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The effects of microdose LSD on time perception: a randomised, double-blind, placebo-controlled trial

Rationale Previous research demonstrating that lysergic acid diethylamide (LSD) produces alterations in time perception has implications for its impact on conscious states and a range of psychological functions that necessitate precise interval timing. However, interpretation of this research is hin... Full description

Journal Title: Psychopharmacology 2018-11-26, Vol.236 (4), p.1159-1170
Main Author: Yanakieva, Steliana
Other Authors: Polychroni, Naya , Family, Neiloufar , Williams, Luke T. J , Luke, David P , Terhune, Devin B
Format: Electronic Article Electronic Article
Language: English
Subjects:
LSD
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0033-3158
Link: https://www.ncbi.nlm.nih.gov/pubmed/30478716
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6591199
title: The effects of microdose LSD on time perception: a randomised, double-blind, placebo-controlled trial
format: Article
creator:
  • Yanakieva, Steliana
  • Polychroni, Naya
  • Family, Neiloufar
  • Williams, Luke T. J
  • Luke, David P
  • Terhune, Devin B
subjects:
  • Adults
  • Aged
  • Analysis
  • Biomedical and Life Sciences
  • Biomedicine
  • Clinical trials
  • Consciousness
  • Interval timing
  • Intervals
  • LSD
  • LSD (Drug)
  • Lysergic acid diethylamide
  • Lysergide
  • Microdosing
  • Neurophysiology
  • Neurosciences
  • Older adults
  • Oral administration
  • Original Investigation
  • Perception
  • Pharmacology/Toxicology
  • Psychiatry
  • Randomization
  • Reproduction
  • Striatum
  • Temporal perception
  • Time perception
ispartof: Psychopharmacology, 2018-11-26, Vol.236 (4), p.1159-1170
description: Rationale Previous research demonstrating that lysergic acid diethylamide (LSD) produces alterations in time perception has implications for its impact on conscious states and a range of psychological functions that necessitate precise interval timing. However, interpretation of this research is hindered by methodological limitations and an inability to dissociate direct neurochemical effects on interval timing from indirect effects attributable to altered states of consciousness. Methods We conducted a randomised, double-blind, placebo-controlled study contrasting oral administration of placebo with three microdoses of LSD (5, 10, and 20 μg) in older adults. Subjective drug effects were regularly recorded and interval timing was assessed using a temporal reproduction task spanning subsecond and suprasecond intervals. Results LSD conditions were not associated with any robust changes in self-report indices of perception, mentation, or concentration. LSD reliably produced over-reproduction of temporal intervals of 2000 ms and longer with these effects most pronounced in the 10 μg dose condition. Hierarchical regression analyses indicated that LSD-mediated over-reproduction was independent of marginal differences in self-reported drug effects across conditions. Conclusions These results suggest that microdose LSD produces temporal dilation of suprasecond intervals in the absence of subjective alterations of consciousness.
language: eng
source:
identifier: ISSN: 0033-3158
fulltext: no_fulltext
issn:
  • 0033-3158
  • 1432-2072
url: Link


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titleThe effects of microdose LSD on time perception: a randomised, double-blind, placebo-controlled trial
creatorYanakieva, Steliana ; Polychroni, Naya ; Family, Neiloufar ; Williams, Luke T. J ; Luke, David P ; Terhune, Devin B
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descriptionRationale Previous research demonstrating that lysergic acid diethylamide (LSD) produces alterations in time perception has implications for its impact on conscious states and a range of psychological functions that necessitate precise interval timing. However, interpretation of this research is hindered by methodological limitations and an inability to dissociate direct neurochemical effects on interval timing from indirect effects attributable to altered states of consciousness. Methods We conducted a randomised, double-blind, placebo-controlled study contrasting oral administration of placebo with three microdoses of LSD (5, 10, and 20 μg) in older adults. Subjective drug effects were regularly recorded and interval timing was assessed using a temporal reproduction task spanning subsecond and suprasecond intervals. Results LSD conditions were not associated with any robust changes in self-report indices of perception, mentation, or concentration. LSD reliably produced over-reproduction of temporal intervals of 2000 ms and longer with these effects most pronounced in the 10 μg dose condition. Hierarchical regression analyses indicated that LSD-mediated over-reproduction was independent of marginal differences in self-reported drug effects across conditions. Conclusions These results suggest that microdose LSD produces temporal dilation of suprasecond intervals in the absence of subjective alterations of consciousness.
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subjectAdults ; Aged ; Analysis ; Biomedical and Life Sciences ; Biomedicine ; Clinical trials ; Consciousness ; Interval timing ; Intervals ; LSD ; LSD (Drug) ; Lysergic acid diethylamide ; Lysergide ; Microdosing ; Neurophysiology ; Neurosciences ; Older adults ; Oral administration ; Original Investigation ; Perception ; Pharmacology/Toxicology ; Psychiatry ; Randomization ; Reproduction ; Striatum ; Temporal perception ; Time perception
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abstractRationale Previous research demonstrating that lysergic acid diethylamide (LSD) produces alterations in time perception has implications for its impact on conscious states and a range of psychological functions that necessitate precise interval timing. However, interpretation of this research is hindered by methodological limitations and an inability to dissociate direct neurochemical effects on interval timing from indirect effects attributable to altered states of consciousness. Methods We conducted a randomised, double-blind, placebo-controlled study contrasting oral administration of placebo with three microdoses of LSD (5, 10, and 20 μg) in older adults. Subjective drug effects were regularly recorded and interval timing was assessed using a temporal reproduction task spanning subsecond and suprasecond intervals. Results LSD conditions were not associated with any robust changes in self-report indices of perception, mentation, or concentration. LSD reliably produced over-reproduction of temporal intervals of 2000 ms and longer with these effects most pronounced in the 10 μg dose condition. Hierarchical regression analyses indicated that LSD-mediated over-reproduction was independent of marginal differences in self-reported drug effects across conditions. Conclusions These results suggest that microdose LSD produces temporal dilation of suprasecond intervals in the absence of subjective alterations of consciousness.
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doi10.1007/s00213-018-5119-x
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