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Efficacy and tolerability of rosuvastatin and atorvastatin when force-titrated in patients with primary hypercholesterolemia: results from the ECLIPSE study

Patients at high risk of cardiovascular disease frequently fail to reach recommended low-density lipoprotein cholesterol (LDL-C) goals, partly because statin doses are not titrated to optimal effect. The ECLIPSE study was designed to compare the efficacy and safety of force-titrated treatment with r... Full description

Journal Title: Cardiology 2008, Vol.111 (4), p.219-28
Main Author: Faergeman, Ole
Other Authors: Hill, Laurie , Windler, Eberhard , Wiklund, Olov , Asmar, Roland , Duffield, Emma , Sosef, Froukje
Format: Electronic Article Electronic Article
Language: English
Subjects:
Aged
Atorvastatin Calcium
Canada
Cardiovascular disease
Cholesterol
Cholesterol, LDL - blood
CoA Reductase Inhibitors
Coronary Disease
Coronary Disease - prevention & control
Drug dosages
Drug therapy
European Union
Female
Fluorobenzenes
Fluorobenzenes - administration & dosage
Fluorobenzenes - adverse effects
Heptanoic Acids
Heptanoic Acids - administration & dosage
Heptanoic Acids - adverse effects
Humans
Hydroxymethylglutaryl
Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage
Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects
Hypercholesterolemia
Hypercholesterolemia - blood
Hypercholesterolemia - drug therapy
Lipids
lipids (amino acids
Male
MEDICAL AND HEALTH SCIENCES
MEDICIN OCH HÄLSOVETENSKAP
metabolic diseases
Middle Aged
nutritional
peptides
proteins
Pyrimidines
Pyrimidines - administration & dosage
Pyrimidines - adverse effects
Pyrroles
Pyrroles - administration & dosage
Pyrroles - adverse effects
Risk
Risk Assessment
Risk Factors
Rosuvastatin Calcium
Statins
Sulfonamides
Sulfonamides - administration & dosage
Sulfonamides - adverse effects
Quelle: Alma/SFX Local Collection
Publisher: Switzerland: S. Karger AG
ID: ISSN: 0008-6312
Zum Text:
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recordid: cdi_swepub_primary_oai_gup_ub_gu_se_70461
title: Efficacy and tolerability of rosuvastatin and atorvastatin when force-titrated in patients with primary hypercholesterolemia: results from the ECLIPSE study
format: Article
creator:
  • Faergeman, Ole
  • Hill, Laurie
  • Windler, Eberhard
  • Wiklund, Olov
  • Asmar, Roland
  • Duffield, Emma
  • Sosef, Froukje
subjects:
  • Aged
  • Atorvastatin Calcium
  • Canada
  • Cardiovascular disease
  • Cholesterol
  • Cholesterol, LDL - blood
  • CoA Reductase Inhibitors
  • Coronary Disease
  • Coronary Disease - prevention & control
  • Drug dosages
  • Drug therapy
  • European Union
  • Female
  • Fluorobenzenes
  • Fluorobenzenes - administration & dosage
  • Fluorobenzenes - adverse effects
  • Heptanoic Acids
  • Heptanoic Acids - administration & dosage
  • Heptanoic Acids - adverse effects
  • Humans
  • Hydroxymethylglutaryl
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects
  • Hypercholesterolemia
  • Hypercholesterolemia - blood
  • Hypercholesterolemia - drug therapy
  • Lipids
  • lipids (amino acids
  • Male
  • MEDICAL AND HEALTH SCIENCES
  • MEDICIN OCH HÄLSOVETENSKAP
  • metabolic diseases
  • Middle Aged
  • nutritional
  • peptides
  • proteins
  • Pyrimidines
  • Pyrimidines - administration & dosage
  • Pyrimidines - adverse effects
  • Pyrroles
  • Pyrroles - administration & dosage
  • Pyrroles - adverse effects
  • Risk
  • Risk Assessment
  • Risk Factors
  • Rosuvastatin Calcium
  • Statins
  • Sulfonamides
  • Sulfonamides - administration & dosage
  • Sulfonamides - adverse effects
ispartof: Cardiology, 2008, Vol.111 (4), p.219-28
description: Patients at high risk of cardiovascular disease frequently fail to reach recommended low-density lipoprotein cholesterol (LDL-C) goals, partly because statin doses are not titrated to optimal effect. The ECLIPSE study was designed to compare the efficacy and safety of force-titrated treatment with rosuvastatin (10-40 mg) with that of atorvastatin (10-80 mg) in high-risk patients with hypercholesterolemia. In this 24-week, open-label, randomized, multinational, parallel-group study, 1,036 patients were randomized to rosuvastatin (n = 522) or atorvastatin (n = 514). At all time points, a significantly greater percentage of patients on rosuvastatin treatment achieved the NCEP ATP III LDL-C goal of
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0008-6312
fulltext: fulltext
issn:
  • 0008-6312
  • 1421-9751
  • 1421-9751
url: Link


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titleEfficacy and tolerability of rosuvastatin and atorvastatin when force-titrated in patients with primary hypercholesterolemia: results from the ECLIPSE study
sourceAlma/SFX Local Collection
creatorFaergeman, Ole ; Hill, Laurie ; Windler, Eberhard ; Wiklund, Olov ; Asmar, Roland ; Duffield, Emma ; Sosef, Froukje
creatorcontribFaergeman, Ole ; Hill, Laurie ; Windler, Eberhard ; Wiklund, Olov ; Asmar, Roland ; Duffield, Emma ; Sosef, Froukje ; ECLIPSE Study Investigators ; Wallenberg Laboratory ; Institute of Medicine, Department of Molecular and Clinical Medicine ; Göteborgs universitet ; Gothenburg University ; Sahlgrenska Academy ; Sahlgrenska akademin ; Wallenberglaboratoriet ; Institutionen för medicin, avdelningen för molekylär och klinisk medicin
descriptionPatients at high risk of cardiovascular disease frequently fail to reach recommended low-density lipoprotein cholesterol (LDL-C) goals, partly because statin doses are not titrated to optimal effect. The ECLIPSE study was designed to compare the efficacy and safety of force-titrated treatment with rosuvastatin (10-40 mg) with that of atorvastatin (10-80 mg) in high-risk patients with hypercholesterolemia. In this 24-week, open-label, randomized, multinational, parallel-group study, 1,036 patients were randomized to rosuvastatin (n = 522) or atorvastatin (n = 514). At all time points, a significantly greater percentage of patients on rosuvastatin treatment achieved the NCEP ATP III LDL-C goal of <100 mg/dl (2.5 mmol/l), the 2003 European LDL-C target of <2.5 or 3.0 mmol/l (100 or 115 mg/dl) and the LDL-C goal of <70 mg/dl (1.8 mmol/l), a goal suggested for very high-risk patients (p < 0.001 for all). Rosuvastatin also achieved significantly greater improvements in components of the atherogenic lipid profile versus atorvastatin. Both treatments were well tolerated. Rosuvastatin titrated across its recommended dose range provides a more favorable effect on lipoprotein variables than atorvastatin, enabling more high-risk patients to achieve recommended LDL-C goals.
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1Hill, Laurie
2Windler, Eberhard
3Wiklund, Olov
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5Duffield, Emma
6Sosef, Froukje
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8Wallenberg Laboratory
9Institute of Medicine, Department of Molecular and Clinical Medicine
10Göteborgs universitet
11Gothenburg University
12Sahlgrenska Academy
13Sahlgrenska akademin
14Wallenberglaboratoriet
15Institutionen för medicin, avdelningen för molekylär och klinisk medicin
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0Efficacy and tolerability of rosuvastatin and atorvastatin when force-titrated in patients with primary hypercholesterolemia: results from the ECLIPSE study
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descriptionPatients at high risk of cardiovascular disease frequently fail to reach recommended low-density lipoprotein cholesterol (LDL-C) goals, partly because statin doses are not titrated to optimal effect. The ECLIPSE study was designed to compare the efficacy and safety of force-titrated treatment with rosuvastatin (10-40 mg) with that of atorvastatin (10-80 mg) in high-risk patients with hypercholesterolemia. In this 24-week, open-label, randomized, multinational, parallel-group study, 1,036 patients were randomized to rosuvastatin (n = 522) or atorvastatin (n = 514). At all time points, a significantly greater percentage of patients on rosuvastatin treatment achieved the NCEP ATP III LDL-C goal of <100 mg/dl (2.5 mmol/l), the 2003 European LDL-C target of <2.5 or 3.0 mmol/l (100 or 115 mg/dl) and the LDL-C goal of <70 mg/dl (1.8 mmol/l), a goal suggested for very high-risk patients (p < 0.001 for all). Rosuvastatin also achieved significantly greater improvements in components of the atherogenic lipid profile versus atorvastatin. Both treatments were well tolerated. Rosuvastatin titrated across its recommended dose range provides a more favorable effect on lipoprotein variables than atorvastatin, enabling more high-risk patients to achieve recommended LDL-C goals.
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1Atorvastatin Calcium
2Canada
3Cardiovascular disease
4Cholesterol
5Cholesterol, LDL - blood
6CoA Reductase Inhibitors
7Coronary Disease
8Coronary Disease - prevention & control
9Drug dosages
10Drug therapy
11European Union
12Female
13Fluorobenzenes
14Fluorobenzenes - administration & dosage
15Fluorobenzenes - adverse effects
16Heptanoic Acids
17Heptanoic Acids - administration & dosage
18Heptanoic Acids - adverse effects
19Humans
20Hydroxymethylglutaryl
21Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage
22Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects
23Hypercholesterolemia
24Hypercholesterolemia - blood
25Hypercholesterolemia - drug therapy
26Lipids
27lipids (amino acids
28Male
29MEDICAL AND HEALTH SCIENCES
30MEDICIN OCH HÄLSOVETENSKAP
31metabolic diseases
32Middle Aged
33nutritional
34peptides
35proteins
36Pyrimidines
37Pyrimidines - administration & dosage
38Pyrimidines - adverse effects
39Pyrroles
40Pyrroles - administration & dosage
41Pyrroles - adverse effects
42Risk
43Risk Assessment
44Risk Factors
45Rosuvastatin Calcium
46Statins
47Sulfonamides
48Sulfonamides - administration & dosage
49Sulfonamides - adverse effects
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titleEfficacy and tolerability of rosuvastatin and atorvastatin when force-titrated in patients with primary hypercholesterolemia: results from the ECLIPSE study
authorFaergeman, Ole ; Hill, Laurie ; Windler, Eberhard ; Wiklund, Olov ; Asmar, Roland ; Duffield, Emma ; Sosef, Froukje
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1Atorvastatin Calcium
2Canada
3Cardiovascular disease
4Cholesterol
5Cholesterol, LDL - blood
6CoA Reductase Inhibitors
7Coronary Disease
8Coronary Disease - prevention & control
9Drug dosages
10Drug therapy
11European Union
12Female
13Fluorobenzenes
14Fluorobenzenes - administration & dosage
15Fluorobenzenes - adverse effects
16Heptanoic Acids
17Heptanoic Acids - administration & dosage
18Heptanoic Acids - adverse effects
19Humans
20Hydroxymethylglutaryl
21Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage
22Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects
23Hypercholesterolemia
24Hypercholesterolemia - blood
25Hypercholesterolemia - drug therapy
26Lipids
27lipids (amino acids
28Male
29MEDICAL AND HEALTH SCIENCES
30MEDICIN OCH HÄLSOVETENSKAP
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32Middle Aged
33nutritional
34peptides
35proteins
36Pyrimidines
37Pyrimidines - administration & dosage
38Pyrimidines - adverse effects
39Pyrroles
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41Pyrroles - adverse effects
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49Sulfonamides - adverse effects
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8Wallenberg Laboratory
9Institute of Medicine, Department of Molecular and Clinical Medicine
10Göteborgs universitet
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atitleEfficacy and tolerability of rosuvastatin and atorvastatin when force-titrated in patients with primary hypercholesterolemia: results from the ECLIPSE study
jtitleCardiology
addtitleCardiology
date2008
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volume111
issue4
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pages219-28
issn
00008-6312
11421-9751
eissn1421-9751
abstractPatients at high risk of cardiovascular disease frequently fail to reach recommended low-density lipoprotein cholesterol (LDL-C) goals, partly because statin doses are not titrated to optimal effect. The ECLIPSE study was designed to compare the efficacy and safety of force-titrated treatment with rosuvastatin (10-40 mg) with that of atorvastatin (10-80 mg) in high-risk patients with hypercholesterolemia. In this 24-week, open-label, randomized, multinational, parallel-group study, 1,036 patients were randomized to rosuvastatin (n = 522) or atorvastatin (n = 514). At all time points, a significantly greater percentage of patients on rosuvastatin treatment achieved the NCEP ATP III LDL-C goal of <100 mg/dl (2.5 mmol/l), the 2003 European LDL-C target of <2.5 or 3.0 mmol/l (100 or 115 mg/dl) and the LDL-C goal of <70 mg/dl (1.8 mmol/l), a goal suggested for very high-risk patients (p < 0.001 for all). Rosuvastatin also achieved significantly greater improvements in components of the atherogenic lipid profile versus atorvastatin. Both treatments were well tolerated. Rosuvastatin titrated across its recommended dose range provides a more favorable effect on lipoprotein variables than atorvastatin, enabling more high-risk patients to achieve recommended LDL-C goals.
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pmid18434729
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