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Glycemia but not the Metabolic Syndrome is Associated with Cognitive Decline: Findings from the European Male Ageing Study

Objective Previous research has indicated that components of the metabolic syndrome (MetS), such as hyperglycemia and hypertension, are negatively associated with cognition. However, evidence that MetS itself is related to cognitive performance has been inconsistent. This longitudinal study investig... Full description

Journal Title: The American journal of geriatric psychiatry 2017, Vol.25 (6), p.662-671
Main Author: Overman, Margot J., M.Sc
Other Authors: Pendleton, Neil, M.D , O'Neill, Terence W., M.D , Bartfai, Gyorgy, M.D , Casanueva, Felipe F., M.D., B.Sc , Forti, Gianni, M.D , Rastrelli, Giulia, M.D , Giwercman, Aleksander, M.D , Han, Thang S., Ph.D , Huhtaniemi, Ilpo T., M.D , Kula, Krzysztof, M.D , Lean, Michael E.J., M.D , Punab, Margus, M.D , Lee, David M., Ph.D , Correa, Elon S., Ph.D , Ahern, Tomas, M.D , Laurent, Michaël R., M.D , Verschueren, Sabine M.P., Ph.D , Antonio, Leen, M.D , Gielen, Evelien, M.D , Rutter, Martin K., M.D , Vanderschueren, Dirk, M.D , Wu, Frederick C.W., M.D , Tournoy, Jos, M.D
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: Elsevier Inc
ID: ISSN: 1064-7481
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title: Glycemia but not the Metabolic Syndrome is Associated with Cognitive Decline: Findings from the European Male Ageing Study
format: Article
creator:
  • Overman, Margot J., M.Sc
  • Pendleton, Neil, M.D
  • O'Neill, Terence W., M.D
  • Bartfai, Gyorgy, M.D
  • Casanueva, Felipe F., M.D., B.Sc
  • Forti, Gianni, M.D
  • Rastrelli, Giulia, M.D
  • Giwercman, Aleksander, M.D
  • Han, Thang S., Ph.D
  • Huhtaniemi, Ilpo T., M.D
  • Kula, Krzysztof, M.D
  • Lean, Michael E.J., M.D
  • Punab, Margus, M.D
  • Lee, David M., Ph.D
  • Correa, Elon S., Ph.D
  • Ahern, Tomas, M.D
  • Laurent, Michaël R., M.D
  • Verschueren, Sabine M.P., Ph.D
  • Antonio, Leen, M.D
  • Gielen, Evelien, M.D
  • Rutter, Martin K., M.D
  • Vanderschueren, Dirk, M.D
  • Wu, Frederick C.W., M.D
  • Tournoy, Jos, M.D
subjects:
  • Adult
  • Aged
  • Aging
  • Aging - psychology
  • Annan medicin och hälsovetenskap
  • C-Reactive Protein - metabolism
  • Cognition
  • Cognitive ability
  • Cognitive Dysfunction - complications
  • Cognitive Dysfunction - metabolism
  • Geriatric Assessment
  • Gerontologi, medicinsk/hälsovetenskaplig inriktning
  • Gerontology, specializing in Medical and Health Sciences
  • Humans
  • Hyperglycemia - complications
  • Hyperglycemia - metabolism
  • Hyperglycemia - psychology
  • Inflammation - complications
  • Inflammation - metabolism
  • Internal Medicine
  • Longitudinal Studies
  • Male
  • Male health
  • Medical and Health Sciences
  • Medicin och hälsovetenskap
  • Mens health
  • Metabolic syndrome
  • Metabolic Syndrome - complications
  • Metabolic Syndrome - metabolism
  • Metabolic Syndrome - psychology
  • Middle Aged
  • Multicenter study
  • Other Medical Sciences
  • Risk factors
ispartof: The American journal of geriatric psychiatry, 2017, Vol.25 (6), p.662-671
description: Objective Previous research has indicated that components of the metabolic syndrome (MetS), such as hyperglycemia and hypertension, are negatively associated with cognition. However, evidence that MetS itself is related to cognitive performance has been inconsistent. This longitudinal study investigates whether MetS or its components affect cognitive decline in aging men and whether any interaction with inflammation exists. Methods Over a mean of 4.4 years (SD ± 0.3), men aged 40–79 years from the multicenter European Male Ageing Study were recruited. Cognitive functioning was assessed using the Rey-Osterrieth Complex Figure (ROCF), the Camden Topographical Recognition Memory (CTRM) task, and the Digit Symbol Substitution Test (DSST). High-sensitivity C-reactive protein (hs-CRP) levels were measured using a chemiluminescent immunometric assay. Results Overall, 1,913 participants contributed data to the ROCF analyses and 1,965 subjects contributed to the CTRM and DSST analyses. In multiple regression models the presence of baseline MetS was not associated with cognitive decline over time (p > 0.05). However, logistic ordinal regressions indicated that high glucose levels were related to a greater risk of decline on the ROCF Copy (β = −0.42, p 
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1064-7481
fulltext: fulltext
issn:
  • 1064-7481
  • 1545-7214
url: Link


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titleGlycemia but not the Metabolic Syndrome is Associated with Cognitive Decline: Findings from the European Male Ageing Study
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creatorOverman, Margot J., M.Sc ; Pendleton, Neil, M.D ; O'Neill, Terence W., M.D ; Bartfai, Gyorgy, M.D ; Casanueva, Felipe F., M.D., B.Sc ; Forti, Gianni, M.D ; Rastrelli, Giulia, M.D ; Giwercman, Aleksander, M.D ; Han, Thang S., Ph.D ; Huhtaniemi, Ilpo T., M.D ; Kula, Krzysztof, M.D ; Lean, Michael E.J., M.D ; Punab, Margus, M.D ; Lee, David M., Ph.D ; Correa, Elon S., Ph.D ; Ahern, Tomas, M.D ; Laurent, Michaël R., M.D ; Verschueren, Sabine M.P., Ph.D ; Antonio, Leen, M.D ; Gielen, Evelien, M.D ; Rutter, Martin K., M.D ; Vanderschueren, Dirk, M.D ; Wu, Frederick C.W., M.D ; Tournoy, Jos, M.D
creatorcontribOverman, Margot J., M.Sc ; Pendleton, Neil, M.D ; O'Neill, Terence W., M.D ; Bartfai, Gyorgy, M.D ; Casanueva, Felipe F., M.D., B.Sc ; Forti, Gianni, M.D ; Rastrelli, Giulia, M.D ; Giwercman, Aleksander, M.D ; Han, Thang S., Ph.D ; Huhtaniemi, Ilpo T., M.D ; Kula, Krzysztof, M.D ; Lean, Michael E.J., M.D ; Punab, Margus, M.D ; Lee, David M., Ph.D ; Correa, Elon S., Ph.D ; Ahern, Tomas, M.D ; Laurent, Michaël R., M.D ; Verschueren, Sabine M.P., Ph.D ; Antonio, Leen, M.D ; Gielen, Evelien, M.D ; Rutter, Martin K., M.D ; Vanderschueren, Dirk, M.D ; Wu, Frederick C.W., M.D ; Tournoy, Jos, M.D ; EMAS study group
descriptionObjective Previous research has indicated that components of the metabolic syndrome (MetS), such as hyperglycemia and hypertension, are negatively associated with cognition. However, evidence that MetS itself is related to cognitive performance has been inconsistent. This longitudinal study investigates whether MetS or its components affect cognitive decline in aging men and whether any interaction with inflammation exists. Methods Over a mean of 4.4 years (SD ± 0.3), men aged 40–79 years from the multicenter European Male Ageing Study were recruited. Cognitive functioning was assessed using the Rey-Osterrieth Complex Figure (ROCF), the Camden Topographical Recognition Memory (CTRM) task, and the Digit Symbol Substitution Test (DSST). High-sensitivity C-reactive protein (hs-CRP) levels were measured using a chemiluminescent immunometric assay. Results Overall, 1,913 participants contributed data to the ROCF analyses and 1,965 subjects contributed to the CTRM and DSST analyses. In multiple regression models the presence of baseline MetS was not associated with cognitive decline over time (p > 0.05). However, logistic ordinal regressions indicated that high glucose levels were related to a greater risk of decline on the ROCF Copy (β = −0.42, p < 0.05) and the DSST (β = −0.39, p < 0.001). There was neither a main effect of hs-CRP levels nor an interaction effect of hs-CRP and MetS at baseline on cognitive decline. Conclusion No evidence was found for a relationship between MetS or inflammation and cognitive decline in this sample of aging men. However, glycemia was negatively associated with visuoconstructional abilities and processing speed.
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languageeng
publisherEngland: Elsevier Inc
subjectAdult ; Aged ; Aging ; Aging - psychology ; Annan medicin och hälsovetenskap ; C-Reactive Protein - metabolism ; Cognition ; Cognitive ability ; Cognitive Dysfunction - complications ; Cognitive Dysfunction - metabolism ; Geriatric Assessment ; Gerontologi, medicinsk/hälsovetenskaplig inriktning ; Gerontology, specializing in Medical and Health Sciences ; Humans ; Hyperglycemia - complications ; Hyperglycemia - metabolism ; Hyperglycemia - psychology ; Inflammation - complications ; Inflammation - metabolism ; Internal Medicine ; Longitudinal Studies ; Male ; Male health ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Mens health ; Metabolic syndrome ; Metabolic Syndrome - complications ; Metabolic Syndrome - metabolism ; Metabolic Syndrome - psychology ; Middle Aged ; Multicenter study ; Other Medical Sciences ; Risk factors
ispartofThe American journal of geriatric psychiatry, 2017, Vol.25 (6), p.662-671
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2Copyright © 2017 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.
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0Overman, Margot J., M.Sc
1Pendleton, Neil, M.D
2O'Neill, Terence W., M.D
3Bartfai, Gyorgy, M.D
4Casanueva, Felipe F., M.D., B.Sc
5Forti, Gianni, M.D
6Rastrelli, Giulia, M.D
7Giwercman, Aleksander, M.D
8Han, Thang S., Ph.D
9Huhtaniemi, Ilpo T., M.D
10Kula, Krzysztof, M.D
11Lean, Michael E.J., M.D
12Punab, Margus, M.D
13Lee, David M., Ph.D
14Correa, Elon S., Ph.D
15Ahern, Tomas, M.D
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17Verschueren, Sabine M.P., Ph.D
18Antonio, Leen, M.D
19Gielen, Evelien, M.D
20Rutter, Martin K., M.D
21Vanderschueren, Dirk, M.D
22Wu, Frederick C.W., M.D
23Tournoy, Jos, M.D
24EMAS study group
title
0Glycemia but not the Metabolic Syndrome is Associated with Cognitive Decline: Findings from the European Male Ageing Study
1The American journal of geriatric psychiatry
addtitleAm J Geriatr Psychiatry
descriptionObjective Previous research has indicated that components of the metabolic syndrome (MetS), such as hyperglycemia and hypertension, are negatively associated with cognition. However, evidence that MetS itself is related to cognitive performance has been inconsistent. This longitudinal study investigates whether MetS or its components affect cognitive decline in aging men and whether any interaction with inflammation exists. Methods Over a mean of 4.4 years (SD ± 0.3), men aged 40–79 years from the multicenter European Male Ageing Study were recruited. Cognitive functioning was assessed using the Rey-Osterrieth Complex Figure (ROCF), the Camden Topographical Recognition Memory (CTRM) task, and the Digit Symbol Substitution Test (DSST). High-sensitivity C-reactive protein (hs-CRP) levels were measured using a chemiluminescent immunometric assay. Results Overall, 1,913 participants contributed data to the ROCF analyses and 1,965 subjects contributed to the CTRM and DSST analyses. In multiple regression models the presence of baseline MetS was not associated with cognitive decline over time (p > 0.05). However, logistic ordinal regressions indicated that high glucose levels were related to a greater risk of decline on the ROCF Copy (β = −0.42, p < 0.05) and the DSST (β = −0.39, p < 0.001). There was neither a main effect of hs-CRP levels nor an interaction effect of hs-CRP and MetS at baseline on cognitive decline. Conclusion No evidence was found for a relationship between MetS or inflammation and cognitive decline in this sample of aging men. However, glycemia was negatively associated with visuoconstructional abilities and processing speed.
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7Giwercman, Aleksander, M.D
8Han, Thang S., Ph.D
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titleGlycemia but not the Metabolic Syndrome is Associated with Cognitive Decline: Findings from the European Male Ageing Study
authorOverman, Margot J., M.Sc ; Pendleton, Neil, M.D ; O'Neill, Terence W., M.D ; Bartfai, Gyorgy, M.D ; Casanueva, Felipe F., M.D., B.Sc ; Forti, Gianni, M.D ; Rastrelli, Giulia, M.D ; Giwercman, Aleksander, M.D ; Han, Thang S., Ph.D ; Huhtaniemi, Ilpo T., M.D ; Kula, Krzysztof, M.D ; Lean, Michael E.J., M.D ; Punab, Margus, M.D ; Lee, David M., Ph.D ; Correa, Elon S., Ph.D ; Ahern, Tomas, M.D ; Laurent, Michaël R., M.D ; Verschueren, Sabine M.P., Ph.D ; Antonio, Leen, M.D ; Gielen, Evelien, M.D ; Rutter, Martin K., M.D ; Vanderschueren, Dirk, M.D ; Wu, Frederick C.W., M.D ; Tournoy, Jos, M.D
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abstractObjective Previous research has indicated that components of the metabolic syndrome (MetS), such as hyperglycemia and hypertension, are negatively associated with cognition. However, evidence that MetS itself is related to cognitive performance has been inconsistent. This longitudinal study investigates whether MetS or its components affect cognitive decline in aging men and whether any interaction with inflammation exists. Methods Over a mean of 4.4 years (SD ± 0.3), men aged 40–79 years from the multicenter European Male Ageing Study were recruited. Cognitive functioning was assessed using the Rey-Osterrieth Complex Figure (ROCF), the Camden Topographical Recognition Memory (CTRM) task, and the Digit Symbol Substitution Test (DSST). High-sensitivity C-reactive protein (hs-CRP) levels were measured using a chemiluminescent immunometric assay. Results Overall, 1,913 participants contributed data to the ROCF analyses and 1,965 subjects contributed to the CTRM and DSST analyses. In multiple regression models the presence of baseline MetS was not associated with cognitive decline over time (p > 0.05). However, logistic ordinal regressions indicated that high glucose levels were related to a greater risk of decline on the ROCF Copy (β = −0.42, p < 0.05) and the DSST (β = −0.39, p < 0.001). There was neither a main effect of hs-CRP levels nor an interaction effect of hs-CRP and MetS at baseline on cognitive decline. Conclusion No evidence was found for a relationship between MetS or inflammation and cognitive decline in this sample of aging men. However, glycemia was negatively associated with visuoconstructional abilities and processing speed.
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