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Vascular Risk Factors and Dementia: 40-Year Follow-Up of a Population-Based Cohort

Aims: Our aim was to evaluate the longitudinal associations of individual and multiple vascular risk factors with the subsequent development of dementia and Alzheimer’s disease (AD). Methods: The Uppsala Longitudinal Study of Adult Men started in 1970 when the 2,268 participants were 50 years old. B... Full description

Journal Title: Dementia and geriatric cognitive disorders 2011-08, Vol.31 (6), p.460-466
Main Author: Rönnemaa, Elina
Other Authors: Zethelius, Björn , Lannfelt, Lars , Kilander, Lena
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Basel, Switzerland: Karger
ID: ISSN: 1420-8008
Zum Text:
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recordid: cdi_swepub_primary_oai_DiVA_org_uu_158428
title: Vascular Risk Factors and Dementia: 40-Year Follow-Up of a Population-Based Cohort
format: Article
creator:
  • Rönnemaa, Elina
  • Zethelius, Björn
  • Lannfelt, Lars
  • Kilander, Lena
subjects:
  • Aged
  • Alzheimer's disease
  • Apolipoprotein epsilon 4
  • Apolipoproteins E - genetics
  • Biological and medical sciences
  • Blood Glucose - metabolism
  • Blood Pressure
  • Body Mass Index
  • Cardiovascular Diseases - complications
  • Cardiovascular Diseases - epidemiology
  • Cholesterol - blood
  • Cohort Studies
  • Data Interpretation, Statistical
  • Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
  • Dementia
  • Dementia - complications
  • Dementia - epidemiology
  • Dementia - genetics
  • Epidemiology
  • Glucose
  • Humans
  • Hypertension
  • Lipids
  • Male
  • Medical and Health Sciences
  • Medical sciences
  • MEDICIN
  • Medicin och hälsovetenskap
  • MEDICINE
  • Middle Aged
  • Neurology
  • Obesity
  • Original Research Article
  • Population
  • Proportional Hazards Models
  • Risk Factors
  • Smoking
  • Smoking - adverse effects
  • Sweden - epidemiology
  • Vascular dementia
  • Vascular diseases and vascular malformations of the nervous system
ispartof: Dementia and geriatric cognitive disorders, 2011-08, Vol.31 (6), p.460-466
description: Aims: Our aim was to evaluate the longitudinal associations of individual and multiple vascular risk factors with the subsequent development of dementia and Alzheimer’s disease (AD). Methods: The Uppsala Longitudinal Study of Adult Men started in 1970 when the 2,268 participants were 50 years old. Baseline investigations included determinations of blood pressure, fasting glucose, cholesterol, BMI and smoking status. Over a maximum follow-up of 40 years, 349 participants were diagnosed with dementia, out of which 127 had AD. Analyses were repeated using a re-examination of the cohort at 70 years of age as a baseline. Results: No associations between vascular risk factors and AD were found. For all-type dementia, the association between high systolic blood pressure and dementia was the most consistent. High fasting glucose was associated with increased risk of all-type dementia only when measured at 70 years. Individuals with both an APOE Ε4 allele and vascular risk factors had the greatest dementia risk. Conclusion: Vascular risk factors influence the future risk of dementia, in particular vascular and mixed-type rather than AD. The impact of vascular risk factors on dementia in a longitudinal study depends on the age at baseline and the length of follow-up.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1420-8008
fulltext: fulltext
issn:
  • 1420-8008
  • 1421-9824
  • 1421-9824
url: Link


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descriptionAims: Our aim was to evaluate the longitudinal associations of individual and multiple vascular risk factors with the subsequent development of dementia and Alzheimer’s disease (AD). Methods: The Uppsala Longitudinal Study of Adult Men started in 1970 when the 2,268 participants were 50 years old. Baseline investigations included determinations of blood pressure, fasting glucose, cholesterol, BMI and smoking status. Over a maximum follow-up of 40 years, 349 participants were diagnosed with dementia, out of which 127 had AD. Analyses were repeated using a re-examination of the cohort at 70 years of age as a baseline. Results: No associations between vascular risk factors and AD were found. For all-type dementia, the association between high systolic blood pressure and dementia was the most consistent. High fasting glucose was associated with increased risk of all-type dementia only when measured at 70 years. Individuals with both an APOE Ε4 allele and vascular risk factors had the greatest dementia risk. Conclusion: Vascular risk factors influence the future risk of dementia, in particular vascular and mixed-type rather than AD. The impact of vascular risk factors on dementia in a longitudinal study depends on the age at baseline and the length of follow-up.
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subjectAged ; Alzheimer's disease ; Apolipoprotein epsilon 4 ; Apolipoproteins E - genetics ; Biological and medical sciences ; Blood Glucose - metabolism ; Blood Pressure ; Body Mass Index ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - epidemiology ; Cholesterol - blood ; Cohort Studies ; Data Interpretation, Statistical ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dementia ; Dementia - complications ; Dementia - epidemiology ; Dementia - genetics ; Epidemiology ; Glucose ; Humans ; Hypertension ; Lipids ; Male ; Medical and Health Sciences ; Medical sciences ; MEDICIN ; Medicin och hälsovetenskap ; MEDICINE ; Middle Aged ; Neurology ; Obesity ; Original Research Article ; Population ; Proportional Hazards Models ; Risk Factors ; Smoking ; Smoking - adverse effects ; Sweden - epidemiology ; Vascular dementia ; Vascular diseases and vascular malformations of the nervous system
ispartofDementia and geriatric cognitive disorders, 2011-08, Vol.31 (6), p.460-466
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descriptionAims: Our aim was to evaluate the longitudinal associations of individual and multiple vascular risk factors with the subsequent development of dementia and Alzheimer’s disease (AD). Methods: The Uppsala Longitudinal Study of Adult Men started in 1970 when the 2,268 participants were 50 years old. Baseline investigations included determinations of blood pressure, fasting glucose, cholesterol, BMI and smoking status. Over a maximum follow-up of 40 years, 349 participants were diagnosed with dementia, out of which 127 had AD. Analyses were repeated using a re-examination of the cohort at 70 years of age as a baseline. Results: No associations between vascular risk factors and AD were found. For all-type dementia, the association between high systolic blood pressure and dementia was the most consistent. High fasting glucose was associated with increased risk of all-type dementia only when measured at 70 years. Individuals with both an APOE Ε4 allele and vascular risk factors had the greatest dementia risk. Conclusion: Vascular risk factors influence the future risk of dementia, in particular vascular and mixed-type rather than AD. The impact of vascular risk factors on dementia in a longitudinal study depends on the age at baseline and the length of follow-up.
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6Blood Pressure
7Body Mass Index
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9Cardiovascular Diseases - epidemiology
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12Data Interpretation, Statistical
13Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
14Dementia
15Dementia - complications
16Dementia - epidemiology
17Dementia - genetics
18Epidemiology
19Glucose
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21Hypertension
22Lipids
23Male
24Medical and Health Sciences
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29Middle Aged
30Neurology
31Obesity
32Original Research Article
33Population
34Proportional Hazards Models
35Risk Factors
36Smoking
37Smoking - adverse effects
38Sweden - epidemiology
39Vascular dementia
40Vascular diseases and vascular malformations of the nervous system
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31Obesity
32Original Research Article
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34Proportional Hazards Models
35Risk Factors
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38Sweden - epidemiology
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40Vascular diseases and vascular malformations of the nervous system
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volume31
issue6
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abstractAims: Our aim was to evaluate the longitudinal associations of individual and multiple vascular risk factors with the subsequent development of dementia and Alzheimer’s disease (AD). Methods: The Uppsala Longitudinal Study of Adult Men started in 1970 when the 2,268 participants were 50 years old. Baseline investigations included determinations of blood pressure, fasting glucose, cholesterol, BMI and smoking status. Over a maximum follow-up of 40 years, 349 participants were diagnosed with dementia, out of which 127 had AD. Analyses were repeated using a re-examination of the cohort at 70 years of age as a baseline. Results: No associations between vascular risk factors and AD were found. For all-type dementia, the association between high systolic blood pressure and dementia was the most consistent. High fasting glucose was associated with increased risk of all-type dementia only when measured at 70 years. Individuals with both an APOE Ε4 allele and vascular risk factors had the greatest dementia risk. Conclusion: Vascular risk factors influence the future risk of dementia, in particular vascular and mixed-type rather than AD. The impact of vascular risk factors on dementia in a longitudinal study depends on the age at baseline and the length of follow-up.
copBasel, Switzerland
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pmid21791923
doi10.1159/000330020
tpages7