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Can an airway challenge test predict respiratory diseases? A population-based international study

Background Evidence on the longitudinal association of airway responsiveness with respiratory diseases is scarce. The best indicator of responsiveness is still undetermined. Objective We investigated the association of airway responsiveness with the incidence of asthma, chronic obstructive pulmonary... Full description

Journal Title: Journal of allergy and clinical immunology 2013, Vol.133 (1), p.104-110.e4
Main Author: Marcon, Alessandro, PhD
Other Authors: Cerveri, Isa, MD , Wjst, Matthias, MD , Antó, Josep, MD, PhD , Heinrich, Joachim, PhD , Janson, Christer, MD , Jarvis, Deborah, MBBS, MRCP, FFPH, MD , Leynaert, Bénédicte, PhD , Probst-Hensch, Nicole, Dr phil II, PhD, MPH , Svanes, Cecilie, MD, PhD , Toren, Kjell, MD , Burney, Peter, MD , de Marco, Roberto, PhD
Format: Electronic Article Electronic Article
Language: English
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Quelle: Alma/SFX Local Collection
Publisher: New York, NY: Elsevier Inc
ID: ISSN: 0091-6749
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recordid: cdi_swepub_primary_oai_gup_ub_gu_se_195138
title: Can an airway challenge test predict respiratory diseases? A population-based international study
format: Article
creator:
  • Marcon, Alessandro, PhD
  • Cerveri, Isa, MD
  • Wjst, Matthias, MD
  • Antó, Josep, MD, PhD
  • Heinrich, Joachim, PhD
  • Janson, Christer, MD
  • Jarvis, Deborah, MBBS, MRCP, FFPH, MD
  • Leynaert, Bénédicte, PhD
  • Probst-Hensch, Nicole, Dr phil II, PhD, MPH
  • Svanes, Cecilie, MD, PhD
  • Toren, Kjell, MD
  • Burney, Peter, MD
  • de Marco, Roberto, PhD
subjects:
  • Abridged Index Medicus
  • Adult
  • airflow obstruction
  • airway
  • Airway hyperresponsiveness
  • allergic rhinitis
  • Allergies
  • Allergy and Immunology
  • Analysis
  • article
  • Asthma
  • Asthma - diagnosis
  • Asthma - epidemiology
  • Biological and medical sciences
  • Body mass index
  • Bronchial Hyperreactivity - diagnosis
  • Bronchial Hyperreactivity - epidemiology
  • Bronchial Provocation Tests - methods
  • chronic obstructive lung disease
  • Chronic obstructive pulmonary disease
  • controlled study
  • diagnostic test accuracy study
  • dose response
  • Environmental health
  • European Community Respiratory Health Survey
  • Female
  • follow up
  • Follow-Up Studies
  • forced expiratory volume
  • forced vital capacity
  • Fundamental and applied biological sciences. Psychology
  • Fundamental immunology
  • health survey
  • human
  • Humans
  • Immunopathology
  • Incidence
  • inhalation test
  • lung function test
  • Lungmedicin och allergi
  • major clinical study
  • Male
  • Medical and Health Sciences
  • Medical research
  • Medical sciences
  • Medical tests
  • Medicin och hälsovetenskap
  • Medicine, Experimental
  • methacholine
  • Methacholine Chloride
  • Mortality
  • Multicenter Studies as Topic
  • multicenter study
  • Non tumoral diseases
  • Otorhinolaryngology. Stomatology
  • Poisson distribution
  • predictive value
  • Predictive Value of Tests
  • predictor variable
  • priority journal
  • Public health
  • Pulmonary Disease, Chronic Obstructive - diagnosis
  • Pulmonary Disease, Chronic Obstructive - epidemiology
  • Respiratory Medicine and Allergy
  • respiratory tract allergy
  • respiratory tract disease
  • Rhinitis, Allergic
  • Rhinitis, Allergic, Perennial - diagnosis
  • risk factor
  • Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
  • Sensitivity analysis
  • Sensitivity and Specificity
  • Spirometry
  • Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
  • young adult
ispartof: Journal of allergy and clinical immunology, 2013, Vol.133 (1), p.104-110.e4
description: Background Evidence on the longitudinal association of airway responsiveness with respiratory diseases is scarce. The best indicator of responsiveness is still undetermined. Objective We investigated the association of airway responsiveness with the incidence of asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis. Methods We studied 3851 subjects who underwent spirometry and methacholine challenge tests both at baseline (1991-1993), when they were 20 to 44 years old, and at follow-up (1999-2002) in the European Community Respiratory Health Survey. Airway responsiveness was defined based on the methacholine dose-response slope on both occasions. Incidence rate ratios for the association of airway responsiveness with disease occurrence were computed by using Poisson regression. Results With respect to reference (slope of the fourth quintile or greater), subjects with the greatest degree of airway responsiveness (slope less than the first quintile) showed the greatest risk of developing asthma, COPD, and allergic rhinitis (incidence rate ratios of 10.82, 5.53, and 4.84, respectively; all P  < .01). A low slope predicted disease occurrence, even in subjects who did not reach a 20% decrease in FEV1 at the cumulative dose of 1 mg of methacholine (PD20 >1 mg). A decrease in slope over time was an independent predictor of disease risk. Conclusion Airway responsiveness predicted new-onset asthma, COPD, and allergic rhinitis. Our study supports the use of a continuous noncensored indicator of airway responsiveness, such as the slope of the methacholine dose-response curve, in clinical practice and research because it showed clear advantages over PD20.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0091-6749
fulltext: fulltext
issn:
  • 0091-6749
  • 1097-6825
  • 1097-6825
url: Link


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titleCan an airway challenge test predict respiratory diseases? A population-based international study
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creatorMarcon, Alessandro, PhD ; Cerveri, Isa, MD ; Wjst, Matthias, MD ; Antó, Josep, MD, PhD ; Heinrich, Joachim, PhD ; Janson, Christer, MD ; Jarvis, Deborah, MBBS, MRCP, FFPH, MD ; Leynaert, Bénédicte, PhD ; Probst-Hensch, Nicole, Dr phil II, PhD, MPH ; Svanes, Cecilie, MD, PhD ; Toren, Kjell, MD ; Burney, Peter, MD ; de Marco, Roberto, PhD
creatorcontribMarcon, Alessandro, PhD ; Cerveri, Isa, MD ; Wjst, Matthias, MD ; Antó, Josep, MD, PhD ; Heinrich, Joachim, PhD ; Janson, Christer, MD ; Jarvis, Deborah, MBBS, MRCP, FFPH, MD ; Leynaert, Bénédicte, PhD ; Probst-Hensch, Nicole, Dr phil II, PhD, MPH ; Svanes, Cecilie, MD, PhD ; Toren, Kjell, MD ; Burney, Peter, MD ; de Marco, Roberto, PhD ; Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa ; Sahlgrenska akademin ; Göteborgs universitet ; Gothenburg University ; Institute of Medicine, School of Public Health and Community Medicine ; Sahlgrenska Academy
descriptionBackground Evidence on the longitudinal association of airway responsiveness with respiratory diseases is scarce. The best indicator of responsiveness is still undetermined. Objective We investigated the association of airway responsiveness with the incidence of asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis. Methods We studied 3851 subjects who underwent spirometry and methacholine challenge tests both at baseline (1991-1993), when they were 20 to 44 years old, and at follow-up (1999-2002) in the European Community Respiratory Health Survey. Airway responsiveness was defined based on the methacholine dose-response slope on both occasions. Incidence rate ratios for the association of airway responsiveness with disease occurrence were computed by using Poisson regression. Results With respect to reference (slope of the fourth quintile or greater), subjects with the greatest degree of airway responsiveness (slope less than the first quintile) showed the greatest risk of developing asthma, COPD, and allergic rhinitis (incidence rate ratios of 10.82, 5.53, and 4.84, respectively; all P  < .01). A low slope predicted disease occurrence, even in subjects who did not reach a 20% decrease in FEV1 at the cumulative dose of 1 mg of methacholine (PD20 >1 mg). A decrease in slope over time was an independent predictor of disease risk. Conclusion Airway responsiveness predicted new-onset asthma, COPD, and allergic rhinitis. Our study supports the use of a continuous noncensored indicator of airway responsiveness, such as the slope of the methacholine dose-response curve, in clinical practice and research because it showed clear advantages over PD20.
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publisherNew York, NY: Elsevier Inc
subjectAbridged Index Medicus ; Adult ; airflow obstruction ; airway ; Airway hyperresponsiveness ; allergic rhinitis ; Allergies ; Allergy and Immunology ; Analysis ; article ; Asthma ; Asthma - diagnosis ; Asthma - epidemiology ; Biological and medical sciences ; Body mass index ; Bronchial Hyperreactivity - diagnosis ; Bronchial Hyperreactivity - epidemiology ; Bronchial Provocation Tests - methods ; chronic obstructive lung disease ; Chronic obstructive pulmonary disease ; controlled study ; diagnostic test accuracy study ; dose response ; Environmental health ; European Community Respiratory Health Survey ; Female ; follow up ; Follow-Up Studies ; forced expiratory volume ; forced vital capacity ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; health survey ; human ; Humans ; Immunopathology ; Incidence ; inhalation test ; lung function test ; Lungmedicin och allergi ; major clinical study ; Male ; Medical and Health Sciences ; Medical research ; Medical sciences ; Medical tests ; Medicin och hälsovetenskap ; Medicine, Experimental ; methacholine ; Methacholine Chloride ; Mortality ; Multicenter Studies as Topic ; multicenter study ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Poisson distribution ; predictive value ; Predictive Value of Tests ; predictor variable ; priority journal ; Public health ; Pulmonary Disease, Chronic Obstructive - diagnosis ; Pulmonary Disease, Chronic Obstructive - epidemiology ; Respiratory Medicine and Allergy ; respiratory tract allergy ; respiratory tract disease ; Rhinitis, Allergic ; Rhinitis, Allergic, Perennial - diagnosis ; risk factor ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Sensitivity analysis ; Sensitivity and Specificity ; Spirometry ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology ; young adult
ispartofJournal of allergy and clinical immunology, 2013, Vol.133 (1), p.104-110.e4
rights
0American Academy of Allergy, Asthma & Immunology
12013 American Academy of Allergy, Asthma & Immunology
22015 INIST-CNRS
3Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
4COPYRIGHT 2014 Elsevier B.V.
5Copyright Elsevier Limited Jan 2014
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0Marcon, Alessandro, PhD
1Cerveri, Isa, MD
2Wjst, Matthias, MD
3Antó, Josep, MD, PhD
4Heinrich, Joachim, PhD
5Janson, Christer, MD
6Jarvis, Deborah, MBBS, MRCP, FFPH, MD
7Leynaert, Bénédicte, PhD
8Probst-Hensch, Nicole, Dr phil II, PhD, MPH
9Svanes, Cecilie, MD, PhD
10Toren, Kjell, MD
11Burney, Peter, MD
12de Marco, Roberto, PhD
13Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
14Sahlgrenska akademin
15Göteborgs universitet
16Gothenburg University
17Institute of Medicine, School of Public Health and Community Medicine
18Sahlgrenska Academy
title
0Can an airway challenge test predict respiratory diseases? A population-based international study
1Journal of allergy and clinical immunology
addtitleJ Allergy Clin Immunol
descriptionBackground Evidence on the longitudinal association of airway responsiveness with respiratory diseases is scarce. The best indicator of responsiveness is still undetermined. Objective We investigated the association of airway responsiveness with the incidence of asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis. Methods We studied 3851 subjects who underwent spirometry and methacholine challenge tests both at baseline (1991-1993), when they were 20 to 44 years old, and at follow-up (1999-2002) in the European Community Respiratory Health Survey. Airway responsiveness was defined based on the methacholine dose-response slope on both occasions. Incidence rate ratios for the association of airway responsiveness with disease occurrence were computed by using Poisson regression. Results With respect to reference (slope of the fourth quintile or greater), subjects with the greatest degree of airway responsiveness (slope less than the first quintile) showed the greatest risk of developing asthma, COPD, and allergic rhinitis (incidence rate ratios of 10.82, 5.53, and 4.84, respectively; all P  < .01). A low slope predicted disease occurrence, even in subjects who did not reach a 20% decrease in FEV1 at the cumulative dose of 1 mg of methacholine (PD20 >1 mg). A decrease in slope over time was an independent predictor of disease risk. Conclusion Airway responsiveness predicted new-onset asthma, COPD, and allergic rhinitis. Our study supports the use of a continuous noncensored indicator of airway responsiveness, such as the slope of the methacholine dose-response curve, in clinical practice and research because it showed clear advantages over PD20.
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2airflow obstruction
3airway
4Airway hyperresponsiveness
5allergic rhinitis
6Allergies
7Allergy and Immunology
8Analysis
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13Biological and medical sciences
14Body mass index
15Bronchial Hyperreactivity - diagnosis
16Bronchial Hyperreactivity - epidemiology
17Bronchial Provocation Tests - methods
18chronic obstructive lung disease
19Chronic obstructive pulmonary disease
20controlled study
21diagnostic test accuracy study
22dose response
23Environmental health
24European Community Respiratory Health Survey
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32health survey
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38lung function test
39Lungmedicin och allergi
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43Medical research
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46Medicin och hälsovetenskap
47Medicine, Experimental
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49Methacholine Chloride
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51Multicenter Studies as Topic
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53Non tumoral diseases
54Otorhinolaryngology. Stomatology
55Poisson distribution
56predictive value
57Predictive Value of Tests
58predictor variable
59priority journal
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61Pulmonary Disease, Chronic Obstructive - diagnosis
62Pulmonary Disease, Chronic Obstructive - epidemiology
63Respiratory Medicine and Allergy
64respiratory tract allergy
65respiratory tract disease
66Rhinitis, Allergic
67Rhinitis, Allergic, Perennial - diagnosis
68risk factor
69Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
70Sensitivity analysis
71Sensitivity and Specificity
72Spirometry
73Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
74young adult
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titleCan an airway challenge test predict respiratory diseases? A population-based international study
authorMarcon, Alessandro, PhD ; Cerveri, Isa, MD ; Wjst, Matthias, MD ; Antó, Josep, MD, PhD ; Heinrich, Joachim, PhD ; Janson, Christer, MD ; Jarvis, Deborah, MBBS, MRCP, FFPH, MD ; Leynaert, Bénédicte, PhD ; Probst-Hensch, Nicole, Dr phil II, PhD, MPH ; Svanes, Cecilie, MD, PhD ; Toren, Kjell, MD ; Burney, Peter, MD ; de Marco, Roberto, PhD
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7Allergy and Immunology
8Analysis
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10Asthma
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14Body mass index
15Bronchial Hyperreactivity - diagnosis
16Bronchial Hyperreactivity - epidemiology
17Bronchial Provocation Tests - methods
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21diagnostic test accuracy study
22dose response
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24European Community Respiratory Health Survey
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27Follow-Up Studies
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29forced vital capacity
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39Lungmedicin och allergi
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63Respiratory Medicine and Allergy
64respiratory tract allergy
65respiratory tract disease
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67Rhinitis, Allergic, Perennial - diagnosis
68risk factor
69Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
70Sensitivity analysis
71Sensitivity and Specificity
72Spirometry
73Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
74young adult
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abstractBackground Evidence on the longitudinal association of airway responsiveness with respiratory diseases is scarce. The best indicator of responsiveness is still undetermined. Objective We investigated the association of airway responsiveness with the incidence of asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis. Methods We studied 3851 subjects who underwent spirometry and methacholine challenge tests both at baseline (1991-1993), when they were 20 to 44 years old, and at follow-up (1999-2002) in the European Community Respiratory Health Survey. Airway responsiveness was defined based on the methacholine dose-response slope on both occasions. Incidence rate ratios for the association of airway responsiveness with disease occurrence were computed by using Poisson regression. Results With respect to reference (slope of the fourth quintile or greater), subjects with the greatest degree of airway responsiveness (slope less than the first quintile) showed the greatest risk of developing asthma, COPD, and allergic rhinitis (incidence rate ratios of 10.82, 5.53, and 4.84, respectively; all P  < .01). A low slope predicted disease occurrence, even in subjects who did not reach a 20% decrease in FEV1 at the cumulative dose of 1 mg of methacholine (PD20 >1 mg). A decrease in slope over time was an independent predictor of disease risk. Conclusion Airway responsiveness predicted new-onset asthma, COPD, and allergic rhinitis. Our study supports the use of a continuous noncensored indicator of airway responsiveness, such as the slope of the methacholine dose-response curve, in clinical practice and research because it showed clear advantages over PD20.
copNew York, NY
pubElsevier Inc
pmid23683511
doi10.1016/j.jaci.2013.03.040