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Regulation of pyruvate metabolism and human disease

Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in the cellular cytoplasm, and is ultimately destined for transport into mitochondria as a master fuel input undergirding ci... Full description

Journal Title: Cellular and Molecular Life Sciences 2013-12-21, Vol.71 (14), p.2577-2604
Main Author: Gray, Lawrence R
Other Authors: Tompkins, Sean C , Taylor, Eric B
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Basel: Springer Basel
ID: ISSN: 1420-682X
Link: https://www.ncbi.nlm.nih.gov/pubmed/24363178
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recordid: cdi_springer_journals_10_1007_s00018_013_1539_2
title: Regulation of pyruvate metabolism and human disease
format: Article
creator:
  • Gray, Lawrence R
  • Tompkins, Sean C
  • Taylor, Eric B
subjects:
  • Biochemistry
  • Biomedical and Life Sciences
  • Biomedicine
  • Cell Biology
  • Cellular
  • Cellular biology
  • Citric acid
  • Citric Acid Cycle
  • Cytosol - metabolism
  • Enzymes
  • general
  • Glucose metabolism
  • Heart Diseases - metabolism
  • Heart failure
  • Human disease
  • Humans
  • Life Sciences
  • Metabolism
  • Mitochondria
  • Mitochondria - metabolism
  • Mitochondrial DNA
  • Mitochondrial pyruvate carrier (MPC)
  • Models, Biological
  • Molecular Biology
  • Molecular Medicine
  • Molecular Neuroscience
  • Neoplasms - metabolism
  • Neurodegenerative Diseases - metabolism
  • Pathology
  • Pharmacology
  • Physiological aspects
  • Pyruvate
  • Pyruvate Metabolism, Inborn Errors - metabolism
  • Pyruvic Acid - chemistry
  • Pyruvic Acid - metabolism
  • Review
ispartof: Cellular and Molecular Life Sciences, 2013-12-21, Vol.71 (14), p.2577-2604
description: Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in the cellular cytoplasm, and is ultimately destined for transport into mitochondria as a master fuel input undergirding citric acid cycle carbon flux. In mitochondria, pyruvate drives ATP production by oxidative phosphorylation and multiple biosynthetic pathways intersecting the citric acid cycle. Mitochondrial pyruvate metabolism is regulated by many enzymes, including the recently discovered mitochondria pyruvate carrier, pyruvate dehydrogenase, and pyruvate carboxylase, to modulate overall pyruvate carbon flux. Mutations in any of the genes encoding for proteins regulating pyruvate metabolism may lead to disease. Numerous cases have been described. Aberrant pyruvate metabolism plays an especially prominent role in cancer, heart failure, and neurodegeneration. Because most major diseases involve aberrant metabolism, understanding and exploiting pyruvate carbon flux may yield novel treatments that enhance human health.
language: eng
source:
identifier: ISSN: 1420-682X
fulltext: no_fulltext
issn:
  • 1420-682X
  • 1420-9071
url: Link


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descriptionPyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in the cellular cytoplasm, and is ultimately destined for transport into mitochondria as a master fuel input undergirding citric acid cycle carbon flux. In mitochondria, pyruvate drives ATP production by oxidative phosphorylation and multiple biosynthetic pathways intersecting the citric acid cycle. Mitochondrial pyruvate metabolism is regulated by many enzymes, including the recently discovered mitochondria pyruvate carrier, pyruvate dehydrogenase, and pyruvate carboxylase, to modulate overall pyruvate carbon flux. Mutations in any of the genes encoding for proteins regulating pyruvate metabolism may lead to disease. Numerous cases have been described. Aberrant pyruvate metabolism plays an especially prominent role in cancer, heart failure, and neurodegeneration. Because most major diseases involve aberrant metabolism, understanding and exploiting pyruvate carbon flux may yield novel treatments that enhance human health.
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subjectBiochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cellular ; Cellular biology ; Citric acid ; Citric Acid Cycle ; Cytosol - metabolism ; Enzymes ; general ; Glucose metabolism ; Heart Diseases - metabolism ; Heart failure ; Human disease ; Humans ; Life Sciences ; Metabolism ; Mitochondria ; Mitochondria - metabolism ; Mitochondrial DNA ; Mitochondrial pyruvate carrier (MPC) ; Models, Biological ; Molecular Biology ; Molecular Medicine ; Molecular Neuroscience ; Neoplasms - metabolism ; Neurodegenerative Diseases - metabolism ; Pathology ; Pharmacology ; Physiological aspects ; Pyruvate ; Pyruvate Metabolism, Inborn Errors - metabolism ; Pyruvic Acid - chemistry ; Pyruvic Acid - metabolism ; Review
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descriptionPyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in the cellular cytoplasm, and is ultimately destined for transport into mitochondria as a master fuel input undergirding citric acid cycle carbon flux. In mitochondria, pyruvate drives ATP production by oxidative phosphorylation and multiple biosynthetic pathways intersecting the citric acid cycle. Mitochondrial pyruvate metabolism is regulated by many enzymes, including the recently discovered mitochondria pyruvate carrier, pyruvate dehydrogenase, and pyruvate carboxylase, to modulate overall pyruvate carbon flux. Mutations in any of the genes encoding for proteins regulating pyruvate metabolism may lead to disease. Numerous cases have been described. Aberrant pyruvate metabolism plays an especially prominent role in cancer, heart failure, and neurodegeneration. Because most major diseases involve aberrant metabolism, understanding and exploiting pyruvate carbon flux may yield novel treatments that enhance human health.
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abstractPyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in the cellular cytoplasm, and is ultimately destined for transport into mitochondria as a master fuel input undergirding citric acid cycle carbon flux. In mitochondria, pyruvate drives ATP production by oxidative phosphorylation and multiple biosynthetic pathways intersecting the citric acid cycle. Mitochondrial pyruvate metabolism is regulated by many enzymes, including the recently discovered mitochondria pyruvate carrier, pyruvate dehydrogenase, and pyruvate carboxylase, to modulate overall pyruvate carbon flux. Mutations in any of the genes encoding for proteins regulating pyruvate metabolism may lead to disease. Numerous cases have been described. Aberrant pyruvate metabolism plays an especially prominent role in cancer, heart failure, and neurodegeneration. Because most major diseases involve aberrant metabolism, understanding and exploiting pyruvate carbon flux may yield novel treatments that enhance human health.
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pmid24363178
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