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Expression of mesothelin in thymic carcinoma and its potential therapeutic significance

Highlights • Mesothelin, a cell surface antigen is a target for tumor-directed therapy. • Thymic carcinomas frequently demonstrate strong mesothelin expression. • High mesothelin expression in thymic carcinoma is associated with longer survival. • Mesothelin-directed therapy should be evaluated in a... Full description

Journal Title: Lung cancer (Amsterdam Netherlands), 2016, Vol.101, p.104-110
Main Author: Thomas, Anish, MD
Other Authors: Chen, Yuanbin, MD PhD , Berman, Arlene, MS , Schrump, David S., MD , Giaccone, Giuseppe, MD PhD , Pastan, Ira, MD , Venzon, David J., PhD , Liewehr, David J., MS , Steinberg, Seth M., PhD , Miettinen, Markku, MD , Hassan, Raffit, MD , Rajan, Arun, MD
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Ireland: Elsevier B.V
ID: ISSN: 0169-5002
Link: https://www.ncbi.nlm.nih.gov/pubmed/27794397
Zum Text:
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title: Expression of mesothelin in thymic carcinoma and its potential therapeutic significance
format: Article
creator:
  • Thomas, Anish, MD
  • Chen, Yuanbin, MD PhD
  • Berman, Arlene, MS
  • Schrump, David S., MD
  • Giaccone, Giuseppe, MD PhD
  • Pastan, Ira, MD
  • Venzon, David J., PhD
  • Liewehr, David J., MS
  • Steinberg, Seth M., PhD
  • Miettinen, Markku, MD
  • Hassan, Raffit, MD
  • Rajan, Arun, MD
subjects:
  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens
  • Biomarkers, Tumor - metabolism
  • Cancer
  • Carcinoma
  • Female
  • GPI-Linked Proteins - blood
  • GPI-Linked Proteins - metabolism
  • Health aspects
  • Hematology, Oncology and Palliative Medicine
  • Humans
  • Immunohistochemistry
  • Immunotherapy
  • Male
  • Mediastinal Neoplasms - epidemiology
  • Mediastinal Neoplasms - metabolism
  • Mediastinal Neoplasms - pathology
  • Mesothelin
  • Middle Aged
  • Neoplasms, Glandular and Epithelial - classification
  • Neoplasms, Glandular and Epithelial - pathology
  • Prevalence
  • Pulmonary/Respiratory
  • Survival
  • Therapeutic target
  • Thymic carcinoma
  • Thymoma
  • Thymoma - epidemiology
  • Thymoma - ethnology
  • Thymoma - metabolism
  • Thymoma - pathology
  • Thymus Neoplasms - classification
  • Thymus Neoplasms - pathology
ispartof: Lung cancer (Amsterdam, Netherlands), 2016, Vol.101, p.104-110
description: Highlights • Mesothelin, a cell surface antigen is a target for tumor-directed therapy. • Thymic carcinomas frequently demonstrate strong mesothelin expression. • High mesothelin expression in thymic carcinoma is associated with longer survival. • Mesothelin-directed therapy should be evaluated in advanced thymic carcinoma.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0169-5002
fulltext: fulltext
issn:
  • 0169-5002
  • 1872-8332
url: Link


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titleExpression of mesothelin in thymic carcinoma and its potential therapeutic significance
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descriptionHighlights • Mesothelin, a cell surface antigen is a target for tumor-directed therapy. • Thymic carcinomas frequently demonstrate strong mesothelin expression. • High mesothelin expression in thymic carcinoma is associated with longer survival. • Mesothelin-directed therapy should be evaluated in advanced thymic carcinoma.
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subjectAdult ; Aged ; Aged, 80 and over ; Antigens ; Biomarkers, Tumor - metabolism ; Cancer ; Carcinoma ; Female ; GPI-Linked Proteins - blood ; GPI-Linked Proteins - metabolism ; Health aspects ; Hematology, Oncology and Palliative Medicine ; Humans ; Immunohistochemistry ; Immunotherapy ; Male ; Mediastinal Neoplasms - epidemiology ; Mediastinal Neoplasms - metabolism ; Mediastinal Neoplasms - pathology ; Mesothelin ; Middle Aged ; Neoplasms, Glandular and Epithelial - classification ; Neoplasms, Glandular and Epithelial - pathology ; Prevalence ; Pulmonary/Respiratory ; Survival ; Therapeutic target ; Thymic carcinoma ; Thymoma ; Thymoma - epidemiology ; Thymoma - ethnology ; Thymoma - metabolism ; Thymoma - pathology ; Thymus Neoplasms - classification ; Thymus Neoplasms - pathology
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descriptionHighlights • Mesothelin, a cell surface antigen is a target for tumor-directed therapy. • Thymic carcinomas frequently demonstrate strong mesothelin expression. • High mesothelin expression in thymic carcinoma is associated with longer survival. • Mesothelin-directed therapy should be evaluated in advanced thymic carcinoma.
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8GPI-Linked Proteins - blood
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10Health aspects
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17Mediastinal Neoplasms - metabolism
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abstractHighlights • Mesothelin, a cell surface antigen is a target for tumor-directed therapy. • Thymic carcinomas frequently demonstrate strong mesothelin expression. • High mesothelin expression in thymic carcinoma is associated with longer survival. • Mesothelin-directed therapy should be evaluated in advanced thymic carcinoma.
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doi10.1016/j.lungcan.2016.09.015
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