84Berrisford, Richard
85Elliott, Jackie
86Falk, Stephen J
87Goldin, Rob
88Hanna, George
89Hollowood, Andrew A
90Krysztopik, Richard
91Metcalfe, Chris
92Noble, Sian
93Sanders, Grant
94Streets, Christopher G
95Titcomb, Dan R
96Wheatley, Tim
97Optima prelim study group
98CSAW study group
99HAND-1 study group
100the Romio feasibility study group
101By-Band-Sleeve study group
102Romio feasibility study group
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1Elsevier:ScienceDirect:Open Access
2Medline
3MEDLINE
4MEDLINE (Ovid)
5MEDLINE
6MEDLINE
7PubMed
8CrossRef
9Academic OneFile (A&I only)
10ProQuest Central (Corporate)
11Bacteriology Abstracts (Microbiology B)
12Calcium & Calcified Tissue Abstracts
13Nursing & Allied Health Database
14Health and Safety Science Abstracts (Full archive)
15Industrial and Applied Microbiology Abstracts (Microbiology A)
16Neurosciences Abstracts
17Toxicology Abstracts
18Virology and AIDS Abstracts
19Health & Medical Collection
20ProQuest Central (purchase pre-March 2016)
21Healthcare Administration Database (Alumni)
22Medical Database (Alumni Edition)
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24Public Health Database
25Technology Research Database
26Hospital Premium Collection
27Hospital Premium Collection (Alumni Edition)
28ProQuest Central (Alumni) (purchase pre-March 2016)
29Research Library (Alumni Edition)
30ProQuest Central (Alumni Edition)
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32ProQuest Central
33Environmental Sciences and Pollution Management
34ProQuest Central Korea
35Engineering Research Database
36Health Research Premium Collection
37Health Research Premium Collection (Alumni)
38ProQuest Central Student
39Research Library Prep
40AIDS and Cancer Research Abstracts
41ProQuest Health & Medical Complete (Alumni)
42Nursing & Allied Health Database (Alumni Edition)
43Health & Medical Collection (Alumni Edition)
44Healthcare Administration Database
45Medical Database
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47Algology Mycology and Protozoology Abstracts (Microbiology C)
48Research Library (Corporate)
49Nursing & Allied Health Premium
50Biotechnology and BioEngineering Abstracts
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52ProQuest One Academic Eastern Edition
53ProQuest One Academic
54ProQuest One Academic UKI Edition
55ProQuest Central China
56ProQuest Central Basic
57MEDLINE - Academic
58OpenAIRE (Open Access)
59OpenAIRE
60PubMed Central (Full Participant titles)
jtitleJournal of Clinical Epidemiology
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Rooshenas, Leila
1Scott, Lauren J
2Blazeby, Jane M
3Rogers, Chris A
4Tilling, Kate M
5Husbands, Samantha
6Conefrey, Carmel
7Mills, Nicola
8Stein, Robert C
9Metcalfe, Chris
10Carr, Andrew J
11Beard, David J
12Davis, Tim
13Paramasivan, Sangeetha
14Jepson, Marcus
15Avery, Kerry
16Elliott, Daisy
17Wilson, Caroline
18Donovan, Jenny L
19Rogers, Chris A
20Andrews, Robert
21Blazeby, Jane M
22Byrne, James
23Donovan, Jenny L
24Kelly, Jamie
25Mazza, Graziella
26Mahon, David
27Noble, Hamish
28Reeves, Barnaby C
29Thompson, Janice L
30Wordsworth, Sarah
31Welbourn, Richard
32Beard, David
33Carr, Andrew
34Cook, Jonathan
35Cooper, Cushla
36Dean, Benjamin
37Gray, Alastair
38Gwilym, Stephen
39Judge, Andrew
40Merritt, Naomi
41Moser, Jane
42Rees, Jonathan
43Rombach, Ines
44Savulescu, Julian
45Tracey, Irene
46Wartolowska, Karolina
47Harrison, Eleanor
48Tan, Wei
49Mills, Nicola
50Karantana, Alexia
51Sprange, Kirsty
52Duley, Lelia
53Elliott, Daisy
54Hollingworth, William
55Montgomery, Alan A
56Davis, Tim
57Stein, Rob
58Bartlett, John
59Cameron, David
60Campbell, Amy
61Canney, Peter
62Dunn, Janet
63Earl, Helena
64Falzon, Mary
65Francis, Adele
66Hall, Peter
67Harmer, Victoria
68Higgins, Helen
69Hiller, Louise
70Hughes-Davies, Luke
71Hulme, Claire
72Macpherson, Iain
73Makris, Andreas
74Marshall, Andrea
75McCabe, Christopher
76Morgan, Adrienne
77Pinder, Sarah
78Poole, Christopher
79Provenzano, Elena
80Rea, Daniel
81Stallard, Nigel
82Avery, Kerry N.L
83Barham, C. Paul
84Berrisford, Richard
85Elliott, Jackie
86Falk, Stephen J
87Goldin, Rob
88Hanna, George
89Hollowood, Andrew A
90Krysztopik, Richard
91Metcalfe, Chris
92Noble, Sian
93Sanders, Grant
94Streets, Christopher G
95Titcomb, Dan R
96Wheatley, Tim
aucorp
0Optima prelim study group
1CSAW study group
2HAND-1 study group
3the Romio feasibility study group
4By-Band-Sleeve study group
5Romio feasibility study group
formatjournal
genrearticle
ristypeJOUR
atitleThe QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation
jtitleJournal of Clinical Epidemiology
addtitleJ Clin Epidemiol
date2019-02
risdate2019
volume106
spage108
epage120
pages108-120
issn0895-4356
eissn1878-5921
notesThese authors made equal contributions.
abstractTo evaluate the impact of the QuinteT Recruitment Intervention (QRI) on recruitment in challenging randomized controlled trials (RCTs) that have applied the intervention. The QRI aims to understand recruitment difficulties and then implements “QRI actions” to address these as recruitment proceeds. A mixed-methods study, comprising (1) before-and-after comparisons of recruitment rates and the numbers of patients approached and (2) qualitative case studies, including documentary analysis and interviews with RCT investigators. Five UK-based publicly funded RCTs were included in the evaluation. All recruited to target. Randomized controlled trial 2 and RCT 5 both received up-front prerecruitment training before the intervention was applied. Randomized controlled trial 2 did not encounter recruitment issues and recruited above target from its outset. Recruitment difficulties, particularly communication issues, were identified and addressed through QRI actions in RCTs 1, 3, 4, and 5. Randomization rates significantly improved after QRI action in RCTs 1, 3, and 4. Quintet Recruitment Intervention actions addressed issues with approaching eligible patients in RCTs 3 and 5, which both saw significant increases in the number of patients approached. Trial investigators reported that the QRI had unearthed issues they had been unaware of and reportedly changed their practices after QRI action. There is promising evidence to suggest that the QRI can support recruitment to difficult RCTs. This needs to be substantiated with future controlled evaluations.
copUnited States
pubElsevier Inc
pmid30339938
doi10.1016/j.jclinepi.2018.10.004
oafree_for_read