Expression of mesothelin in thymic carcinoma and its potential therapeutic significance

Highlights • Mesothelin, a cell surface antigen is a target for tumor-directed therapy. • Thymic carcinomas frequently demonstrate strong mesothelin expression. • High mesothelin expression in thymic carcinoma is associated with longer survival. • Mesothelin-directed therapy should be evaluated in a... Full description

Journal Title:	Lung cancer (Amsterdam Netherlands), 2016, Vol.101, p.104-110
Main Author:	Thomas, Anish, MD
Other Authors:	Chen, Yuanbin, MD PhD , Berman, Arlene, MS , Schrump, David S., MD , Giaccone, Giuseppe, MD PhD , Pastan, Ira, MD , Venzon, David J., PhD , Liewehr, David J., MS , Steinberg, Seth M., PhD , Miettinen, Markku, MD , Hassan, Raffit, MD , Rajan, Arun, MD
Format:	Electronic Article
Language:	English
Subjects:	Adult Aged Aged, 80 and over Antigens Biomarkers, Tumor - metabolism Cancer Carcinoma Female GPI-Linked Proteins - blood GPI-Linked Proteins - metabolism Health aspects Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry Immunotherapy Male Mediastinal Neoplasms - epidemiology Mediastinal Neoplasms - metabolism Mediastinal Neoplasms - pathology Mesothelin Middle Aged Neoplasms, Glandular and Epithelial - classification Neoplasms, Glandular and Epithelial - pathology Prevalence Pulmonary/Respiratory Survival Therapeutic target Thymic carcinoma Thymoma Thymoma - epidemiology Thymoma - ethnology Thymoma - metabolism Thymoma - pathology Thymus Neoplasms - classification Thymus Neoplasms - pathology
Quelle:	Alma/SFX Local Collection
Publisher:	Ireland: Elsevier B.V
ID:	ISSN: 0169-5002
Link:	https://www.ncbi.nlm.nih.gov/pubmed/27794397
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title:	Expression of mesothelin in thymic carcinoma and its potential therapeutic significance
format:	Article
creator:	Thomas, Anish, MD Chen, Yuanbin, MD PhD Berman, Arlene, MS Schrump, David S., MD Giaccone, Giuseppe, MD PhD Pastan, Ira, MD Venzon, David J., PhD Liewehr, David J., MS Steinberg, Seth M., PhD Miettinen, Markku, MD Hassan, Raffit, MD Rajan, Arun, MD
subjects:	Adult Aged Aged, 80 and over Antigens Biomarkers, Tumor - metabolism Cancer Carcinoma Female GPI-Linked Proteins - blood GPI-Linked Proteins - metabolism Health aspects Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry Immunotherapy Male Mediastinal Neoplasms - epidemiology Mediastinal Neoplasms - metabolism Mediastinal Neoplasms - pathology Mesothelin Middle Aged Neoplasms, Glandular and Epithelial - classification Neoplasms, Glandular and Epithelial - pathology Prevalence Pulmonary/Respiratory Survival Therapeutic target Thymic carcinoma Thymoma Thymoma - epidemiology Thymoma - ethnology Thymoma - metabolism Thymoma - pathology Thymus Neoplasms - classification Thymus Neoplasms - pathology
ispartof:	Lung cancer (Amsterdam, Netherlands), 2016, Vol.101, p.104-110
description:	Highlights • Mesothelin, a cell surface antigen is a target for tumor-directed therapy. • Thymic carcinomas frequently demonstrate strong mesothelin expression. • High mesothelin expression in thymic carcinoma is associated with longer survival. • Mesothelin-directed therapy should be evaluated in advanced thymic carcinoma.
language:	eng
source:	Alma/SFX Local Collection
identifier:	ISSN: 0169-5002
fulltext:	fulltext
issn:	0169-5002 1872-8332
url:	Link

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Expression of mesothelin in thymic carcinoma and its potential therapeutic significance

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Alma/SFX Local Collection

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Thomas, Anish, MD ; Chen, Yuanbin, MD PhD ; Berman, Arlene, MS ; Schrump, David S., MD ; Giaccone, Giuseppe, MD PhD ; Pastan, Ira, MD ; Venzon, David J., PhD ; Liewehr, David J., MS ; Steinberg, Seth M., PhD ; Miettinen, Markku, MD ; Hassan, Raffit, MD ; Rajan, Arun, MD

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0	ISSN: 0169-5002
1	EISSN: 1872-8332
2	DOI: 10.1016/j.lungcan.2016.09.015
3	PMID: 27794397

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Ireland: Elsevier B.V

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Adult ; Aged ; Aged, 80 and over ; Antigens ; Biomarkers, Tumor - metabolism ; Cancer ; Carcinoma ; Female ; GPI-Linked Proteins - blood ; GPI-Linked Proteins - metabolism ; Health aspects ; Hematology, Oncology and Palliative Medicine ; Humans ; Immunohistochemistry ; Immunotherapy ; Male ; Mediastinal Neoplasms - epidemiology ; Mediastinal Neoplasms - metabolism ; Mediastinal Neoplasms - pathology ; Mesothelin ; Middle Aged ; Neoplasms, Glandular and Epithelial - classification ; Neoplasms, Glandular and Epithelial - pathology ; Prevalence ; Pulmonary/Respiratory ; Survival ; Therapeutic target ; Thymic carcinoma ; Thymoma ; Thymoma - epidemiology ; Thymoma - ethnology ; Thymoma - metabolism ; Thymoma - pathology ; Thymus Neoplasms - classification ; Thymus Neoplasms - pathology

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Lung cancer (Amsterdam, Netherlands), 2016, Vol.101, p.104-110

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0	Thomas, Anish, MD
1	Chen, Yuanbin, MD PhD
2	Berman, Arlene, MS
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4	Giaccone, Giuseppe, MD PhD
5	Pastan, Ira, MD
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7	Liewehr, David J., MS
8	Steinberg, Seth M., PhD
9	Miettinen, Markku, MD
10	Hassan, Raffit, MD
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Lung Cancer

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21	Neoplasms, Glandular and Epithelial - classification
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5	Pastan, Ira, MD
6	Venzon, David J., PhD
7	Liewehr, David J., MS
8	Steinberg, Seth M., PhD
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creationdate	2016
title	Expression of mesothelin in thymic carcinoma and its potential therapeutic significance
author	Thomas, Anish, MD ; Chen, Yuanbin, MD PhD ; Berman, Arlene, MS ; Schrump, David S., MD ; Giaccone, Giuseppe, MD PhD ; Pastan, Ira, MD ; Venzon, David J., PhD ; Liewehr, David J., MS ; Steinberg, Seth M., PhD ; Miettinen, Markku, MD ; Hassan, Raffit, MD ; Rajan, Arun, MD

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1	Aged
2	Aged, 80 and over
3	Antigens
4	Biomarkers, Tumor - metabolism
5	Cancer
6	Carcinoma
7	Female
8	GPI-Linked Proteins - blood
9	GPI-Linked Proteins - metabolism
10	Health aspects
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12	Humans
13	Immunohistochemistry
14	Immunotherapy
15	Male
16	Mediastinal Neoplasms - epidemiology
17	Mediastinal Neoplasms - metabolism
18	Mediastinal Neoplasms - pathology
19	Mesothelin
20	Middle Aged
21	Neoplasms, Glandular and Epithelial - classification
22	Neoplasms, Glandular and Epithelial - pathology
23	Prevalence
24	Pulmonary/Respiratory
25	Survival
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27	Thymic carcinoma
28	Thymoma
29	Thymoma - epidemiology
30	Thymoma - ethnology
31	Thymoma - metabolism
32	Thymoma - pathology
33	Thymus Neoplasms - classification
34	Thymus Neoplasms - pathology

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0	Thomas, Anish, MD
1	Chen, Yuanbin, MD PhD
2	Berman, Arlene, MS
3	Schrump, David S., MD
4	Giaccone, Giuseppe, MD PhD
5	Pastan, Ira, MD
6	Venzon, David J., PhD
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0	Thomas, Anish, MD
1	Chen, Yuanbin, MD PhD
2	Berman, Arlene, MS
3	Schrump, David S., MD
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5	Pastan, Ira, MD
6	Venzon, David J., PhD
7	Liewehr, David J., MS
8	Steinberg, Seth M., PhD
9	Miettinen, Markku, MD
10	Hassan, Raffit, MD
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Expression of mesothelin in thymic carcinoma and its potential therapeutic significance

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Lung cancer (Amsterdam, Netherlands)

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Lung Cancer

date

2016

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0169-5002

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abstract

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Ireland

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Elsevier B.V

pmid

27794397

doi

10.1016/j.lungcan.2016.09.015

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Expression of mesothelin in thymic carcinoma and its potential therapeutic significance