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HIV-1 subtype distribution and diversity over 18 years in Rakai, Uganda

The Rakai Community Cohort Study in south central Uganda has surveyed persons aged 15-49 since 1994. Antiretroviral therapy (ART) was introduced in 2004. HIV p24 and gp41 subtype distribution and viral diversity were studied from blood samples collected at three surveys in 1994-1995, 2002-2003, 2008... Full description

Journal Title: AIDS research and human retroviruses 2020, Vol.36 (ja), p.522-526
Main Author: Lamers, Susanna
Other Authors: Rose, Rebecca , Cross, Sissy , Rodriguez, Christopher W , Redd, Andrew D , Quinn, Thomas C , Serwadda, David , Kagaayi, Joseph , Galiwango, Ronald M. , Gray, Ronald , Grabowski, Mary , Laeyendecker, Oliver
Format: Electronic Article Electronic Article
Language: English
Subjects:
HIV
Quelle: Alma/SFX Local Collection
Publisher: United States: Mary Ann Liebert, Inc
ID: ISSN: 0889-2229
Link: https://www.ncbi.nlm.nih.gov/pubmed/32281387
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title: HIV-1 subtype distribution and diversity over 18 years in Rakai, Uganda
format: Article
creator:
  • Lamers, Susanna
  • Rose, Rebecca
  • Cross, Sissy
  • Rodriguez, Christopher W
  • Redd, Andrew D
  • Quinn, Thomas C
  • Serwadda, David
  • Kagaayi, Joseph
  • Galiwango, Ronald M.
  • Gray, Ronald
  • Grabowski, Mary
  • Laeyendecker, Oliver
subjects:
  • AIDS/HIV
  • Antiretroviral agents
  • Antiretroviral therapy
  • Genetic diversity
  • Glycoprotein gp41
  • HIV
  • Human immunodeficiency virus
  • Polls & surveys
  • sequence diversity
  • Sequence Notes
  • subtype change
  • Uganda
ispartof: AIDS research and human retroviruses, 2020, Vol.36 (ja), p.522-526
description: The Rakai Community Cohort Study in south central Uganda has surveyed persons aged 15-49 since 1994. Antiretroviral therapy (ART) was introduced in 2004. HIV p24 and gp41 subtype distribution and viral diversity were studied from blood samples collected at three surveys in 1994-1995, 2002-2003, 2008-2009 which were compared to a new survey round from 2011-2012. These included 1364 HIV+ individuals. For both p24 and gp41 domains, the genetic diversity within subtypes A and D was significantly increasing in the pre-ART era and decreased between the last two survey rounds in the ART era (p
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0889-2229
fulltext: fulltext
issn:
  • 0889-2229
  • 1931-8405
url: Link


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creatorLamers, Susanna ; Rose, Rebecca ; Cross, Sissy ; Rodriguez, Christopher W ; Redd, Andrew D ; Quinn, Thomas C ; Serwadda, David ; Kagaayi, Joseph ; Galiwango, Ronald M. ; Gray, Ronald ; Grabowski, Mary ; Laeyendecker, Oliver
creatorcontribLamers, Susanna ; Rose, Rebecca ; Cross, Sissy ; Rodriguez, Christopher W ; Redd, Andrew D ; Quinn, Thomas C ; Serwadda, David ; Kagaayi, Joseph ; Galiwango, Ronald M. ; Gray, Ronald ; Grabowski, Mary ; Laeyendecker, Oliver
descriptionThe Rakai Community Cohort Study in south central Uganda has surveyed persons aged 15-49 since 1994. Antiretroviral therapy (ART) was introduced in 2004. HIV p24 and gp41 subtype distribution and viral diversity were studied from blood samples collected at three surveys in 1994-1995, 2002-2003, 2008-2009 which were compared to a new survey round from 2011-2012. These included 1364 HIV+ individuals. For both p24 and gp41 domains, the genetic diversity within subtypes A and D was significantly increasing in the pre-ART era and decreased between the last two survey rounds in the ART era (p<0.01). This study suggests that despite ongoing mixing of viral subtypes, an association with the introduction of ART to a reduction of intra-subtype viral genomic diversity may be occurring, which can be explored in ongoing studies.
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subjectAIDS/HIV ; Antiretroviral agents ; Antiretroviral therapy ; Genetic diversity ; Glycoprotein gp41 ; HIV ; Human immunodeficiency virus ; Polls & surveys ; sequence diversity ; Sequence Notes ; subtype change ; Uganda
ispartofAIDS research and human retroviruses, 2020, Vol.36 (ja), p.522-526
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abstractThe Rakai Community Cohort Study in south central Uganda has surveyed persons aged 15-49 since 1994. Antiretroviral therapy (ART) was introduced in 2004. HIV p24 and gp41 subtype distribution and viral diversity were studied from blood samples collected at three surveys in 1994-1995, 2002-2003, 2008-2009 which were compared to a new survey round from 2011-2012. These included 1364 HIV+ individuals. For both p24 and gp41 domains, the genetic diversity within subtypes A and D was significantly increasing in the pre-ART era and decreased between the last two survey rounds in the ART era (p<0.01). This study suggests that despite ongoing mixing of viral subtypes, an association with the introduction of ART to a reduction of intra-subtype viral genomic diversity may be occurring, which can be explored in ongoing studies.
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doi10.1089/AID.2020.0062
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