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Upregulation of long non-coding RNA TUG1 correlates with poor prognosis and disease status in osteosarcoma

The pathogenesis of osteosarcoma involves complex genetic and epigenetic factors. This study was to explore the impact and clinical relevance of long non-coding RNA (lncRNA), Taurine up-regulated gene 1 (TUG1) on patients with osteosarcoma. Seventy-six osteosarcoma tissues and matched adjacent norma... Full description

Journal Title: Tumor biology 2015-10-25, Vol.37 (4), p.4445-4455
Main Author: Ma, Bing
Other Authors: Li, Meng , Zhang, Lei , Huang, Ming , Lei, Jun-Bin , Fu, Gui-Hong , Liu, Chun-Xin , Lai, Qi-Wen , Chen, Qing-Quan , Wang, Yi-Lian
Format: Electronic Article Electronic Article
Language: English
Subjects:
RNA
Quelle: Alma/SFX Local Collection
Publisher: Dordrecht: Springer Netherlands
ID: ISSN: 1010-4283
Link: https://www.ncbi.nlm.nih.gov/pubmed/26499949
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title: Upregulation of long non-coding RNA TUG1 correlates with poor prognosis and disease status in osteosarcoma
format: Article
creator:
  • Ma, Bing
  • Li, Meng
  • Zhang, Lei
  • Huang, Ming
  • Lei, Jun-Bin
  • Fu, Gui-Hong
  • Liu, Chun-Xin
  • Lai, Qi-Wen
  • Chen, Qing-Quan
  • Wang, Yi-Lian
subjects:
  • Adolescent
  • Adult
  • Alkaline Phosphatase - metabolism
  • Analysis
  • Area Under Curve
  • Biomarkers, Tumor - blood
  • Biomarkers, Tumor - genetics
  • Biomedical and Life Sciences
  • Biomedicine
  • Bone Neoplasms - blood
  • Bone Neoplasms - diagnosis
  • Bone Neoplasms - genetics
  • Bone Neoplasms - mortality
  • Cancer
  • Cancer Research
  • Case-Control Studies
  • Chemotherapy
  • Development and progression
  • Disease-Free Survival
  • Epigenetic inheritance
  • Female
  • Gene Expression
  • Humans
  • Kaplan-Meier Estimate
  • lncRNA
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Original Article
  • Osteosarcoma
  • Osteosarcoma - blood
  • Osteosarcoma - diagnosis
  • Osteosarcoma - genetics
  • Osteosarcoma - mortality
  • Phosphatases
  • Prognosis
  • Proportional Hazards Models
  • RNA
  • RNA, Long Noncoding - blood
  • RNA, Long Noncoding - genetics
  • ROC Curve
  • Taurine
  • TUG1
  • Up-Regulation
  • Young Adult
ispartof: Tumor biology, 2015-10-25, Vol.37 (4), p.4445-4455
description: The pathogenesis of osteosarcoma involves complex genetic and epigenetic factors. This study was to explore the impact and clinical relevance of long non-coding RNA (lncRNA), Taurine up-regulated gene 1 (TUG1) on patients with osteosarcoma. Seventy-six osteosarcoma tissues and matched adjacent normal tissues were included for analysis. The plasma samples were obtained from 29 patients with osteosarcoma at pre-operation and post-operation, 42 at newly diagnosed, 18 who experienced disease progression or relapse, 45 post-treatment, 36 patients with benign bone tumor, and 20 healthy donors. Quantitative real-time reverse transcript polymerase chain reactions were used to assess the correlation of the expression levels of TUG1 with clinical parameters of osteosarcoma patients. TUG1 was significantly overexpressed in the osteosarcoma tissues compared with matched adjacent normal tissues ( P  
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1010-4283
fulltext: fulltext
issn:
  • 1010-4283
  • 1423-0380
url: Link


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titleUpregulation of long non-coding RNA TUG1 correlates with poor prognosis and disease status in osteosarcoma
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creatorMa, Bing ; Li, Meng ; Zhang, Lei ; Huang, Ming ; Lei, Jun-Bin ; Fu, Gui-Hong ; Liu, Chun-Xin ; Lai, Qi-Wen ; Chen, Qing-Quan ; Wang, Yi-Lian
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descriptionThe pathogenesis of osteosarcoma involves complex genetic and epigenetic factors. This study was to explore the impact and clinical relevance of long non-coding RNA (lncRNA), Taurine up-regulated gene 1 (TUG1) on patients with osteosarcoma. Seventy-six osteosarcoma tissues and matched adjacent normal tissues were included for analysis. The plasma samples were obtained from 29 patients with osteosarcoma at pre-operation and post-operation, 42 at newly diagnosed, 18 who experienced disease progression or relapse, 45 post-treatment, 36 patients with benign bone tumor, and 20 healthy donors. Quantitative real-time reverse transcript polymerase chain reactions were used to assess the correlation of the expression levels of TUG1 with clinical parameters of osteosarcoma patients. TUG1 was significantly overexpressed in the osteosarcoma tissues compared with matched adjacent normal tissues ( P  < 0.01) and was closely correlated with tumor size, post-operative chemotherapy, and Enneking surgical stage. Upregulation of TUG1 strongly correlated with poor prognosis and was an independent prognostic indicator for overall survival (HR = 2.78, 95% CI = 1.29–6.00, P  = 0.009) and progression-free survival (HR = 1.81, 95% CI = 1.01–3.54, P  = 0.037). Our constructed nomogram containing TUG1 had more predictive accuracy than that without TUG1 (c-index 0.807 versus 0.776, respectively). In addition, for plasma samples, TUG1 expression levels were obviously decreased in post-operative patients (mean ΔC T −4.98 ± 0.22) compared with pre-operation patients (mean ΔC T −6.09 ± 0.74), and the changes of TUG1 expression levels were significantly associated with disease status. Receiver operating characteristic (ROC) curve analysis demonstrated that TUG1 could distinguish patients with osteosarcoma from healthy individuals compared with alkaline phosphatase (ALP) (the area under curve 0.849 versus 0.544). TUG1 was overexpressed in patients with osteosarcoma and strongly correlated with disease status. In addition, TUG1 may serve as a molecular indicator in maintaining surveillance and forecasting prognosis.
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subjectAdolescent ; Adult ; Alkaline Phosphatase - metabolism ; Analysis ; Area Under Curve ; Biomarkers, Tumor - blood ; Biomarkers, Tumor - genetics ; Biomedical and Life Sciences ; Biomedicine ; Bone Neoplasms - blood ; Bone Neoplasms - diagnosis ; Bone Neoplasms - genetics ; Bone Neoplasms - mortality ; Cancer ; Cancer Research ; Case-Control Studies ; Chemotherapy ; Development and progression ; Disease-Free Survival ; Epigenetic inheritance ; Female ; Gene Expression ; Humans ; Kaplan-Meier Estimate ; lncRNA ; Male ; Middle Aged ; Multivariate Analysis ; Original Article ; Osteosarcoma ; Osteosarcoma - blood ; Osteosarcoma - diagnosis ; Osteosarcoma - genetics ; Osteosarcoma - mortality ; Phosphatases ; Prognosis ; Proportional Hazards Models ; RNA ; RNA, Long Noncoding - blood ; RNA, Long Noncoding - genetics ; ROC Curve ; Taurine ; TUG1 ; Up-Regulation ; Young Adult
ispartofTumor biology, 2015-10-25, Vol.37 (4), p.4445-4455
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4Lei, Jun-Bin
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6Liu, Chun-Xin
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8Chen, Qing-Quan
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descriptionThe pathogenesis of osteosarcoma involves complex genetic and epigenetic factors. This study was to explore the impact and clinical relevance of long non-coding RNA (lncRNA), Taurine up-regulated gene 1 (TUG1) on patients with osteosarcoma. Seventy-six osteosarcoma tissues and matched adjacent normal tissues were included for analysis. The plasma samples were obtained from 29 patients with osteosarcoma at pre-operation and post-operation, 42 at newly diagnosed, 18 who experienced disease progression or relapse, 45 post-treatment, 36 patients with benign bone tumor, and 20 healthy donors. Quantitative real-time reverse transcript polymerase chain reactions were used to assess the correlation of the expression levels of TUG1 with clinical parameters of osteosarcoma patients. TUG1 was significantly overexpressed in the osteosarcoma tissues compared with matched adjacent normal tissues ( P  < 0.01) and was closely correlated with tumor size, post-operative chemotherapy, and Enneking surgical stage. Upregulation of TUG1 strongly correlated with poor prognosis and was an independent prognostic indicator for overall survival (HR = 2.78, 95% CI = 1.29–6.00, P  = 0.009) and progression-free survival (HR = 1.81, 95% CI = 1.01–3.54, P  = 0.037). Our constructed nomogram containing TUG1 had more predictive accuracy than that without TUG1 (c-index 0.807 versus 0.776, respectively). In addition, for plasma samples, TUG1 expression levels were obviously decreased in post-operative patients (mean ΔC T −4.98 ± 0.22) compared with pre-operation patients (mean ΔC T −6.09 ± 0.74), and the changes of TUG1 expression levels were significantly associated with disease status. Receiver operating characteristic (ROC) curve analysis demonstrated that TUG1 could distinguish patients with osteosarcoma from healthy individuals compared with alkaline phosphatase (ALP) (the area under curve 0.849 versus 0.544). TUG1 was overexpressed in patients with osteosarcoma and strongly correlated with disease status. In addition, TUG1 may serve as a molecular indicator in maintaining surveillance and forecasting prognosis.
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18Disease-Free Survival
19Epigenetic inheritance
20Female
21Gene Expression
22Humans
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26Middle Aged
27Multivariate Analysis
28Original Article
29Osteosarcoma
30Osteosarcoma - blood
31Osteosarcoma - diagnosis
32Osteosarcoma - genetics
33Osteosarcoma - mortality
34Phosphatases
35Prognosis
36Proportional Hazards Models
37RNA
38RNA, Long Noncoding - blood
39RNA, Long Noncoding - genetics
40ROC Curve
41Taurine
42TUG1
43Up-Regulation
44Young Adult
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titleUpregulation of long non-coding RNA TUG1 correlates with poor prognosis and disease status in osteosarcoma
authorMa, Bing ; Li, Meng ; Zhang, Lei ; Huang, Ming ; Lei, Jun-Bin ; Fu, Gui-Hong ; Liu, Chun-Xin ; Lai, Qi-Wen ; Chen, Qing-Quan ; Wang, Yi-Lian
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abstractThe pathogenesis of osteosarcoma involves complex genetic and epigenetic factors. This study was to explore the impact and clinical relevance of long non-coding RNA (lncRNA), Taurine up-regulated gene 1 (TUG1) on patients with osteosarcoma. Seventy-six osteosarcoma tissues and matched adjacent normal tissues were included for analysis. The plasma samples were obtained from 29 patients with osteosarcoma at pre-operation and post-operation, 42 at newly diagnosed, 18 who experienced disease progression or relapse, 45 post-treatment, 36 patients with benign bone tumor, and 20 healthy donors. Quantitative real-time reverse transcript polymerase chain reactions were used to assess the correlation of the expression levels of TUG1 with clinical parameters of osteosarcoma patients. TUG1 was significantly overexpressed in the osteosarcoma tissues compared with matched adjacent normal tissues ( P  < 0.01) and was closely correlated with tumor size, post-operative chemotherapy, and Enneking surgical stage. Upregulation of TUG1 strongly correlated with poor prognosis and was an independent prognostic indicator for overall survival (HR = 2.78, 95% CI = 1.29–6.00, P  = 0.009) and progression-free survival (HR = 1.81, 95% CI = 1.01–3.54, P  = 0.037). Our constructed nomogram containing TUG1 had more predictive accuracy than that without TUG1 (c-index 0.807 versus 0.776, respectively). In addition, for plasma samples, TUG1 expression levels were obviously decreased in post-operative patients (mean ΔC T −4.98 ± 0.22) compared with pre-operation patients (mean ΔC T −6.09 ± 0.74), and the changes of TUG1 expression levels were significantly associated with disease status. Receiver operating characteristic (ROC) curve analysis demonstrated that TUG1 could distinguish patients with osteosarcoma from healthy individuals compared with alkaline phosphatase (ALP) (the area under curve 0.849 versus 0.544). TUG1 was overexpressed in patients with osteosarcoma and strongly correlated with disease status. In addition, TUG1 may serve as a molecular indicator in maintaining surveillance and forecasting prognosis.
copDordrecht
pubSpringer Netherlands
pmid26499949
doi10.1007/s13277-015-4301-6