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The Impact of Awareness of and Concern About Memory Performance on the Prediction of Progression From Mild Cognitive Impairment to Alzheimer Disease Dementia

•MCI who progressed to AD overestimated memory performance at baseline.•MCI who remained stable underestimated memory performance at baseline.•Progressor MCI group showed more concern about memory at baseline than Stable MCI.•Only Progressor MCI appeared to show less concern about memory over time.... Full description

Journal Title: The American journal of geriatric psychiatry 2018-08, Vol.26 (8), p.896-904
Main Author: Munro, Catherine E
Other Authors: Donovan, Nancy J , Amariglio, Rebecca E , Papp, Kate V , Marshall, Gad A , Rentz, Dorene M , Pascual-Leone, Alvaro , Sperling, Reisa A , Locascio, Joseph J , Vannini, Patrizia
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: Elsevier Inc
ID: ISSN: 1064-7481
Link: https://www.ncbi.nlm.nih.gov/pubmed/29866588
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6959130
title: The Impact of Awareness of and Concern About Memory Performance on the Prediction of Progression From Mild Cognitive Impairment to Alzheimer Disease Dementia
format: Article
creator:
  • Munro, Catherine E
  • Donovan, Nancy J
  • Amariglio, Rebecca E
  • Papp, Kate V
  • Marshall, Gad A
  • Rentz, Dorene M
  • Pascual-Leone, Alvaro
  • Sperling, Reisa A
  • Locascio, Joseph J
  • Vannini, Patrizia
subjects:
  • Aged
  • Agnosia - complications
  • Agnosia - psychology
  • Alzheimer disease
  • Alzheimer Disease - complications
  • Alzheimer Disease - psychology
  • Alzheimers disease
  • Anxiety - psychology
  • Article
  • Awareness
  • clinical progression
  • Cognitive development
  • Cognitive Dysfunction - complications
  • Cognitive Dysfunction - psychology
  • Dementia
  • Disease Progression
  • Female
  • Humans
  • Male
  • Memory
  • mental disorders
  • mild cognitive impairment
  • Neuropsychological Tests
  • Self awareness
  • subjective memory complaints
ispartof: The American journal of geriatric psychiatry, 2018-08, Vol.26 (8), p.896-904
description: •MCI who progressed to AD overestimated memory performance at baseline.•MCI who remained stable underestimated memory performance at baseline.•Progressor MCI group showed more concern about memory at baseline than Stable MCI.•Only Progressor MCI appeared to show less concern about memory over time. To investigate the relationship of awareness of and concern about memory performance to progression from mild cognitive impairment (MCI) to Alzheimer disease (AD) dementia. Participants (n = 33) had a diagnosis of MCI at baseline and a diagnosis of MCI or AD dementia at follow-up. Participants were categorized as “Stable-MCI” if they retained an MCI diagnosis at follow-up (mean follow-up = 18.0 months) or “Progressor-MCI” if they were diagnosed with AD dementia at follow-up (mean follow-up = 21.6 months). Awareness was measured using the residual from regressing a participant's objective memory score onto their subjective complaint score (i.e., residual
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1064-7481
fulltext: fulltext
issn:
  • 1064-7481
  • 1545-7214
url: Link


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titleThe Impact of Awareness of and Concern About Memory Performance on the Prediction of Progression From Mild Cognitive Impairment to Alzheimer Disease Dementia
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creatorMunro, Catherine E ; Donovan, Nancy J ; Amariglio, Rebecca E ; Papp, Kate V ; Marshall, Gad A ; Rentz, Dorene M ; Pascual-Leone, Alvaro ; Sperling, Reisa A ; Locascio, Joseph J ; Vannini, Patrizia
creatorcontribMunro, Catherine E ; Donovan, Nancy J ; Amariglio, Rebecca E ; Papp, Kate V ; Marshall, Gad A ; Rentz, Dorene M ; Pascual-Leone, Alvaro ; Sperling, Reisa A ; Locascio, Joseph J ; Vannini, Patrizia
description•MCI who progressed to AD overestimated memory performance at baseline.•MCI who remained stable underestimated memory performance at baseline.•Progressor MCI group showed more concern about memory at baseline than Stable MCI.•Only Progressor MCI appeared to show less concern about memory over time. To investigate the relationship of awareness of and concern about memory performance to progression from mild cognitive impairment (MCI) to Alzheimer disease (AD) dementia. Participants (n = 33) had a diagnosis of MCI at baseline and a diagnosis of MCI or AD dementia at follow-up. Participants were categorized as “Stable-MCI” if they retained an MCI diagnosis at follow-up (mean follow-up = 18.0 months) or “Progressor-MCI” if they were diagnosed with AD dementia at follow-up (mean follow-up = 21.6 months). Awareness was measured using the residual from regressing a participant's objective memory score onto their subjective complaint score (i.e., residual<0 indicates overestimation of performance). Concern was assessed using a questionnaire examining the degree of concern when forgetting. Logistic regression was used to determine whether the presence of these syndromes could predict future diagnosis of AD dementia, and repeated measures analysis of covariance tests were used to examine longitudinal patterns of these syndromes. Baseline anosognosia was apparent in the Progressor-MCI group, whereas participants in the Stable-MCI group demonstrated relative awareness of their memory performance. Baseline awareness scores successfully predicted whether an individual would progress to AD-dementia. Neither group showed change in awareness of performance over time. Neither group showed differences in concern about memory performance at baseline or change in concern about performance over time. These data suggest that anosognosia may appear prior to the onset of AD dementia, while anosodiaphoria likely does not appear until later in the AD continuum. Additionally, neither group showed significant changes in awareness or concern over time, suggesting that change in these variables may happen over longer periods.
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subjectAged ; Agnosia - complications ; Agnosia - psychology ; Alzheimer disease ; Alzheimer Disease - complications ; Alzheimer Disease - psychology ; Alzheimers disease ; Anxiety - psychology ; Article ; Awareness ; clinical progression ; Cognitive development ; Cognitive Dysfunction - complications ; Cognitive Dysfunction - psychology ; Dementia ; Disease Progression ; Female ; Humans ; Male ; Memory ; mental disorders ; mild cognitive impairment ; Neuropsychological Tests ; Self awareness ; subjective memory complaints
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description•MCI who progressed to AD overestimated memory performance at baseline.•MCI who remained stable underestimated memory performance at baseline.•Progressor MCI group showed more concern about memory at baseline than Stable MCI.•Only Progressor MCI appeared to show less concern about memory over time. To investigate the relationship of awareness of and concern about memory performance to progression from mild cognitive impairment (MCI) to Alzheimer disease (AD) dementia. Participants (n = 33) had a diagnosis of MCI at baseline and a diagnosis of MCI or AD dementia at follow-up. Participants were categorized as “Stable-MCI” if they retained an MCI diagnosis at follow-up (mean follow-up = 18.0 months) or “Progressor-MCI” if they were diagnosed with AD dementia at follow-up (mean follow-up = 21.6 months). Awareness was measured using the residual from regressing a participant's objective memory score onto their subjective complaint score (i.e., residual<0 indicates overestimation of performance). Concern was assessed using a questionnaire examining the degree of concern when forgetting. Logistic regression was used to determine whether the presence of these syndromes could predict future diagnosis of AD dementia, and repeated measures analysis of covariance tests were used to examine longitudinal patterns of these syndromes. Baseline anosognosia was apparent in the Progressor-MCI group, whereas participants in the Stable-MCI group demonstrated relative awareness of their memory performance. Baseline awareness scores successfully predicted whether an individual would progress to AD-dementia. Neither group showed change in awareness of performance over time. Neither group showed differences in concern about memory performance at baseline or change in concern about performance over time. These data suggest that anosognosia may appear prior to the onset of AD dementia, while anosodiaphoria likely does not appear until later in the AD continuum. Additionally, neither group showed significant changes in awareness or concern over time, suggesting that change in these variables may happen over longer periods.
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titleThe Impact of Awareness of and Concern About Memory Performance on the Prediction of Progression From Mild Cognitive Impairment to Alzheimer Disease Dementia
authorMunro, Catherine E ; Donovan, Nancy J ; Amariglio, Rebecca E ; Papp, Kate V ; Marshall, Gad A ; Rentz, Dorene M ; Pascual-Leone, Alvaro ; Sperling, Reisa A ; Locascio, Joseph J ; Vannini, Patrizia
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abstract•MCI who progressed to AD overestimated memory performance at baseline.•MCI who remained stable underestimated memory performance at baseline.•Progressor MCI group showed more concern about memory at baseline than Stable MCI.•Only Progressor MCI appeared to show less concern about memory over time. To investigate the relationship of awareness of and concern about memory performance to progression from mild cognitive impairment (MCI) to Alzheimer disease (AD) dementia. Participants (n = 33) had a diagnosis of MCI at baseline and a diagnosis of MCI or AD dementia at follow-up. Participants were categorized as “Stable-MCI” if they retained an MCI diagnosis at follow-up (mean follow-up = 18.0 months) or “Progressor-MCI” if they were diagnosed with AD dementia at follow-up (mean follow-up = 21.6 months). Awareness was measured using the residual from regressing a participant's objective memory score onto their subjective complaint score (i.e., residual<0 indicates overestimation of performance). Concern was assessed using a questionnaire examining the degree of concern when forgetting. Logistic regression was used to determine whether the presence of these syndromes could predict future diagnosis of AD dementia, and repeated measures analysis of covariance tests were used to examine longitudinal patterns of these syndromes. Baseline anosognosia was apparent in the Progressor-MCI group, whereas participants in the Stable-MCI group demonstrated relative awareness of their memory performance. Baseline awareness scores successfully predicted whether an individual would progress to AD-dementia. Neither group showed change in awareness of performance over time. Neither group showed differences in concern about memory performance at baseline or change in concern about performance over time. These data suggest that anosognosia may appear prior to the onset of AD dementia, while anosodiaphoria likely does not appear until later in the AD continuum. Additionally, neither group showed significant changes in awareness or concern over time, suggesting that change in these variables may happen over longer periods.
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