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Human renal function maturation: a quantitative description using weight and postmenstrual age

This study pools published data to describe the increase in glomerular filtration rate (GFR) from very premature neonates to young adults. The data comprises measured GFR (using polyfructose, 51 Cr-EDTA, mannitol or iohexol) from eight studies ( n  = 923) and involved very premature neonates (22 wee... Full description

Journal Title: Pediatric nephrology (Berlin West), 2009-01-01, Vol.24 (1), p.67-76
Main Author: Rhodin, Malin M
Other Authors: Anderson, Brian J , Peters, A. Michael , Coulthard, Malcolm G , Wilkins, Barry , Cole, Michael , Chatelut, Etienne , Grubb, Anders , Veal, Gareth J , Keir, Michael J , Holford, Nick H. G
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0931-041X
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title: Human renal function maturation: a quantitative description using weight and postmenstrual age
format: Article
creator:
  • Rhodin, Malin M
  • Anderson, Brian J
  • Peters, A. Michael
  • Coulthard, Malcolm G
  • Wilkins, Barry
  • Cole, Michael
  • Chatelut, Etienne
  • Grubb, Anders
  • Veal, Gareth J
  • Keir, Michael J
  • Holford, Nick H. G
subjects:
  • Adolescent
  • Adult
  • Aging - physiology
  • Allometry
  • Basic Medicine
  • Body composition
  • Body Weight - physiology
  • Child
  • Child, Preschool
  • Databases, Factual
  • Farmaceutiska vetenskaper
  • FARMACI
  • Farmakologi och toxikologi
  • Fat-free mass
  • Female
  • Fetal Growth Retardation - physiopathology
  • Gestational Age
  • Glomerular filtration rate
  • Glomerular Filtration Rate - physiology
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Premature - growth & development
  • Kidney - growth & development
  • Kidney Function Tests
  • Lean body weight
  • Läkemedelskemi
  • Male
  • Medical and Health Sciences
  • Medicin och hälsovetenskap
  • Medicinal Chemistry
  • Medicine & Public Health
  • Medicinska och farmaceutiska grundvetenskaper
  • Nephrology
  • Original Article
  • Pediatrics
  • Pharmaceutical Sciences
  • Pharmacology and Toxicology
  • PHARMACY
  • Postmenstrual age
  • Renal function
  • Urology
  • Young Adult
ispartof: Pediatric nephrology (Berlin, West), 2009-01-01, Vol.24 (1), p.67-76
description: This study pools published data to describe the increase in glomerular filtration rate (GFR) from very premature neonates to young adults. The data comprises measured GFR (using polyfructose, 51 Cr-EDTA, mannitol or iohexol) from eight studies ( n  = 923) and involved very premature neonates (22 weeks postmenstrual age) to adulthood (31 years). A nonlinear mixed effects approach (NONMEM) was used to examine the influences of size and maturation on renal function. Size was the primary covariate, and GFR was standardized for a body weight of 70 kg using an allometric power model. Postmenstrual age (PMA) was a better descriptor of maturational changes than postnatal age (PNA). A sigmoid hyperbolic model described the nonlinear relationship between GFR maturation and PMA. Assuming an allometric coefficient of 3/4, the fully mature (adult) GFR is predicted to be 121.2 mL/min per 70 kg [95% confidence interval (CI) 117–125]. Half of the adult value is reached at 47.7 post-menstrual weeks (95%CI 45.1–50.5), with a Hill coefficient of 3.40 (95%CI 3.03–3.80). At 1-year postnatal age, the GFR is predicted to be 90% of the adult GFR. Glomerular filtration rate can be predicted with a consistent relationship from early prematurity to adulthood. We propose that this offers a clinically useful definition of renal function in children and young adults that is independent of the predictable changes associated with age and size.
language: eng
source:
identifier: ISSN: 0931-041X
fulltext: no_fulltext
issn:
  • 0931-041X
  • 1432-198X
  • 1432-198X
url: Link


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titleHuman renal function maturation: a quantitative description using weight and postmenstrual age
creatorRhodin, Malin M ; Anderson, Brian J ; Peters, A. Michael ; Coulthard, Malcolm G ; Wilkins, Barry ; Cole, Michael ; Chatelut, Etienne ; Grubb, Anders ; Veal, Gareth J ; Keir, Michael J ; Holford, Nick H. G
creatorcontribRhodin, Malin M ; Anderson, Brian J ; Peters, A. Michael ; Coulthard, Malcolm G ; Wilkins, Barry ; Cole, Michael ; Chatelut, Etienne ; Grubb, Anders ; Veal, Gareth J ; Keir, Michael J ; Holford, Nick H. G
descriptionThis study pools published data to describe the increase in glomerular filtration rate (GFR) from very premature neonates to young adults. The data comprises measured GFR (using polyfructose, 51 Cr-EDTA, mannitol or iohexol) from eight studies ( n  = 923) and involved very premature neonates (22 weeks postmenstrual age) to adulthood (31 years). A nonlinear mixed effects approach (NONMEM) was used to examine the influences of size and maturation on renal function. Size was the primary covariate, and GFR was standardized for a body weight of 70 kg using an allometric power model. Postmenstrual age (PMA) was a better descriptor of maturational changes than postnatal age (PNA). A sigmoid hyperbolic model described the nonlinear relationship between GFR maturation and PMA. Assuming an allometric coefficient of 3/4, the fully mature (adult) GFR is predicted to be 121.2 mL/min per 70 kg [95% confidence interval (CI) 117–125]. Half of the adult value is reached at 47.7 post-menstrual weeks (95%CI 45.1–50.5), with a Hill coefficient of 3.40 (95%CI 3.03–3.80). At 1-year postnatal age, the GFR is predicted to be 90% of the adult GFR. Glomerular filtration rate can be predicted with a consistent relationship from early prematurity to adulthood. We propose that this offers a clinically useful definition of renal function in children and young adults that is independent of the predictable changes associated with age and size.
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languageeng
publisherBerlin/Heidelberg: Springer Berlin Heidelberg
subjectAdolescent ; Adult ; Aging - physiology ; Allometry ; Basic Medicine ; Body composition ; Body Weight - physiology ; Child ; Child, Preschool ; Databases, Factual ; Farmaceutiska vetenskaper ; FARMACI ; Farmakologi och toxikologi ; Fat-free mass ; Female ; Fetal Growth Retardation - physiopathology ; Gestational Age ; Glomerular filtration rate ; Glomerular Filtration Rate - physiology ; Humans ; Infant ; Infant, Newborn ; Infant, Premature - growth & development ; Kidney - growth & development ; Kidney Function Tests ; Lean body weight ; Läkemedelskemi ; Male ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Medicinal Chemistry ; Medicine & Public Health ; Medicinska och farmaceutiska grundvetenskaper ; Nephrology ; Original Article ; Pediatrics ; Pharmaceutical Sciences ; Pharmacology and Toxicology ; PHARMACY ; Postmenstrual age ; Renal function ; Urology ; Young Adult
ispartofPediatric nephrology (Berlin, West), 2009-01-01, Vol.24 (1), p.67-76
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1Anderson, Brian J
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4Wilkins, Barry
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6Chatelut, Etienne
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8Veal, Gareth J
9Keir, Michael J
10Holford, Nick H. G
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0Human renal function maturation: a quantitative description using weight and postmenstrual age
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descriptionThis study pools published data to describe the increase in glomerular filtration rate (GFR) from very premature neonates to young adults. The data comprises measured GFR (using polyfructose, 51 Cr-EDTA, mannitol or iohexol) from eight studies ( n  = 923) and involved very premature neonates (22 weeks postmenstrual age) to adulthood (31 years). A nonlinear mixed effects approach (NONMEM) was used to examine the influences of size and maturation on renal function. Size was the primary covariate, and GFR was standardized for a body weight of 70 kg using an allometric power model. Postmenstrual age (PMA) was a better descriptor of maturational changes than postnatal age (PNA). A sigmoid hyperbolic model described the nonlinear relationship between GFR maturation and PMA. Assuming an allometric coefficient of 3/4, the fully mature (adult) GFR is predicted to be 121.2 mL/min per 70 kg [95% confidence interval (CI) 117–125]. Half of the adult value is reached at 47.7 post-menstrual weeks (95%CI 45.1–50.5), with a Hill coefficient of 3.40 (95%CI 3.03–3.80). At 1-year postnatal age, the GFR is predicted to be 90% of the adult GFR. Glomerular filtration rate can be predicted with a consistent relationship from early prematurity to adulthood. We propose that this offers a clinically useful definition of renal function in children and young adults that is independent of the predictable changes associated with age and size.
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2Aging - physiology
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5Body composition
6Body Weight - physiology
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9Databases, Factual
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18Glomerular Filtration Rate - physiology
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21Infant, Newborn
22Infant, Premature - growth & development
23Kidney - growth & development
24Kidney Function Tests
25Lean body weight
26Läkemedelskemi
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28Medical and Health Sciences
29Medicin och hälsovetenskap
30Medicinal Chemistry
31Medicine & Public Health
32Medicinska och farmaceutiska grundvetenskaper
33Nephrology
34Original Article
35Pediatrics
36Pharmaceutical Sciences
37Pharmacology and Toxicology
38PHARMACY
39Postmenstrual age
40Renal function
41Urology
42Young Adult
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titleHuman renal function maturation: a quantitative description using weight and postmenstrual age
authorRhodin, Malin M ; Anderson, Brian J ; Peters, A. Michael ; Coulthard, Malcolm G ; Wilkins, Barry ; Cole, Michael ; Chatelut, Etienne ; Grubb, Anders ; Veal, Gareth J ; Keir, Michael J ; Holford, Nick H. G
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1Adult
2Aging - physiology
3Allometry
4Basic Medicine
5Body composition
6Body Weight - physiology
7Child
8Child, Preschool
9Databases, Factual
10Farmaceutiska vetenskaper
11FARMACI
12Farmakologi och toxikologi
13Fat-free mass
14Female
15Fetal Growth Retardation - physiopathology
16Gestational Age
17Glomerular filtration rate
18Glomerular Filtration Rate - physiology
19Humans
20Infant
21Infant, Newborn
22Infant, Premature - growth & development
23Kidney - growth & development
24Kidney Function Tests
25Lean body weight
26Läkemedelskemi
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28Medical and Health Sciences
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31Medicine & Public Health
32Medicinska och farmaceutiska grundvetenskaper
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abstractThis study pools published data to describe the increase in glomerular filtration rate (GFR) from very premature neonates to young adults. The data comprises measured GFR (using polyfructose, 51 Cr-EDTA, mannitol or iohexol) from eight studies ( n  = 923) and involved very premature neonates (22 weeks postmenstrual age) to adulthood (31 years). A nonlinear mixed effects approach (NONMEM) was used to examine the influences of size and maturation on renal function. Size was the primary covariate, and GFR was standardized for a body weight of 70 kg using an allometric power model. Postmenstrual age (PMA) was a better descriptor of maturational changes than postnatal age (PNA). A sigmoid hyperbolic model described the nonlinear relationship between GFR maturation and PMA. Assuming an allometric coefficient of 3/4, the fully mature (adult) GFR is predicted to be 121.2 mL/min per 70 kg [95% confidence interval (CI) 117–125]. Half of the adult value is reached at 47.7 post-menstrual weeks (95%CI 45.1–50.5), with a Hill coefficient of 3.40 (95%CI 3.03–3.80). At 1-year postnatal age, the GFR is predicted to be 90% of the adult GFR. Glomerular filtration rate can be predicted with a consistent relationship from early prematurity to adulthood. We propose that this offers a clinically useful definition of renal function in children and young adults that is independent of the predictable changes associated with age and size.
copBerlin/Heidelberg
pubSpringer Berlin Heidelberg
pmid18846389
doi10.1007/s00467-008-0997-5