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Older age is a strong predictor for poor outcome in intracerebral haemorrhage: the INTERACT2 study

Global ageing contributes greatly to the burden of stroke. We investigated the influence of age on the baseline profile and on outcomes in acute intracerebral haemorrhage (ICH) among participants of the INTERACT2 study. INTERACT2 was an international, randomised controlled trial in 2839 patients wit... Full description

Journal Title: Age and ageing 2015, Vol.44 (3), p.422-427
Main Author: Rådholm, Karin
Other Authors: Arima, Hisatomi , Lindley, Richard I , Wang, Jiguang , Tzourio, Christophe , Robinson, Thompson , Heeley, Emma , Anderson, Craig S , Chalmers, John
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: England: Oxford University Press
ID: ISSN: 0002-0729
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title: Older age is a strong predictor for poor outcome in intracerebral haemorrhage: the INTERACT2 study
format: Article
creator:
  • Rådholm, Karin
  • Arima, Hisatomi
  • Lindley, Richard I
  • Wang, Jiguang
  • Tzourio, Christophe
  • Robinson, Thompson
  • Heeley, Emma
  • Anderson, Craig S
  • Chalmers, John
subjects:
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Allmänmedicin
  • Analysis
  • Blood pressure
  • cardiovascular diseases
  • Care and treatment
  • Cerebral Hemorrhage - epidemiology
  • Cerebral Hemorrhage - mortality
  • Cerebral Hemorrhage - therapy
  • Clinical Medicine
  • Clinical outcomes
  • Clinical trials
  • Confidence intervals
  • Disabled Persons - statistics & numerical data
  • Elderly
  • Female
  • General Practice
  • Health aspects
  • Hemorrhage
  • Humans
  • Intracerebral hemorrhage
  • Klinisk medicin
  • Male
  • Medical and Health Sciences
  • Medicin och hälsovetenskap
  • Middle Aged
  • Older people
  • Predictions
  • Quality of Life
  • Risk factors
  • Stroke
  • Stroke (Disease)
  • Stroke - epidemiology
  • Stroke - mortality
  • Stroke - therapy
  • Treatment Outcome
  • Usage
  • Young Adult
ispartof: Age and ageing, 2015, Vol.44 (3), p.422-427
description: Global ageing contributes greatly to the burden of stroke. We investigated the influence of age on the baseline profile and on outcomes in acute intracerebral haemorrhage (ICH) among participants of the INTERACT2 study. INTERACT2 was an international, randomised controlled trial in 2839 patients with spontaneous ICH within 6 h of onset and elevated systolic blood pressure (SBP; 150-220 mmHg) who were allocated to receive intensive (target SBP
language: eng
source:
identifier: ISSN: 0002-0729
fulltext: no_fulltext
issn:
  • 0002-0729
  • 1468-2834
  • 1468-2834
url: Link


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titleOlder age is a strong predictor for poor outcome in intracerebral haemorrhage: the INTERACT2 study
creatorRådholm, Karin ; Arima, Hisatomi ; Lindley, Richard I ; Wang, Jiguang ; Tzourio, Christophe ; Robinson, Thompson ; Heeley, Emma ; Anderson, Craig S ; Chalmers, John
creatorcontribRådholm, Karin ; Arima, Hisatomi ; Lindley, Richard I ; Wang, Jiguang ; Tzourio, Christophe ; Robinson, Thompson ; Heeley, Emma ; Anderson, Craig S ; Chalmers, John ; INTERACT2 Investigators ; for the INTERACT2 Investigators
descriptionGlobal ageing contributes greatly to the burden of stroke. We investigated the influence of age on the baseline profile and on outcomes in acute intracerebral haemorrhage (ICH) among participants of the INTERACT2 study. INTERACT2 was an international, randomised controlled trial in 2839 patients with spontaneous ICH within 6 h of onset and elevated systolic blood pressure (SBP; 150-220 mmHg) who were allocated to receive intensive (target SBP <140 mmHg within 1 h) or guideline-recommended (target SBP <180 mmHg) blood pressure lowering treatment. Stroke severity was assessed with the National Institutes of Health Stroke Scale. Poor outcome was defined as death or major disability ('dependency', modified Rankin Scale scores 3-6) at 90 days. Health-related quality of life (HRQoL) was assessed with the European Quality of Life-5 Dimensions (EQ-5D) questionnaire. Associations between age and outcomes were analysed in multivariable logistic regression models. Stroke severity increased in categories of older age (P-trend 0.002). Stroke patients over 75 years old were four times more likely to die or be disabled at 90 days than those <52 years when other confounders were accounted for (odds ratio 4.36, 95% confidence interval 3.12-6.08). Older age was also associated with decreasing HRQoL, across mobility, self-care, usual activities and depression (all P-trend <0.001), and pain or discomfort (P-trend 0.022). In the INTERACT2 cohort, older people had more severe ICH and worse outcomes (death, major disability and HRQoL). These data will help guide clinicians manage older people with haemorrhagic stroke. http://www.clinicaltrials.gov (NCT00716079).
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subjectAdult ; Age Factors ; Aged ; Aged, 80 and over ; Allmänmedicin ; Analysis ; Blood pressure ; cardiovascular diseases ; Care and treatment ; Cerebral Hemorrhage - epidemiology ; Cerebral Hemorrhage - mortality ; Cerebral Hemorrhage - therapy ; Clinical Medicine ; Clinical outcomes ; Clinical trials ; Confidence intervals ; Disabled Persons - statistics & numerical data ; Elderly ; Female ; General Practice ; Health aspects ; Hemorrhage ; Humans ; Intracerebral hemorrhage ; Klinisk medicin ; Male ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Middle Aged ; Older people ; Predictions ; Quality of Life ; Risk factors ; Stroke ; Stroke (Disease) ; Stroke - epidemiology ; Stroke - mortality ; Stroke - therapy ; Treatment Outcome ; Usage ; Young Adult
ispartofAge and ageing, 2015, Vol.44 (3), p.422-427
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1Arima, Hisatomi
2Lindley, Richard I
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7Anderson, Craig S
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descriptionGlobal ageing contributes greatly to the burden of stroke. We investigated the influence of age on the baseline profile and on outcomes in acute intracerebral haemorrhage (ICH) among participants of the INTERACT2 study. INTERACT2 was an international, randomised controlled trial in 2839 patients with spontaneous ICH within 6 h of onset and elevated systolic blood pressure (SBP; 150-220 mmHg) who were allocated to receive intensive (target SBP <140 mmHg within 1 h) or guideline-recommended (target SBP <180 mmHg) blood pressure lowering treatment. Stroke severity was assessed with the National Institutes of Health Stroke Scale. Poor outcome was defined as death or major disability ('dependency', modified Rankin Scale scores 3-6) at 90 days. Health-related quality of life (HRQoL) was assessed with the European Quality of Life-5 Dimensions (EQ-5D) questionnaire. Associations between age and outcomes were analysed in multivariable logistic regression models. Stroke severity increased in categories of older age (P-trend 0.002). Stroke patients over 75 years old were four times more likely to die or be disabled at 90 days than those <52 years when other confounders were accounted for (odds ratio 4.36, 95% confidence interval 3.12-6.08). Older age was also associated with decreasing HRQoL, across mobility, self-care, usual activities and depression (all P-trend <0.001), and pain or discomfort (P-trend 0.022). In the INTERACT2 cohort, older people had more severe ICH and worse outcomes (death, major disability and HRQoL). These data will help guide clinicians manage older people with haemorrhagic stroke. http://www.clinicaltrials.gov (NCT00716079).
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titleOlder age is a strong predictor for poor outcome in intracerebral haemorrhage: the INTERACT2 study
authorRådholm, Karin ; Arima, Hisatomi ; Lindley, Richard I ; Wang, Jiguang ; Tzourio, Christophe ; Robinson, Thompson ; Heeley, Emma ; Anderson, Craig S ; Chalmers, John
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abstractGlobal ageing contributes greatly to the burden of stroke. We investigated the influence of age on the baseline profile and on outcomes in acute intracerebral haemorrhage (ICH) among participants of the INTERACT2 study. INTERACT2 was an international, randomised controlled trial in 2839 patients with spontaneous ICH within 6 h of onset and elevated systolic blood pressure (SBP; 150-220 mmHg) who were allocated to receive intensive (target SBP <140 mmHg within 1 h) or guideline-recommended (target SBP <180 mmHg) blood pressure lowering treatment. Stroke severity was assessed with the National Institutes of Health Stroke Scale. Poor outcome was defined as death or major disability ('dependency', modified Rankin Scale scores 3-6) at 90 days. Health-related quality of life (HRQoL) was assessed with the European Quality of Life-5 Dimensions (EQ-5D) questionnaire. Associations between age and outcomes were analysed in multivariable logistic regression models. Stroke severity increased in categories of older age (P-trend 0.002). Stroke patients over 75 years old were four times more likely to die or be disabled at 90 days than those <52 years when other confounders were accounted for (odds ratio 4.36, 95% confidence interval 3.12-6.08). Older age was also associated with decreasing HRQoL, across mobility, self-care, usual activities and depression (all P-trend <0.001), and pain or discomfort (P-trend 0.022). In the INTERACT2 cohort, older people had more severe ICH and worse outcomes (death, major disability and HRQoL). These data will help guide clinicians manage older people with haemorrhagic stroke. http://www.clinicaltrials.gov (NCT00716079).
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