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Association between Change in Body Composition and Change in Inflammatory Markers: An 11-Year Follow-Up in the Whitehall II Study

Context: Obesity is associated with low-grade inflammation, but the long-term effects of weight change on inflammation are unknown. Objective: The aim was to examine the association of change in weight, body mass index (BMI), and waist circumference with change in C-reactive protein (CRP) and IL-6 a... Full description

Journal Title: The journal of clinical endocrinology and metabolism 2010-12, Vol.95 (12), p.5370-5374
Main Author: Fransson, Eleonor I
Other Authors: Batty, G. David , Tabák, Adam G , Brunner, Eric J , Kumari, Meena , Shipley, Martin J , Singh-Manoux, Archana , Kivimäki, Mika
Format: Electronic Article Electronic Article
Language: English
Subjects:
Adult
Biological and medical sciences
Biomarkers - blood
Body Composition - physiology
Body Height
Body Mass Index
Body Weight
C-Reactive Protein - metabolism
Clinical Medicine
Cohort Studies
Dermatologi och venerologi, klinisk genetik, invärtesmedicin
Dermatology and venerology,clinical genetics, internal medicine
education
Endocrinology
Endocrinology and Diabetes
Endocrinopathies
Endokrinologi
Endokrinologi och diabetes
Feeding. Feeding behavior
Female
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
Humans
Inflammation - blood
Inflammation - epidemiology
Inflammation - metabolism
Interleukin-5 - blood
Internal medicine
Invärtesmedicin
Klinisk medicin
Life Sciences
Male
Medical and Health Sciences
Medical sciences
MEDICIN
Medicin och hälsovetenskap
MEDICINE
metabolic diseases
Middle Aged
nutritional
Obesity - blood
Obesity - complications
Obesity - metabolism
Original
Original Article
Santé publique et épidémiologie
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: endocrinology
Waist Circumference
Weight Gain - physiology
Publisher: Bethesda, MD: Endocrine Society
ID: ISSN: 0021-972X
Zum Text:
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recordid: cdi_swepub_primary_oai_DiVA_org_hj_12818
title: Association between Change in Body Composition and Change in Inflammatory Markers: An 11-Year Follow-Up in the Whitehall II Study
format: Article
creator:
  • Fransson, Eleonor I
  • Batty, G. David
  • Tabák, Adam G
  • Brunner, Eric J
  • Kumari, Meena
  • Shipley, Martin J
  • Singh-Manoux, Archana
  • Kivimäki, Mika
subjects:
  • Adult
  • Biological and medical sciences
  • Biomarkers - blood
  • Body Composition - physiology
  • Body Height
  • Body Mass Index
  • Body Weight
  • C-Reactive Protein - metabolism
  • Clinical Medicine
  • Cohort Studies
  • Dermatologi och venerologi, klinisk genetik, invärtesmedicin
  • Dermatology and venerology,clinical genetics, internal medicine
  • education
  • Endocrinology
  • Endocrinology and Diabetes
  • Endocrinopathies
  • Endokrinologi
  • Endokrinologi och diabetes
  • Feeding. Feeding behavior
  • Female
  • Follow-Up Studies
  • Fundamental and applied biological sciences. Psychology
  • Humans
  • Inflammation - blood
  • Inflammation - epidemiology
  • Inflammation - metabolism
  • Interleukin-5 - blood
  • Internal medicine
  • Invärtesmedicin
  • Klinisk medicin
  • Life Sciences
  • Male
  • Medical and Health Sciences
  • Medical sciences
  • MEDICIN
  • Medicin och hälsovetenskap
  • MEDICINE
  • metabolic diseases
  • Middle Aged
  • nutritional
  • Obesity - blood
  • Obesity - complications
  • Obesity - metabolism
  • Original
  • Original Article
  • Santé publique et épidémiologie
  • Vertebrates: anatomy and physiology, studies on body, several organs or systems
  • Vertebrates: endocrinology
  • Waist Circumference
  • Weight Gain - physiology
ispartof: The journal of clinical endocrinology and metabolism, 2010-12, Vol.95 (12), p.5370-5374
description: Context: Obesity is associated with low-grade inflammation, but the long-term effects of weight change on inflammation are unknown. Objective: The aim was to examine the association of change in weight, body mass index (BMI), and waist circumference with change in C-reactive protein (CRP) and IL-6 and to assess whether this association is modified by baseline obesity status. Design and Setting: The design was a prospective cohort study among civil servants (the Whitehall II Study, UK). We used data from two clinical screenings carried out in 1991–1993 and 2002–2004 (mean follow-up, 11.3 yr). Participants: We studied 2496 men and 1026 women [mean age, 49.4 (sd = 6.0) yr at baseline] with measurements on inflammatory markers and anthropometry at both baseline and follow-up. Main Outcome Measures: We measured change in serum CRP and IL-6 during follow-up. Results: The mean increases in CRP and IL-6 were 0.08 [95% confidence interval (CI), 0.07–0.09] mg/liter and 0.04 (95% CI, 0.03–0.05) pg/ml per 1-kg increase in body weight during follow-up. Study members with a BMI less than 25 kg/m2 at baseline had an average increase in CRP of 0.06 (95% CI, 0.05–0.08) mg/liter per 1-kg increase in body weight, whereas the increase in those who were overweight (25 ≤ BMI < 30 kg/m2) and obese (BMI ≥30 kg/m2) was greater: 0.08 (95% CI, 0.06–0.09) mg/liter and 0.11 (95% CI, 0.07–0.14) mg/liter, respectively (P value for interaction = 0.002). Similar patterns were observed for changes in BMI and waist circumference. Conclusions: Those who were overweight or obese at baseline had a greater absolute increase in CRP per unit increase in weight, BMI, and waist circumference than people who were normal weight. An increase in weight, body mass index and waist circumference was associated with an increase in inflammatory markers over 11 years, especially among overweight and obese people.
language: eng
source:
identifier: ISSN: 0021-972X
fulltext: no_fulltext
issn:
  • 0021-972X
  • 1945-7197
  • 1945-7197
url: Link


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titleAssociation between Change in Body Composition and Change in Inflammatory Markers: An 11-Year Follow-Up in the Whitehall II Study
creatorFransson, Eleonor I ; Batty, G. David ; Tabák, Adam G ; Brunner, Eric J ; Kumari, Meena ; Shipley, Martin J ; Singh-Manoux, Archana ; Kivimäki, Mika
creatorcontribFransson, Eleonor I ; Batty, G. David ; Tabák, Adam G ; Brunner, Eric J ; Kumari, Meena ; Shipley, Martin J ; Singh-Manoux, Archana ; Kivimäki, Mika
descriptionContext: Obesity is associated with low-grade inflammation, but the long-term effects of weight change on inflammation are unknown. Objective: The aim was to examine the association of change in weight, body mass index (BMI), and waist circumference with change in C-reactive protein (CRP) and IL-6 and to assess whether this association is modified by baseline obesity status. Design and Setting: The design was a prospective cohort study among civil servants (the Whitehall II Study, UK). We used data from two clinical screenings carried out in 1991–1993 and 2002–2004 (mean follow-up, 11.3 yr). Participants: We studied 2496 men and 1026 women [mean age, 49.4 (sd = 6.0) yr at baseline] with measurements on inflammatory markers and anthropometry at both baseline and follow-up. Main Outcome Measures: We measured change in serum CRP and IL-6 during follow-up. Results: The mean increases in CRP and IL-6 were 0.08 [95% confidence interval (CI), 0.07–0.09] mg/liter and 0.04 (95% CI, 0.03–0.05) pg/ml per 1-kg increase in body weight during follow-up. Study members with a BMI less than 25 kg/m2 at baseline had an average increase in CRP of 0.06 (95% CI, 0.05–0.08) mg/liter per 1-kg increase in body weight, whereas the increase in those who were overweight (25 ≤ BMI < 30 kg/m2) and obese (BMI ≥30 kg/m2) was greater: 0.08 (95% CI, 0.06–0.09) mg/liter and 0.11 (95% CI, 0.07–0.14) mg/liter, respectively (P value for interaction = 0.002). Similar patterns were observed for changes in BMI and waist circumference. Conclusions: Those who were overweight or obese at baseline had a greater absolute increase in CRP per unit increase in weight, BMI, and waist circumference than people who were normal weight. An increase in weight, body mass index and waist circumference was associated with an increase in inflammatory markers over 11 years, especially among overweight and obese people.
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3DOI: 10.1210/jc.2010-0730
4PMID: 20719833
5CODEN: JCEMAZ
languageeng
publisherBethesda, MD: Endocrine Society
subjectAdult ; Biological and medical sciences ; Biomarkers - blood ; Body Composition - physiology ; Body Height ; Body Mass Index ; Body Weight ; C-Reactive Protein - metabolism ; Clinical Medicine ; Cohort Studies ; Dermatologi och venerologi, klinisk genetik, invärtesmedicin ; Dermatology and venerology,clinical genetics, internal medicine ; education ; Endocrinology ; Endocrinology and Diabetes ; Endocrinopathies ; Endokrinologi ; Endokrinologi och diabetes ; Feeding. Feeding behavior ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Humans ; Inflammation - blood ; Inflammation - epidemiology ; Inflammation - metabolism ; Interleukin-5 - blood ; Internal medicine ; Invärtesmedicin ; Klinisk medicin ; Life Sciences ; Male ; Medical and Health Sciences ; Medical sciences ; MEDICIN ; Medicin och hälsovetenskap ; MEDICINE ; metabolic diseases ; Middle Aged ; nutritional ; Obesity - blood ; Obesity - complications ; Obesity - metabolism ; Original ; Original Article ; Santé publique et épidémiologie ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology ; Waist Circumference ; Weight Gain - physiology
ispartofThe journal of clinical endocrinology and metabolism, 2010-12, Vol.95 (12), p.5370-5374
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0Fransson, Eleonor I
1Batty, G. David
2Tabák, Adam G
3Brunner, Eric J
4Kumari, Meena
5Shipley, Martin J
6Singh-Manoux, Archana
7Kivimäki, Mika
title
0Association between Change in Body Composition and Change in Inflammatory Markers: An 11-Year Follow-Up in the Whitehall II Study
1The journal of clinical endocrinology and metabolism
addtitleJ Clin Endocrinol Metab
descriptionContext: Obesity is associated with low-grade inflammation, but the long-term effects of weight change on inflammation are unknown. Objective: The aim was to examine the association of change in weight, body mass index (BMI), and waist circumference with change in C-reactive protein (CRP) and IL-6 and to assess whether this association is modified by baseline obesity status. Design and Setting: The design was a prospective cohort study among civil servants (the Whitehall II Study, UK). We used data from two clinical screenings carried out in 1991–1993 and 2002–2004 (mean follow-up, 11.3 yr). Participants: We studied 2496 men and 1026 women [mean age, 49.4 (sd = 6.0) yr at baseline] with measurements on inflammatory markers and anthropometry at both baseline and follow-up. Main Outcome Measures: We measured change in serum CRP and IL-6 during follow-up. Results: The mean increases in CRP and IL-6 were 0.08 [95% confidence interval (CI), 0.07–0.09] mg/liter and 0.04 (95% CI, 0.03–0.05) pg/ml per 1-kg increase in body weight during follow-up. Study members with a BMI less than 25 kg/m2 at baseline had an average increase in CRP of 0.06 (95% CI, 0.05–0.08) mg/liter per 1-kg increase in body weight, whereas the increase in those who were overweight (25 ≤ BMI < 30 kg/m2) and obese (BMI ≥30 kg/m2) was greater: 0.08 (95% CI, 0.06–0.09) mg/liter and 0.11 (95% CI, 0.07–0.14) mg/liter, respectively (P value for interaction = 0.002). Similar patterns were observed for changes in BMI and waist circumference. Conclusions: Those who were overweight or obese at baseline had a greater absolute increase in CRP per unit increase in weight, BMI, and waist circumference than people who were normal weight. An increase in weight, body mass index and waist circumference was associated with an increase in inflammatory markers over 11 years, especially among overweight and obese people.
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0Adult
1Biological and medical sciences
2Biomarkers - blood
3Body Composition - physiology
4Body Height
5Body Mass Index
6Body Weight
7C-Reactive Protein - metabolism
8Clinical Medicine
9Cohort Studies
10Dermatologi och venerologi, klinisk genetik, invärtesmedicin
11Dermatology and venerology,clinical genetics, internal medicine
12education
13Endocrinology
14Endocrinology and Diabetes
15Endocrinopathies
16Endokrinologi
17Endokrinologi och diabetes
18Feeding. Feeding behavior
19Female
20Follow-Up Studies
21Fundamental and applied biological sciences. Psychology
22Humans
23Inflammation - blood
24Inflammation - epidemiology
25Inflammation - metabolism
26Interleukin-5 - blood
27Internal medicine
28Invärtesmedicin
29Klinisk medicin
30Life Sciences
31Male
32Medical and Health Sciences
33Medical sciences
34MEDICIN
35Medicin och hälsovetenskap
36MEDICINE
37metabolic diseases
38Middle Aged
39nutritional
40Obesity - blood
41Obesity - complications
42Obesity - metabolism
43Original
44Original Article
45Santé publique et épidémiologie
46Vertebrates: anatomy and physiology, studies on body, several organs or systems
47Vertebrates: endocrinology
48Waist Circumference
49Weight Gain - physiology
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2Tabák, Adam G
3Brunner, Eric J
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titleAssociation between Change in Body Composition and Change in Inflammatory Markers: An 11-Year Follow-Up in the Whitehall II Study
authorFransson, Eleonor I ; Batty, G. David ; Tabák, Adam G ; Brunner, Eric J ; Kumari, Meena ; Shipley, Martin J ; Singh-Manoux, Archana ; Kivimäki, Mika
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1Biological and medical sciences
2Biomarkers - blood
3Body Composition - physiology
4Body Height
5Body Mass Index
6Body Weight
7C-Reactive Protein - metabolism
8Clinical Medicine
9Cohort Studies
10Dermatologi och venerologi, klinisk genetik, invärtesmedicin
11Dermatology and venerology,clinical genetics, internal medicine
12education
13Endocrinology
14Endocrinology and Diabetes
15Endocrinopathies
16Endokrinologi
17Endokrinologi och diabetes
18Feeding. Feeding behavior
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20Follow-Up Studies
21Fundamental and applied biological sciences. Psychology
22Humans
23Inflammation - blood
24Inflammation - epidemiology
25Inflammation - metabolism
26Interleukin-5 - blood
27Internal medicine
28Invärtesmedicin
29Klinisk medicin
30Life Sciences
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32Medical and Health Sciences
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35Medicin och hälsovetenskap
36MEDICINE
37metabolic diseases
38Middle Aged
39nutritional
40Obesity - blood
41Obesity - complications
42Obesity - metabolism
43Original
44Original Article
45Santé publique et épidémiologie
46Vertebrates: anatomy and physiology, studies on body, several organs or systems
47Vertebrates: endocrinology
48Waist Circumference
49Weight Gain - physiology
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1Batty, G. David
2Tabák, Adam G
3Brunner, Eric J
4Kumari, Meena
5Shipley, Martin J
6Singh-Manoux, Archana
7Kivimäki, Mika
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1Batty, G. David
2Tabák, Adam G
3Brunner, Eric J
4Kumari, Meena
5Shipley, Martin J
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7Kivimäki, Mika
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atitleAssociation between Change in Body Composition and Change in Inflammatory Markers: An 11-Year Follow-Up in the Whitehall II Study
jtitleThe journal of clinical endocrinology and metabolism
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date2010-12
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volume95
issue12
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pages5370-5374
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notesAddress all correspondence and requests for reprints to: Eleonor Fransson, Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, United Kingdom. E-mail: e.fransson@ucl.ac.uk.
abstractContext: Obesity is associated with low-grade inflammation, but the long-term effects of weight change on inflammation are unknown. Objective: The aim was to examine the association of change in weight, body mass index (BMI), and waist circumference with change in C-reactive protein (CRP) and IL-6 and to assess whether this association is modified by baseline obesity status. Design and Setting: The design was a prospective cohort study among civil servants (the Whitehall II Study, UK). We used data from two clinical screenings carried out in 1991–1993 and 2002–2004 (mean follow-up, 11.3 yr). Participants: We studied 2496 men and 1026 women [mean age, 49.4 (sd = 6.0) yr at baseline] with measurements on inflammatory markers and anthropometry at both baseline and follow-up. Main Outcome Measures: We measured change in serum CRP and IL-6 during follow-up. Results: The mean increases in CRP and IL-6 were 0.08 [95% confidence interval (CI), 0.07–0.09] mg/liter and 0.04 (95% CI, 0.03–0.05) pg/ml per 1-kg increase in body weight during follow-up. Study members with a BMI less than 25 kg/m2 at baseline had an average increase in CRP of 0.06 (95% CI, 0.05–0.08) mg/liter per 1-kg increase in body weight, whereas the increase in those who were overweight (25 ≤ BMI < 30 kg/m2) and obese (BMI ≥30 kg/m2) was greater: 0.08 (95% CI, 0.06–0.09) mg/liter and 0.11 (95% CI, 0.07–0.14) mg/liter, respectively (P value for interaction = 0.002). Similar patterns were observed for changes in BMI and waist circumference. Conclusions: Those who were overweight or obese at baseline had a greater absolute increase in CRP per unit increase in weight, BMI, and waist circumference than people who were normal weight. An increase in weight, body mass index and waist circumference was associated with an increase in inflammatory markers over 11 years, especially among overweight and obese people.
copBethesda, MD
pubEndocrine Society
pmid20719833
doi10.1210/jc.2010-0730
oafree_for_read