schliessen

Filtern

 

Bibliotheken

Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study

Summary Background Reduced muscular strength, as measured by grip strength, has been associated with an increased risk of all-cause and cardiovascular mortality. Grip strength is appealing as a simple, quick, and inexpensive means of stratifying an individual's risk of cardiovascular death. However,... Full description

Journal Title: The Lancet (British edition) 2015, Vol.386 (9990), p.266-273
Main Author: Leong, Darryl P, Dr
Other Authors: Teo, Koon K, Prof , Rangarajan, Sumathy, MSc , Lopez-Jaramillo, Patricio, Prof , Avezum, Alvaro, MD , Orlandini, Andres, MD , Seron, Pamela, MSc , Ahmed, Suad H, PhD , Rosengren, Annika, Prof , Kelishadi, Roya, Prof , Rahman, Omar, Prof , Swaminathan, Sumathi, PhD , Iqbal, Romaina, PhD , Gupta, Rajeev, PhD , Lear, Scott A, Prof , Oguz, Aytekin, Prof , Yusoff, Khalid, Prof , Zatonska, Katarzyna, MD , Chifamba, Jephat, MPhil , Igumbor, Ehimario, Prof , Mohan, Viswanathan, PhD , Anjana, Ranjit Mohan, MD , Gu, Hongqiu, PhD , Li, Wei, Prof , Yusuf, Salim, Prof
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: Elsevier Ltd
ID: ISSN: 0140-6736
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_swepub_primary_oai_gup_ub_gu_se_220656
title: Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study
format: Article
creator:
  • Leong, Darryl P, Dr
  • Teo, Koon K, Prof
  • Rangarajan, Sumathy, MSc
  • Lopez-Jaramillo, Patricio, Prof
  • Avezum, Alvaro, MD
  • Orlandini, Andres, MD
  • Seron, Pamela, MSc
  • Ahmed, Suad H, PhD
  • Rosengren, Annika, Prof
  • Kelishadi, Roya, Prof
  • Rahman, Omar, Prof
  • Swaminathan, Sumathi, PhD
  • Iqbal, Romaina, PhD
  • Gupta, Rajeev, PhD
  • Lear, Scott A, Prof
  • Oguz, Aytekin, Prof
  • Yusoff, Khalid, Prof
  • Zatonska, Katarzyna, MD
  • Chifamba, Jephat, MPhil
  • Igumbor, Ehimario, Prof
  • Mohan, Viswanathan, PhD
  • Anjana, Ranjit Mohan, MD
  • Gu, Hongqiu, PhD
  • Li, Wei, Prof
  • Yusuf, Salim, Prof
subjects:
  • Abridged Index Medicus
  • Accidental Falls
  • Accidental Falls - statistics & numerical data
  • Adult
  • Age Factors
  • Aged
  • Analysis
  • Cardiovascular disease
  • Cardiovascular Diseases
  • Cardiovascular Diseases - mortality
  • Cardiovascular Diseases - physiopathology
  • Cause of Death
  • Chronic obstructive pulmonary disease
  • Clinical Medicine
  • Epidemiology
  • Exercise
  • Exercise - physiology
  • Female
  • Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
  • Global Health
  • Hand Strength
  • Hand Strength - physiology
  • Health risk assessment
  • Heart attacks
  • Hospitalization
  • Hospitalization - statistics & numerical data
  • Humans
  • Internal Medicine
  • Klinisk medicin
  • Male
  • Medical prognosis
  • Middle Aged
  • Mortality
  • Motor ability
  • Neoplasms
  • Neoplasms - mortality
  • Neoplasms - physiopathology
  • Physical fitness
  • physiology
  • physiopathology
  • Prognosis
  • Prospective Studies
  • Public Health, Global Health, Social Medicine and Epidemiology
  • Respiratory Tract Diseases
  • Respiratory Tract Diseases - mortality
  • Respiratory Tract Diseases - physiopathology
  • Risk Factors
  • Rural Health
  • Sex Factors
  • statistics & numerical data
  • Urban Health
ispartof: The Lancet (British edition), 2015, Vol.386 (9990), p.266-273
description: Summary Background Reduced muscular strength, as measured by grip strength, has been associated with an increased risk of all-cause and cardiovascular mortality. Grip strength is appealing as a simple, quick, and inexpensive means of stratifying an individual's risk of cardiovascular death. However, the prognostic value of grip strength with respect to the number and range of populations and confounders is unknown. The aim of this study was to assess the independent prognostic importance of grip strength measurement in socioculturally and economically diverse countries. Methods The Prospective Urban-Rural Epidemiology (PURE) study is a large, longitudinal population study done in 17 countries of varying incomes and sociocultural settings. We enrolled an unbiased sample of households, which were eligible if at least one household member was aged 35–70 years and if household members intended to stay at that address for another 4 years. Participants were assessed for grip strength, measured using a Jamar dynamometer. During a median follow-up of 4·0 years (IQR 2·9–5·1), we assessed all-cause mortality, cardiovascular mortality, non-cardiovascular mortality, myocardial infarction, stroke, diabetes, cancer, pneumonia, hospital admission for pneumonia or chronic obstructive pulmonary disease (COPD), hospital admission for any respiratory disease (including COPD, asthma, tuberculosis, and pneumonia), injury due to fall, and fracture. Study outcomes were adjudicated using source documents by a local investigator, and a subset were adjudicated centrally. Findings Between January, 2003, and December, 2009, a total of 142 861 participants were enrolled in the PURE study, of whom 139 691 with known vital status were included in the analysis. During a median follow-up of 4·0 years (IQR 2·9–5·1), 3379 (2%) of 139 691 participants died. After adjustment, the association between grip strength and each outcome, with the exceptions of cancer and hospital admission due to respiratory illness, was similar across country-income strata. Grip strength was inversely associated with all-cause mortality (hazard ratio per 5 kg reduction in grip strength 1·16, 95% CI 1·13–1·20; p
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
  • 1474-547X
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.8653574
LOCALfalse
PrimoNMBib
record
control
sourceidgale_swepu
recordidTN_cdi_swepub_primary_oai_gup_ub_gu_se_220656
sourceformatXML
sourcesystemPC
galeidA518037784
sourcerecordidA518037784
originalsourceidFETCH-LOGICAL-1829t-af8ff7831091114694e5ee5d76f7fc49cced0c99a35492024f3d002af9498d813
addsrcrecordideNqNkn9r1DAcxosobk5fglLwnxt4M0nTtJmgjHH-gIFjeuB_IZd-08vsJTVpT-7dm-707nYMNwotCZ_nk6R5kuQlRicYYfb2G8IUjVmRsRGmx4wgFEePkkNMCzrOafHjcXK4QQ6SZyFcR4QylD9NDkjOS4IZOkz0pXe1daEzKl3KpofU6bT2pk1D58HW3fw01cZWxtYh1d4t0m4OaQyFFlRnlpBO_Uza9Kr3skknralgYVzj6lU6upxeTY6jp69Wz5MnWjYBXvz9HiXTj5Pv55_HF18_fTk_uxjjkvBuLHWpdVFmGHGMMWWcQg6QVwXThVaUKwUVUpzLLKecIEJ1ViFEpOaUl1WJs6NkvPaG39D2M9F6s5B-JZw0ou5bEafqXgQQhCCWs8iP1nzr3a8eQicWJihoGmnB9UFgxktECoYG9es99Nr13sbTDBTjGKGMbalaNiCM1a7zUg1ScZbjEmVFUdL_UpRkZUaiLlInd1DxGf6xcha0ifO3tA8K7K7w6o6A2DW-2QFmfTAWQnwFU8-7UMs-hNsbeAC-u3y-xlXsU_CgN_eFkRhaLm5aLoYKC0zFTcsF2247XvECqk3qX60j8G5PrEwnO-NsPJ9p7tV_WKchNnVpwIugDNjYPeNj6UXlzL2G93sG1RhrlGx-wgrCtjgiEIHWksERKz8YWPYH_JYtKw
sourcetypeOpen Access Repository
isCDItrue
recordtypearticle
pqid1696910036
display
typearticle
titlePrognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study
sourceAlma/SFX Local Collection
creatorLeong, Darryl P, Dr ; Teo, Koon K, Prof ; Rangarajan, Sumathy, MSc ; Lopez-Jaramillo, Patricio, Prof ; Avezum, Alvaro, MD ; Orlandini, Andres, MD ; Seron, Pamela, MSc ; Ahmed, Suad H, PhD ; Rosengren, Annika, Prof ; Kelishadi, Roya, Prof ; Rahman, Omar, Prof ; Swaminathan, Sumathi, PhD ; Iqbal, Romaina, PhD ; Gupta, Rajeev, PhD ; Lear, Scott A, Prof ; Oguz, Aytekin, Prof ; Yusoff, Khalid, Prof ; Zatonska, Katarzyna, MD ; Chifamba, Jephat, MPhil ; Igumbor, Ehimario, Prof ; Mohan, Viswanathan, PhD ; Anjana, Ranjit Mohan, MD ; Gu, Hongqiu, PhD ; Li, Wei, Prof ; Yusuf, Salim, Prof
creatorcontribLeong, Darryl P, Dr ; Teo, Koon K, Prof ; Rangarajan, Sumathy, MSc ; Lopez-Jaramillo, Patricio, Prof ; Avezum, Alvaro, MD ; Orlandini, Andres, MD ; Seron, Pamela, MSc ; Ahmed, Suad H, PhD ; Rosengren, Annika, Prof ; Kelishadi, Roya, Prof ; Rahman, Omar, Prof ; Swaminathan, Sumathi, PhD ; Iqbal, Romaina, PhD ; Gupta, Rajeev, PhD ; Lear, Scott A, Prof ; Oguz, Aytekin, Prof ; Yusoff, Khalid, Prof ; Zatonska, Katarzyna, MD ; Chifamba, Jephat, MPhil ; Igumbor, Ehimario, Prof ; Mohan, Viswanathan, PhD ; Anjana, Ranjit Mohan, MD ; Gu, Hongqiu, PhD ; Li, Wei, Prof ; Yusuf, Salim, Prof ; Prospective Urban Rural Epidemiology (PURE) Study investigators ; Sahlgrenska akademin ; Institute of Medicine, Department of Molecular and Clinical Medicine ; Institutionen för medicin, avdelningen för molekylär och klinisk medicin ; Göteborgs universitet ; Gothenburg University ; Sahlgrenska Academy
descriptionSummary Background Reduced muscular strength, as measured by grip strength, has been associated with an increased risk of all-cause and cardiovascular mortality. Grip strength is appealing as a simple, quick, and inexpensive means of stratifying an individual's risk of cardiovascular death. However, the prognostic value of grip strength with respect to the number and range of populations and confounders is unknown. The aim of this study was to assess the independent prognostic importance of grip strength measurement in socioculturally and economically diverse countries. Methods The Prospective Urban-Rural Epidemiology (PURE) study is a large, longitudinal population study done in 17 countries of varying incomes and sociocultural settings. We enrolled an unbiased sample of households, which were eligible if at least one household member was aged 35–70 years and if household members intended to stay at that address for another 4 years. Participants were assessed for grip strength, measured using a Jamar dynamometer. During a median follow-up of 4·0 years (IQR 2·9–5·1), we assessed all-cause mortality, cardiovascular mortality, non-cardiovascular mortality, myocardial infarction, stroke, diabetes, cancer, pneumonia, hospital admission for pneumonia or chronic obstructive pulmonary disease (COPD), hospital admission for any respiratory disease (including COPD, asthma, tuberculosis, and pneumonia), injury due to fall, and fracture. Study outcomes were adjudicated using source documents by a local investigator, and a subset were adjudicated centrally. Findings Between January, 2003, and December, 2009, a total of 142 861 participants were enrolled in the PURE study, of whom 139 691 with known vital status were included in the analysis. During a median follow-up of 4·0 years (IQR 2·9–5·1), 3379 (2%) of 139 691 participants died. After adjustment, the association between grip strength and each outcome, with the exceptions of cancer and hospital admission due to respiratory illness, was similar across country-income strata. Grip strength was inversely associated with all-cause mortality (hazard ratio per 5 kg reduction in grip strength 1·16, 95% CI 1·13–1·20; p<0·0001), cardiovascular mortality (1·17, 1·11–1·24; p<0·0001), non-cardiovascular mortality (1·17, 1·12–1·21; p<0·0001), myocardial infarction (1·07, 1·02–1·11; p=0·002), and stroke (1·09, 1·05–1·15; p<0·0001). Grip strength was a stronger predictor of all-cause and cardiovascular mortality than systolic blood pressure. We found no significant association between grip strength and incident diabetes, risk of hospital admission for pneumonia or COPD, injury from fall, or fracture. In high-income countries, the risk of cancer and grip strength were positively associated (0·916, 0·880–0·953; p<0·0001), but this association was not found in middle-income and low-income countries. Interpretation This study suggests that measurement of grip strength is a simple, inexpensive risk-stratifying method for all-cause death, cardiovascular death, and cardiovascular disease. Further research is needed to identify determinants of muscular strength and to test whether improvement in strength reduces mortality and cardiovascular disease. Funding Full funding sources listed at end of paper (see Acknowledgments).
identifier
0ISSN: 0140-6736
1ISSN: 1474-547X
2EISSN: 1474-547X
3DOI: 10.1016/S0140-6736(14)62000-6
4PMID: 25982160
5CODEN: LANCAO
languageeng
publisherEngland: Elsevier Ltd
subjectAbridged Index Medicus ; Accidental Falls ; Accidental Falls - statistics & numerical data ; Adult ; Age Factors ; Aged ; Analysis ; Cardiovascular disease ; Cardiovascular Diseases ; Cardiovascular Diseases - mortality ; Cardiovascular Diseases - physiopathology ; Cause of Death ; Chronic obstructive pulmonary disease ; Clinical Medicine ; Epidemiology ; Exercise ; Exercise - physiology ; Female ; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ; Global Health ; Hand Strength ; Hand Strength - physiology ; Health risk assessment ; Heart attacks ; Hospitalization ; Hospitalization - statistics & numerical data ; Humans ; Internal Medicine ; Klinisk medicin ; Male ; Medical prognosis ; Middle Aged ; Mortality ; Motor ability ; Neoplasms ; Neoplasms - mortality ; Neoplasms - physiopathology ; Physical fitness ; physiology ; physiopathology ; Prognosis ; Prospective Studies ; Public Health, Global Health, Social Medicine and Epidemiology ; Respiratory Tract Diseases ; Respiratory Tract Diseases - mortality ; Respiratory Tract Diseases - physiopathology ; Risk Factors ; Rural Health ; Sex Factors ; statistics & numerical data ; Urban Health
ispartofThe Lancet (British edition), 2015, Vol.386 (9990), p.266-273
rights
0Elsevier Ltd
12015 Elsevier Ltd
2Copyright © 2015 Elsevier Ltd. All rights reserved.
3COPYRIGHT 2015 Elsevier B.V.
4Copyright Elsevier Limited Jul 18, 2015
lds50peer_reviewed
citedbyFETCH-LOGICAL-1829t-af8ff7831091114694e5ee5d76f7fc49cced0c99a35492024f3d002af9498d813
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25982160$$D View this record in MEDLINE/PubMed
1$$Uhttps://gup.ub.gu.se/publication/220656$$DView record from Swedish Publication Index
search
creatorcontrib
0Leong, Darryl P, Dr
1Teo, Koon K, Prof
2Rangarajan, Sumathy, MSc
3Lopez-Jaramillo, Patricio, Prof
4Avezum, Alvaro, MD
5Orlandini, Andres, MD
6Seron, Pamela, MSc
7Ahmed, Suad H, PhD
8Rosengren, Annika, Prof
9Kelishadi, Roya, Prof
10Rahman, Omar, Prof
11Swaminathan, Sumathi, PhD
12Iqbal, Romaina, PhD
13Gupta, Rajeev, PhD
14Lear, Scott A, Prof
15Oguz, Aytekin, Prof
16Yusoff, Khalid, Prof
17Zatonska, Katarzyna, MD
18Chifamba, Jephat, MPhil
19Igumbor, Ehimario, Prof
20Mohan, Viswanathan, PhD
21Anjana, Ranjit Mohan, MD
22Gu, Hongqiu, PhD
23Li, Wei, Prof
24Yusuf, Salim, Prof
25Prospective Urban Rural Epidemiology (PURE) Study investigators
26Sahlgrenska akademin
27Institute of Medicine, Department of Molecular and Clinical Medicine
28Institutionen för medicin, avdelningen för molekylär och klinisk medicin
29Göteborgs universitet
30Gothenburg University
31Sahlgrenska Academy
title
0Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study
1The Lancet (British edition)
addtitleLancet
descriptionSummary Background Reduced muscular strength, as measured by grip strength, has been associated with an increased risk of all-cause and cardiovascular mortality. Grip strength is appealing as a simple, quick, and inexpensive means of stratifying an individual's risk of cardiovascular death. However, the prognostic value of grip strength with respect to the number and range of populations and confounders is unknown. The aim of this study was to assess the independent prognostic importance of grip strength measurement in socioculturally and economically diverse countries. Methods The Prospective Urban-Rural Epidemiology (PURE) study is a large, longitudinal population study done in 17 countries of varying incomes and sociocultural settings. We enrolled an unbiased sample of households, which were eligible if at least one household member was aged 35–70 years and if household members intended to stay at that address for another 4 years. Participants were assessed for grip strength, measured using a Jamar dynamometer. During a median follow-up of 4·0 years (IQR 2·9–5·1), we assessed all-cause mortality, cardiovascular mortality, non-cardiovascular mortality, myocardial infarction, stroke, diabetes, cancer, pneumonia, hospital admission for pneumonia or chronic obstructive pulmonary disease (COPD), hospital admission for any respiratory disease (including COPD, asthma, tuberculosis, and pneumonia), injury due to fall, and fracture. Study outcomes were adjudicated using source documents by a local investigator, and a subset were adjudicated centrally. Findings Between January, 2003, and December, 2009, a total of 142 861 participants were enrolled in the PURE study, of whom 139 691 with known vital status were included in the analysis. During a median follow-up of 4·0 years (IQR 2·9–5·1), 3379 (2%) of 139 691 participants died. After adjustment, the association between grip strength and each outcome, with the exceptions of cancer and hospital admission due to respiratory illness, was similar across country-income strata. Grip strength was inversely associated with all-cause mortality (hazard ratio per 5 kg reduction in grip strength 1·16, 95% CI 1·13–1·20; p<0·0001), cardiovascular mortality (1·17, 1·11–1·24; p<0·0001), non-cardiovascular mortality (1·17, 1·12–1·21; p<0·0001), myocardial infarction (1·07, 1·02–1·11; p=0·002), and stroke (1·09, 1·05–1·15; p<0·0001). Grip strength was a stronger predictor of all-cause and cardiovascular mortality than systolic blood pressure. We found no significant association between grip strength and incident diabetes, risk of hospital admission for pneumonia or COPD, injury from fall, or fracture. In high-income countries, the risk of cancer and grip strength were positively associated (0·916, 0·880–0·953; p<0·0001), but this association was not found in middle-income and low-income countries. Interpretation This study suggests that measurement of grip strength is a simple, inexpensive risk-stratifying method for all-cause death, cardiovascular death, and cardiovascular disease. Further research is needed to identify determinants of muscular strength and to test whether improvement in strength reduces mortality and cardiovascular disease. Funding Full funding sources listed at end of paper (see Acknowledgments).
subject
0Abridged Index Medicus
1Accidental Falls
2Accidental Falls - statistics & numerical data
3Adult
4Age Factors
5Aged
6Analysis
7Cardiovascular disease
8Cardiovascular Diseases
9Cardiovascular Diseases - mortality
10Cardiovascular Diseases - physiopathology
11Cause of Death
12Chronic obstructive pulmonary disease
13Clinical Medicine
14Epidemiology
15Exercise
16Exercise - physiology
17Female
18Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
19Global Health
20Hand Strength
21Hand Strength - physiology
22Health risk assessment
23Heart attacks
24Hospitalization
25Hospitalization - statistics & numerical data
26Humans
27Internal Medicine
28Klinisk medicin
29Male
30Medical prognosis
31Middle Aged
32Mortality
33Motor ability
34Neoplasms
35Neoplasms - mortality
36Neoplasms - physiopathology
37Physical fitness
38physiology
39physiopathology
40Prognosis
41Prospective Studies
42Public Health, Global Health, Social Medicine and Epidemiology
43Respiratory Tract Diseases
44Respiratory Tract Diseases - mortality
45Respiratory Tract Diseases - physiopathology
46Risk Factors
47Rural Health
48Sex Factors
49statistics & numerical data
50Urban Health
issn
00140-6736
11474-547X
21474-547X
fulltexttrue
rsrctypearticle
creationdate2015
recordtypearticle
recordideNqNkn9r1DAcxosobk5fglLwnxt4M0nTtJmgjHH-gIFjeuB_IZd-08vsJTVpT-7dm-707nYMNwotCZ_nk6R5kuQlRicYYfb2G8IUjVmRsRGmx4wgFEePkkNMCzrOafHjcXK4QQ6SZyFcR4QylD9NDkjOS4IZOkz0pXe1daEzKl3KpofU6bT2pk1D58HW3fw01cZWxtYh1d4t0m4OaQyFFlRnlpBO_Uza9Kr3skknralgYVzj6lU6upxeTY6jp69Wz5MnWjYBXvz9HiXTj5Pv55_HF18_fTk_uxjjkvBuLHWpdVFmGHGMMWWcQg6QVwXThVaUKwUVUpzLLKecIEJ1ViFEpOaUl1WJs6NkvPaG39D2M9F6s5B-JZw0ou5bEafqXgQQhCCWs8iP1nzr3a8eQicWJihoGmnB9UFgxktECoYG9es99Nr13sbTDBTjGKGMbalaNiCM1a7zUg1ScZbjEmVFUdL_UpRkZUaiLlInd1DxGf6xcha0ifO3tA8K7K7w6o6A2DW-2QFmfTAWQnwFU8-7UMs-hNsbeAC-u3y-xlXsU_CgN_eFkRhaLm5aLoYKC0zFTcsF2247XvECqk3qX60j8G5PrEwnO-NsPJ9p7tV_WKchNnVpwIugDNjYPeNj6UXlzL2G93sG1RhrlGx-wgrCtjgiEIHWksERKz8YWPYH_JYtKw
startdate2015
enddate2015
creator
0Leong, Darryl P, Dr
1Teo, Koon K, Prof
2Rangarajan, Sumathy, MSc
3Lopez-Jaramillo, Patricio, Prof
4Avezum, Alvaro, MD
5Orlandini, Andres, MD
6Seron, Pamela, MSc
7Ahmed, Suad H, PhD
8Rosengren, Annika, Prof
9Kelishadi, Roya, Prof
10Rahman, Omar, Prof
11Swaminathan, Sumathi, PhD
12Iqbal, Romaina, PhD
13Gupta, Rajeev, PhD
14Lear, Scott A, Prof
15Oguz, Aytekin, Prof
16Yusoff, Khalid, Prof
17Zatonska, Katarzyna, MD
18Chifamba, Jephat, MPhil
19Igumbor, Ehimario, Prof
20Mohan, Viswanathan, PhD
21Anjana, Ranjit Mohan, MD
22Gu, Hongqiu, PhD
23Li, Wei, Prof
24Yusuf, Salim, Prof
general
0Elsevier Ltd
1Elsevier B.V
2Elsevier Limited
scope
0CGR
1CUY
2CVF
3ECM
4EIF
5NPM
6AAYXX
7CITATION
8BKMMT
9BSHEE
100TT
110TZ
120U~
133V.
147QL
157QP
167RV
177TK
187U7
197U9
207X7
217XB
2288A
2388C
2488E
2588G
2688I
278AF
288AO
298C1
308C2
318FE
328FH
338FI
348FJ
358FK
368G5
37ABUWG
38AN0
39ASE
40AZQEC
41BBNVY
42BEC
43BENPR
44BHPHI
45C1K
46DWQXO
47FPQ
48FYUFA
49GHDGH
50GNUQQ
51GUQSH
52H94
53HCIFZ
54K6X
55K9-
56K9.
57KB0
58KB~
59LK8
60M0R
61M0S
62M0T
63M1P
64M2M
65M2O
66M2P
67M7N
68M7P
69MBDVC
70NAPCQ
71PQEST
72PQQKQ
73PQUKI
74Q9U
75S0X
767X8
77ADTPV
78AOWAS
sort
creationdate2015
titlePrognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study
authorLeong, Darryl P, Dr ; Teo, Koon K, Prof ; Rangarajan, Sumathy, MSc ; Lopez-Jaramillo, Patricio, Prof ; Avezum, Alvaro, MD ; Orlandini, Andres, MD ; Seron, Pamela, MSc ; Ahmed, Suad H, PhD ; Rosengren, Annika, Prof ; Kelishadi, Roya, Prof ; Rahman, Omar, Prof ; Swaminathan, Sumathi, PhD ; Iqbal, Romaina, PhD ; Gupta, Rajeev, PhD ; Lear, Scott A, Prof ; Oguz, Aytekin, Prof ; Yusoff, Khalid, Prof ; Zatonska, Katarzyna, MD ; Chifamba, Jephat, MPhil ; Igumbor, Ehimario, Prof ; Mohan, Viswanathan, PhD ; Anjana, Ranjit Mohan, MD ; Gu, Hongqiu, PhD ; Li, Wei, Prof ; Yusuf, Salim, Prof
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1829t-af8ff7831091114694e5ee5d76f7fc49cced0c99a35492024f3d002af9498d813
rsrctypearticles
prefilterarticles
languageeng
creationdate2015
topic
0Abridged Index Medicus
1Accidental Falls
2Accidental Falls - statistics & numerical data
3Adult
4Age Factors
5Aged
6Analysis
7Cardiovascular disease
8Cardiovascular Diseases
9Cardiovascular Diseases - mortality
10Cardiovascular Diseases - physiopathology
11Cause of Death
12Chronic obstructive pulmonary disease
13Clinical Medicine
14Epidemiology
15Exercise
16Exercise - physiology
17Female
18Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
19Global Health
20Hand Strength
21Hand Strength - physiology
22Health risk assessment
23Heart attacks
24Hospitalization
25Hospitalization - statistics & numerical data
26Humans
27Internal Medicine
28Klinisk medicin
29Male
30Medical prognosis
31Middle Aged
32Mortality
33Motor ability
34Neoplasms
35Neoplasms - mortality
36Neoplasms - physiopathology
37Physical fitness
38physiology
39physiopathology
40Prognosis
41Prospective Studies
42Public Health, Global Health, Social Medicine and Epidemiology
43Respiratory Tract Diseases
44Respiratory Tract Diseases - mortality
45Respiratory Tract Diseases - physiopathology
46Risk Factors
47Rural Health
48Sex Factors
49statistics & numerical data
50Urban Health
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Leong, Darryl P, Dr
1Teo, Koon K, Prof
2Rangarajan, Sumathy, MSc
3Lopez-Jaramillo, Patricio, Prof
4Avezum, Alvaro, MD
5Orlandini, Andres, MD
6Seron, Pamela, MSc
7Ahmed, Suad H, PhD
8Rosengren, Annika, Prof
9Kelishadi, Roya, Prof
10Rahman, Omar, Prof
11Swaminathan, Sumathi, PhD
12Iqbal, Romaina, PhD
13Gupta, Rajeev, PhD
14Lear, Scott A, Prof
15Oguz, Aytekin, Prof
16Yusoff, Khalid, Prof
17Zatonska, Katarzyna, MD
18Chifamba, Jephat, MPhil
19Igumbor, Ehimario, Prof
20Mohan, Viswanathan, PhD
21Anjana, Ranjit Mohan, MD
22Gu, Hongqiu, PhD
23Li, Wei, Prof
24Yusuf, Salim, Prof
25Prospective Urban Rural Epidemiology (PURE) Study investigators
26Sahlgrenska akademin
27Institute of Medicine, Department of Molecular and Clinical Medicine
28Institutionen för medicin, avdelningen för molekylär och klinisk medicin
29Göteborgs universitet
30Gothenburg University
31Sahlgrenska Academy
collection
0Medline
1MEDLINE
2MEDLINE (Ovid)
3MEDLINE
4MEDLINE
5PubMed
6CrossRef
7Gale General OneFile (A&I only)
8Academic OneFile (A&I only)
9News PRO
10Pharma and Biotech Premium PRO
11Global News & ABI/Inform Professional
12ProQuest Central (Corporate)
13Bacteriology Abstracts (Microbiology B)
14Calcium & Calcified Tissue Abstracts
15Nursing & Allied Health Database
16Neurosciences Abstracts
17Toxicology Abstracts
18Virology and AIDS Abstracts
19Health & Medical Collection
20ProQuest Central (purchase pre-March 2016)
21Biology Database (Alumni Edition)
22Healthcare Administration Database (Alumni)
23Medical Database (Alumni Edition)
24Psychology Database (Alumni)
25Science Database (Alumni Edition)
26STEM Database
27ProQuest Pharma Collection
28Public Health Database
29Lancet Titles
30ProQuest SciTech Collection
31ProQuest Natural Science Collection
32Hospital Premium Collection
33Hospital Premium Collection (Alumni Edition)
34ProQuest Central (Alumni) (purchase pre-March 2016)
35Research Library (Alumni Edition)
36ProQuest Central (Alumni Edition)
37British Nursing Database
38British Nursing Index
39ProQuest Central Essentials
40Biological Science Collection
41eLibrary
42ProQuest Central
43Natural Science Collection
44Environmental Sciences and Pollution Management
45ProQuest Central Korea
46British Nursing Index (BNI) (1985 to Present)
47Health Research Premium Collection
48Health Research Premium Collection (Alumni)
49ProQuest Central Student
50Research Library Prep
51AIDS and Cancer Research Abstracts
52SciTech Premium Collection
53British Nursing Index
54Consumer Health Database (Alumni Edition)
55ProQuest Health & Medical Complete (Alumni)
56Nursing & Allied Health Database (Alumni Edition)
57ProQuest Newsstand Professional
58ProQuest Biological Science Collection
59Consumer Health Database
60Health & Medical Collection (Alumni Edition)
61Healthcare Administration Database
62Medical Database
63Psychology Database
64Research Library
65Science Database
66Algology Mycology and Protozoology Abstracts (Microbiology C)
67Biological Science Database
68Research Library (Corporate)
69Nursing & Allied Health Premium
70ProQuest One Academic Eastern Edition
71ProQuest One Academic
72ProQuest One Academic UKI Edition
73ProQuest Central Basic
74SIRS Editorial
75MEDLINE - Academic
76SwePub
77SwePub Articles
jtitleThe Lancet (British edition)
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Leong, Darryl P, Dr
1Teo, Koon K, Prof
2Rangarajan, Sumathy, MSc
3Lopez-Jaramillo, Patricio, Prof
4Avezum, Alvaro, MD
5Orlandini, Andres, MD
6Seron, Pamela, MSc
7Ahmed, Suad H, PhD
8Rosengren, Annika, Prof
9Kelishadi, Roya, Prof
10Rahman, Omar, Prof
11Swaminathan, Sumathi, PhD
12Iqbal, Romaina, PhD
13Gupta, Rajeev, PhD
14Lear, Scott A, Prof
15Oguz, Aytekin, Prof
16Yusoff, Khalid, Prof
17Zatonska, Katarzyna, MD
18Chifamba, Jephat, MPhil
19Igumbor, Ehimario, Prof
20Mohan, Viswanathan, PhD
21Anjana, Ranjit Mohan, MD
22Gu, Hongqiu, PhD
23Li, Wei, Prof
24Yusuf, Salim, Prof
aucorp
0Prospective Urban Rural Epidemiology (PURE) Study investigators
1Sahlgrenska akademin
2Institute of Medicine, Department of Molecular and Clinical Medicine
3Institutionen för medicin, avdelningen för molekylär och klinisk medicin
4Göteborgs universitet
5Gothenburg University
6Sahlgrenska Academy
formatjournal
genrearticle
ristypeJOUR
atitlePrognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study
jtitleThe Lancet (British edition)
addtitleLancet
date2015
risdate2015
volume386
issue9990
spage266
epage273
pages266-273
issn
00140-6736
11474-547X
eissn1474-547X
codenLANCAO
abstractSummary Background Reduced muscular strength, as measured by grip strength, has been associated with an increased risk of all-cause and cardiovascular mortality. Grip strength is appealing as a simple, quick, and inexpensive means of stratifying an individual's risk of cardiovascular death. However, the prognostic value of grip strength with respect to the number and range of populations and confounders is unknown. The aim of this study was to assess the independent prognostic importance of grip strength measurement in socioculturally and economically diverse countries. Methods The Prospective Urban-Rural Epidemiology (PURE) study is a large, longitudinal population study done in 17 countries of varying incomes and sociocultural settings. We enrolled an unbiased sample of households, which were eligible if at least one household member was aged 35–70 years and if household members intended to stay at that address for another 4 years. Participants were assessed for grip strength, measured using a Jamar dynamometer. During a median follow-up of 4·0 years (IQR 2·9–5·1), we assessed all-cause mortality, cardiovascular mortality, non-cardiovascular mortality, myocardial infarction, stroke, diabetes, cancer, pneumonia, hospital admission for pneumonia or chronic obstructive pulmonary disease (COPD), hospital admission for any respiratory disease (including COPD, asthma, tuberculosis, and pneumonia), injury due to fall, and fracture. Study outcomes were adjudicated using source documents by a local investigator, and a subset were adjudicated centrally. Findings Between January, 2003, and December, 2009, a total of 142 861 participants were enrolled in the PURE study, of whom 139 691 with known vital status were included in the analysis. During a median follow-up of 4·0 years (IQR 2·9–5·1), 3379 (2%) of 139 691 participants died. After adjustment, the association between grip strength and each outcome, with the exceptions of cancer and hospital admission due to respiratory illness, was similar across country-income strata. Grip strength was inversely associated with all-cause mortality (hazard ratio per 5 kg reduction in grip strength 1·16, 95% CI 1·13–1·20; p<0·0001), cardiovascular mortality (1·17, 1·11–1·24; p<0·0001), non-cardiovascular mortality (1·17, 1·12–1·21; p<0·0001), myocardial infarction (1·07, 1·02–1·11; p=0·002), and stroke (1·09, 1·05–1·15; p<0·0001). Grip strength was a stronger predictor of all-cause and cardiovascular mortality than systolic blood pressure. We found no significant association between grip strength and incident diabetes, risk of hospital admission for pneumonia or COPD, injury from fall, or fracture. In high-income countries, the risk of cancer and grip strength were positively associated (0·916, 0·880–0·953; p<0·0001), but this association was not found in middle-income and low-income countries. Interpretation This study suggests that measurement of grip strength is a simple, inexpensive risk-stratifying method for all-cause death, cardiovascular death, and cardiovascular disease. Further research is needed to identify determinants of muscular strength and to test whether improvement in strength reduces mortality and cardiovascular disease. Funding Full funding sources listed at end of paper (see Acknowledgments).
copEngland
pubElsevier Ltd
pmid25982160
doi10.1016/S0140-6736(14)62000-6