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Role of the ubiquitin system in regulating ion transport

Ion channels and transporters play a critical role in ion and fluid homeostasis and thus in normal animal physiology and pathology. Tight regulation of these transmembrane proteins is therefore essential. In recent years, many studies have focused their attention on the role of the ubiquitin system... Full description

Journal Title: Pflugers Archiv : European journal of physiology 2010-10-23, Vol.461 (1), p.1-21
Main Author: Rotin, Daniela
Other Authors: Staub, Olivier
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 0031-6768
Link: https://www.ncbi.nlm.nih.gov/pubmed/20972579
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recordid: cdi_springer_journals_10_1007_s00424_010_0893_2
title: Role of the ubiquitin system in regulating ion transport
format: Article
creator:
  • Rotin, Daniela
  • Staub, Olivier
subjects:
  • Aldosterone
  • Aldosterone - physiology
  • Animals
  • Biomedical and Life Sciences
  • Biomedicine
  • Calcium Channels - physiology
  • Cell Biology
  • Children's hospitals
  • Chloride Channels - physiology
  • Corticosteroids
  • Cystic fibrosis
  • Cystic Fibrosis Transmembrane Conductance Regulator - physiology
  • Endocytosis - physiology
  • Endoplasmic Reticulum - physiology
  • Endosomal Sorting Complexes Required for Transport - physiology
  • Epithelial Sodium Channels - metabolism
  • Human Physiology
  • Humans
  • Immediate-Early Proteins - physiology
  • Invited Review
  • Ion Transport - physiology
  • Ligases
  • macromolecular substances
  • Membrane proteins
  • Membrane Proteins - metabolism
  • Molecular Medicine
  • Nedd4 Ubiquitin Protein Ligases
  • Neurosciences
  • Physiological aspects
  • Potassium Channels, Voltage-Gated - physiology
  • Protein-Serine-Threonine Kinases - physiology
  • Receptors
  • Small Ubiquitin-Related Modifier Proteins - physiology
  • Sodium Channels - physiology
  • Ubiquitin
  • Ubiquitin - physiology
  • Ubiquitin-Protein Ligases - physiology
  • Ubiquitination - physiology
  • Vasopressins - physiology
ispartof: Pflugers Archiv : European journal of physiology, 2010-10-23, Vol.461 (1), p.1-21
description: Ion channels and transporters play a critical role in ion and fluid homeostasis and thus in normal animal physiology and pathology. Tight regulation of these transmembrane proteins is therefore essential. In recent years, many studies have focused their attention on the role of the ubiquitin system in regulating ion channels and transporters, initialed by the discoveries of the role of this system in processing of Cystic Fibrosis Transmembrane Regulator (CFTR), and in regulating endocytosis of the epithelial Na + channel (ENaC) by the Nedd4 family of ubiquitin ligases (mainly Nedd4-2). In this review, we discuss the role of the ubiquitin system in ER Associated Degradation (ERAD) of ion channels, and in the regulation of endocytosis and lysosomal sorting of ion channels and transporters, focusing primarily in mammalian cells. We also briefly discuss the role of ubiquitin like molecules (such as SUMO) in such regulation, for which much less is known so far.
language: eng
source:
identifier: ISSN: 0031-6768
fulltext: no_fulltext
issn:
  • 0031-6768
  • 1432-2013
url: Link


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descriptionIon channels and transporters play a critical role in ion and fluid homeostasis and thus in normal animal physiology and pathology. Tight regulation of these transmembrane proteins is therefore essential. In recent years, many studies have focused their attention on the role of the ubiquitin system in regulating ion channels and transporters, initialed by the discoveries of the role of this system in processing of Cystic Fibrosis Transmembrane Regulator (CFTR), and in regulating endocytosis of the epithelial Na + channel (ENaC) by the Nedd4 family of ubiquitin ligases (mainly Nedd4-2). In this review, we discuss the role of the ubiquitin system in ER Associated Degradation (ERAD) of ion channels, and in the regulation of endocytosis and lysosomal sorting of ion channels and transporters, focusing primarily in mammalian cells. We also briefly discuss the role of ubiquitin like molecules (such as SUMO) in such regulation, for which much less is known so far.
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subjectAldosterone ; Aldosterone - physiology ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Calcium Channels - physiology ; Cell Biology ; Children's hospitals ; Chloride Channels - physiology ; Corticosteroids ; Cystic fibrosis ; Cystic Fibrosis Transmembrane Conductance Regulator - physiology ; Endocytosis - physiology ; Endoplasmic Reticulum - physiology ; Endosomal Sorting Complexes Required for Transport - physiology ; Epithelial Sodium Channels - metabolism ; Human Physiology ; Humans ; Immediate-Early Proteins - physiology ; Invited Review ; Ion Transport - physiology ; Ligases ; macromolecular substances ; Membrane proteins ; Membrane Proteins - metabolism ; Molecular Medicine ; Nedd4 Ubiquitin Protein Ligases ; Neurosciences ; Physiological aspects ; Potassium Channels, Voltage-Gated - physiology ; Protein-Serine-Threonine Kinases - physiology ; Receptors ; Small Ubiquitin-Related Modifier Proteins - physiology ; Sodium Channels - physiology ; Ubiquitin ; Ubiquitin - physiology ; Ubiquitin-Protein Ligases - physiology ; Ubiquitination - physiology ; Vasopressins - physiology
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descriptionIon channels and transporters play a critical role in ion and fluid homeostasis and thus in normal animal physiology and pathology. Tight regulation of these transmembrane proteins is therefore essential. In recent years, many studies have focused their attention on the role of the ubiquitin system in regulating ion channels and transporters, initialed by the discoveries of the role of this system in processing of Cystic Fibrosis Transmembrane Regulator (CFTR), and in regulating endocytosis of the epithelial Na + channel (ENaC) by the Nedd4 family of ubiquitin ligases (mainly Nedd4-2). In this review, we discuss the role of the ubiquitin system in ER Associated Degradation (ERAD) of ion channels, and in the regulation of endocytosis and lysosomal sorting of ion channels and transporters, focusing primarily in mammalian cells. We also briefly discuss the role of ubiquitin like molecules (such as SUMO) in such regulation, for which much less is known so far.
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0Aldosterone
1Aldosterone - physiology
2Animals
3Biomedical and Life Sciences
4Biomedicine
5Calcium Channels - physiology
6Cell Biology
7Children's hospitals
8Chloride Channels - physiology
9Corticosteroids
10Cystic fibrosis
11Cystic Fibrosis Transmembrane Conductance Regulator - physiology
12Endocytosis - physiology
13Endoplasmic Reticulum - physiology
14Endosomal Sorting Complexes Required for Transport - physiology
15Epithelial Sodium Channels - metabolism
16Human Physiology
17Humans
18Immediate-Early Proteins - physiology
19Invited Review
20Ion Transport - physiology
21Ligases
22macromolecular substances
23Membrane proteins
24Membrane Proteins - metabolism
25Molecular Medicine
26Nedd4 Ubiquitin Protein Ligases
27Neurosciences
28Physiological aspects
29Potassium Channels, Voltage-Gated - physiology
30Protein-Serine-Threonine Kinases - physiology
31Receptors
32Small Ubiquitin-Related Modifier Proteins - physiology
33Sodium Channels - physiology
34Ubiquitin
35Ubiquitin - physiology
36Ubiquitin-Protein Ligases - physiology
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2Animals
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5Calcium Channels - physiology
6Cell Biology
7Children's hospitals
8Chloride Channels - physiology
9Corticosteroids
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33Sodium Channels - physiology
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35Ubiquitin - physiology
36Ubiquitin-Protein Ligases - physiology
37Ubiquitination - physiology
38Vasopressins - physiology
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abstractIon channels and transporters play a critical role in ion and fluid homeostasis and thus in normal animal physiology and pathology. Tight regulation of these transmembrane proteins is therefore essential. In recent years, many studies have focused their attention on the role of the ubiquitin system in regulating ion channels and transporters, initialed by the discoveries of the role of this system in processing of Cystic Fibrosis Transmembrane Regulator (CFTR), and in regulating endocytosis of the epithelial Na + channel (ENaC) by the Nedd4 family of ubiquitin ligases (mainly Nedd4-2). In this review, we discuss the role of the ubiquitin system in ER Associated Degradation (ERAD) of ion channels, and in the regulation of endocytosis and lysosomal sorting of ion channels and transporters, focusing primarily in mammalian cells. We also briefly discuss the role of ubiquitin like molecules (such as SUMO) in such regulation, for which much less is known so far.
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pubSpringer-Verlag
pmid20972579
doi10.1007/s00424-010-0893-2
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