A heterogeneous response of liver and skeletal muscle fat to the combination of a Paleolithic diet and exercise in obese individuals with type 2 diabetes: a randomised controlled trial
| Journal Title: | Diabetologia 2018-04-26, Vol.61 (7), p.1548-1559 |
| Main Author: | Otten, Julia |
| Other Authors: | Stomby, Andreas , Waling, Maria , Isaksson, Andreas , Söderström, Ingegerd , Ryberg, Mats , Svensson, Michael , Hauksson, Jón , Olsson, Tommy |
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 Electronic Article
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| Language: |
English |
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| Publisher: | Berlin/Heidelberg: Springer Berlin Heidelberg |
| ID: | ISSN: 0012-186X |
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| recordid: | cdi_swepub_primary_oai_DiVA_org_umu_150764 |
| title: | A heterogeneous response of liver and skeletal muscle fat to the combination of a Paleolithic diet and exercise in obese individuals with type 2 diabetes: a randomised controlled trial |
| format: | Article |
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| ispartof: | Diabetologia, 2018-04-26, Vol.61 (7), p.1548-1559 |
| description: | Aims/hypothesis The aim of the study was to investigate ectopic fat deposition and insulin sensitivity, in a parallel single-blinded randomised controlled trial, comparing Paleolithic diet alone with the combination of Paleolithic diet and exercise in individuals with type 2 diabetes. Methods Thirty-two individuals with type 2 diabetes with BMI 25–40 kg/m 2 and 30–70 years of age followed a Paleolithic diet ad libitum for 12 weeks. In addition, study participants were randomised by computer program to either supervised combined exercise training (PD-EX group) or standard care exercise recommendations (PD group). Staff performing examinations and assessing outcomes were blinded to group assignment. Thirteen participants were analysed in each group: hepatic and peripheral insulin sensitivity were measured using the hyperinsulinaemic–euglycaemic clamp technique combined with [6,6- 2 H 2 ]glucose infusion, and liver fat was assessed by proton magnetic resonance spectroscopy; both analyses were secondary endpoints. Intramyocellular lipid (IMCL) content was measured by magnetic resonance spectroscopy as a secondary analysis. All examinations were performed at Umeå University Hospital, Umeå, Sweden. Results Both study groups showed a median body weight loss of 7 kg. Fat mass decreased by 5.7 kg in the PD group and by 6.5 kg in the PD-EX group. Maximum oxygen uptake increased in the PD-EX group only. Liver fat showed a consistent reduction (74% decrease) in the PD group, while the response in the PD-EX group was heterogeneous ( p |
| language: | eng |
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| identifier: | ISSN: 0012-186X |
| fulltext: | no_fulltext |
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| url: | Link |
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