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Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease

Aims/hypothesis Ceramides and IL-6 have a role in immune–inflammatory responses and cardiovascular diseases, and are suggested to be involved in insulin and glucose metabolism. We sought to assess the associations of circulating levels of IL-6, TNF-α and high-sensitivity C reactive protein (hsCRP),... Full description

Journal Title: Diabetologia 2009-08-11, Vol.52 (12), p.2612-2615
Main Author: de Mello, V. D. F
Other Authors: Lankinen, M , Schwab, U , Kolehmainen, M , Lehto, S , Seppänen-Laakso, T , Orešič, M , Pulkkinen, L , Uusitupa, M , Erkkilä, A. T
Format: Electronic Article Electronic Article
Language: English
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Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 0012-186X
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title: Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease
format: Article
creator:
  • de Mello, V. D. F
  • Lankinen, M
  • Schwab, U
  • Kolehmainen, M
  • Lehto, S
  • Seppänen-Laakso, T
  • Orešič, M
  • Pulkkinen, L
  • Uusitupa, M
  • Erkkilä, A. T
subjects:
  • 0 Not Open Access
  • A1 Refereed journal article
  • Analysis
  • Basic Medicine
  • Biological and medical sciences
  • C-Reactive Protein - metabolism
  • Cardiac patients
  • Cardiology. Vascular system
  • Cardiovascular disease
  • Care and treatment
  • Ceramides
  • Ceramides - blood
  • Coronary Disease - blood
  • Coronary Disease - physiopathology
  • Coronary heart disease
  • Cross-Sectional Studies
  • Dextrose
  • Diabetes. Impaired glucose tolerance
  • Diacylglycerols
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Fysiologi
  • Glucose
  • Glucose metabolism
  • Heart
  • Human Physiology
  • Humans
  • IL-6
  • Inflammation
  • Inflammation - blood
  • Insulin resistance
  • Interleukin-6 - blood
  • Internal Medicine
  • Ischemia - blood
  • Ischemia - physiopathology
  • Lipidomics
  • Lipids - blood
  • Liquid chromatography
  • Medical and Health Sciences
  • Medical sciences
  • Medicin och hälsovetenskap
  • Medicine
  • Medicine & Public Health
  • Medicinska och farmaceutiska grundvetenskaper
  • Metabolic Diseases
  • Metabolites
  • minedu
  • Myocardial Infarction - blood
  • Myocardial Infarction - physiopathology
  • openaccess
  • Physiology
  • Plant lipids
  • Public health
  • publicationtypes
  • Short Communication
  • Tumor Necrosis Factor-alpha - blood
  • Universities and colleges
  • virta
ispartof: Diabetologia, 2009-08-11, Vol.52 (12), p.2612-2615
description: Aims/hypothesis Ceramides and IL-6 have a role in immune–inflammatory responses and cardiovascular diseases, and are suggested to be involved in insulin and glucose metabolism. We sought to assess the associations of circulating levels of IL-6, TNF-α and high-sensitivity C reactive protein (hsCRP), which are inflammatory markers related to insulin resistance (IR), with the plasma lipid metabolites ceramides and diacylglycerols (DAG) in patients with CHD. Methods Cross-sectional analyses were carried out on data from 33 patients with CHD. Serum levels of the inflammatory markers and plasma lipid metabolites (lipidomics approach performed by ultra-performance liquid chromatography coupled to electrospray ionisation MS) were measured at the same time point as insulin resistance (IR) (HOMA-IR index). Results Serum circulating levels of IL-6 were strongly correlated with plasma ceramide concentrations ( r  = 0.59, p  
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
  • 1432-0428
url: Link


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titleLink between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease
creatorde Mello, V. D. F ; Lankinen, M ; Schwab, U ; Kolehmainen, M ; Lehto, S ; Seppänen-Laakso, T ; Orešič, M ; Pulkkinen, L ; Uusitupa, M ; Erkkilä, A. T
creatorcontribde Mello, V. D. F ; Lankinen, M ; Schwab, U ; Kolehmainen, M ; Lehto, S ; Seppänen-Laakso, T ; Orešič, M ; Pulkkinen, L ; Uusitupa, M ; Erkkilä, A. T
descriptionAims/hypothesis Ceramides and IL-6 have a role in immune–inflammatory responses and cardiovascular diseases, and are suggested to be involved in insulin and glucose metabolism. We sought to assess the associations of circulating levels of IL-6, TNF-α and high-sensitivity C reactive protein (hsCRP), which are inflammatory markers related to insulin resistance (IR), with the plasma lipid metabolites ceramides and diacylglycerols (DAG) in patients with CHD. Methods Cross-sectional analyses were carried out on data from 33 patients with CHD. Serum levels of the inflammatory markers and plasma lipid metabolites (lipidomics approach performed by ultra-performance liquid chromatography coupled to electrospray ionisation MS) were measured at the same time point as insulin resistance (IR) (HOMA-IR index). Results Serum circulating levels of IL-6 were strongly correlated with plasma ceramide concentrations ( r  = 0.59, p  < 0.001). Adjustments for serum TNF-α or hsCRP levels, smoking, BMI, age, sex or HOMA-IR did not change the results ( p  < 0.001). After adjustments for the effect of serum inflammatory markers (TNF-α or hsCRP), HOMA-IR and BMI the correlation between plasma DAG and serum IL-6 ( r  = 0.33) was also significant ( p  < 0.03). In a linear regression model, circulating levels of both ceramides and TNF-α had a significant independent influence on circulating levels of IL-6, altogether accounting for 41% of its variation ( p  < 0.001). Conclusions/interpretation Our results strongly suggest that the link between ceramides, IR and inflammation is related to the inflammatory marker IL-6. Ceramides may contribute to the induction of inflammation involved in IR states that frequently coexist with CHD. Trial registration: ClinicalTrials.gov NCT00720655 Funding: The study was supported by the Finnish Cultural Foundation, the North-Savo Regional Fund of the Finnish Cultural Foundation, the Yrjö Jahnsson Foundation, the Sigrid Juselius Foundation, the Juho Vainio Foundation, the Kuopio University Hospital (grant 510RA07), the Academy of Finland (Projects 117844 and 118590) and by the Nordic Centre of Excellence on ‘Systems biology in controlled dietary interventions and cohort studies’ (SYSDIET), Project 070014.
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languageeng
publisherBerlin/Heidelberg: Springer-Verlag
subject0 Not Open Access ; A1 Refereed journal article ; Analysis ; Basic Medicine ; Biological and medical sciences ; C-Reactive Protein - metabolism ; Cardiac patients ; Cardiology. Vascular system ; Cardiovascular disease ; Care and treatment ; Ceramides ; Ceramides - blood ; Coronary Disease - blood ; Coronary Disease - physiopathology ; Coronary heart disease ; Cross-Sectional Studies ; Dextrose ; Diabetes. Impaired glucose tolerance ; Diacylglycerols ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fysiologi ; Glucose ; Glucose metabolism ; Heart ; Human Physiology ; Humans ; IL-6 ; Inflammation ; Inflammation - blood ; Insulin resistance ; Interleukin-6 - blood ; Internal Medicine ; Ischemia - blood ; Ischemia - physiopathology ; Lipidomics ; Lipids - blood ; Liquid chromatography ; Medical and Health Sciences ; Medical sciences ; Medicin och hälsovetenskap ; Medicine ; Medicine & Public Health ; Medicinska och farmaceutiska grundvetenskaper ; Metabolic Diseases ; Metabolites ; minedu ; Myocardial Infarction - blood ; Myocardial Infarction - physiopathology ; openaccess ; Physiology ; Plant lipids ; Public health ; publicationtypes ; Short Communication ; Tumor Necrosis Factor-alpha - blood ; Universities and colleges ; virta
ispartofDiabetologia, 2009-08-11, Vol.52 (12), p.2612-2615
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0de Mello, V. D. F
1Lankinen, M
2Schwab, U
3Kolehmainen, M
4Lehto, S
5Seppänen-Laakso, T
6Orešič, M
7Pulkkinen, L
8Uusitupa, M
9Erkkilä, A. T
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0Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease
1Diabetologia
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descriptionAims/hypothesis Ceramides and IL-6 have a role in immune–inflammatory responses and cardiovascular diseases, and are suggested to be involved in insulin and glucose metabolism. We sought to assess the associations of circulating levels of IL-6, TNF-α and high-sensitivity C reactive protein (hsCRP), which are inflammatory markers related to insulin resistance (IR), with the plasma lipid metabolites ceramides and diacylglycerols (DAG) in patients with CHD. Methods Cross-sectional analyses were carried out on data from 33 patients with CHD. Serum levels of the inflammatory markers and plasma lipid metabolites (lipidomics approach performed by ultra-performance liquid chromatography coupled to electrospray ionisation MS) were measured at the same time point as insulin resistance (IR) (HOMA-IR index). Results Serum circulating levels of IL-6 were strongly correlated with plasma ceramide concentrations ( r  = 0.59, p  < 0.001). Adjustments for serum TNF-α or hsCRP levels, smoking, BMI, age, sex or HOMA-IR did not change the results ( p  < 0.001). After adjustments for the effect of serum inflammatory markers (TNF-α or hsCRP), HOMA-IR and BMI the correlation between plasma DAG and serum IL-6 ( r  = 0.33) was also significant ( p  < 0.03). In a linear regression model, circulating levels of both ceramides and TNF-α had a significant independent influence on circulating levels of IL-6, altogether accounting for 41% of its variation ( p  < 0.001). Conclusions/interpretation Our results strongly suggest that the link between ceramides, IR and inflammation is related to the inflammatory marker IL-6. Ceramides may contribute to the induction of inflammation involved in IR states that frequently coexist with CHD. Trial registration: ClinicalTrials.gov NCT00720655 Funding: The study was supported by the Finnish Cultural Foundation, the North-Savo Regional Fund of the Finnish Cultural Foundation, the Yrjö Jahnsson Foundation, the Sigrid Juselius Foundation, the Juho Vainio Foundation, the Kuopio University Hospital (grant 510RA07), the Academy of Finland (Projects 117844 and 118590) and by the Nordic Centre of Excellence on ‘Systems biology in controlled dietary interventions and cohort studies’ (SYSDIET), Project 070014.
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12Coronary Disease - blood
13Coronary Disease - physiopathology
14Coronary heart disease
15Cross-Sectional Studies
16Dextrose
17Diabetes. Impaired glucose tolerance
18Diacylglycerols
19Endocrine pancreas. Apud cells (diseases)
20Endocrinopathies
21Etiopathogenesis. Screening. Investigations. Target tissue resistance
22Fysiologi
23Glucose
24Glucose metabolism
25Heart
26Human Physiology
27Humans
28IL-6
29Inflammation
30Inflammation - blood
31Insulin resistance
32Interleukin-6 - blood
33Internal Medicine
34Ischemia - blood
35Ischemia - physiopathology
36Lipidomics
37Lipids - blood
38Liquid chromatography
39Medical and Health Sciences
40Medical sciences
41Medicin och hälsovetenskap
42Medicine
43Medicine & Public Health
44Medicinska och farmaceutiska grundvetenskaper
45Metabolic Diseases
46Metabolites
47minedu
48Myocardial Infarction - blood
49Myocardial Infarction - physiopathology
50openaccess
51Physiology
52Plant lipids
53Public health
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titleLink between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease
authorde Mello, V. D. F ; Lankinen, M ; Schwab, U ; Kolehmainen, M ; Lehto, S ; Seppänen-Laakso, T ; Orešič, M ; Pulkkinen, L ; Uusitupa, M ; Erkkilä, A. T
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1A1 Refereed journal article
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3Basic Medicine
4Biological and medical sciences
5C-Reactive Protein - metabolism
6Cardiac patients
7Cardiology. Vascular system
8Cardiovascular disease
9Care and treatment
10Ceramides
11Ceramides - blood
12Coronary Disease - blood
13Coronary Disease - physiopathology
14Coronary heart disease
15Cross-Sectional Studies
16Dextrose
17Diabetes. Impaired glucose tolerance
18Diacylglycerols
19Endocrine pancreas. Apud cells (diseases)
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atitleLink between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease
jtitleDiabetologia
stitleDiabetologia
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date2009-08-11
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volume52
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pages2612-2615
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abstractAims/hypothesis Ceramides and IL-6 have a role in immune–inflammatory responses and cardiovascular diseases, and are suggested to be involved in insulin and glucose metabolism. We sought to assess the associations of circulating levels of IL-6, TNF-α and high-sensitivity C reactive protein (hsCRP), which are inflammatory markers related to insulin resistance (IR), with the plasma lipid metabolites ceramides and diacylglycerols (DAG) in patients with CHD. Methods Cross-sectional analyses were carried out on data from 33 patients with CHD. Serum levels of the inflammatory markers and plasma lipid metabolites (lipidomics approach performed by ultra-performance liquid chromatography coupled to electrospray ionisation MS) were measured at the same time point as insulin resistance (IR) (HOMA-IR index). Results Serum circulating levels of IL-6 were strongly correlated with plasma ceramide concentrations ( r  = 0.59, p  < 0.001). Adjustments for serum TNF-α or hsCRP levels, smoking, BMI, age, sex or HOMA-IR did not change the results ( p  < 0.001). After adjustments for the effect of serum inflammatory markers (TNF-α or hsCRP), HOMA-IR and BMI the correlation between plasma DAG and serum IL-6 ( r  = 0.33) was also significant ( p  < 0.03). In a linear regression model, circulating levels of both ceramides and TNF-α had a significant independent influence on circulating levels of IL-6, altogether accounting for 41% of its variation ( p  < 0.001). Conclusions/interpretation Our results strongly suggest that the link between ceramides, IR and inflammation is related to the inflammatory marker IL-6. Ceramides may contribute to the induction of inflammation involved in IR states that frequently coexist with CHD. Trial registration: ClinicalTrials.gov NCT00720655 Funding: The study was supported by the Finnish Cultural Foundation, the North-Savo Regional Fund of the Finnish Cultural Foundation, the Yrjö Jahnsson Foundation, the Sigrid Juselius Foundation, the Juho Vainio Foundation, the Kuopio University Hospital (grant 510RA07), the Academy of Finland (Projects 117844 and 118590) and by the Nordic Centre of Excellence on ‘Systems biology in controlled dietary interventions and cohort studies’ (SYSDIET), Project 070014.
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