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The role of periostin in tissue remodeling across health and disease

Periostin, also termed osteoblast-specific factor 2, is a matricellular protein with known functions in osteology, tissue repair, oncology, cardiovascular and respiratory systems, and in various inflammatory settings. However, most of the research to date has been conducted in divergent and circumsc... Full description

Journal Title: Cellular and Molecular Life Sciences 2013-10-22, Vol.71 (7), p.1279-1288
Main Author: Conway, Simon J
Other Authors: Izuhara, Kenji , Kudo, Yasusei , Litvin, Judith , Markwald, Roger , Ouyang, Gaoliang , Arron, Joseph R , Holweg, Cecile T. J , Kudo, Akira
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Basel: Springer Basel
ID: ISSN: 1420-682X
Link: https://www.ncbi.nlm.nih.gov/pubmed/24146092
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title: The role of periostin in tissue remodeling across health and disease
format: Article
creator:
  • Conway, Simon J
  • Izuhara, Kenji
  • Kudo, Yasusei
  • Litvin, Judith
  • Markwald, Roger
  • Ouyang, Gaoliang
  • Arron, Joseph R
  • Holweg, Cecile T. J
  • Kudo, Akira
subjects:
  • Biochemistry
  • Biomedical and Life Sciences
  • Biomedicine
  • Cell Adhesion Molecules - genetics
  • Cell Adhesion Molecules - metabolism
  • Cell Adhesion Molecules - physiology
  • Cell Biology
  • Cell Differentiation
  • Cellular
  • Cellular biology
  • Connective Tissue - metabolism
  • Developmental biology
  • Extracellular matrix
  • Extracellular Matrix - metabolism
  • general
  • Humans
  • Life Sciences
  • Molecular Biology
  • Molecular Medicine
  • Molecular Neuroscience
  • Neoplasms - metabolism
  • Neoplasms - pathology
  • Periostin
  • Pharmacology
  • Physiological aspects
  • Protein expression
  • Proteins
  • Regeneration - genetics
  • Regeneration - physiology
  • Remodeling
  • Repair
  • Review
  • Signal transduction
  • Stem cells
  • Tumor Microenvironment
  • Wound Healing
ispartof: Cellular and Molecular Life Sciences, 2013-10-22, Vol.71 (7), p.1279-1288
description: Periostin, also termed osteoblast-specific factor 2, is a matricellular protein with known functions in osteology, tissue repair, oncology, cardiovascular and respiratory systems, and in various inflammatory settings. However, most of the research to date has been conducted in divergent and circumscribed areas meaning that the overall understanding of this intriguing molecule remains fragmented. Here, we integrate the available evidence on periostin expression, its normal role in development, and whether it plays a similar function during pathologic repair, regeneration, and disease in order to bring together the different research fields in which periostin investigations are ongoing. In spite of the seemingly disparate roles of periostin in health and disease, tissue remodeling as a response to insult/injury is emerging as a common functional denominator of this matricellular molecule. Periostin is transiently upregulated during cell fate changes, either physiologic or pathologic. Combining observations from various conditions, a common pattern of events can be suggested, including periostin localization during development, insult and injury, epithelial–mesenchymal transition, extracellular matrix restructuring, and remodeling. We propose mesenchymal remodeling as an overarching role for the matricellular protein periostin, across physiology and disease. Periostin may be seen as an important structural mediator, balancing appropriate versus inappropriate tissue adaption in response to insult/injury.
language: eng
source:
identifier: ISSN: 1420-682X
fulltext: no_fulltext
issn:
  • 1420-682X
  • 1420-9071
url: Link


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titleThe role of periostin in tissue remodeling across health and disease
creatorConway, Simon J ; Izuhara, Kenji ; Kudo, Yasusei ; Litvin, Judith ; Markwald, Roger ; Ouyang, Gaoliang ; Arron, Joseph R ; Holweg, Cecile T. J ; Kudo, Akira
creatorcontribConway, Simon J ; Izuhara, Kenji ; Kudo, Yasusei ; Litvin, Judith ; Markwald, Roger ; Ouyang, Gaoliang ; Arron, Joseph R ; Holweg, Cecile T. J ; Kudo, Akira
descriptionPeriostin, also termed osteoblast-specific factor 2, is a matricellular protein with known functions in osteology, tissue repair, oncology, cardiovascular and respiratory systems, and in various inflammatory settings. However, most of the research to date has been conducted in divergent and circumscribed areas meaning that the overall understanding of this intriguing molecule remains fragmented. Here, we integrate the available evidence on periostin expression, its normal role in development, and whether it plays a similar function during pathologic repair, regeneration, and disease in order to bring together the different research fields in which periostin investigations are ongoing. In spite of the seemingly disparate roles of periostin in health and disease, tissue remodeling as a response to insult/injury is emerging as a common functional denominator of this matricellular molecule. Periostin is transiently upregulated during cell fate changes, either physiologic or pathologic. Combining observations from various conditions, a common pattern of events can be suggested, including periostin localization during development, insult and injury, epithelial–mesenchymal transition, extracellular matrix restructuring, and remodeling. We propose mesenchymal remodeling as an overarching role for the matricellular protein periostin, across physiology and disease. Periostin may be seen as an important structural mediator, balancing appropriate versus inappropriate tissue adaption in response to insult/injury.
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subjectBiochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Adhesion Molecules - genetics ; Cell Adhesion Molecules - metabolism ; Cell Adhesion Molecules - physiology ; Cell Biology ; Cell Differentiation ; Cellular ; Cellular biology ; Connective Tissue - metabolism ; Developmental biology ; Extracellular matrix ; Extracellular Matrix - metabolism ; general ; Humans ; Life Sciences ; Molecular Biology ; Molecular Medicine ; Molecular Neuroscience ; Neoplasms - metabolism ; Neoplasms - pathology ; Periostin ; Pharmacology ; Physiological aspects ; Protein expression ; Proteins ; Regeneration - genetics ; Regeneration - physiology ; Remodeling ; Repair ; Review ; Signal transduction ; Stem cells ; Tumor Microenvironment ; Wound Healing
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descriptionPeriostin, also termed osteoblast-specific factor 2, is a matricellular protein with known functions in osteology, tissue repair, oncology, cardiovascular and respiratory systems, and in various inflammatory settings. However, most of the research to date has been conducted in divergent and circumscribed areas meaning that the overall understanding of this intriguing molecule remains fragmented. Here, we integrate the available evidence on periostin expression, its normal role in development, and whether it plays a similar function during pathologic repair, regeneration, and disease in order to bring together the different research fields in which periostin investigations are ongoing. In spite of the seemingly disparate roles of periostin in health and disease, tissue remodeling as a response to insult/injury is emerging as a common functional denominator of this matricellular molecule. Periostin is transiently upregulated during cell fate changes, either physiologic or pathologic. Combining observations from various conditions, a common pattern of events can be suggested, including periostin localization during development, insult and injury, epithelial–mesenchymal transition, extracellular matrix restructuring, and remodeling. We propose mesenchymal remodeling as an overarching role for the matricellular protein periostin, across physiology and disease. Periostin may be seen as an important structural mediator, balancing appropriate versus inappropriate tissue adaption in response to insult/injury.
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abstractPeriostin, also termed osteoblast-specific factor 2, is a matricellular protein with known functions in osteology, tissue repair, oncology, cardiovascular and respiratory systems, and in various inflammatory settings. However, most of the research to date has been conducted in divergent and circumscribed areas meaning that the overall understanding of this intriguing molecule remains fragmented. Here, we integrate the available evidence on periostin expression, its normal role in development, and whether it plays a similar function during pathologic repair, regeneration, and disease in order to bring together the different research fields in which periostin investigations are ongoing. In spite of the seemingly disparate roles of periostin in health and disease, tissue remodeling as a response to insult/injury is emerging as a common functional denominator of this matricellular molecule. Periostin is transiently upregulated during cell fate changes, either physiologic or pathologic. Combining observations from various conditions, a common pattern of events can be suggested, including periostin localization during development, insult and injury, epithelial–mesenchymal transition, extracellular matrix restructuring, and remodeling. We propose mesenchymal remodeling as an overarching role for the matricellular protein periostin, across physiology and disease. Periostin may be seen as an important structural mediator, balancing appropriate versus inappropriate tissue adaption in response to insult/injury.
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