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Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester-margarine treatment

Cholesterol absorption and metabolism and LDL and HDL kinetics were investigated in 11 hypercholesterolaemic non-insulin-dependent diabetic men off and on a hypolipidaemic treatment with sitostanol ester, (3 g sitostanol daily) dissolved in rapeseed oil margarine, by a double-blind crossover study d... Full description

Journal Title: Diabetologia 1994-08, Vol.37 (8), p.773-780
Main Author: Gylling, H
Other Authors: Miettinen, T A
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 0012-186X
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recordid: cdi_springer_primary_1994_125_37_8_BF00404334
title: Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester-margarine treatment
format: Article
creator:
  • Gylling, H
  • Miettinen, T A
subjects:
  • Apolipoproteins A - blood
  • Biological and medical sciences
  • Blood Glucose - metabolism
  • Body Mass Index
  • Brassica
  • Cholesterol
  • Cholesterol - blood
  • Cholesterol - metabolism
  • cholesterol absorption
  • cholesterol synthesis
  • Cholesterol, Dietary
  • Cholesterol, HDL - blood
  • Cholesterol, LDL - blood
  • Cross-Over Studies
  • Diabetes Mellitus, Type 2 - complications
  • Diabetes Mellitus, Type 2 - metabolism
  • Diabetes. Impaired glucose tolerance
  • Double-Blind Method
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • Energy Intake
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Fatty Acids, Monounsaturated
  • Glycated Hemoglobin A - analysis
  • Human Physiology
  • Humans
  • Hypercholesterolemia - complications
  • Hypercholesterolemia - metabolism
  • Hypercholesterolemia - therapy
  • Internal Medicine
  • lipoprotein kinetics
  • Lipoproteins - blood
  • Male
  • Margarine
  • Medical sciences
  • Medicine & Public Health
  • Metabolic Diseases
  • Middle Aged
  • non-insulin-dependent diabetes
  • Phospholipids - blood
  • Plant Oils
  • plant sterols
  • precursor sterols
  • Rapeseed Oil
  • Sialic Acids - blood
  • sitostanol
  • Sitosterols - administration & dosage
  • Sitosterols - therapeutic use
  • Triglycerides - blood
  • Vitamin E - blood
ispartof: Diabetologia, 1994-08, Vol.37 (8), p.773-780
description: Cholesterol absorption and metabolism and LDL and HDL kinetics were investigated in 11 hypercholesterolaemic non-insulin-dependent diabetic men off and on a hypolipidaemic treatment with sitostanol ester, (3 g sitostanol daily) dissolved in rapeseed oil margarine, by a double-blind crossover study design. Serum total, VLDL and LDL cholesterol and apoprotein B fell significantly by 6±2, 12±6, 9±3 and 6±2%, mean ±SEM, and HDL cholesterol was increased by 11±4% (p
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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titleSerum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester-margarine treatment
creatorGylling, H ; Miettinen, T A
creatorcontribGylling, H ; Miettinen, T A
descriptionCholesterol absorption and metabolism and LDL and HDL kinetics were investigated in 11 hypercholesterolaemic non-insulin-dependent diabetic men off and on a hypolipidaemic treatment with sitostanol ester, (3 g sitostanol daily) dissolved in rapeseed oil margarine, by a double-blind crossover study design. Serum total, VLDL and LDL cholesterol and apoprotein B fell significantly by 6±2, 12±6, 9±3 and 6±2%, mean ±SEM, and HDL cholesterol was increased by 11±4% (p<0.05) by sitostanol ester. LDL cholesterol and apoprotein B were significantly decreased in the dense (1.037–1.055 g/ml), but not light, LDL subfraction due to a significantly diminished transport rate for LDL apoprotein B, while the fractional catabolic rate was unchanged. HDL kinetics, measured with autologous apoprotein AI, was unaffected by sitostanol ester. Cholesterol absorption efficiency was markedly reduced from 25±2 to 9±2% (p<0.001) during sitostanol ester followed by proportionately decreased serum plant sterol proportions. Cholesterol precursor sterol proportions in serum, fecal neutral sterol excretion, and cholesterol synthesis, cholesterol transport, and biliary secretion were all significantly increased by sitostanol ester. We conclude that the sitostanol ester-induced decrease in cholesterol absorption compensatorily stimulated cholesterol synthesis, had no effect on fractional catabolic rate, but decreased transport rate for LDL apoprotein B so that serum total, VLDL and LDL cholesterol levels were decreased. Dietary rapeseed oil margarine rich in sitostanol ester was well tolerated, appears to be safe from the nutritional point of view and effective for lowering VLDL and LDL cholesterol and increasing HDL cholesterol in hypercholesterolaemic non-insulin-dependent diabetic subjects.
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0ISSN: 0012-186X
1EISSN: 1432-0428
2DOI: 10.1007/BF00404334
3PMID: 7988779
languageeng
publisherBerlin/Heidelberg: Springer-Verlag
subjectApolipoproteins A - blood ; Biological and medical sciences ; Blood Glucose - metabolism ; Body Mass Index ; Brassica ; Cholesterol ; Cholesterol - blood ; Cholesterol - metabolism ; cholesterol absorption ; cholesterol synthesis ; Cholesterol, Dietary ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Cross-Over Studies ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes. Impaired glucose tolerance ; Double-Blind Method ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Energy Intake ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fatty Acids, Monounsaturated ; Glycated Hemoglobin A - analysis ; Human Physiology ; Humans ; Hypercholesterolemia - complications ; Hypercholesterolemia - metabolism ; Hypercholesterolemia - therapy ; Internal Medicine ; lipoprotein kinetics ; Lipoproteins - blood ; Male ; Margarine ; Medical sciences ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; non-insulin-dependent diabetes ; Phospholipids - blood ; Plant Oils ; plant sterols ; precursor sterols ; Rapeseed Oil ; Sialic Acids - blood ; sitostanol ; Sitosterols - administration & dosage ; Sitosterols - therapeutic use ; Triglycerides - blood ; Vitamin E - blood
ispartofDiabetologia, 1994-08, Vol.37 (8), p.773-780
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1Miettinen, T A
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0Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester-margarine treatment
1Diabetologia
addtitle
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descriptionCholesterol absorption and metabolism and LDL and HDL kinetics were investigated in 11 hypercholesterolaemic non-insulin-dependent diabetic men off and on a hypolipidaemic treatment with sitostanol ester, (3 g sitostanol daily) dissolved in rapeseed oil margarine, by a double-blind crossover study design. Serum total, VLDL and LDL cholesterol and apoprotein B fell significantly by 6±2, 12±6, 9±3 and 6±2%, mean ±SEM, and HDL cholesterol was increased by 11±4% (p<0.05) by sitostanol ester. LDL cholesterol and apoprotein B were significantly decreased in the dense (1.037–1.055 g/ml), but not light, LDL subfraction due to a significantly diminished transport rate for LDL apoprotein B, while the fractional catabolic rate was unchanged. HDL kinetics, measured with autologous apoprotein AI, was unaffected by sitostanol ester. Cholesterol absorption efficiency was markedly reduced from 25±2 to 9±2% (p<0.001) during sitostanol ester followed by proportionately decreased serum plant sterol proportions. Cholesterol precursor sterol proportions in serum, fecal neutral sterol excretion, and cholesterol synthesis, cholesterol transport, and biliary secretion were all significantly increased by sitostanol ester. We conclude that the sitostanol ester-induced decrease in cholesterol absorption compensatorily stimulated cholesterol synthesis, had no effect on fractional catabolic rate, but decreased transport rate for LDL apoprotein B so that serum total, VLDL and LDL cholesterol levels were decreased. Dietary rapeseed oil margarine rich in sitostanol ester was well tolerated, appears to be safe from the nutritional point of view and effective for lowering VLDL and LDL cholesterol and increasing HDL cholesterol in hypercholesterolaemic non-insulin-dependent diabetic subjects.
subject
0Apolipoproteins A - blood
1Biological and medical sciences
2Blood Glucose - metabolism
3Body Mass Index
4Brassica
5Cholesterol
6Cholesterol - blood
7Cholesterol - metabolism
8cholesterol absorption
9cholesterol synthesis
10Cholesterol, Dietary
11Cholesterol, HDL - blood
12Cholesterol, LDL - blood
13Cross-Over Studies
14Diabetes Mellitus, Type 2 - complications
15Diabetes Mellitus, Type 2 - metabolism
16Diabetes. Impaired glucose tolerance
17Double-Blind Method
18Endocrine pancreas. Apud cells (diseases)
19Endocrinopathies
20Energy Intake
21Etiopathogenesis. Screening. Investigations. Target tissue resistance
22Fatty Acids, Monounsaturated
23Glycated Hemoglobin A - analysis
24Human Physiology
25Humans
26Hypercholesterolemia - complications
27Hypercholesterolemia - metabolism
28Hypercholesterolemia - therapy
29Internal Medicine
30lipoprotein kinetics
31Lipoproteins - blood
32Male
33Margarine
34Medical sciences
35Medicine & Public Health
36Metabolic Diseases
37Middle Aged
38non-insulin-dependent diabetes
39Phospholipids - blood
40Plant Oils
41plant sterols
42precursor sterols
43Rapeseed Oil
44Sialic Acids - blood
45sitostanol
46Sitosterols - administration & dosage
47Sitosterols - therapeutic use
48Triglycerides - blood
49Vitamin E - blood
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titleSerum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester-margarine treatment
authorGylling, H ; Miettinen, T A
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0Apolipoproteins A - blood
1Biological and medical sciences
2Blood Glucose - metabolism
3Body Mass Index
4Brassica
5Cholesterol
6Cholesterol - blood
7Cholesterol - metabolism
8cholesterol absorption
9cholesterol synthesis
10Cholesterol, Dietary
11Cholesterol, HDL - blood
12Cholesterol, LDL - blood
13Cross-Over Studies
14Diabetes Mellitus, Type 2 - complications
15Diabetes Mellitus, Type 2 - metabolism
16Diabetes. Impaired glucose tolerance
17Double-Blind Method
18Endocrine pancreas. Apud cells (diseases)
19Endocrinopathies
20Energy Intake
21Etiopathogenesis. Screening. Investigations. Target tissue resistance
22Fatty Acids, Monounsaturated
23Glycated Hemoglobin A - analysis
24Human Physiology
25Humans
26Hypercholesterolemia - complications
27Hypercholesterolemia - metabolism
28Hypercholesterolemia - therapy
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30lipoprotein kinetics
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37Middle Aged
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42precursor sterols
43Rapeseed Oil
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45sitostanol
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47Sitosterols - therapeutic use
48Triglycerides - blood
49Vitamin E - blood
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jtitleDiabetologia
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date1994-08
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abstractCholesterol absorption and metabolism and LDL and HDL kinetics were investigated in 11 hypercholesterolaemic non-insulin-dependent diabetic men off and on a hypolipidaemic treatment with sitostanol ester, (3 g sitostanol daily) dissolved in rapeseed oil margarine, by a double-blind crossover study design. Serum total, VLDL and LDL cholesterol and apoprotein B fell significantly by 6±2, 12±6, 9±3 and 6±2%, mean ±SEM, and HDL cholesterol was increased by 11±4% (p<0.05) by sitostanol ester. LDL cholesterol and apoprotein B were significantly decreased in the dense (1.037–1.055 g/ml), but not light, LDL subfraction due to a significantly diminished transport rate for LDL apoprotein B, while the fractional catabolic rate was unchanged. HDL kinetics, measured with autologous apoprotein AI, was unaffected by sitostanol ester. Cholesterol absorption efficiency was markedly reduced from 25±2 to 9±2% (p<0.001) during sitostanol ester followed by proportionately decreased serum plant sterol proportions. Cholesterol precursor sterol proportions in serum, fecal neutral sterol excretion, and cholesterol synthesis, cholesterol transport, and biliary secretion were all significantly increased by sitostanol ester. We conclude that the sitostanol ester-induced decrease in cholesterol absorption compensatorily stimulated cholesterol synthesis, had no effect on fractional catabolic rate, but decreased transport rate for LDL apoprotein B so that serum total, VLDL and LDL cholesterol levels were decreased. Dietary rapeseed oil margarine rich in sitostanol ester was well tolerated, appears to be safe from the nutritional point of view and effective for lowering VLDL and LDL cholesterol and increasing HDL cholesterol in hypercholesterolaemic non-insulin-dependent diabetic subjects.
copBerlin/Heidelberg
pubSpringer-Verlag
pmid7988779
doi10.1007/BF00404334