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Common clinical markers predict end-stage renal disease in children with obstructive uropathy

Background Obstructive uropathy (OU) is a common cause of end-stage renal disease (ESRD) in children. Children who escape the newborn period with mild-to-moderate chronic kidney disease (CKD) continue to be at increased risk. The predictive ability of clinically available markers throughout childhoo... Full description

Journal Title: Pediatric nephrology (Berlin West), 2018-10-13, Vol.34 (3), p.443-448
Main Author: McLeod, Daryl J
Other Authors: Ching, Christina B , Sebastião, Yuri V , Greenberg, Jason H , Furth, Susan L , McHugh, Kirk M , Becknell, Brian
Format: Electronic Article Electronic Article
Language: English
Subjects:
Age
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0931-041X
Link: https://www.ncbi.nlm.nih.gov/pubmed/30317433
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title: Common clinical markers predict end-stage renal disease in children with obstructive uropathy
format: Article
creator:
  • McLeod, Daryl J
  • Ching, Christina B
  • Sebastião, Yuri V
  • Greenberg, Jason H
  • Furth, Susan L
  • McHugh, Kirk M
  • Becknell, Brian
subjects:
  • Adolescent
  • Age
  • Article
  • Biological markers
  • Biomarkers - blood
  • Biomarkers - urine
  • Carbon dioxide
  • Case-Control Studies
  • Child
  • Children
  • Chronic kidney disease
  • Chronic kidney failure
  • CKiD
  • Creatinine
  • Diagnosis
  • Disease Progression
  • End-stage renal disease
  • Female
  • Genetic aspects
  • Glomerular Filtration Rate
  • Hemoglobin
  • Humans
  • Kidney diseases
  • Kidney Failure, Chronic - diagnosis
  • Kidney Failure, Chronic - etiology
  • Kidney Failure, Chronic - therapy
  • Kidney Function Tests - methods
  • Kidneys
  • Longitudinal Studies
  • Male
  • male genital diseases
  • Medicine
  • Medicine & Public Health
  • Nephrology
  • Obstruction
  • Original Article
  • Pediatrics
  • Physiological aspects
  • Prediction
  • Prospective Studies
  • Renal Replacement Therapy - statistics & numerical data
  • United States - epidemiology
  • Ureteral Obstruction - blood
  • Ureteral Obstruction - complications
  • Ureteral Obstruction - congenital
  • Ureteral Obstruction - urine
  • Urine
  • urologic
  • Urology
  • Uropathy
  • Usage
  • Vesico-Ureteral Reflux - blood
  • Vesico-Ureteral Reflux - complications
  • Vesico-Ureteral Reflux - congenital
  • Vesico-Ureteral Reflux - urine
  • What’s New in Chronic Kidney Disease
ispartof: Pediatric nephrology (Berlin, West), 2018-10-13, Vol.34 (3), p.443-448
description: Background Obstructive uropathy (OU) is a common cause of end-stage renal disease (ESRD) in children. Children who escape the newborn period with mild-to-moderate chronic kidney disease (CKD) continue to be at increased risk. The predictive ability of clinically available markers throughout childhood is poorly defined. Methods Patients with OU were identified in the Chronic Kidney Disease in Children Study. The primary outcome of interest was renal replacement therapy (RRT) (cases). Controls were age matched and defined as patients within the OU cohort who did not require RRT during study follow-up. Results In total, 27 cases and 41 age-matched controls were identified. Median age at baseline and age at outcome measurement were 10 vs. 16 years, respectively. First available glomerular filtration rate (GFR) (36.9 vs. 53.5 mL/min per 1.73 m 2 ), urine protein/creatinine (Cr) (0.40 vs. 0.22 mg/mg) and microalbumin/Cr (0.58 vs. 0.03 mg/mg), and serum CO 2 (20 vs. 22 mmol/L) and hemoglobin (12.4 vs. 13.2 g/dL) differed significantly between cases and controls, respectively. GFR declined 3.07 mL/min per 1.73 m 2 /year faster in cases compared to that in controls ( p  
language: eng
source:
identifier: ISSN: 0931-041X
fulltext: no_fulltext
issn:
  • 0931-041X
  • 1432-198X
url: Link


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titleCommon clinical markers predict end-stage renal disease in children with obstructive uropathy
creatorMcLeod, Daryl J ; Ching, Christina B ; Sebastião, Yuri V ; Greenberg, Jason H ; Furth, Susan L ; McHugh, Kirk M ; Becknell, Brian
creatorcontribMcLeod, Daryl J ; Ching, Christina B ; Sebastião, Yuri V ; Greenberg, Jason H ; Furth, Susan L ; McHugh, Kirk M ; Becknell, Brian
descriptionBackground Obstructive uropathy (OU) is a common cause of end-stage renal disease (ESRD) in children. Children who escape the newborn period with mild-to-moderate chronic kidney disease (CKD) continue to be at increased risk. The predictive ability of clinically available markers throughout childhood is poorly defined. Methods Patients with OU were identified in the Chronic Kidney Disease in Children Study. The primary outcome of interest was renal replacement therapy (RRT) (cases). Controls were age matched and defined as patients within the OU cohort who did not require RRT during study follow-up. Results In total, 27 cases and 41 age-matched controls were identified. Median age at baseline and age at outcome measurement were 10 vs. 16 years, respectively. First available glomerular filtration rate (GFR) (36.9 vs. 53.5 mL/min per 1.73 m 2 ), urine protein/creatinine (Cr) (0.40 vs. 0.22 mg/mg) and microalbumin/Cr (0.58 vs. 0.03 mg/mg), and serum CO 2 (20 vs. 22 mmol/L) and hemoglobin (12.4 vs. 13.2 g/dL) differed significantly between cases and controls, respectively. GFR declined 3.07 mL/min per 1.73 m 2 /year faster in cases compared to that in controls ( p  < 0.0001). Urine protein/Cr and microalbumin/Cr increased by 0.16 and 0.11 per year more in cases compared to those in controls, respectively ( p  ≤ 0.001 for both). Serum phosphate increased by 0.11 mg/dL and serum albumin and hemoglobin decreased by 0.04 (g/dL) and 0.14 (g/dL) per year more for cases compared to those for controls, respectively ( p  < 0.05 for all). Conclusions Age-specific baseline and longitudinal measures of readily available clinical measures predict progression to ESRD in children with mild-to-moderate CKD from OU.
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1EISSN: 1432-198X
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languageeng
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subjectAdolescent ; Age ; Article ; Biological markers ; Biomarkers - blood ; Biomarkers - urine ; Carbon dioxide ; Case-Control Studies ; Child ; Children ; Chronic kidney disease ; Chronic kidney failure ; CKiD ; Creatinine ; Diagnosis ; Disease Progression ; End-stage renal disease ; Female ; Genetic aspects ; Glomerular Filtration Rate ; Hemoglobin ; Humans ; Kidney diseases ; Kidney Failure, Chronic - diagnosis ; Kidney Failure, Chronic - etiology ; Kidney Failure, Chronic - therapy ; Kidney Function Tests - methods ; Kidneys ; Longitudinal Studies ; Male ; male genital diseases ; Medicine ; Medicine & Public Health ; Nephrology ; Obstruction ; Original Article ; Pediatrics ; Physiological aspects ; Prediction ; Prospective Studies ; Renal Replacement Therapy - statistics & numerical data ; United States - epidemiology ; Ureteral Obstruction - blood ; Ureteral Obstruction - complications ; Ureteral Obstruction - congenital ; Ureteral Obstruction - urine ; Urine ; urologic ; Urology ; Uropathy ; Usage ; Vesico-Ureteral Reflux - blood ; Vesico-Ureteral Reflux - complications ; Vesico-Ureteral Reflux - congenital ; Vesico-Ureteral Reflux - urine ; What’s New in Chronic Kidney Disease
ispartofPediatric nephrology (Berlin, West), 2018-10-13, Vol.34 (3), p.443-448
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5McHugh, Kirk M
6Becknell, Brian
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0Common clinical markers predict end-stage renal disease in children with obstructive uropathy
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descriptionBackground Obstructive uropathy (OU) is a common cause of end-stage renal disease (ESRD) in children. Children who escape the newborn period with mild-to-moderate chronic kidney disease (CKD) continue to be at increased risk. The predictive ability of clinically available markers throughout childhood is poorly defined. Methods Patients with OU were identified in the Chronic Kidney Disease in Children Study. The primary outcome of interest was renal replacement therapy (RRT) (cases). Controls were age matched and defined as patients within the OU cohort who did not require RRT during study follow-up. Results In total, 27 cases and 41 age-matched controls were identified. Median age at baseline and age at outcome measurement were 10 vs. 16 years, respectively. First available glomerular filtration rate (GFR) (36.9 vs. 53.5 mL/min per 1.73 m 2 ), urine protein/creatinine (Cr) (0.40 vs. 0.22 mg/mg) and microalbumin/Cr (0.58 vs. 0.03 mg/mg), and serum CO 2 (20 vs. 22 mmol/L) and hemoglobin (12.4 vs. 13.2 g/dL) differed significantly between cases and controls, respectively. GFR declined 3.07 mL/min per 1.73 m 2 /year faster in cases compared to that in controls ( p  < 0.0001). Urine protein/Cr and microalbumin/Cr increased by 0.16 and 0.11 per year more in cases compared to those in controls, respectively ( p  ≤ 0.001 for both). Serum phosphate increased by 0.11 mg/dL and serum albumin and hemoglobin decreased by 0.04 (g/dL) and 0.14 (g/dL) per year more for cases compared to those for controls, respectively ( p  < 0.05 for all). Conclusions Age-specific baseline and longitudinal measures of readily available clinical measures predict progression to ESRD in children with mild-to-moderate CKD from OU.
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18Genetic aspects
19Glomerular Filtration Rate
20Hemoglobin
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22Kidney diseases
23Kidney Failure, Chronic - diagnosis
24Kidney Failure, Chronic - etiology
25Kidney Failure, Chronic - therapy
26Kidney Function Tests - methods
27Kidneys
28Longitudinal Studies
29Male
30male genital diseases
31Medicine
32Medicine & Public Health
33Nephrology
34Obstruction
35Original Article
36Pediatrics
37Physiological aspects
38Prediction
39Prospective Studies
40Renal Replacement Therapy - statistics & numerical data
41United States - epidemiology
42Ureteral Obstruction - blood
43Ureteral Obstruction - complications
44Ureteral Obstruction - congenital
45Ureteral Obstruction - urine
46Urine
47urologic
48Urology
49Uropathy
50Usage
51Vesico-Ureteral Reflux - blood
52Vesico-Ureteral Reflux - complications
53Vesico-Ureteral Reflux - congenital
54Vesico-Ureteral Reflux - urine
55What’s New in Chronic Kidney Disease
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issn0931-041X
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abstractBackground Obstructive uropathy (OU) is a common cause of end-stage renal disease (ESRD) in children. Children who escape the newborn period with mild-to-moderate chronic kidney disease (CKD) continue to be at increased risk. The predictive ability of clinically available markers throughout childhood is poorly defined. Methods Patients with OU were identified in the Chronic Kidney Disease in Children Study. The primary outcome of interest was renal replacement therapy (RRT) (cases). Controls were age matched and defined as patients within the OU cohort who did not require RRT during study follow-up. Results In total, 27 cases and 41 age-matched controls were identified. Median age at baseline and age at outcome measurement were 10 vs. 16 years, respectively. First available glomerular filtration rate (GFR) (36.9 vs. 53.5 mL/min per 1.73 m 2 ), urine protein/creatinine (Cr) (0.40 vs. 0.22 mg/mg) and microalbumin/Cr (0.58 vs. 0.03 mg/mg), and serum CO 2 (20 vs. 22 mmol/L) and hemoglobin (12.4 vs. 13.2 g/dL) differed significantly between cases and controls, respectively. GFR declined 3.07 mL/min per 1.73 m 2 /year faster in cases compared to that in controls ( p  < 0.0001). Urine protein/Cr and microalbumin/Cr increased by 0.16 and 0.11 per year more in cases compared to those in controls, respectively ( p  ≤ 0.001 for both). Serum phosphate increased by 0.11 mg/dL and serum albumin and hemoglobin decreased by 0.04 (g/dL) and 0.14 (g/dL) per year more for cases compared to those for controls, respectively ( p  < 0.05 for all). Conclusions Age-specific baseline and longitudinal measures of readily available clinical measures predict progression to ESRD in children with mild-to-moderate CKD from OU.
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pmid30317433
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