schliessen

Filtern

 

Bibliotheken

Cover Image

Social Engagement and Amyloid-β-Related Cognitive Decline in Cognitively Normal Older Adults

•What is the primary question addressed by this study? Do cognitive decline and social disengagement co-occur in cognitively normal older adults and are these changes related to brain amyloid-β, a pathologic marker of Alzheimer's disease?•What is the main finding of this study? In a longitudinal stu... Full description

Journal Title: The American journal of geriatric psychiatry 2019-11, Vol.27 (11), p.1247-1256
Main Author: Biddle, Kelsey D
Other Authors: d'Oleire Uquillas, Federico , Jacobs, Heidi I.L , Zide, Benjamin , Kirn, Dylan R , Rentz, Dorene M , Johnson, Keith A , Sperling, Reisa A , Donovan, Nancy J
Format: Electronic Article Electronic Article
Language: English
Subjects:
ALZHEIMERS-DISEASE PATHOLOGY
ASSOCIATION
Beta-amyloid
BURDEN
Cognition
Cognitive ability
DEFINITION
DEMENTIA
INDIVIDUALS
LONELINESS
NETWORKS
Older people
preclinical Alzheimer's disease
social engagement
Social interaction
TAU
TRAJECTORIES
Quelle: Alma/SFX Local Collection
Publisher: England: Elsevier Inc
ID: ISSN: 1064-7481
Link: https://www.ncbi.nlm.nih.gov/pubmed/31248770
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6778491
title: Social Engagement and Amyloid-β-Related Cognitive Decline in Cognitively Normal Older Adults
format: Article
creator:
  • Biddle, Kelsey D
  • d'Oleire Uquillas, Federico
  • Jacobs, Heidi I.L
  • Zide, Benjamin
  • Kirn, Dylan R
  • Rentz, Dorene M
  • Johnson, Keith A
  • Sperling, Reisa A
  • Donovan, Nancy J
subjects:
  • ALZHEIMERS-DISEASE PATHOLOGY
  • ASSOCIATION
  • Beta-amyloid
  • BURDEN
  • Cognition
  • Cognitive ability
  • DEFINITION
  • DEMENTIA
  • INDIVIDUALS
  • LONELINESS
  • NETWORKS
  • Older people
  • preclinical Alzheimer's disease
  • social engagement
  • Social interaction
  • TAU
  • TRAJECTORIES
ispartof: The American journal of geriatric psychiatry, 2019-11, Vol.27 (11), p.1247-1256
description: •What is the primary question addressed by this study? Do cognitive decline and social disengagement co-occur in cognitively normal older adults and are these changes related to brain amyloid-β, a pathologic marker of Alzheimer's disease?•What is the main finding of this study? In a longitudinal study of 217 community-dwelling, cognitively normal older adults, lower baseline social engagement was associated with steeper cognitive decline in those with higher amyloid-β levels. Lower-range but normal baseline cognitive performance was associated with decline in social engagement independent of amyloid-β level.•What is the meaning of the finding? Cognitive abilities and social function are related processes in older adults. Level of social engagement contributes to cognitive change in the high-risk group of older adults who are unimpaired but have evidence of Alzheimer's pathologic change. Public health recommendations promote social engagement to reduce risk of cognitive decline and dementia. The objective of this study was to evaluate the longitudinal associations of social engagement and cognition in cognitively normal older adults with varying levels of neocortical amyloid-β, the Alzheimer's disease (AD) pathologic marker. Two hundred seventeen men and women, age 63–89 underwent assessments for social engagement and cognitive performance at baseline and 3 years later using the Community Healthy Activities Model Program for Seniors questionnaire and the Preclinical Alzheimer Cognitive Composite (PACC). Amyloid-β was measured using Pittsburgh compound B-PET. Multivariable regression models estimated main and interactive effects of baseline social engagement and amyloid-β on cognitive change. Reciprocal models estimated main and interactive effects of baseline cognitive performance and amyloid-β on change in social engagement. Baseline social engagement was associated with PACC change as a modifier but not as a main effect. Lower baseline social engagement was associated with greater amyloid-β-related PACC decline, while higher baseline social engagement was associated with relative preservation of PACC scores (β = 0.05, p = 0.03). Reciprocally, lower baseline PACC score was associated with decline in social engagement score (β = 1.1, p = 0.02). This association was not modified by amyloid-β, and there was no direct association of amyloid-β with change in social engagement. Low social engagement may be a marker of neurocognitive vulnerability in older adults
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1064-7481
fulltext: fulltext
issn:
  • 1064-7481
  • 1545-7214
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.6223195
LOCALfalse
PrimoNMBib
record
control
sourceidproquest_pubme
recordidTN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6778491
sourceformatXML
sourcesystemPC
sourcerecordid2250608772
originalsourceidFETCH-LOGICAL-c397t-a532835a88126cc422953f87bd7c21c52643772a3ebe19badb38f9b3eeae986e3
addsrcrecordideNp9kctuEzEUhkcIREvhBVigkdiwmeD72BJCikILSBWVuCyR5fGcpA4eO7VnIuW1eJA-Ew4p4bJgZfv48-_zn7-qnmI0wwiLl-vZ2qw2M4KwmiE-Q4jfq04xZ7xpCWb3yx4J1rRM4pPqUc5rhJBQgj2sTigmTLYtOq2-forWGV-fh5VZwQBhrE3o6_mw89H1ze335iN4M0JfL-IquNFtoX4D1rsAtQu_i35Xf4hpKEpXvodUz_vJj_lx9WBpfIYnd-tZ9eXi_PPiXXN59fb9Yn7ZWKrasTGcEkm5kRITYS0jRHG6lG3Xt5Zgy4lgtG2JodABVp3pOyqXqqMABpQUQM-q1wfdzdQN0NtiIxmvN8kNJu10NE7_fRPctV7FrRZtK5nCReDFnUCKNxPkUQ8uW_DeBIhT1oRwJFAZGSno83_QdZxSKPY0oZjx0jylhSIHyqaYc4LlsRmM9D49vdb79PQ-PY24LumVR8_-tHF88iuuAnw7AMEk6_IRmIafHm0qtcGYPCZnr8cplGBSduNOB78fgHfWjC6GrJkQknOqtBUKl5MFraCTugPJBMcc9Xw_lFeH36BEt3WQdLYOgoXeJbCj7qP7n5sf7JLTGA
sourcetypeOpen Access Repository
isCDItrue
recordtypearticle
pqid2314522933
display
typearticle
titleSocial Engagement and Amyloid-β-Related Cognitive Decline in Cognitively Normal Older Adults
sourceAlma/SFX Local Collection
creatorBiddle, Kelsey D ; d'Oleire Uquillas, Federico ; Jacobs, Heidi I.L ; Zide, Benjamin ; Kirn, Dylan R ; Rentz, Dorene M ; Johnson, Keith A ; Sperling, Reisa A ; Donovan, Nancy J
creatorcontribBiddle, Kelsey D ; d'Oleire Uquillas, Federico ; Jacobs, Heidi I.L ; Zide, Benjamin ; Kirn, Dylan R ; Rentz, Dorene M ; Johnson, Keith A ; Sperling, Reisa A ; Donovan, Nancy J
description•What is the primary question addressed by this study? Do cognitive decline and social disengagement co-occur in cognitively normal older adults and are these changes related to brain amyloid-β, a pathologic marker of Alzheimer's disease?•What is the main finding of this study? In a longitudinal study of 217 community-dwelling, cognitively normal older adults, lower baseline social engagement was associated with steeper cognitive decline in those with higher amyloid-β levels. Lower-range but normal baseline cognitive performance was associated with decline in social engagement independent of amyloid-β level.•What is the meaning of the finding? Cognitive abilities and social function are related processes in older adults. Level of social engagement contributes to cognitive change in the high-risk group of older adults who are unimpaired but have evidence of Alzheimer's pathologic change. Public health recommendations promote social engagement to reduce risk of cognitive decline and dementia. The objective of this study was to evaluate the longitudinal associations of social engagement and cognition in cognitively normal older adults with varying levels of neocortical amyloid-β, the Alzheimer's disease (AD) pathologic marker. Two hundred seventeen men and women, age 63–89 underwent assessments for social engagement and cognitive performance at baseline and 3 years later using the Community Healthy Activities Model Program for Seniors questionnaire and the Preclinical Alzheimer Cognitive Composite (PACC). Amyloid-β was measured using Pittsburgh compound B-PET. Multivariable regression models estimated main and interactive effects of baseline social engagement and amyloid-β on cognitive change. Reciprocal models estimated main and interactive effects of baseline cognitive performance and amyloid-β on change in social engagement. Baseline social engagement was associated with PACC change as a modifier but not as a main effect. Lower baseline social engagement was associated with greater amyloid-β-related PACC decline, while higher baseline social engagement was associated with relative preservation of PACC scores (β = 0.05, p = 0.03). Reciprocally, lower baseline PACC score was associated with decline in social engagement score (β = 1.1, p = 0.02). This association was not modified by amyloid-β, and there was no direct association of amyloid-β with change in social engagement. Low social engagement may be a marker of neurocognitive vulnerability in older adults who are cognitively normal but have evidence of AD pathophysiologic change. Understanding changes in social engagement in older adults may lead to earlier diagnosis of AD and advances in evidence-based prevention and treatment.
identifier
0ISSN: 1064-7481
1EISSN: 1545-7214
2DOI: 10.1016/j.jagp.2019.05.005
3PMID: 31248770
languageeng
publisherEngland: Elsevier Inc
subjectALZHEIMERS-DISEASE PATHOLOGY ; ASSOCIATION ; Beta-amyloid ; BURDEN ; Cognition ; Cognitive ability ; DEFINITION ; DEMENTIA ; INDIVIDUALS ; LONELINESS ; NETWORKS ; Older people ; preclinical Alzheimer's disease ; social engagement ; Social interaction ; TAU ; TRAJECTORIES
ispartofThe American journal of geriatric psychiatry, 2019-11, Vol.27 (11), p.1247-1256
rights
02019 American Association for Geriatric Psychiatry
1info:eu-repo/semantics/closedAccess
2Copyright © 2019 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.
3Copyright Elsevier Limited Nov 2019
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31248770$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Biddle, Kelsey D
1d'Oleire Uquillas, Federico
2Jacobs, Heidi I.L
3Zide, Benjamin
4Kirn, Dylan R
5Rentz, Dorene M
6Johnson, Keith A
7Sperling, Reisa A
8Donovan, Nancy J
title
0Social Engagement and Amyloid-β-Related Cognitive Decline in Cognitively Normal Older Adults
1The American journal of geriatric psychiatry
addtitleAm J Geriatr Psychiatry
description•What is the primary question addressed by this study? Do cognitive decline and social disengagement co-occur in cognitively normal older adults and are these changes related to brain amyloid-β, a pathologic marker of Alzheimer's disease?•What is the main finding of this study? In a longitudinal study of 217 community-dwelling, cognitively normal older adults, lower baseline social engagement was associated with steeper cognitive decline in those with higher amyloid-β levels. Lower-range but normal baseline cognitive performance was associated with decline in social engagement independent of amyloid-β level.•What is the meaning of the finding? Cognitive abilities and social function are related processes in older adults. Level of social engagement contributes to cognitive change in the high-risk group of older adults who are unimpaired but have evidence of Alzheimer's pathologic change. Public health recommendations promote social engagement to reduce risk of cognitive decline and dementia. The objective of this study was to evaluate the longitudinal associations of social engagement and cognition in cognitively normal older adults with varying levels of neocortical amyloid-β, the Alzheimer's disease (AD) pathologic marker. Two hundred seventeen men and women, age 63–89 underwent assessments for social engagement and cognitive performance at baseline and 3 years later using the Community Healthy Activities Model Program for Seniors questionnaire and the Preclinical Alzheimer Cognitive Composite (PACC). Amyloid-β was measured using Pittsburgh compound B-PET. Multivariable regression models estimated main and interactive effects of baseline social engagement and amyloid-β on cognitive change. Reciprocal models estimated main and interactive effects of baseline cognitive performance and amyloid-β on change in social engagement. Baseline social engagement was associated with PACC change as a modifier but not as a main effect. Lower baseline social engagement was associated with greater amyloid-β-related PACC decline, while higher baseline social engagement was associated with relative preservation of PACC scores (β = 0.05, p = 0.03). Reciprocally, lower baseline PACC score was associated with decline in social engagement score (β = 1.1, p = 0.02). This association was not modified by amyloid-β, and there was no direct association of amyloid-β with change in social engagement. Low social engagement may be a marker of neurocognitive vulnerability in older adults who are cognitively normal but have evidence of AD pathophysiologic change. Understanding changes in social engagement in older adults may lead to earlier diagnosis of AD and advances in evidence-based prevention and treatment.
subject
0ALZHEIMERS-DISEASE PATHOLOGY
1ASSOCIATION
2Beta-amyloid
3BURDEN
4Cognition
5Cognitive ability
6DEFINITION
7DEMENTIA
8INDIVIDUALS
9LONELINESS
10NETWORKS
11Older people
12preclinical Alzheimer's disease
13social engagement
14Social interaction
15TAU
16TRAJECTORIES
issn
01064-7481
11545-7214
fulltexttrue
rsrctypearticle
creationdate2019
recordtypearticle
recordideNp9kctuEzEUhkcIREvhBVigkdiwmeD72BJCikILSBWVuCyR5fGcpA4eO7VnIuW1eJA-Ew4p4bJgZfv48-_zn7-qnmI0wwiLl-vZ2qw2M4KwmiE-Q4jfq04xZ7xpCWb3yx4J1rRM4pPqUc5rhJBQgj2sTigmTLYtOq2-forWGV-fh5VZwQBhrE3o6_mw89H1ze335iN4M0JfL-IquNFtoX4D1rsAtQu_i35Xf4hpKEpXvodUz_vJj_lx9WBpfIYnd-tZ9eXi_PPiXXN59fb9Yn7ZWKrasTGcEkm5kRITYS0jRHG6lG3Xt5Zgy4lgtG2JodABVp3pOyqXqqMABpQUQM-q1wfdzdQN0NtiIxmvN8kNJu10NE7_fRPctV7FrRZtK5nCReDFnUCKNxPkUQ8uW_DeBIhT1oRwJFAZGSno83_QdZxSKPY0oZjx0jylhSIHyqaYc4LlsRmM9D49vdb79PQ-PY24LumVR8_-tHF88iuuAnw7AMEk6_IRmIafHm0qtcGYPCZnr8cplGBSduNOB78fgHfWjC6GrJkQknOqtBUKl5MFraCTugPJBMcc9Xw_lFeH36BEt3WQdLYOgoXeJbCj7qP7n5sf7JLTGA
startdate201911
enddate201911
creator
0Biddle, Kelsey D
1d'Oleire Uquillas, Federico
2Jacobs, Heidi I.L
3Zide, Benjamin
4Kirn, Dylan R
5Rentz, Dorene M
6Johnson, Keith A
7Sperling, Reisa A
8Donovan, Nancy J
general
0Elsevier Inc
1Elsevier Limited
scope
05DI
15DJ
2QVL
3NPM
4AAYXX
5CITATION
64T-
7K9.
87X8
95PM
sort
creationdate201911
titleSocial Engagement and Amyloid-β-Related Cognitive Decline in Cognitively Normal Older Adults
authorBiddle, Kelsey D ; d'Oleire Uquillas, Federico ; Jacobs, Heidi I.L ; Zide, Benjamin ; Kirn, Dylan R ; Rentz, Dorene M ; Johnson, Keith A ; Sperling, Reisa A ; Donovan, Nancy J
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-c397t-a532835a88126cc422953f87bd7c21c52643772a3ebe19badb38f9b3eeae986e3
rsrctypearticles
prefilterarticles
languageeng
creationdate2019
topic
0ALZHEIMERS-DISEASE PATHOLOGY
1ASSOCIATION
2Beta-amyloid
3BURDEN
4Cognition
5Cognitive ability
6DEFINITION
7DEMENTIA
8INDIVIDUALS
9LONELINESS
10NETWORKS
11Older people
12preclinical Alzheimer's disease
13social engagement
14Social interaction
15TAU
16TRAJECTORIES
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Biddle, Kelsey D
1d'Oleire Uquillas, Federico
2Jacobs, Heidi I.L
3Zide, Benjamin
4Kirn, Dylan R
5Rentz, Dorene M
6Johnson, Keith A
7Sperling, Reisa A
8Donovan, Nancy J
collection
0NARCIS
1NARCIS: Datasets
2NARCIS:Publications
3PubMed
4CrossRef
5Docstoc
6ProQuest Health & Medical Complete (Alumni)
7MEDLINE - Academic
8PubMed Central (Full Participant titles)
jtitleThe American journal of geriatric psychiatry
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Biddle, Kelsey D
1d'Oleire Uquillas, Federico
2Jacobs, Heidi I.L
3Zide, Benjamin
4Kirn, Dylan R
5Rentz, Dorene M
6Johnson, Keith A
7Sperling, Reisa A
8Donovan, Nancy J
formatjournal
genrearticle
ristypeJOUR
atitleSocial Engagement and Amyloid-β-Related Cognitive Decline in Cognitively Normal Older Adults
jtitleThe American journal of geriatric psychiatry
addtitleAm J Geriatr Psychiatry
date2019-11
risdate2019
volume27
issue11
spage1247
epage1256
pages1247-1256
issn1064-7481
eissn1545-7214
abstract•What is the primary question addressed by this study? Do cognitive decline and social disengagement co-occur in cognitively normal older adults and are these changes related to brain amyloid-β, a pathologic marker of Alzheimer's disease?•What is the main finding of this study? In a longitudinal study of 217 community-dwelling, cognitively normal older adults, lower baseline social engagement was associated with steeper cognitive decline in those with higher amyloid-β levels. Lower-range but normal baseline cognitive performance was associated with decline in social engagement independent of amyloid-β level.•What is the meaning of the finding? Cognitive abilities and social function are related processes in older adults. Level of social engagement contributes to cognitive change in the high-risk group of older adults who are unimpaired but have evidence of Alzheimer's pathologic change. Public health recommendations promote social engagement to reduce risk of cognitive decline and dementia. The objective of this study was to evaluate the longitudinal associations of social engagement and cognition in cognitively normal older adults with varying levels of neocortical amyloid-β, the Alzheimer's disease (AD) pathologic marker. Two hundred seventeen men and women, age 63–89 underwent assessments for social engagement and cognitive performance at baseline and 3 years later using the Community Healthy Activities Model Program for Seniors questionnaire and the Preclinical Alzheimer Cognitive Composite (PACC). Amyloid-β was measured using Pittsburgh compound B-PET. Multivariable regression models estimated main and interactive effects of baseline social engagement and amyloid-β on cognitive change. Reciprocal models estimated main and interactive effects of baseline cognitive performance and amyloid-β on change in social engagement. Baseline social engagement was associated with PACC change as a modifier but not as a main effect. Lower baseline social engagement was associated with greater amyloid-β-related PACC decline, while higher baseline social engagement was associated with relative preservation of PACC scores (β = 0.05, p = 0.03). Reciprocally, lower baseline PACC score was associated with decline in social engagement score (β = 1.1, p = 0.02). This association was not modified by amyloid-β, and there was no direct association of amyloid-β with change in social engagement. Low social engagement may be a marker of neurocognitive vulnerability in older adults who are cognitively normal but have evidence of AD pathophysiologic change. Understanding changes in social engagement in older adults may lead to earlier diagnosis of AD and advances in evidence-based prevention and treatment.
copEngland
pubElsevier Inc
pmid31248770
doi10.1016/j.jagp.2019.05.005