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Prospective associations of dietary carbohydrate, fat, and protein intake with β-cell function in the CODAM study

Purpose Type 2 diabetes mellitus (T2DM) is characterized by both impaired pancreatic β-cell function (BCF) and insulin resistance. In the etiology of T2DM, BCF basically determines whether a person with a certain degree of insulin resistance develops T2DM, as β-cells are able to compensatorily incre... Full description

Journal Title: European Journal of Nutrition 2019, Vol.58 (2), p.597-608
Main Author: den Biggelaar, Louise J. C. J
Other Authors: Eussen, Simone J. P. M , Sep, Simone J. S , Mari, Anea , Ferrannini, Ele , van Greevenbroek, Marleen M , van der Kallen, Carla J , Schalkwijk, Casper G , Arts, Ilja C. W , Stehouwer, Coen D. A , Dagnelie, Pieter C
Format: Electronic Article Electronic Article
Language: English
Subjects:
Fat
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 1436-6207
Link: https://www.ncbi.nlm.nih.gov/pubmed/29525890
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6437317
title: Prospective associations of dietary carbohydrate, fat, and protein intake with β-cell function in the CODAM study
format: Article
creator:
  • den Biggelaar, Louise J. C. J
  • Eussen, Simone J. P. M
  • Sep, Simone J. S
  • Mari, Anea
  • Ferrannini, Ele
  • van Greevenbroek, Marleen M
  • van der Kallen, Carla J
  • Schalkwijk, Casper G
  • Arts, Ilja C. W
  • Stehouwer, Coen D. A
  • Dagnelie, Pieter C
subjects:
  • ACIDS
  • Adult
  • Aged
  • Carbohydrate
  • Cell function
  • Chemistry
  • Chemistry and Materials Science
  • Cholesterol
  • Cohort Studies
  • Diabetes mellitus
  • Diabetes mellitus (non-insulin dependent)
  • Diabetes Mellitus, Type 2 - metabolism
  • Dietary Carbohydrates - metabolism
  • Dietary Carbohydrates - pharmacology
  • Dietary Fats - metabolism
  • Dietary Fats - pharmacology
  • Dietary fiber
  • Dietary intake
  • Dietary Proteins - metabolism
  • Dietary Proteins - pharmacology
  • Etiology
  • Fat
  • Female
  • FIBER
  • Follow-Up Studies
  • Glucose
  • GLUCOSE-TOLERANCE
  • GLYCEMIC INDEX
  • Humans
  • Insulin
  • Insulin resistance
  • INSULIN SENSITIVITY
  • Insulin-Secreting Cells - metabolism
  • Male
  • Middle Aged
  • Nutrition
  • Original Contribution
  • Pancreas
  • Population studies
  • Potentiation
  • Prospective Studies
  • Protein
  • RELATIVE VALIDITY
  • RESISTANCE
  • RISK
  • SECRETION
  • Trans fats
  • Type 2 diabetes mellitus
  • TYPE-2
  • β-Cell function
ispartof: European Journal of Nutrition, 2019, Vol.58 (2), p.597-608
description: Purpose Type 2 diabetes mellitus (T2DM) is characterized by both impaired pancreatic β-cell function (BCF) and insulin resistance. In the etiology of T2DM, BCF basically determines whether a person with a certain degree of insulin resistance develops T2DM, as β-cells are able to compensatorily increase insulin secretion. The effects of dietary intake on BCF are largely unknown. Our study aim was to investigate whether dietary macronutrient intake predicts BCF. Methods Prospective data (median follow-up 7 years) of 303 individuals recruited from the CODAM study population (aged 40–70 years, 39% women) were analyzed. BCF was measured by C-peptide deconvolution and physiological modeling of data from a 5-point, 75-g, 2-h oral glucose tolerance test. Macronutrient intake was estimated by a 178-item Food Frequency Questionnaire. Results Associations adjusted for relevant covariates of baseline macronutrient intake with model-derived parameters describing BCF (glucose sensitivity, rate sensitivity or potentiation) or C-peptidogenic index were detected for trans fat [standardized regression coefficient (95%-CI) glucose sensitivity − 0.14 (− 0.26, − 0.01)] per g, cholesterol [potentiation 0.20 (0.02, 0.37)] per 100 mg, dietary fiber [glucose sensitivity 0.21 (0.08, 0.33)] per 10 g, MUFA glucose sensitivity 0.16 (0.02, 0.31) per 10 g, and polysaccharide [potentiation − 0.24 (− 0.43, − 0.05), C-peptidogenic index − 0.16 (− 0.29 − 0.03); odds ratio lowest versus highest tertile (95%-CI) rate sensitivity 1.51 (1.06, 2.15)) per 50 g. Conclusions In this population at high risk for developing T2DM, polysaccharide and trans fat intake were associated with worse BCF, whereas increased intake of MUFA, dietary cholesterol, and fiber were associated with better BCF.
language: eng
source:
identifier: ISSN: 1436-6207
fulltext: no_fulltext
issn:
  • 1436-6207
  • 1436-6215
url: Link


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titleProspective associations of dietary carbohydrate, fat, and protein intake with β-cell function in the CODAM study
creatorden Biggelaar, Louise J. C. J ; Eussen, Simone J. P. M ; Sep, Simone J. S ; Mari, Anea ; Ferrannini, Ele ; van Greevenbroek, Marleen M ; van der Kallen, Carla J ; Schalkwijk, Casper G ; Arts, Ilja C. W ; Stehouwer, Coen D. A ; Dagnelie, Pieter C
creatorcontribden Biggelaar, Louise J. C. J ; Eussen, Simone J. P. M ; Sep, Simone J. S ; Mari, Anea ; Ferrannini, Ele ; van Greevenbroek, Marleen M ; van der Kallen, Carla J ; Schalkwijk, Casper G ; Arts, Ilja C. W ; Stehouwer, Coen D. A ; Dagnelie, Pieter C
descriptionPurpose Type 2 diabetes mellitus (T2DM) is characterized by both impaired pancreatic β-cell function (BCF) and insulin resistance. In the etiology of T2DM, BCF basically determines whether a person with a certain degree of insulin resistance develops T2DM, as β-cells are able to compensatorily increase insulin secretion. The effects of dietary intake on BCF are largely unknown. Our study aim was to investigate whether dietary macronutrient intake predicts BCF. Methods Prospective data (median follow-up 7 years) of 303 individuals recruited from the CODAM study population (aged 40–70 years, 39% women) were analyzed. BCF was measured by C-peptide deconvolution and physiological modeling of data from a 5-point, 75-g, 2-h oral glucose tolerance test. Macronutrient intake was estimated by a 178-item Food Frequency Questionnaire. Results Associations adjusted for relevant covariates of baseline macronutrient intake with model-derived parameters describing BCF (glucose sensitivity, rate sensitivity or potentiation) or C-peptidogenic index were detected for trans fat [standardized regression coefficient (95%-CI) glucose sensitivity − 0.14 (− 0.26, − 0.01)] per g, cholesterol [potentiation 0.20 (0.02, 0.37)] per 100 mg, dietary fiber [glucose sensitivity 0.21 (0.08, 0.33)] per 10 g, MUFA glucose sensitivity 0.16 (0.02, 0.31) per 10 g, and polysaccharide [potentiation − 0.24 (− 0.43, − 0.05), C-peptidogenic index − 0.16 (− 0.29 − 0.03); odds ratio lowest versus highest tertile (95%-CI) rate sensitivity 1.51 (1.06, 2.15)) per 50 g. Conclusions In this population at high risk for developing T2DM, polysaccharide and trans fat intake were associated with worse BCF, whereas increased intake of MUFA, dietary cholesterol, and fiber were associated with better BCF.
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0ISSN: 1436-6207
1EISSN: 1436-6215
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3PMID: 29525890
languageeng
publisherBerlin/Heidelberg: Springer Berlin Heidelberg
subjectACIDS ; Adult ; Aged ; Carbohydrate ; Cell function ; Chemistry ; Chemistry and Materials Science ; Cholesterol ; Cohort Studies ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - metabolism ; Dietary Carbohydrates - metabolism ; Dietary Carbohydrates - pharmacology ; Dietary Fats - metabolism ; Dietary Fats - pharmacology ; Dietary fiber ; Dietary intake ; Dietary Proteins - metabolism ; Dietary Proteins - pharmacology ; Etiology ; Fat ; Female ; FIBER ; Follow-Up Studies ; Glucose ; GLUCOSE-TOLERANCE ; GLYCEMIC INDEX ; Humans ; Insulin ; Insulin resistance ; INSULIN SENSITIVITY ; Insulin-Secreting Cells - metabolism ; Male ; Middle Aged ; Nutrition ; Original Contribution ; Pancreas ; Population studies ; Potentiation ; Prospective Studies ; Protein ; RELATIVE VALIDITY ; RESISTANCE ; RISK ; SECRETION ; Trans fats ; Type 2 diabetes mellitus ; TYPE-2 ; β-Cell function
ispartofEuropean Journal of Nutrition, 2019, Vol.58 (2), p.597-608
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0den Biggelaar, Louise J. C. J
1Eussen, Simone J. P. M
2Sep, Simone J. S
3Mari, Anea
4Ferrannini, Ele
5van Greevenbroek, Marleen M
6van der Kallen, Carla J
7Schalkwijk, Casper G
8Arts, Ilja C. W
9Stehouwer, Coen D. A
10Dagnelie, Pieter C
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0Prospective associations of dietary carbohydrate, fat, and protein intake with β-cell function in the CODAM study
1European Journal of Nutrition
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0Eur J Nutr
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descriptionPurpose Type 2 diabetes mellitus (T2DM) is characterized by both impaired pancreatic β-cell function (BCF) and insulin resistance. In the etiology of T2DM, BCF basically determines whether a person with a certain degree of insulin resistance develops T2DM, as β-cells are able to compensatorily increase insulin secretion. The effects of dietary intake on BCF are largely unknown. Our study aim was to investigate whether dietary macronutrient intake predicts BCF. Methods Prospective data (median follow-up 7 years) of 303 individuals recruited from the CODAM study population (aged 40–70 years, 39% women) were analyzed. BCF was measured by C-peptide deconvolution and physiological modeling of data from a 5-point, 75-g, 2-h oral glucose tolerance test. Macronutrient intake was estimated by a 178-item Food Frequency Questionnaire. Results Associations adjusted for relevant covariates of baseline macronutrient intake with model-derived parameters describing BCF (glucose sensitivity, rate sensitivity or potentiation) or C-peptidogenic index were detected for trans fat [standardized regression coefficient (95%-CI) glucose sensitivity − 0.14 (− 0.26, − 0.01)] per g, cholesterol [potentiation 0.20 (0.02, 0.37)] per 100 mg, dietary fiber [glucose sensitivity 0.21 (0.08, 0.33)] per 10 g, MUFA glucose sensitivity 0.16 (0.02, 0.31) per 10 g, and polysaccharide [potentiation − 0.24 (− 0.43, − 0.05), C-peptidogenic index − 0.16 (− 0.29 − 0.03); odds ratio lowest versus highest tertile (95%-CI) rate sensitivity 1.51 (1.06, 2.15)) per 50 g. Conclusions In this population at high risk for developing T2DM, polysaccharide and trans fat intake were associated with worse BCF, whereas increased intake of MUFA, dietary cholesterol, and fiber were associated with better BCF.
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0ACIDS
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3Carbohydrate
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5Chemistry
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9Diabetes mellitus
10Diabetes mellitus (non-insulin dependent)
11Diabetes Mellitus, Type 2 - metabolism
12Dietary Carbohydrates - metabolism
13Dietary Carbohydrates - pharmacology
14Dietary Fats - metabolism
15Dietary Fats - pharmacology
16Dietary fiber
17Dietary intake
18Dietary Proteins - metabolism
19Dietary Proteins - pharmacology
20Etiology
21Fat
22Female
23FIBER
24Follow-Up Studies
25Glucose
26GLUCOSE-TOLERANCE
27GLYCEMIC INDEX
28Humans
29Insulin
30Insulin resistance
31INSULIN SENSITIVITY
32Insulin-Secreting Cells - metabolism
33Male
34Middle Aged
35Nutrition
36Original Contribution
37Pancreas
38Population studies
39Potentiation
40Prospective Studies
41Protein
42RELATIVE VALIDITY
43RESISTANCE
44RISK
45SECRETION
46Trans fats
47Type 2 diabetes mellitus
48TYPE-2
49β-Cell function
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1Eussen, Simone J. P. M
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4Ferrannini, Ele
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6van der Kallen, Carla J
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titleProspective associations of dietary carbohydrate, fat, and protein intake with β-cell function in the CODAM study
authorden Biggelaar, Louise J. C. J ; Eussen, Simone J. P. M ; Sep, Simone J. S ; Mari, Anea ; Ferrannini, Ele ; van Greevenbroek, Marleen M ; van der Kallen, Carla J ; Schalkwijk, Casper G ; Arts, Ilja C. W ; Stehouwer, Coen D. A ; Dagnelie, Pieter C
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0ACIDS
1Adult
2Aged
3Carbohydrate
4Cell function
5Chemistry
6Chemistry and Materials Science
7Cholesterol
8Cohort Studies
9Diabetes mellitus
10Diabetes mellitus (non-insulin dependent)
11Diabetes Mellitus, Type 2 - metabolism
12Dietary Carbohydrates - metabolism
13Dietary Carbohydrates - pharmacology
14Dietary Fats - metabolism
15Dietary Fats - pharmacology
16Dietary fiber
17Dietary intake
18Dietary Proteins - metabolism
19Dietary Proteins - pharmacology
20Etiology
21Fat
22Female
23FIBER
24Follow-Up Studies
25Glucose
26GLUCOSE-TOLERANCE
27GLYCEMIC INDEX
28Humans
29Insulin
30Insulin resistance
31INSULIN SENSITIVITY
32Insulin-Secreting Cells - metabolism
33Male
34Middle Aged
35Nutrition
36Original Contribution
37Pancreas
38Population studies
39Potentiation
40Prospective Studies
41Protein
42RELATIVE VALIDITY
43RESISTANCE
44RISK
45SECRETION
46Trans fats
47Type 2 diabetes mellitus
48TYPE-2
49β-Cell function
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1Eussen, Simone J. P. M
2Sep, Simone J. S
3Mari, Anea
4Ferrannini, Ele
5van Greevenbroek, Marleen M
6van der Kallen, Carla J
7Schalkwijk, Casper G
8Arts, Ilja C. W
9Stehouwer, Coen D. A
10Dagnelie, Pieter C
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6van der Kallen, Carla J
7Schalkwijk, Casper G
8Arts, Ilja C. W
9Stehouwer, Coen D. A
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abstractPurpose Type 2 diabetes mellitus (T2DM) is characterized by both impaired pancreatic β-cell function (BCF) and insulin resistance. In the etiology of T2DM, BCF basically determines whether a person with a certain degree of insulin resistance develops T2DM, as β-cells are able to compensatorily increase insulin secretion. The effects of dietary intake on BCF are largely unknown. Our study aim was to investigate whether dietary macronutrient intake predicts BCF. Methods Prospective data (median follow-up 7 years) of 303 individuals recruited from the CODAM study population (aged 40–70 years, 39% women) were analyzed. BCF was measured by C-peptide deconvolution and physiological modeling of data from a 5-point, 75-g, 2-h oral glucose tolerance test. Macronutrient intake was estimated by a 178-item Food Frequency Questionnaire. Results Associations adjusted for relevant covariates of baseline macronutrient intake with model-derived parameters describing BCF (glucose sensitivity, rate sensitivity or potentiation) or C-peptidogenic index were detected for trans fat [standardized regression coefficient (95%-CI) glucose sensitivity − 0.14 (− 0.26, − 0.01)] per g, cholesterol [potentiation 0.20 (0.02, 0.37)] per 100 mg, dietary fiber [glucose sensitivity 0.21 (0.08, 0.33)] per 10 g, MUFA glucose sensitivity 0.16 (0.02, 0.31) per 10 g, and polysaccharide [potentiation − 0.24 (− 0.43, − 0.05), C-peptidogenic index − 0.16 (− 0.29 − 0.03); odds ratio lowest versus highest tertile (95%-CI) rate sensitivity 1.51 (1.06, 2.15)) per 50 g. Conclusions In this population at high risk for developing T2DM, polysaccharide and trans fat intake were associated with worse BCF, whereas increased intake of MUFA, dietary cholesterol, and fiber were associated with better BCF.
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