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Effect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factors

Purpose Wild blueberries (WB) ( Vaccinium angustifolium ) are rich sources of polyphenols, such as flavonols, phenolic acids and anthocyanins (ACNs), reported to decrease the risk of cardiovascular and degenerative diseases. This study investigated the effect of regular consumption of a WB or a plac... Full description

Journal Title: European journal of nutrition 2012-06-26, Vol.52 (3), p.949-961
Main Author: Riso, Patrizia
Other Authors: Klimis-Zacas, Dorothy , Del Bo’, Cristian , Martini, Daniela , Campolo, Jonica , Vendrame, Stefano , Møller, Peter , Loft, Steffen , De Maria, Renata , Porrini, Marisa
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 1436-6207
Link: https://www.ncbi.nlm.nih.gov/pubmed/22733001
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recordid: cdi_springer_journals_10_1007_s00394_012_0402_9
title: Effect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factors
format: Article
creator:
  • Riso, Patrizia
  • Klimis-Zacas, Dorothy
  • Del Bo’, Cristian
  • Martini, Daniela
  • Campolo, Jonica
  • Vendrame, Stefano
  • Møller, Peter
  • Loft, Steffen
  • De Maria, Renata
  • Porrini, Marisa
subjects:
  • Adult
  • Anthocyanin
  • Antioxidants - administration & dosage
  • Antioxidants - therapeutic use
  • Beverages - analysis
  • Biomarkers - blood
  • Blood lipids
  • Blueberry Plants - chemistry
  • Cardiovascular diseases
  • Cardiovascular Diseases - epidemiology
  • Cardiovascular Diseases - immunology
  • Cardiovascular Diseases - metabolism
  • Cardiovascular Diseases - prevention & control
  • Cardiovascular risk
  • Chemistry
  • Chemistry and Materials Science
  • Chromophores
  • Cinnamates - administration & dosage
  • Cinnamates - therapeutic use
  • Cross-Over Studies
  • DNA Damage
  • Endothelial function
  • Endothelium
  • Endothelium, Vascular - immunology
  • Endothelium, Vascular - metabolism
  • Flavonoids - administration & dosage
  • Flavonoids - therapeutic use
  • Fruit - chemistry
  • Humans
  • Inflammation
  • Italy - epidemiology
  • Male
  • Middle Aged
  • Nitric oxide
  • Nutrition
  • Original Contribution
  • Oxidation-Reduction
  • Oxidative Stress
  • Polyphenols
  • Purines - blood
  • Purines - chemistry
  • Pyrimidines - blood
  • Pyrimidines - chemistry
  • Risk Factors
  • Scienze Tecniche Dietetiche Applicate
  • Settore MED
  • Wild blueberry
ispartof: European journal of nutrition, 2012-06-26, Vol.52 (3), p.949-961
description: Purpose Wild blueberries (WB) ( Vaccinium angustifolium ) are rich sources of polyphenols, such as flavonols, phenolic acids and anthocyanins (ACNs), reported to decrease the risk of cardiovascular and degenerative diseases. This study investigated the effect of regular consumption of a WB or a placebo (PL) drink on markers of oxidative stress, inflammation and endothelial function in subjects with risk factors for cardiovascular disease. Methods Eighteen male volunteers (ages 47.8 ± 9.7 years; body mass index 24.8 ± 2.6 kg/m 2 ) received according to a cross-over design, a WB (25 g freeze-dried powder, providing 375 mg of ACNs) or a PL drink for 6 weeks, spaced by a 6-week wash-out. Endogenous and oxidatively induced DNA damage in blood mononuclear cells, serum interleukin levels, reactive hyperemia index, nitric oxide, soluble vascular adhesion molecule concentration and other variables were analyzed. Results Wild blueberry drink intake significantly reduced the levels of endogenously oxidized DNA bases (from 12.5 ± 5.6 % to 9.6 ± 3.5 %, p  ≤ 0.01) and the levels of H 2 O 2 -induced DNA damage (from 45.8 ± 7.9 % to 37.2 ± 9.1 %, p  ≤ 0.01), while no effect was found after the PL drink. No significant differences were detected for markers of endothelial function and the other variables under study. Conclusions In conclusion, the consumption of the WB drink for 6 weeks significantly reduced the levels of oxidized DNA bases and increased the resistance to oxidatively induced DNA damage. Future studies should address in greater detail the role of WB in endothelial function. This study was registered at www.isrctn.org as ISRCTN47732406.
language: eng
source:
identifier: ISSN: 1436-6207
fulltext: no_fulltext
issn:
  • 1436-6207
  • 1436-6215
url: Link


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titleEffect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factors
creatorRiso, Patrizia ; Klimis-Zacas, Dorothy ; Del Bo’, Cristian ; Martini, Daniela ; Campolo, Jonica ; Vendrame, Stefano ; Møller, Peter ; Loft, Steffen ; De Maria, Renata ; Porrini, Marisa
creatorcontribRiso, Patrizia ; Klimis-Zacas, Dorothy ; Del Bo’, Cristian ; Martini, Daniela ; Campolo, Jonica ; Vendrame, Stefano ; Møller, Peter ; Loft, Steffen ; De Maria, Renata ; Porrini, Marisa
descriptionPurpose Wild blueberries (WB) ( Vaccinium angustifolium ) are rich sources of polyphenols, such as flavonols, phenolic acids and anthocyanins (ACNs), reported to decrease the risk of cardiovascular and degenerative diseases. This study investigated the effect of regular consumption of a WB or a placebo (PL) drink on markers of oxidative stress, inflammation and endothelial function in subjects with risk factors for cardiovascular disease. Methods Eighteen male volunteers (ages 47.8 ± 9.7 years; body mass index 24.8 ± 2.6 kg/m 2 ) received according to a cross-over design, a WB (25 g freeze-dried powder, providing 375 mg of ACNs) or a PL drink for 6 weeks, spaced by a 6-week wash-out. Endogenous and oxidatively induced DNA damage in blood mononuclear cells, serum interleukin levels, reactive hyperemia index, nitric oxide, soluble vascular adhesion molecule concentration and other variables were analyzed. Results Wild blueberry drink intake significantly reduced the levels of endogenously oxidized DNA bases (from 12.5 ± 5.6 % to 9.6 ± 3.5 %, p  ≤ 0.01) and the levels of H 2 O 2 -induced DNA damage (from 45.8 ± 7.9 % to 37.2 ± 9.1 %, p  ≤ 0.01), while no effect was found after the PL drink. No significant differences were detected for markers of endothelial function and the other variables under study. Conclusions In conclusion, the consumption of the WB drink for 6 weeks significantly reduced the levels of oxidized DNA bases and increased the resistance to oxidatively induced DNA damage. Future studies should address in greater detail the role of WB in endothelial function. This study was registered at www.isrctn.org as ISRCTN47732406.
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subjectAdult ; Anthocyanin ; Antioxidants - administration & dosage ; Antioxidants - therapeutic use ; Beverages - analysis ; Biomarkers - blood ; Blood lipids ; Blueberry Plants - chemistry ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - immunology ; Cardiovascular Diseases - metabolism ; Cardiovascular Diseases - prevention & control ; Cardiovascular risk ; Chemistry ; Chemistry and Materials Science ; Chromophores ; Cinnamates - administration & dosage ; Cinnamates - therapeutic use ; Cross-Over Studies ; DNA Damage ; Endothelial function ; Endothelium ; Endothelium, Vascular - immunology ; Endothelium, Vascular - metabolism ; Flavonoids - administration & dosage ; Flavonoids - therapeutic use ; Fruit - chemistry ; Humans ; Inflammation ; Italy - epidemiology ; Male ; Middle Aged ; Nitric oxide ; Nutrition ; Original Contribution ; Oxidation-Reduction ; Oxidative Stress ; Polyphenols ; Purines - blood ; Purines - chemistry ; Pyrimidines - blood ; Pyrimidines - chemistry ; Risk Factors ; Scienze Tecniche Dietetiche Applicate ; Settore MED ; Wild blueberry
ispartofEuropean journal of nutrition, 2012-06-26, Vol.52 (3), p.949-961
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5Vendrame, Stefano
6Møller, Peter
7Loft, Steffen
8De Maria, Renata
9Porrini, Marisa
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0Effect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factors
1European journal of nutrition
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descriptionPurpose Wild blueberries (WB) ( Vaccinium angustifolium ) are rich sources of polyphenols, such as flavonols, phenolic acids and anthocyanins (ACNs), reported to decrease the risk of cardiovascular and degenerative diseases. This study investigated the effect of regular consumption of a WB or a placebo (PL) drink on markers of oxidative stress, inflammation and endothelial function in subjects with risk factors for cardiovascular disease. Methods Eighteen male volunteers (ages 47.8 ± 9.7 years; body mass index 24.8 ± 2.6 kg/m 2 ) received according to a cross-over design, a WB (25 g freeze-dried powder, providing 375 mg of ACNs) or a PL drink for 6 weeks, spaced by a 6-week wash-out. Endogenous and oxidatively induced DNA damage in blood mononuclear cells, serum interleukin levels, reactive hyperemia index, nitric oxide, soluble vascular adhesion molecule concentration and other variables were analyzed. Results Wild blueberry drink intake significantly reduced the levels of endogenously oxidized DNA bases (from 12.5 ± 5.6 % to 9.6 ± 3.5 %, p  ≤ 0.01) and the levels of H 2 O 2 -induced DNA damage (from 45.8 ± 7.9 % to 37.2 ± 9.1 %, p  ≤ 0.01), while no effect was found after the PL drink. No significant differences were detected for markers of endothelial function and the other variables under study. Conclusions In conclusion, the consumption of the WB drink for 6 weeks significantly reduced the levels of oxidized DNA bases and increased the resistance to oxidatively induced DNA damage. Future studies should address in greater detail the role of WB in endothelial function. This study was registered at www.isrctn.org as ISRCTN47732406.
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4Beverages - analysis
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6Blood lipids
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9Cardiovascular Diseases - epidemiology
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13Cardiovascular risk
14Chemistry
15Chemistry and Materials Science
16Chromophores
17Cinnamates - administration & dosage
18Cinnamates - therapeutic use
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20DNA Damage
21Endothelial function
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24Endothelium, Vascular - metabolism
25Flavonoids - administration & dosage
26Flavonoids - therapeutic use
27Fruit - chemistry
28Humans
29Inflammation
30Italy - epidemiology
31Male
32Middle Aged
33Nitric oxide
34Nutrition
35Original Contribution
36Oxidation-Reduction
37Oxidative Stress
38Polyphenols
39Purines - blood
40Purines - chemistry
41Pyrimidines - blood
42Pyrimidines - chemistry
43Risk Factors
44Scienze Tecniche Dietetiche Applicate
45Settore MED
46Wild blueberry
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titleEffect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factors
authorRiso, Patrizia ; Klimis-Zacas, Dorothy ; Del Bo’, Cristian ; Martini, Daniela ; Campolo, Jonica ; Vendrame, Stefano ; Møller, Peter ; Loft, Steffen ; De Maria, Renata ; Porrini, Marisa
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1Anthocyanin
2Antioxidants - administration & dosage
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5Biomarkers - blood
6Blood lipids
7Blueberry Plants - chemistry
8Cardiovascular diseases
9Cardiovascular Diseases - epidemiology
10Cardiovascular Diseases - immunology
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12Cardiovascular Diseases - prevention & control
13Cardiovascular risk
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15Chemistry and Materials Science
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39Purines - blood
40Purines - chemistry
41Pyrimidines - blood
42Pyrimidines - chemistry
43Risk Factors
44Scienze Tecniche Dietetiche Applicate
45Settore MED
46Wild blueberry
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atitleEffect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factors
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pages949-961
issn1436-6207
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abstractPurpose Wild blueberries (WB) ( Vaccinium angustifolium ) are rich sources of polyphenols, such as flavonols, phenolic acids and anthocyanins (ACNs), reported to decrease the risk of cardiovascular and degenerative diseases. This study investigated the effect of regular consumption of a WB or a placebo (PL) drink on markers of oxidative stress, inflammation and endothelial function in subjects with risk factors for cardiovascular disease. Methods Eighteen male volunteers (ages 47.8 ± 9.7 years; body mass index 24.8 ± 2.6 kg/m 2 ) received according to a cross-over design, a WB (25 g freeze-dried powder, providing 375 mg of ACNs) or a PL drink for 6 weeks, spaced by a 6-week wash-out. Endogenous and oxidatively induced DNA damage in blood mononuclear cells, serum interleukin levels, reactive hyperemia index, nitric oxide, soluble vascular adhesion molecule concentration and other variables were analyzed. Results Wild blueberry drink intake significantly reduced the levels of endogenously oxidized DNA bases (from 12.5 ± 5.6 % to 9.6 ± 3.5 %, p  ≤ 0.01) and the levels of H 2 O 2 -induced DNA damage (from 45.8 ± 7.9 % to 37.2 ± 9.1 %, p  ≤ 0.01), while no effect was found after the PL drink. No significant differences were detected for markers of endothelial function and the other variables under study. Conclusions In conclusion, the consumption of the WB drink for 6 weeks significantly reduced the levels of oxidized DNA bases and increased the resistance to oxidatively induced DNA damage. Future studies should address in greater detail the role of WB in endothelial function. This study was registered at www.isrctn.org as ISRCTN47732406.
copBerlin/Heidelberg
pubSpringer-Verlag
pmid22733001
doi10.1007/s00394-012-0402-9
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