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Dietary intake of lignans and risk of adenocarcinoma of the esophagus and gastroesophageal junction

Purpose: The strong male predominance in esophageal and gastroesophageal junctional adenocarcinoma remains unexplained. Sex hormonal influence has been suggested, but not proven. A protective role of dietary phytoestrogen lignans was hypothesized. Methods: A Swedish nationwide population-based casec... Full description

Journal Title: Cancer causes & control 2012-06-01, Vol.23 (6), p.837-844
Main Author: Lin, Yulan
Other Authors: Yngve, Agneta , Lagergren, Jesper , Lu, Yunxia
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Dordrecht: Springer
ID: ISSN: 0957-5243
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recordid: cdi_springer_journals_10_1007_s10552_012_9952_7
title: Dietary intake of lignans and risk of adenocarcinoma of the esophagus and gastroesophageal junction
format: Article
creator:
  • Lin, Yulan
  • Yngve, Agneta
  • Lagergren, Jesper
  • Lu, Yunxia
subjects:
  • Adenocarcinoma
  • Adenocarcinoma - epidemiology
  • Adenocarcinoma - prevention & control
  • Aged
  • Biomedical and Life Sciences
  • Biomedicine
  • Cancer Research
  • Carcinoma, Squamous Cell - epidemiology
  • Carcinoma, Squamous Cell - prevention & control
  • Case-Control Studies
  • Culinary Arts and Meal Science
  • Diet
  • Epidemiology
  • Esophageal Neoplasms - epidemiology
  • Esophageal Neoplasms - prevention & control
  • Esophagogastric junction
  • Esophagogastric Junction - metabolism
  • Esophagogastric Junction - pathology
  • Esophagus
  • Female
  • Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
  • Food
  • Food intake
  • general
  • Health aspects
  • Health Sciences
  • Hematology
  • Humans
  • Hälsovetenskaper
  • Lignans
  • Lignans - administration & dosage
  • Logistic Models
  • Male
  • Medical and Health Sciences
  • Medicin och hälsovetenskap
  • Middle Aged
  • Måltidskunskap
  • Neoplasm
  • Nutrition
  • Nutrition and Dietetics
  • Näringslära
  • Odds Ratio
  • Oncology
  • Original Paper
  • Phytochemicals
  • Phytoestrogen
  • Phytoestrogens
  • Phytoestrogens - administration & dosage
  • Public Health
  • Public Health, Global Health, Social Medicine and Epidemiology
  • Research
  • Risk Factors
  • Squamous cell carcinoma
  • Stomach Neoplasms - epidemiology
  • Stomach Neoplasms - prevention & control
  • Sweden - epidemiology
  • Tobacco smoking
  • Tumors
ispartof: Cancer causes & control, 2012-06-01, Vol.23 (6), p.837-844
description: Purpose: The strong male predominance in esophageal and gastroesophageal junctional adenocarcinoma remains unexplained. Sex hormonal influence has been suggested, but not proven. A protective role of dietary phytoestrogen lignans was hypothesized. Methods: A Swedish nationwide population-based casecontrol study was conducted in 1995-1997, including 181 cases of esophageal adenocarcinoma, 255 cases of gastroesophageal junctional adenocarcinoma, 158 cases of esophageal squamous cell carcinoma, and 806 control subjects. Data on various exposures, including dietary data, were collected through personal interviews and questionnaires. Dietary intake of lignans was assessed using a food frequency questionnaire and categorized into quartiles based on the consumption among the control participants. Unconditional logistic regression was used to calculate odds ratios (ORs) with 95 % confidence intervals (CIs), including adjustment for all established risk factors. Results: Participants in the highest quartile of intake of lignans compared with the lowest quartile were at a decreased risk of esophageal adenocarcinoma (OR, 0.65; 95 % CI, 0.38-1.12; p for trend = 0.03), gastroesophageal junctional adenocarcinoma (OR, 0.37; 95 % CI, 0.23-0.58; p for trend
language: eng
source:
identifier: ISSN: 0957-5243
fulltext: no_fulltext
issn:
  • 0957-5243
  • 1573-7225
  • 1573-7225
url: Link


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titleDietary intake of lignans and risk of adenocarcinoma of the esophagus and gastroesophageal junction
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creatorcontribLin, Yulan ; Yngve, Agneta ; Lagergren, Jesper ; Lu, Yunxia
descriptionPurpose: The strong male predominance in esophageal and gastroesophageal junctional adenocarcinoma remains unexplained. Sex hormonal influence has been suggested, but not proven. A protective role of dietary phytoestrogen lignans was hypothesized. Methods: A Swedish nationwide population-based casecontrol study was conducted in 1995-1997, including 181 cases of esophageal adenocarcinoma, 255 cases of gastroesophageal junctional adenocarcinoma, 158 cases of esophageal squamous cell carcinoma, and 806 control subjects. Data on various exposures, including dietary data, were collected through personal interviews and questionnaires. Dietary intake of lignans was assessed using a food frequency questionnaire and categorized into quartiles based on the consumption among the control participants. Unconditional logistic regression was used to calculate odds ratios (ORs) with 95 % confidence intervals (CIs), including adjustment for all established risk factors. Results: Participants in the highest quartile of intake of lignans compared with the lowest quartile were at a decreased risk of esophageal adenocarcinoma (OR, 0.65; 95 % CI, 0.38-1.12; p for trend = 0.03), gastroesophageal junctional adenocarcinoma (OR, 0.37; 95 % CI, 0.23-0.58; p for trend <0.0001), and these adenocarcinomas combined (OR, 0.45; 95 % CI, 0.31-0.67; p for trend <0.0001). No clear associations were found between lignan intake and risk of esophageal squamous cell carcinoma. Conclusions: This population-based study indicates that a high dietary intake of lignans decreases the risk of adenocarcinoma of the esophagus and gastroesophageal junction.
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1Cancer causes & control
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descriptionPurpose: The strong male predominance in esophageal and gastroesophageal junctional adenocarcinoma remains unexplained. Sex hormonal influence has been suggested, but not proven. A protective role of dietary phytoestrogen lignans was hypothesized. Methods: A Swedish nationwide population-based casecontrol study was conducted in 1995-1997, including 181 cases of esophageal adenocarcinoma, 255 cases of gastroesophageal junctional adenocarcinoma, 158 cases of esophageal squamous cell carcinoma, and 806 control subjects. Data on various exposures, including dietary data, were collected through personal interviews and questionnaires. Dietary intake of lignans was assessed using a food frequency questionnaire and categorized into quartiles based on the consumption among the control participants. Unconditional logistic regression was used to calculate odds ratios (ORs) with 95 % confidence intervals (CIs), including adjustment for all established risk factors. Results: Participants in the highest quartile of intake of lignans compared with the lowest quartile were at a decreased risk of esophageal adenocarcinoma (OR, 0.65; 95 % CI, 0.38-1.12; p for trend = 0.03), gastroesophageal junctional adenocarcinoma (OR, 0.37; 95 % CI, 0.23-0.58; p for trend <0.0001), and these adenocarcinomas combined (OR, 0.45; 95 % CI, 0.31-0.67; p for trend <0.0001). No clear associations were found between lignan intake and risk of esophageal squamous cell carcinoma. Conclusions: This population-based study indicates that a high dietary intake of lignans decreases the risk of adenocarcinoma of the esophagus and gastroesophageal junction.
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0Adenocarcinoma
1Adenocarcinoma - epidemiology
2Adenocarcinoma - prevention & control
3Aged
4Biomedical and Life Sciences
5Biomedicine
6Cancer Research
7Carcinoma, Squamous Cell - epidemiology
8Carcinoma, Squamous Cell - prevention & control
9Case-Control Studies
10Culinary Arts and Meal Science
11Diet
12Epidemiology
13Esophageal Neoplasms - epidemiology
14Esophageal Neoplasms - prevention & control
15Esophagogastric junction
16Esophagogastric Junction - metabolism
17Esophagogastric Junction - pathology
18Esophagus
19Female
20Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
21Food
22Food intake
23general
24Health aspects
25Health Sciences
26Hematology
27Humans
28Hälsovetenskaper
29Lignans
30Lignans - administration & dosage
31Logistic Models
32Male
33Medical and Health Sciences
34Medicin och hälsovetenskap
35Middle Aged
36Måltidskunskap
37Neoplasm
38Nutrition
39Nutrition and Dietetics
40Näringslära
41Odds Ratio
42Oncology
43Original Paper
44Phytochemicals
45Phytoestrogen
46Phytoestrogens
47Phytoestrogens - administration & dosage
48Public Health
49Public Health, Global Health, Social Medicine and Epidemiology
50Research
51Risk Factors
52Squamous cell carcinoma
53Stomach Neoplasms - epidemiology
54Stomach Neoplasms - prevention & control
55Sweden - epidemiology
56Tobacco smoking
57Tumors
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46Phytoestrogens
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49Public Health, Global Health, Social Medicine and Epidemiology
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atitleDietary intake of lignans and risk of adenocarcinoma of the esophagus and gastroesophageal junction
jtitleCancer causes & control
stitleCancer Causes Control
addtitleCancer Causes Control
date2012-06-01
risdate2012
volume23
issue6
spage837
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pages837-844
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abstractPurpose: The strong male predominance in esophageal and gastroesophageal junctional adenocarcinoma remains unexplained. Sex hormonal influence has been suggested, but not proven. A protective role of dietary phytoestrogen lignans was hypothesized. Methods: A Swedish nationwide population-based casecontrol study was conducted in 1995-1997, including 181 cases of esophageal adenocarcinoma, 255 cases of gastroesophageal junctional adenocarcinoma, 158 cases of esophageal squamous cell carcinoma, and 806 control subjects. Data on various exposures, including dietary data, were collected through personal interviews and questionnaires. Dietary intake of lignans was assessed using a food frequency questionnaire and categorized into quartiles based on the consumption among the control participants. Unconditional logistic regression was used to calculate odds ratios (ORs) with 95 % confidence intervals (CIs), including adjustment for all established risk factors. Results: Participants in the highest quartile of intake of lignans compared with the lowest quartile were at a decreased risk of esophageal adenocarcinoma (OR, 0.65; 95 % CI, 0.38-1.12; p for trend = 0.03), gastroesophageal junctional adenocarcinoma (OR, 0.37; 95 % CI, 0.23-0.58; p for trend <0.0001), and these adenocarcinomas combined (OR, 0.45; 95 % CI, 0.31-0.67; p for trend <0.0001). No clear associations were found between lignan intake and risk of esophageal squamous cell carcinoma. Conclusions: This population-based study indicates that a high dietary intake of lignans decreases the risk of adenocarcinoma of the esophagus and gastroesophageal junction.
copDordrecht
pubSpringer
pmid22527161
doi10.1007/s10552-012-9952-7