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A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)

Purpose To determine the potential of a flavonoid-rich extract from bergamot juice (BJe) to prevent colorectal carcinogenesis (CRC) in vivo. Main methods Pirc rats (F344/NTac-Apc am1137 ), mutated in Apc , the key gene in CRC, were treated with two different doses of BJe (35 mg/kg or 70 mg/kg body w... Full description

Journal Title: European journal of nutrition 2019-03-27, Vol.59 (3), p.885-894
Main Author: Navarra, Michele
Other Authors: Femia, Angelo Pietro , Romagnoli, Andrea , Tortora, Katia , Luceri, Cristina , Cirmi, Santa , Ferlazzo, Nadia , Caderni, Giovanna
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 1436-6207
Link: https://www.ncbi.nlm.nih.gov/pubmed/30919084
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recordid: cdi_springer_journals_10_1007_s00394_019_01948_z
title: A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)
format: Article
creator:
  • Navarra, Michele
  • Femia, Angelo Pietro
  • Romagnoli, Andrea
  • Tortora, Katia
  • Luceri, Cristina
  • Cirmi, Santa
  • Ferlazzo, Nadia
  • Caderni, Giovanna
subjects:
  • Adenomatous polyposis coli
  • Animals
  • Apoptosis
  • Arginase
  • Body weight
  • Carcinogenesis
  • Chemistry
  • Chemistry and Materials Science
  • Citrus
  • Colon
  • Colorectal cancer
  • Colorectal carcinoma
  • Colorectal Neoplasms - prevention & control
  • Cyclooxygenase-2
  • Disease Models, Animal
  • Flavonoids
  • Flavonoids - therapeutic use
  • Fruit and Vegetable Juices
  • Gene regulation
  • IL-1β
  • Inflammation
  • Interleukin 10
  • Interleukin 6
  • Intestine
  • Male
  • Models, Genetic
  • Mucin
  • Nitric-oxide synthase
  • Nutrition
  • Original Contribution
  • p53 Protein
  • Plant Extracts - therapeutic use
  • Rats
  • Rats, Inbred F344
  • Risk groups
  • Rodents
  • Survivin
  • Tumors
ispartof: European journal of nutrition, 2019-03-27, Vol.59 (3), p.885-894
description: Purpose To determine the potential of a flavonoid-rich extract from bergamot juice (BJe) to prevent colorectal carcinogenesis (CRC) in vivo. Main methods Pirc rats (F344/NTac-Apc am1137 ), mutated in Apc , the key gene in CRC, were treated with two different doses of BJe (35 mg/kg or 70 mg/kg body weight, respectively) mixed in the diet for 12 weeks. Then, the entire intestine was surgically removed and dissected for histological, immunohistochemical and molecular analyses. Results Rats treated with BJe showed a significant dose-related reduction in the colon preneoplastic lesions mucin-depleted foci (MDF). Colon and small intestinal tumours were also significantly reduced in rats supplemented with 70 mg/kg of BJe. To elucidate the involved mechanisms, markers of inflammation and apoptosis were determined. Compared to controls, colon tumours from BJe 70 mg/kg-supplemented rats showed a significant down-regulation of inflammation-related genes ( COX-2, iNOS, IL-1β, IL-6 and IL-10 and Arginase 1 ). Moreover, in colon tumours from rats fed with 70 mg/kg BJe, apoptosis was significantly higher than in controls. Up-regulation of p53 and down-regulation of survivin and p21 genes was also observed. Conclusions These data indicate a strong chemopreventive activity of BJe that, at least in part, is due to its pro-apoptotic and anti-inflammatory actions. This effect could be exploited as a strategy to prevent CRC in high-risk patients.
language: eng
source:
identifier: ISSN: 1436-6207
fulltext: no_fulltext
issn:
  • 1436-6207
  • 1436-6215
url: Link


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titleA flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)
creatorNavarra, Michele ; Femia, Angelo Pietro ; Romagnoli, Andrea ; Tortora, Katia ; Luceri, Cristina ; Cirmi, Santa ; Ferlazzo, Nadia ; Caderni, Giovanna
creatorcontribNavarra, Michele ; Femia, Angelo Pietro ; Romagnoli, Andrea ; Tortora, Katia ; Luceri, Cristina ; Cirmi, Santa ; Ferlazzo, Nadia ; Caderni, Giovanna
descriptionPurpose To determine the potential of a flavonoid-rich extract from bergamot juice (BJe) to prevent colorectal carcinogenesis (CRC) in vivo. Main methods Pirc rats (F344/NTac-Apc am1137 ), mutated in Apc , the key gene in CRC, were treated with two different doses of BJe (35 mg/kg or 70 mg/kg body weight, respectively) mixed in the diet for 12 weeks. Then, the entire intestine was surgically removed and dissected for histological, immunohistochemical and molecular analyses. Results Rats treated with BJe showed a significant dose-related reduction in the colon preneoplastic lesions mucin-depleted foci (MDF). Colon and small intestinal tumours were also significantly reduced in rats supplemented with 70 mg/kg of BJe. To elucidate the involved mechanisms, markers of inflammation and apoptosis were determined. Compared to controls, colon tumours from BJe 70 mg/kg-supplemented rats showed a significant down-regulation of inflammation-related genes ( COX-2, iNOS, IL-1β, IL-6 and IL-10 and Arginase 1 ). Moreover, in colon tumours from rats fed with 70 mg/kg BJe, apoptosis was significantly higher than in controls. Up-regulation of p53 and down-regulation of survivin and p21 genes was also observed. Conclusions These data indicate a strong chemopreventive activity of BJe that, at least in part, is due to its pro-apoptotic and anti-inflammatory actions. This effect could be exploited as a strategy to prevent CRC in high-risk patients.
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subjectAdenomatous polyposis coli ; Animals ; Apoptosis ; Arginase ; Body weight ; Carcinogenesis ; Chemistry ; Chemistry and Materials Science ; Citrus ; Colon ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - prevention & control ; Cyclooxygenase-2 ; Disease Models, Animal ; Flavonoids ; Flavonoids - therapeutic use ; Fruit and Vegetable Juices ; Gene regulation ; IL-1β ; Inflammation ; Interleukin 10 ; Interleukin 6 ; Intestine ; Male ; Models, Genetic ; Mucin ; Nitric-oxide synthase ; Nutrition ; Original Contribution ; p53 Protein ; Plant Extracts - therapeutic use ; Rats ; Rats, Inbred F344 ; Risk groups ; Rodents ; Survivin ; Tumors
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descriptionPurpose To determine the potential of a flavonoid-rich extract from bergamot juice (BJe) to prevent colorectal carcinogenesis (CRC) in vivo. Main methods Pirc rats (F344/NTac-Apc am1137 ), mutated in Apc , the key gene in CRC, were treated with two different doses of BJe (35 mg/kg or 70 mg/kg body weight, respectively) mixed in the diet for 12 weeks. Then, the entire intestine was surgically removed and dissected for histological, immunohistochemical and molecular analyses. Results Rats treated with BJe showed a significant dose-related reduction in the colon preneoplastic lesions mucin-depleted foci (MDF). Colon and small intestinal tumours were also significantly reduced in rats supplemented with 70 mg/kg of BJe. To elucidate the involved mechanisms, markers of inflammation and apoptosis were determined. Compared to controls, colon tumours from BJe 70 mg/kg-supplemented rats showed a significant down-regulation of inflammation-related genes ( COX-2, iNOS, IL-1β, IL-6 and IL-10 and Arginase 1 ). Moreover, in colon tumours from rats fed with 70 mg/kg BJe, apoptosis was significantly higher than in controls. Up-regulation of p53 and down-regulation of survivin and p21 genes was also observed. Conclusions These data indicate a strong chemopreventive activity of BJe that, at least in part, is due to its pro-apoptotic and anti-inflammatory actions. This effect could be exploited as a strategy to prevent CRC in high-risk patients.
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titleA flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)
authorNavarra, Michele ; Femia, Angelo Pietro ; Romagnoli, Andrea ; Tortora, Katia ; Luceri, Cristina ; Cirmi, Santa ; Ferlazzo, Nadia ; Caderni, Giovanna
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1Animals
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3Arginase
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10Colorectal cancer
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12Colorectal Neoplasms - prevention & control
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0Navarra, Michele
1Femia, Angelo Pietro
2Romagnoli, Andrea
3Tortora, Katia
4Luceri, Cristina
5Cirmi, Santa
6Ferlazzo, Nadia
7Caderni, Giovanna
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atitleA flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)
jtitleEuropean journal of nutrition
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abstractPurpose To determine the potential of a flavonoid-rich extract from bergamot juice (BJe) to prevent colorectal carcinogenesis (CRC) in vivo. Main methods Pirc rats (F344/NTac-Apc am1137 ), mutated in Apc , the key gene in CRC, were treated with two different doses of BJe (35 mg/kg or 70 mg/kg body weight, respectively) mixed in the diet for 12 weeks. Then, the entire intestine was surgically removed and dissected for histological, immunohistochemical and molecular analyses. Results Rats treated with BJe showed a significant dose-related reduction in the colon preneoplastic lesions mucin-depleted foci (MDF). Colon and small intestinal tumours were also significantly reduced in rats supplemented with 70 mg/kg of BJe. To elucidate the involved mechanisms, markers of inflammation and apoptosis were determined. Compared to controls, colon tumours from BJe 70 mg/kg-supplemented rats showed a significant down-regulation of inflammation-related genes ( COX-2, iNOS, IL-1β, IL-6 and IL-10 and Arginase 1 ). Moreover, in colon tumours from rats fed with 70 mg/kg BJe, apoptosis was significantly higher than in controls. Up-regulation of p53 and down-regulation of survivin and p21 genes was also observed. Conclusions These data indicate a strong chemopreventive activity of BJe that, at least in part, is due to its pro-apoptotic and anti-inflammatory actions. This effect could be exploited as a strategy to prevent CRC in high-risk patients.
copBerlin/Heidelberg
pubSpringer Berlin Heidelberg
pmid30919084
doi10.1007/s00394-019-01948-z
orcididhttps://orcid.org/0000-0002-6492-7820