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PET Imaging of Tau Deposition in the Aging Human Brain

Tau pathology is a hallmark of Alzheimer’s disease (AD) but also occurs in normal cognitive aging. Using the tau PET agent 18F-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and β-amyloid (measured using PiB PET) were dif... Full description

Journal Title: Neuron (Cambridge Mass.), 2016-03-02, Vol.89 (5), p.971-982
Main Author: Schöll, Michael
Other Authors: Lockhart, Samuel N , Schonhaut, Daniel R , O’Neil, James P , Janabi, Mustafa , Ossenkoppele, Rik , Baker, Suzanne L , Vogel, Jacob W , Faria, Jamie , Schwimmer, Henry D , Rabinovici, Gil D , Jagust, William J
Format: Electronic Article Electronic Article
Language: English
Subjects:
age
PET
Tau
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 0896-6273
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title: PET Imaging of Tau Deposition in the Aging Human Brain
format: Article
creator:
  • Schöll, Michael
  • Lockhart, Samuel N
  • Schonhaut, Daniel R
  • O’Neil, James P
  • Janabi, Mustafa
  • Ossenkoppele, Rik
  • Baker, Suzanne L
  • Vogel, Jacob W
  • Faria, Jamie
  • Schwimmer, Henry D
  • Rabinovici, Gil D
  • Jagust, William J
subjects:
  • 1 Biological
  • 1 Normal biological development
  • 60 APPLIED LIFE SCIENCES
  • a-beta
  • Acquired Cognitive Impairment
  • Adult
  • age
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Alzheimer Disease - complications
  • Alzheimer Disease - diagnostic imaging
  • Alzheimer Disease - genetics
  • Alzheimer Disease - pathology
  • Alzheimer's Disease
  • Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD
  • Alzheimers disease
  • Amyloid
  • amyloid-beta
  • Aniline Compounds
  • Aniline Compounds - pharmacokinetics
  • Apolipoproteins E
  • Apolipoproteins E - genetics
  • Article
  • Biomedical Imaging
  • Brain
  • Brain - diagnostic imaging
  • Brain - metabolism
  • Brain Disorders
  • categories
  • cerebrospinal-fluid
  • Clinical Research
  • Cognition & reasoning
  • Cognition Disorders
  • Cognition Disorders - etiology
  • Cognitive Sciences
  • Dementia
  • Emission Tomography
  • endogenous factors
  • episodic memory
  • Ethylene Glycols
  • Ethylene Glycols - pharmacokinetics
  • Female
  • functioning
  • Humans
  • Male
  • Memory
  • mental disorders
  • mild cognitive impairment
  • national institute
  • Neurodegenerative
  • neurofibrillary tangles
  • Neurologi
  • Neurological
  • Neurology
  • Neurology & Neurosurgery
  • Neuroscience(all)
  • Neurosciences
  • Neurosciences & Neurology
  • Neurovetenskaper
  • Older people
  • over
  • Pathology
  • PET
  • PET imaging
  • Pets
  • Positron
  • Positron-Emission Tomography
  • Psychiatric Status Rating Scales
  • Psychology
  • senile plaques
  • Tau
  • tau Proteins
  • tau Proteins - metabolism
  • Thiazoles
  • Thiazoles - pharmacokinetics
  • Tracers (Biology)
  • Young Adult
ispartof: Neuron (Cambridge, Mass.), 2016-03-02, Vol.89 (5), p.971-982
description: Tau pathology is a hallmark of Alzheimer’s disease (AD) but also occurs in normal cognitive aging. Using the tau PET agent 18F-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and β-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging. Older age was related to increased tracer retention in regions of the medial temporal lobe, which predicted worse episodic memory performance. PET detection of tau in other isocortical regions required the presence of cortical β-amyloid and was associated with decline in global cognition. Furthermore, patterns of tracer retention corresponded well with Braak staging of neurofibrillary tau pathology. The present study defined patterns of tau tracer retention in normal aging in relation to age, cognition, and β-amyloid deposition. [Display omitted] •AV-1451 PET imaging allows in vivo Braak tau staging based on tracer uptake•Age and β-amyloid are associated with different patterns of tau tracer retention•Medial temporal tau tracer retention relates to episodic memory decline in aging Schöll, Lockhart, et al. examined tau pathology in vivo using 18F-AV-1451 (tau) PET in healthy aging and found relationships with cognitive function. Confirming neuropathologically established patterns, they also detected different effects of age and β-amyloid on patterns of tau deposition.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0896-6273
fulltext: fulltext
issn:
  • 0896-6273
  • 1097-4199
url: Link


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creatorSchöll, Michael ; Lockhart, Samuel N ; Schonhaut, Daniel R ; O’Neil, James P ; Janabi, Mustafa ; Ossenkoppele, Rik ; Baker, Suzanne L ; Vogel, Jacob W ; Faria, Jamie ; Schwimmer, Henry D ; Rabinovici, Gil D ; Jagust, William J
creatorcontribSchöll, Michael ; Lockhart, Samuel N ; Schonhaut, Daniel R ; O’Neil, James P ; Janabi, Mustafa ; Ossenkoppele, Rik ; Baker, Suzanne L ; Vogel, Jacob W ; Faria, Jamie ; Schwimmer, Henry D ; Rabinovici, Gil D ; Jagust, William J ; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States) ; Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering ; Sahlgrenska akademin ; Göteborgs universitet ; Gothenburg University ; Sahlgrenska Academy ; Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
descriptionTau pathology is a hallmark of Alzheimer’s disease (AD) but also occurs in normal cognitive aging. Using the tau PET agent 18F-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and β-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging. Older age was related to increased tracer retention in regions of the medial temporal lobe, which predicted worse episodic memory performance. PET detection of tau in other isocortical regions required the presence of cortical β-amyloid and was associated with decline in global cognition. Furthermore, patterns of tracer retention corresponded well with Braak staging of neurofibrillary tau pathology. The present study defined patterns of tau tracer retention in normal aging in relation to age, cognition, and β-amyloid deposition. [Display omitted] •AV-1451 PET imaging allows in vivo Braak tau staging based on tracer uptake•Age and β-amyloid are associated with different patterns of tau tracer retention•Medial temporal tau tracer retention relates to episodic memory decline in aging Schöll, Lockhart, et al. examined tau pathology in vivo using 18F-AV-1451 (tau) PET in healthy aging and found relationships with cognitive function. Confirming neuropathologically established patterns, they also detected different effects of age and β-amyloid on patterns of tau deposition.
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languageeng
publisherUnited States: Elsevier Inc
subject1 Biological ; 1 Normal biological development ; 60 APPLIED LIFE SCIENCES ; a-beta ; Acquired Cognitive Impairment ; Adult ; age ; Age Factors ; Aged ; Aged, 80 and over ; Aging ; Alzheimer Disease ; Alzheimer Disease - complications ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - genetics ; Alzheimer Disease - pathology ; Alzheimer's Disease ; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD ; Alzheimers disease ; Amyloid ; amyloid-beta ; Aniline Compounds ; Aniline Compounds - pharmacokinetics ; Apolipoproteins E ; Apolipoproteins E - genetics ; Article ; Biomedical Imaging ; Brain ; Brain - diagnostic imaging ; Brain - metabolism ; Brain Disorders ; categories ; cerebrospinal-fluid ; Clinical Research ; Cognition & reasoning ; Cognition Disorders ; Cognition Disorders - etiology ; Cognitive Sciences ; Dementia ; Emission Tomography ; endogenous factors ; episodic memory ; Ethylene Glycols ; Ethylene Glycols - pharmacokinetics ; Female ; functioning ; Humans ; Male ; Memory ; mental disorders ; mild cognitive impairment ; national institute ; Neurodegenerative ; neurofibrillary tangles ; Neurologi ; Neurological ; Neurology ; Neurology & Neurosurgery ; Neuroscience(all) ; Neurosciences ; Neurosciences & Neurology ; Neurovetenskaper ; Older people ; over ; Pathology ; PET ; PET imaging ; Pets ; Positron ; Positron-Emission Tomography ; Psychiatric Status Rating Scales ; Psychology ; senile plaques ; Tau ; tau Proteins ; tau Proteins - metabolism ; Thiazoles ; Thiazoles - pharmacokinetics ; Tracers (Biology) ; Young Adult
ispartofNeuron (Cambridge, Mass.), 2016-03-02, Vol.89 (5), p.971-982
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1Lockhart, Samuel N
2Schonhaut, Daniel R
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6Baker, Suzanne L
7Vogel, Jacob W
8Faria, Jamie
9Schwimmer, Henry D
10Rabinovici, Gil D
11Jagust, William J
12Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
13Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering
14Sahlgrenska akademin
15Göteborgs universitet
16Gothenburg University
17Sahlgrenska Academy
18Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
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0PET Imaging of Tau Deposition in the Aging Human Brain
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descriptionTau pathology is a hallmark of Alzheimer’s disease (AD) but also occurs in normal cognitive aging. Using the tau PET agent 18F-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and β-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging. Older age was related to increased tracer retention in regions of the medial temporal lobe, which predicted worse episodic memory performance. PET detection of tau in other isocortical regions required the presence of cortical β-amyloid and was associated with decline in global cognition. Furthermore, patterns of tracer retention corresponded well with Braak staging of neurofibrillary tau pathology. The present study defined patterns of tau tracer retention in normal aging in relation to age, cognition, and β-amyloid deposition. [Display omitted] •AV-1451 PET imaging allows in vivo Braak tau staging based on tracer uptake•Age and β-amyloid are associated with different patterns of tau tracer retention•Medial temporal tau tracer retention relates to episodic memory decline in aging Schöll, Lockhart, et al. examined tau pathology in vivo using 18F-AV-1451 (tau) PET in healthy aging and found relationships with cognitive function. Confirming neuropathologically established patterns, they also detected different effects of age and β-amyloid on patterns of tau deposition.
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9Aged, 80 and over
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12Alzheimer Disease - complications
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16Alzheimer's Disease
17Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD
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20amyloid-beta
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35Cognition Disorders
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40endogenous factors
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42Ethylene Glycols
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44Female
45functioning
46Humans
47Male
48Memory
49mental disorders
50mild cognitive impairment
51national institute
52Neurodegenerative
53neurofibrillary tangles
54Neurologi
55Neurological
56Neurology
57Neurology & Neurosurgery
58Neuroscience(all)
59Neurosciences
60Neurosciences & Neurology
61Neurovetenskaper
62Older people
63over
64Pathology
65PET
66PET imaging
67Pets
68Positron
69Positron-Emission Tomography
70Psychiatric Status Rating Scales
71Psychology
72senile plaques
73Tau
74tau Proteins
75tau Proteins - metabolism
76Thiazoles
77Thiazoles - pharmacokinetics
78Tracers (Biology)
79Young Adult
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7Vogel, Jacob W
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titlePET Imaging of Tau Deposition in the Aging Human Brain
authorSchöll, Michael ; Lockhart, Samuel N ; Schonhaut, Daniel R ; O’Neil, James P ; Janabi, Mustafa ; Ossenkoppele, Rik ; Baker, Suzanne L ; Vogel, Jacob W ; Faria, Jamie ; Schwimmer, Henry D ; Rabinovici, Gil D ; Jagust, William J
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76Thiazoles
77Thiazoles - pharmacokinetics
78Tracers (Biology)
79Young Adult
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13Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering
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abstractTau pathology is a hallmark of Alzheimer’s disease (AD) but also occurs in normal cognitive aging. Using the tau PET agent 18F-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and β-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging. Older age was related to increased tracer retention in regions of the medial temporal lobe, which predicted worse episodic memory performance. PET detection of tau in other isocortical regions required the presence of cortical β-amyloid and was associated with decline in global cognition. Furthermore, patterns of tracer retention corresponded well with Braak staging of neurofibrillary tau pathology. The present study defined patterns of tau tracer retention in normal aging in relation to age, cognition, and β-amyloid deposition. [Display omitted] •AV-1451 PET imaging allows in vivo Braak tau staging based on tracer uptake•Age and β-amyloid are associated with different patterns of tau tracer retention•Medial temporal tau tracer retention relates to episodic memory decline in aging Schöll, Lockhart, et al. examined tau pathology in vivo using 18F-AV-1451 (tau) PET in healthy aging and found relationships with cognitive function. Confirming neuropathologically established patterns, they also detected different effects of age and β-amyloid on patterns of tau deposition.
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pmid26938442
doi10.1016/j.neuron.2016.01.028
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