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Raised levels of Il-6, Il-17a, and Il-22 in fatal leptospirosis

Clinical manifestations of leptospirosis range from mild, common cold-like illness, to a life-threatening condition. The host immune response has been hypothesized to play a major role in leptospirosis outcome. Increased levels of inflammatory mediators, such as cytokines, may promote tissue damage... Full description

Journal Title: European journal of clinical microbiology & infectious diseases 2019-09-16, Vol.38 (12), p.2349-2353
Main Author: Wan Yusoff, Wan Shahriman Yushdie
Other Authors: Abdullah, Maha , Sekawi, Zamberi , Amran, Fairuz , Yuhana, Muhammad Yazli , Mohd Taib, Niazlin , Yap, Ivan Kok Seng , Than, Leslie Thian Lung , Md. Shah, Anim , van Belkum, Alex , Amin Nordin, Syafinaz
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0934-9723
Link: https://www.ncbi.nlm.nih.gov/pubmed/31529307
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title: Raised levels of Il-6, Il-17a, and Il-22 in fatal leptospirosis
format: Article
creator:
  • Wan Yusoff, Wan Shahriman Yushdie
  • Abdullah, Maha
  • Sekawi, Zamberi
  • Amran, Fairuz
  • Yuhana, Muhammad Yazli
  • Mohd Taib, Niazlin
  • Yap, Ivan Kok Seng
  • Than, Leslie Thian Lung
  • Md. Shah, Anim
  • van Belkum, Alex
  • Amin Nordin, Syafinaz
subjects:
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers
  • Biomarkers - blood
  • Biomedical and Life Sciences
  • Biomedicine
  • Case-Control Studies
  • Clinical outcome
  • Cytokines
  • Cytokines - blood
  • Female
  • Humans
  • Interleukin-17 - blood
  • Interleukin-6 - blood
  • Interleukins - blood
  • Internal Medicine
  • Leptospirosis
  • Leptospirosis - blood
  • Leptospirosis - mortality
  • Leptospirosis - pathology
  • Leptospirosis - physiopathology
  • Malaysia
  • Malaysia - epidemiology
  • Male
  • Medical Microbiology
  • Middle Aged
  • Multivariate Analysis
  • Odds Ratio
  • Original Article
  • T helper cell
  • Young Adult
ispartof: European journal of clinical microbiology & infectious diseases, 2019-09-16, Vol.38 (12), p.2349-2353
description: Clinical manifestations of leptospirosis range from mild, common cold-like illness, to a life-threatening condition. The host immune response has been hypothesized to play a major role in leptospirosis outcome. Increased levels of inflammatory mediators, such as cytokines, may promote tissue damage that lead to increased disease severity. The question is whether cytokines levels may predict the outcome of leptospirosis and guide patient management. This study aimed to assess the association between Th1-, Th2-, and Th17-related cytokines with the clinical outcome of patients with leptospirosis. Different cytokine levels were measured in fifty-two plasma samples of hospitalized patients diagnosed with leptospirosis in Malaysia (January 2016–December 2017). Patients were divided into two separate categories: survived ( n  = 40) and fatal outcome ( n  = 12). Nineteen plasma samples from healthy individuals were obtained as controls. Cytokine quantification was performed using Simple Plex™ assays from ProteinSimple (San Jose, CA, USA). Measurements were done in triplicate and statistical analysis was performed using GraphPad software and SPSS v20. IL-6 ( p  = 0.033), IL-17A ( p  = 0.022), and IL-22 ( p  = 0.046) were significantly elevated in fatal cases. IL-17A concentration (OR 1.115; 95% CI 1.010–1.231) appeared to be an independent predictor of fatality of leptospirosis. Significantly higher levels of TNF-α ( p  ≤ 0.0001), IL-6 ( p  ≤ 0.0001), IL-10 ( p  ≤ 0.0001), IL-12 ( p  ≤ 0.0001), IL17A ( p  ≤ 0.0001), and IL-18 ( p  ≤ 0.0001) were observed among leptospirosis patients in comparison with healthy controls. Our study shows that certain cytokine levels may serve as possible prognostic biomarkers in leptospirosis patients.
language: eng
source:
identifier: ISSN: 0934-9723
fulltext: no_fulltext
issn:
  • 0934-9723
  • 1435-4373
url: Link


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titleRaised levels of Il-6, Il-17a, and Il-22 in fatal leptospirosis
creatorWan Yusoff, Wan Shahriman Yushdie ; Abdullah, Maha ; Sekawi, Zamberi ; Amran, Fairuz ; Yuhana, Muhammad Yazli ; Mohd Taib, Niazlin ; Yap, Ivan Kok Seng ; Than, Leslie Thian Lung ; Md. Shah, Anim ; van Belkum, Alex ; Amin Nordin, Syafinaz
creatorcontribWan Yusoff, Wan Shahriman Yushdie ; Abdullah, Maha ; Sekawi, Zamberi ; Amran, Fairuz ; Yuhana, Muhammad Yazli ; Mohd Taib, Niazlin ; Yap, Ivan Kok Seng ; Than, Leslie Thian Lung ; Md. Shah, Anim ; van Belkum, Alex ; Amin Nordin, Syafinaz
descriptionClinical manifestations of leptospirosis range from mild, common cold-like illness, to a life-threatening condition. The host immune response has been hypothesized to play a major role in leptospirosis outcome. Increased levels of inflammatory mediators, such as cytokines, may promote tissue damage that lead to increased disease severity. The question is whether cytokines levels may predict the outcome of leptospirosis and guide patient management. This study aimed to assess the association between Th1-, Th2-, and Th17-related cytokines with the clinical outcome of patients with leptospirosis. Different cytokine levels were measured in fifty-two plasma samples of hospitalized patients diagnosed with leptospirosis in Malaysia (January 2016–December 2017). Patients were divided into two separate categories: survived ( n  = 40) and fatal outcome ( n  = 12). Nineteen plasma samples from healthy individuals were obtained as controls. Cytokine quantification was performed using Simple Plex™ assays from ProteinSimple (San Jose, CA, USA). Measurements were done in triplicate and statistical analysis was performed using GraphPad software and SPSS v20. IL-6 ( p  = 0.033), IL-17A ( p  = 0.022), and IL-22 ( p  = 0.046) were significantly elevated in fatal cases. IL-17A concentration (OR 1.115; 95% CI 1.010–1.231) appeared to be an independent predictor of fatality of leptospirosis. Significantly higher levels of TNF-α ( p  ≤ 0.0001), IL-6 ( p  ≤ 0.0001), IL-10 ( p  ≤ 0.0001), IL-12 ( p  ≤ 0.0001), IL17A ( p  ≤ 0.0001), and IL-18 ( p  ≤ 0.0001) were observed among leptospirosis patients in comparison with healthy controls. Our study shows that certain cytokine levels may serve as possible prognostic biomarkers in leptospirosis patients.
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subjectAdolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers ; Biomarkers - blood ; Biomedical and Life Sciences ; Biomedicine ; Case-Control Studies ; Clinical outcome ; Cytokines ; Cytokines - blood ; Female ; Humans ; Interleukin-17 - blood ; Interleukin-6 - blood ; Interleukins - blood ; Internal Medicine ; Leptospirosis ; Leptospirosis - blood ; Leptospirosis - mortality ; Leptospirosis - pathology ; Leptospirosis - physiopathology ; Malaysia ; Malaysia - epidemiology ; Male ; Medical Microbiology ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Original Article ; T helper cell ; Young Adult
ispartofEuropean journal of clinical microbiology & infectious diseases, 2019-09-16, Vol.38 (12), p.2349-2353
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descriptionClinical manifestations of leptospirosis range from mild, common cold-like illness, to a life-threatening condition. The host immune response has been hypothesized to play a major role in leptospirosis outcome. Increased levels of inflammatory mediators, such as cytokines, may promote tissue damage that lead to increased disease severity. The question is whether cytokines levels may predict the outcome of leptospirosis and guide patient management. This study aimed to assess the association between Th1-, Th2-, and Th17-related cytokines with the clinical outcome of patients with leptospirosis. Different cytokine levels were measured in fifty-two plasma samples of hospitalized patients diagnosed with leptospirosis in Malaysia (January 2016–December 2017). Patients were divided into two separate categories: survived ( n  = 40) and fatal outcome ( n  = 12). Nineteen plasma samples from healthy individuals were obtained as controls. Cytokine quantification was performed using Simple Plex™ assays from ProteinSimple (San Jose, CA, USA). Measurements were done in triplicate and statistical analysis was performed using GraphPad software and SPSS v20. IL-6 ( p  = 0.033), IL-17A ( p  = 0.022), and IL-22 ( p  = 0.046) were significantly elevated in fatal cases. IL-17A concentration (OR 1.115; 95% CI 1.010–1.231) appeared to be an independent predictor of fatality of leptospirosis. Significantly higher levels of TNF-α ( p  ≤ 0.0001), IL-6 ( p  ≤ 0.0001), IL-10 ( p  ≤ 0.0001), IL-12 ( p  ≤ 0.0001), IL17A ( p  ≤ 0.0001), and IL-18 ( p  ≤ 0.0001) were observed among leptospirosis patients in comparison with healthy controls. Our study shows that certain cytokine levels may serve as possible prognostic biomarkers in leptospirosis patients.
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titleRaised levels of Il-6, Il-17a, and Il-22 in fatal leptospirosis
authorWan Yusoff, Wan Shahriman Yushdie ; Abdullah, Maha ; Sekawi, Zamberi ; Amran, Fairuz ; Yuhana, Muhammad Yazli ; Mohd Taib, Niazlin ; Yap, Ivan Kok Seng ; Than, Leslie Thian Lung ; Md. Shah, Anim ; van Belkum, Alex ; Amin Nordin, Syafinaz
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abstractClinical manifestations of leptospirosis range from mild, common cold-like illness, to a life-threatening condition. The host immune response has been hypothesized to play a major role in leptospirosis outcome. Increased levels of inflammatory mediators, such as cytokines, may promote tissue damage that lead to increased disease severity. The question is whether cytokines levels may predict the outcome of leptospirosis and guide patient management. This study aimed to assess the association between Th1-, Th2-, and Th17-related cytokines with the clinical outcome of patients with leptospirosis. Different cytokine levels were measured in fifty-two plasma samples of hospitalized patients diagnosed with leptospirosis in Malaysia (January 2016–December 2017). Patients were divided into two separate categories: survived ( n  = 40) and fatal outcome ( n  = 12). Nineteen plasma samples from healthy individuals were obtained as controls. Cytokine quantification was performed using Simple Plex™ assays from ProteinSimple (San Jose, CA, USA). Measurements were done in triplicate and statistical analysis was performed using GraphPad software and SPSS v20. IL-6 ( p  = 0.033), IL-17A ( p  = 0.022), and IL-22 ( p  = 0.046) were significantly elevated in fatal cases. IL-17A concentration (OR 1.115; 95% CI 1.010–1.231) appeared to be an independent predictor of fatality of leptospirosis. Significantly higher levels of TNF-α ( p  ≤ 0.0001), IL-6 ( p  ≤ 0.0001), IL-10 ( p  ≤ 0.0001), IL-12 ( p  ≤ 0.0001), IL17A ( p  ≤ 0.0001), and IL-18 ( p  ≤ 0.0001) were observed among leptospirosis patients in comparison with healthy controls. Our study shows that certain cytokine levels may serve as possible prognostic biomarkers in leptospirosis patients.
copBerlin/Heidelberg
pubSpringer Berlin Heidelberg
pmid31529307
doi10.1007/s10096-019-03699-5