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Asthma control in Europe: A real-world evaluation based on an international population-based study

Background Epidemiologic evidence related to asthma control in patients from the general population is scanty. Objectives We sought to assess asthma control in several European centers according to the Global Initiative for Asthma (GINA) guidelines and to investigate its determinants. Methods In the... Full description

Journal Title: Journal of allergy and clinical immunology 2007, Vol.120 (6), p.1360-1367
Main Author: Cazzoletti, Lucia, MSc
Other Authors: Marcon, Alessandro, MSc , Janson, Christer, MD , Corsico, Angelo, MD, PhD , Jarvis, Deborah, FFPHM , Pin, Isabelle, MD , Accordini, Simone, MSc , Almar, Enrique, MD , Bugiani, Massimiliano, MD , Carolei, Adriana, MSc , Cerveri, Isa, MD , Duran-Tauleria, Enric, BS, MB , Gislason, David, MD , Gulsvik, Amund, MD, PhD , Jõgi, Rain, PhD , Marinoni, Alessandra, PhD , Martínez-Moratalla, Jesús, MD , Vermeire, Paul, MD , de Marco, Roberto, PhD
Format: Electronic Article Electronic Article
Language: English
Subjects:
Age
Quelle: Alma/SFX Local Collection
Publisher: New York, NY: Mosby, Inc
ID: ISSN: 0091-6749
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recordid: cdi_swepub_primary_oai_DiVA_org_uu_16769
title: Asthma control in Europe: A real-world evaluation based on an international population-based study
format: Article
creator:
  • Cazzoletti, Lucia, MSc
  • Marcon, Alessandro, MSc
  • Janson, Christer, MD
  • Corsico, Angelo, MD, PhD
  • Jarvis, Deborah, FFPHM
  • Pin, Isabelle, MD
  • Accordini, Simone, MSc
  • Almar, Enrique, MD
  • Bugiani, Massimiliano, MD
  • Carolei, Adriana, MSc
  • Cerveri, Isa, MD
  • Duran-Tauleria, Enric, BS, MB
  • Gislason, David, MD
  • Gulsvik, Amund, MD, PhD
  • Jõgi, Rain, PhD
  • Marinoni, Alessandra, PhD
  • Martínez-Moratalla, Jesús, MD
  • Vermeire, Paul, MD
  • de Marco, Roberto, PhD
subjects:
  • Abridged Index Medicus
  • Adult
  • Age
  • Allergens
  • Allergens - adverse effects
  • Allergies
  • Allergy and Immunology
  • Animals
  • Asthma
  • Asthma - diagnosis
  • Asthma - drug therapy
  • Asthma - epidemiology
  • Asthma control
  • Asthma/diagnosis/drug therapy/epidemiology
  • Biological and medical sciences
  • Body mass index
  • Cladosporium
  • Cladosporium species
  • Cross
  • Cross-Sectional Studies
  • cross-sectional study
  • Disease Management
  • European Community Respiratory Health Survey
  • European Union
  • Family physicians
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Fundamental immunology
  • Global Initiative for Asthma
  • Humans
  • inhaled corticosteroids
  • Life Sciences
  • Male
  • Medical and Health Sciences
  • Medical sciences
  • MEDICIN
  • Medicin och hälsovetenskap
  • MEDICINE
  • omized Controlled Trials as Topic
  • Population
  • population-based study
  • Practice Guidelines as Topic
  • Practice Guidelines as Topic - standards
  • predictors of uncontrolled asthma
  • Prevalence
  • Questionnaires
  • Randomized Controlled Trials as Topic
  • respiratory tract diseases
  • Risk Factors
  • Santé publique et épidémiologie
  • Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
  • Sectional Studies
  • Severity of Illness Index
  • Surveys and Questionnaires
  • total IgE
ispartof: Journal of allergy and clinical immunology, 2007, Vol.120 (6), p.1360-1367
description: Background Epidemiologic evidence related to asthma control in patients from the general population is scanty. Objectives We sought to assess asthma control in several European centers according to the Global Initiative for Asthma (GINA) guidelines and to investigate its determinants. Methods In the European Community Respiratory Health Survey II (1999-2002), 1241 adults with asthma were identified and classified into inhaled corticosteroid (ICS) users and non-ICS users in the last year. Control was assessed in both groups by using the GINA proposal (controlled, partly controlled, and uncontrolled asthma), and it was related to potential determinants. Results Only 15% (95% CI, 12% to 19%) of subjects who had used ICSs in the last year and 45% (95% CI, 41% to 50%) of non-ICS users had their asthma under control; individuals with uncontrolled asthma accounted for 49% (95% CI, 44% to 53%) and 18% (95% CI, 15% to 21%), respectively. Among ICS users, the prevalence of uncontrolled asthma showed great variability across Europe, ranging from 20% (95% CI, 7% to 41%; Iceland) to 67% (95% CI, 35% to 90%; Italy). Overweight status, chronic cough and phlegm, and sensitization to Cladosporium species were associated with poor control in ICS users. About 65% and 87% of ICS users with uncontrolled and partly controlled asthma, respectively, were on a medication regimen that was less than recommended by the GINA guidelines. Conclusion Six of 7 European asthmatic adults using ICSs in the last year did not achieve good disease control. The large majority of subjects with poorly controlled asthma were using antiasthma drugs in a suboptimal way. A wide variability in asthma control emerged across Europe. Clinical implications Greater attention should be paid to asthma management and to the implementation of the GINA guidelines.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0091-6749
fulltext: fulltext
issn:
  • 0091-6749
  • 1097-6825
  • 1097-6825
url: Link


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titleAsthma control in Europe: A real-world evaluation based on an international population-based study
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creatorCazzoletti, Lucia, MSc ; Marcon, Alessandro, MSc ; Janson, Christer, MD ; Corsico, Angelo, MD, PhD ; Jarvis, Deborah, FFPHM ; Pin, Isabelle, MD ; Accordini, Simone, MSc ; Almar, Enrique, MD ; Bugiani, Massimiliano, MD ; Carolei, Adriana, MSc ; Cerveri, Isa, MD ; Duran-Tauleria, Enric, BS, MB ; Gislason, David, MD ; Gulsvik, Amund, MD, PhD ; Jõgi, Rain, PhD ; Marinoni, Alessandra, PhD ; Martínez-Moratalla, Jesús, MD ; Vermeire, Paul, MD ; de Marco, Roberto, PhD
creatorcontribCazzoletti, Lucia, MSc ; Marcon, Alessandro, MSc ; Janson, Christer, MD ; Corsico, Angelo, MD, PhD ; Jarvis, Deborah, FFPHM ; Pin, Isabelle, MD ; Accordini, Simone, MSc ; Almar, Enrique, MD ; Bugiani, Massimiliano, MD ; Carolei, Adriana, MSc ; Cerveri, Isa, MD ; Duran-Tauleria, Enric, BS, MB ; Gislason, David, MD ; Gulsvik, Amund, MD, PhD ; Jõgi, Rain, PhD ; Marinoni, Alessandra, PhD ; Martínez-Moratalla, Jesús, MD ; Vermeire, Paul, MD ; de Marco, Roberto, PhD ; Therapy and Health Economics Group of the European Community Respiratory Health Survey
descriptionBackground Epidemiologic evidence related to asthma control in patients from the general population is scanty. Objectives We sought to assess asthma control in several European centers according to the Global Initiative for Asthma (GINA) guidelines and to investigate its determinants. Methods In the European Community Respiratory Health Survey II (1999-2002), 1241 adults with asthma were identified and classified into inhaled corticosteroid (ICS) users and non-ICS users in the last year. Control was assessed in both groups by using the GINA proposal (controlled, partly controlled, and uncontrolled asthma), and it was related to potential determinants. Results Only 15% (95% CI, 12% to 19%) of subjects who had used ICSs in the last year and 45% (95% CI, 41% to 50%) of non-ICS users had their asthma under control; individuals with uncontrolled asthma accounted for 49% (95% CI, 44% to 53%) and 18% (95% CI, 15% to 21%), respectively. Among ICS users, the prevalence of uncontrolled asthma showed great variability across Europe, ranging from 20% (95% CI, 7% to 41%; Iceland) to 67% (95% CI, 35% to 90%; Italy). Overweight status, chronic cough and phlegm, and sensitization to Cladosporium species were associated with poor control in ICS users. About 65% and 87% of ICS users with uncontrolled and partly controlled asthma, respectively, were on a medication regimen that was less than recommended by the GINA guidelines. Conclusion Six of 7 European asthmatic adults using ICSs in the last year did not achieve good disease control. The large majority of subjects with poorly controlled asthma were using antiasthma drugs in a suboptimal way. A wide variability in asthma control emerged across Europe. Clinical implications Greater attention should be paid to asthma management and to the implementation of the GINA guidelines.
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subjectAbridged Index Medicus ; Adult ; Age ; Allergens ; Allergens - adverse effects ; Allergies ; Allergy and Immunology ; Animals ; Asthma ; Asthma - diagnosis ; Asthma - drug therapy ; Asthma - epidemiology ; Asthma control ; Asthma/diagnosis/drug therapy/epidemiology ; Biological and medical sciences ; Body mass index ; Cladosporium ; Cladosporium species ; Cross ; Cross-Sectional Studies ; cross-sectional study ; Disease Management ; European Community Respiratory Health Survey ; European Union ; Family physicians ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Global Initiative for Asthma ; Humans ; inhaled corticosteroids ; Life Sciences ; Male ; Medical and Health Sciences ; Medical sciences ; MEDICIN ; Medicin och hälsovetenskap ; MEDICINE ; omized Controlled Trials as Topic ; Population ; population-based study ; Practice Guidelines as Topic ; Practice Guidelines as Topic - standards ; predictors of uncontrolled asthma ; Prevalence ; Questionnaires ; Randomized Controlled Trials as Topic ; respiratory tract diseases ; Risk Factors ; Santé publique et épidémiologie ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Sectional Studies ; Severity of Illness Index ; Surveys and Questionnaires ; total IgE
ispartofJournal of allergy and clinical immunology, 2007, Vol.120 (6), p.1360-1367
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0American Academy of Allergy, Asthma & Immunology
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0Cazzoletti, Lucia, MSc
1Marcon, Alessandro, MSc
2Janson, Christer, MD
3Corsico, Angelo, MD, PhD
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5Pin, Isabelle, MD
6Accordini, Simone, MSc
7Almar, Enrique, MD
8Bugiani, Massimiliano, MD
9Carolei, Adriana, MSc
10Cerveri, Isa, MD
11Duran-Tauleria, Enric, BS, MB
12Gislason, David, MD
13Gulsvik, Amund, MD, PhD
14Jõgi, Rain, PhD
15Marinoni, Alessandra, PhD
16Martínez-Moratalla, Jesús, MD
17Vermeire, Paul, MD
18de Marco, Roberto, PhD
19Therapy and Health Economics Group of the European Community Respiratory Health Survey
title
0Asthma control in Europe: A real-world evaluation based on an international population-based study
1Journal of allergy and clinical immunology
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descriptionBackground Epidemiologic evidence related to asthma control in patients from the general population is scanty. Objectives We sought to assess asthma control in several European centers according to the Global Initiative for Asthma (GINA) guidelines and to investigate its determinants. Methods In the European Community Respiratory Health Survey II (1999-2002), 1241 adults with asthma were identified and classified into inhaled corticosteroid (ICS) users and non-ICS users in the last year. Control was assessed in both groups by using the GINA proposal (controlled, partly controlled, and uncontrolled asthma), and it was related to potential determinants. Results Only 15% (95% CI, 12% to 19%) of subjects who had used ICSs in the last year and 45% (95% CI, 41% to 50%) of non-ICS users had their asthma under control; individuals with uncontrolled asthma accounted for 49% (95% CI, 44% to 53%) and 18% (95% CI, 15% to 21%), respectively. Among ICS users, the prevalence of uncontrolled asthma showed great variability across Europe, ranging from 20% (95% CI, 7% to 41%; Iceland) to 67% (95% CI, 35% to 90%; Italy). Overweight status, chronic cough and phlegm, and sensitization to Cladosporium species were associated with poor control in ICS users. About 65% and 87% of ICS users with uncontrolled and partly controlled asthma, respectively, were on a medication regimen that was less than recommended by the GINA guidelines. Conclusion Six of 7 European asthmatic adults using ICSs in the last year did not achieve good disease control. The large majority of subjects with poorly controlled asthma were using antiasthma drugs in a suboptimal way. A wide variability in asthma control emerged across Europe. Clinical implications Greater attention should be paid to asthma management and to the implementation of the GINA guidelines.
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titleAsthma control in Europe: A real-world evaluation based on an international population-based study
authorCazzoletti, Lucia, MSc ; Marcon, Alessandro, MSc ; Janson, Christer, MD ; Corsico, Angelo, MD, PhD ; Jarvis, Deborah, FFPHM ; Pin, Isabelle, MD ; Accordini, Simone, MSc ; Almar, Enrique, MD ; Bugiani, Massimiliano, MD ; Carolei, Adriana, MSc ; Cerveri, Isa, MD ; Duran-Tauleria, Enric, BS, MB ; Gislason, David, MD ; Gulsvik, Amund, MD, PhD ; Jõgi, Rain, PhD ; Marinoni, Alessandra, PhD ; Martínez-Moratalla, Jesús, MD ; Vermeire, Paul, MD ; de Marco, Roberto, PhD
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9Asthma - diagnosis
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50Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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52Severity of Illness Index
53Surveys and Questionnaires
54total IgE
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abstractBackground Epidemiologic evidence related to asthma control in patients from the general population is scanty. Objectives We sought to assess asthma control in several European centers according to the Global Initiative for Asthma (GINA) guidelines and to investigate its determinants. Methods In the European Community Respiratory Health Survey II (1999-2002), 1241 adults with asthma were identified and classified into inhaled corticosteroid (ICS) users and non-ICS users in the last year. Control was assessed in both groups by using the GINA proposal (controlled, partly controlled, and uncontrolled asthma), and it was related to potential determinants. Results Only 15% (95% CI, 12% to 19%) of subjects who had used ICSs in the last year and 45% (95% CI, 41% to 50%) of non-ICS users had their asthma under control; individuals with uncontrolled asthma accounted for 49% (95% CI, 44% to 53%) and 18% (95% CI, 15% to 21%), respectively. Among ICS users, the prevalence of uncontrolled asthma showed great variability across Europe, ranging from 20% (95% CI, 7% to 41%; Iceland) to 67% (95% CI, 35% to 90%; Italy). Overweight status, chronic cough and phlegm, and sensitization to Cladosporium species were associated with poor control in ICS users. About 65% and 87% of ICS users with uncontrolled and partly controlled asthma, respectively, were on a medication regimen that was less than recommended by the GINA guidelines. Conclusion Six of 7 European asthmatic adults using ICSs in the last year did not achieve good disease control. The large majority of subjects with poorly controlled asthma were using antiasthma drugs in a suboptimal way. A wide variability in asthma control emerged across Europe. Clinical implications Greater attention should be paid to asthma management and to the implementation of the GINA guidelines.
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