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Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

ABSTRACTClinicopathologic correlation studies are critically important for the field of Alzheimer disease (AD) research. Studies on human subjects with autopsy confirmation entail numerous potential biases that affect both their general applicability and the validity of the correlations. Many source... Full description

Journal Title: Journal of neuropathology and experimental neurology 2012-05, Vol.71 (5), p.362-381
Main Author: Nelson, Peter T
Other Authors: Alafuzoff, Irina , Bigio, Eileen H , Bouras, Constantin , Braak, Heiko , Cairns, Nigel J , Castellani, Rudolph J , Crain, Barbara J , Davies, Peter , Tredici, Kelly Del , Duyckaerts, Charles , Frosch, Matthew P , Haroutunian, Vahram , Hof, Patrick R , Hulette, Christine M , Hyman, Bradley T , Iwatsubo, Takeshi , Jellinger, Kurt A , Jicha, Gregory A , Kövari, Enikö , Kukull, Walter A , Leverenz, James B , Love, Seth , Mackenzie, Ian R , Mann, David M , Masliah, Eliezer , McKee, Ann C , Montine, Thomas J , Morris, John C , Schneider, Julie A , Sonnen, Joshua A , Thal, Dietmar R , Trojanowski, John Q , Troncoso, Juan C , Wisniewski, Thomas , Woltjer, Randall L , Beach, Thomas G
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Hagerstown, MD: American Association of Neuropathologists, Inc
ID: ISSN: 0022-3069
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title: Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
format: Article
creator:
  • Nelson, Peter T
  • Alafuzoff, Irina
  • Bigio, Eileen H
  • Bouras, Constantin
  • Braak, Heiko
  • Cairns, Nigel J
  • Castellani, Rudolph J
  • Crain, Barbara J
  • Davies, Peter
  • Tredici, Kelly Del
  • Duyckaerts, Charles
  • Frosch, Matthew P
  • Haroutunian, Vahram
  • Hof, Patrick R
  • Hulette, Christine M
  • Hyman, Bradley T
  • Iwatsubo, Takeshi
  • Jellinger, Kurt A
  • Jicha, Gregory A
  • Kövari, Enikö
  • Kukull, Walter A
  • Leverenz, James B
  • Love, Seth
  • Mackenzie, Ian R
  • Mann, David M
  • Masliah, Eliezer
  • McKee, Ann C
  • Montine, Thomas J
  • Morris, John C
  • Schneider, Julie A
  • Sonnen, Joshua A
  • Thal, Dietmar R
  • Trojanowski, John Q
  • Troncoso, Juan C
  • Wisniewski, Thomas
  • Woltjer, Randall L
  • Beach, Thomas G
subjects:
  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer disease
  • Alzheimer Disease - complications
  • Alzheimer Disease - pathology
  • Amyloid
  • Amyloid beta-Peptides - metabolism
  • Article
  • Biological and medical sciences
  • Brain
  • Brain - metabolism
  • Brain - pathology
  • Cognition & reasoning
  • Cognition Disorders - etiology
  • Cognition Disorders - pathology
  • Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
  • Dementia
  • Disease
  • Epidemiology
  • Humans
  • MAPT
  • Medical and Health Sciences
  • Medical sciences
  • Medicin och hälsovetenskap
  • Neurofibrillary tangles
  • Neurofibrillary Tangles - pathology
  • Neurology
  • Neuropathology
  • Plaque, Amyloid - pathology
  • Statistics as Topic
  • Studies
ispartof: Journal of neuropathology and experimental neurology, 2012-05, Vol.71 (5), p.362-381
description: ABSTRACTClinicopathologic correlation studies are critically important for the field of Alzheimer disease (AD) research. Studies on human subjects with autopsy confirmation entail numerous potential biases that affect both their general applicability and the validity of the correlations. Many sources of data variability can weaken the apparent correlation between cognitive status and AD neuropathologic changes. Indeed, most persons in advanced old age have significant non-AD brain lesions that may alter cognition independently of AD. Worldwide research efforts have evaluated thousands of human subjects to assess the causes of cognitive impairment in the elderly, and these studies have been interpreted in different ways. We review the literature focusing on the correlation of AD neuropathologic changes (i.e. β-amyloid plaques and neurofibrillary tangles) with cognitive impairment. We discuss the various patterns of brain changes that have been observed in elderly individuals to provide a perspective forunderstanding AD clinicopathologic correlation and conclude that evidence from many independent research centers strongly supports the existence of a specific disease, as defined by the presence of Aβ plaques and neurofibrillary tangles. Although Aβ plaques may play a key role in AD pathogenesis, the severity of cognitive impairment correlates best with the burden of neocortical neurofibrillary tangles.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0022-3069
fulltext: fulltext
issn:
  • 0022-3069
  • 1554-6578
  • 1554-6578
url: Link


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titleCorrelation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
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creatorNelson, Peter T ; Alafuzoff, Irina ; Bigio, Eileen H ; Bouras, Constantin ; Braak, Heiko ; Cairns, Nigel J ; Castellani, Rudolph J ; Crain, Barbara J ; Davies, Peter ; Tredici, Kelly Del ; Duyckaerts, Charles ; Frosch, Matthew P ; Haroutunian, Vahram ; Hof, Patrick R ; Hulette, Christine M ; Hyman, Bradley T ; Iwatsubo, Takeshi ; Jellinger, Kurt A ; Jicha, Gregory A ; Kövari, Enikö ; Kukull, Walter A ; Leverenz, James B ; Love, Seth ; Mackenzie, Ian R ; Mann, David M ; Masliah, Eliezer ; McKee, Ann C ; Montine, Thomas J ; Morris, John C ; Schneider, Julie A ; Sonnen, Joshua A ; Thal, Dietmar R ; Trojanowski, John Q ; Troncoso, Juan C ; Wisniewski, Thomas ; Woltjer, Randall L ; Beach, Thomas G
creatorcontribNelson, Peter T ; Alafuzoff, Irina ; Bigio, Eileen H ; Bouras, Constantin ; Braak, Heiko ; Cairns, Nigel J ; Castellani, Rudolph J ; Crain, Barbara J ; Davies, Peter ; Tredici, Kelly Del ; Duyckaerts, Charles ; Frosch, Matthew P ; Haroutunian, Vahram ; Hof, Patrick R ; Hulette, Christine M ; Hyman, Bradley T ; Iwatsubo, Takeshi ; Jellinger, Kurt A ; Jicha, Gregory A ; Kövari, Enikö ; Kukull, Walter A ; Leverenz, James B ; Love, Seth ; Mackenzie, Ian R ; Mann, David M ; Masliah, Eliezer ; McKee, Ann C ; Montine, Thomas J ; Morris, John C ; Schneider, Julie A ; Sonnen, Joshua A ; Thal, Dietmar R ; Trojanowski, John Q ; Troncoso, Juan C ; Wisniewski, Thomas ; Woltjer, Randall L ; Beach, Thomas G
descriptionABSTRACTClinicopathologic correlation studies are critically important for the field of Alzheimer disease (AD) research. Studies on human subjects with autopsy confirmation entail numerous potential biases that affect both their general applicability and the validity of the correlations. Many sources of data variability can weaken the apparent correlation between cognitive status and AD neuropathologic changes. Indeed, most persons in advanced old age have significant non-AD brain lesions that may alter cognition independently of AD. Worldwide research efforts have evaluated thousands of human subjects to assess the causes of cognitive impairment in the elderly, and these studies have been interpreted in different ways. We review the literature focusing on the correlation of AD neuropathologic changes (i.e. β-amyloid plaques and neurofibrillary tangles) with cognitive impairment. We discuss the various patterns of brain changes that have been observed in elderly individuals to provide a perspective forunderstanding AD clinicopathologic correlation and conclude that evidence from many independent research centers strongly supports the existence of a specific disease, as defined by the presence of Aβ plaques and neurofibrillary tangles. Although Aβ plaques may play a key role in AD pathogenesis, the severity of cognitive impairment correlates best with the burden of neocortical neurofibrillary tangles.
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subjectAged ; Aged, 80 and over ; Aging ; Alzheimer disease ; Alzheimer Disease - complications ; Alzheimer Disease - pathology ; Amyloid ; Amyloid beta-Peptides - metabolism ; Article ; Biological and medical sciences ; Brain ; Brain - metabolism ; Brain - pathology ; Cognition & reasoning ; Cognition Disorders - etiology ; Cognition Disorders - pathology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dementia ; Disease ; Epidemiology ; Humans ; MAPT ; Medical and Health Sciences ; Medical sciences ; Medicin och hälsovetenskap ; Neurofibrillary tangles ; Neurofibrillary Tangles - pathology ; Neurology ; Neuropathology ; Plaque, Amyloid - pathology ; Statistics as Topic ; Studies
ispartofJournal of neuropathology and experimental neurology, 2012-05, Vol.71 (5), p.362-381
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1Alafuzoff, Irina
2Bigio, Eileen H
3Bouras, Constantin
4Braak, Heiko
5Cairns, Nigel J
6Castellani, Rudolph J
7Crain, Barbara J
8Davies, Peter
9Tredici, Kelly Del
10Duyckaerts, Charles
11Frosch, Matthew P
12Haroutunian, Vahram
13Hof, Patrick R
14Hulette, Christine M
15Hyman, Bradley T
16Iwatsubo, Takeshi
17Jellinger, Kurt A
18Jicha, Gregory A
19Kövari, Enikö
20Kukull, Walter A
21Leverenz, James B
22Love, Seth
23Mackenzie, Ian R
24Mann, David M
25Masliah, Eliezer
26McKee, Ann C
27Montine, Thomas J
28Morris, John C
29Schneider, Julie A
30Sonnen, Joshua A
31Thal, Dietmar R
32Trojanowski, John Q
33Troncoso, Juan C
34Wisniewski, Thomas
35Woltjer, Randall L
36Beach, Thomas G
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descriptionABSTRACTClinicopathologic correlation studies are critically important for the field of Alzheimer disease (AD) research. Studies on human subjects with autopsy confirmation entail numerous potential biases that affect both their general applicability and the validity of the correlations. Many sources of data variability can weaken the apparent correlation between cognitive status and AD neuropathologic changes. Indeed, most persons in advanced old age have significant non-AD brain lesions that may alter cognition independently of AD. Worldwide research efforts have evaluated thousands of human subjects to assess the causes of cognitive impairment in the elderly, and these studies have been interpreted in different ways. We review the literature focusing on the correlation of AD neuropathologic changes (i.e. β-amyloid plaques and neurofibrillary tangles) with cognitive impairment. We discuss the various patterns of brain changes that have been observed in elderly individuals to provide a perspective forunderstanding AD clinicopathologic correlation and conclude that evidence from many independent research centers strongly supports the existence of a specific disease, as defined by the presence of Aβ plaques and neurofibrillary tangles. Although Aβ plaques may play a key role in AD pathogenesis, the severity of cognitive impairment correlates best with the burden of neocortical neurofibrillary tangles.
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16Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
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18Disease
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20Humans
21MAPT
22Medical and Health Sciences
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26Neurofibrillary Tangles - pathology
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6Castellani, Rudolph J
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8Davies, Peter
9Tredici, Kelly Del
10Duyckaerts, Charles
11Frosch, Matthew P
12Haroutunian, Vahram
13Hof, Patrick R
14Hulette, Christine M
15Hyman, Bradley T
16Iwatsubo, Takeshi
17Jellinger, Kurt A
18Jicha, Gregory A
19Kövari, Enikö
20Kukull, Walter A
21Leverenz, James B
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24Mann, David M
25Masliah, Eliezer
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30Sonnen, Joshua A
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titleCorrelation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
authorNelson, Peter T ; Alafuzoff, Irina ; Bigio, Eileen H ; Bouras, Constantin ; Braak, Heiko ; Cairns, Nigel J ; Castellani, Rudolph J ; Crain, Barbara J ; Davies, Peter ; Tredici, Kelly Del ; Duyckaerts, Charles ; Frosch, Matthew P ; Haroutunian, Vahram ; Hof, Patrick R ; Hulette, Christine M ; Hyman, Bradley T ; Iwatsubo, Takeshi ; Jellinger, Kurt A ; Jicha, Gregory A ; Kövari, Enikö ; Kukull, Walter A ; Leverenz, James B ; Love, Seth ; Mackenzie, Ian R ; Mann, David M ; Masliah, Eliezer ; McKee, Ann C ; Montine, Thomas J ; Morris, John C ; Schneider, Julie A ; Sonnen, Joshua A ; Thal, Dietmar R ; Trojanowski, John Q ; Troncoso, Juan C ; Wisniewski, Thomas ; Woltjer, Randall L ; Beach, Thomas G
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29Plaque, Amyloid - pathology
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30Sonnen, Joshua A
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0Nelson, Peter T
1Alafuzoff, Irina
2Bigio, Eileen H
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6Castellani, Rudolph J
7Crain, Barbara J
8Davies, Peter
9Tredici, Kelly Del
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11Frosch, Matthew P
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16Iwatsubo, Takeshi
17Jellinger, Kurt A
18Jicha, Gregory A
19Kövari, Enikö
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21Leverenz, James B
22Love, Seth
23Mackenzie, Ian R
24Mann, David M
25Masliah, Eliezer
26McKee, Ann C
27Montine, Thomas J
28Morris, John C
29Schneider, Julie A
30Sonnen, Joshua A
31Thal, Dietmar R
32Trojanowski, John Q
33Troncoso, Juan C
34Wisniewski, Thomas
35Woltjer, Randall L
36Beach, Thomas G
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abstractABSTRACTClinicopathologic correlation studies are critically important for the field of Alzheimer disease (AD) research. Studies on human subjects with autopsy confirmation entail numerous potential biases that affect both their general applicability and the validity of the correlations. Many sources of data variability can weaken the apparent correlation between cognitive status and AD neuropathologic changes. Indeed, most persons in advanced old age have significant non-AD brain lesions that may alter cognition independently of AD. Worldwide research efforts have evaluated thousands of human subjects to assess the causes of cognitive impairment in the elderly, and these studies have been interpreted in different ways. We review the literature focusing on the correlation of AD neuropathologic changes (i.e. β-amyloid plaques and neurofibrillary tangles) with cognitive impairment. We discuss the various patterns of brain changes that have been observed in elderly individuals to provide a perspective forunderstanding AD clinicopathologic correlation and conclude that evidence from many independent research centers strongly supports the existence of a specific disease, as defined by the presence of Aβ plaques and neurofibrillary tangles. Although Aβ plaques may play a key role in AD pathogenesis, the severity of cognitive impairment correlates best with the burden of neocortical neurofibrillary tangles.
copHagerstown, MD
pubAmerican Association of Neuropathologists, Inc
pmid22487856
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