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Male sex and vascular risk factors affect cystatin C-derived renal function in older people without diabetes or overt vascular disease

Background/objectives: to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes. Design: a cross-sectional analysis of a healthy subset from the Good Aging in Skåne-cohort study... Full description

Journal Title: Age and Ageing 2014-05, Vol.43 (3), p.411-417
Main Author: Werner, Karin Birgitta
Other Authors: Elmståhl, Sölve , Christensson, Anders , Pihlsgård, Mats
Format: Electronic Article Electronic Article
Language: English
Subjects:
Men
sex
Publisher: England: Oxford University Press
ID: ISSN: 0002-0729
Zum Text:
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title: Male sex and vascular risk factors affect cystatin C-derived renal function in older people without diabetes or overt vascular disease
format: Article
creator:
  • Werner, Karin Birgitta
  • Elmståhl, Sölve
  • Christensson, Anders
  • Pihlsgård, Mats
subjects:
  • Adult
  • Aged
  • Aged, 80 and over
  • Ageing
  • Aging
  • Aging - physiology
  • Analysis
  • Annan medicin och hälsovetenskap
  • Biomarkers - blood
  • Care and treatment
  • Cohort Studies
  • Creatinine - blood
  • Cross-Sectional Studies
  • cystatin C
  • Cystatin C - blood
  • Diabetes
  • Diabetes in old age
  • Diabetes mellitus
  • Diagnosis
  • Elderly
  • Epidemiology
  • female genital diseases
  • Gerontologi, medicinsk/hälsovetenskaplig inriktning
  • Gerontology
  • Gerontology, specializing in Medical and Health Sciences
  • Glomerular Filtration Rate
  • Health Sciences
  • Humans
  • Kidney diseases
  • kidney function
  • Kidney Function Tests - methods
  • Kidney Function Tests - statistics & numerical data
  • Male
  • male genital diseases
  • Males
  • Medical and Health Sciences
  • Medicin och hälsovetenskap
  • Men
  • Observational studies
  • Older people
  • Other Medical Sciences
  • pregnancy complications
  • Renal Insufficiency, Chronic - blood
  • Renal Insufficiency, Chronic - diagnosis
  • Renal Insufficiency, Chronic - epidemiology
  • Renal Insufficiency, Chronic - physiopathology
  • Research Papers
  • Risk Factors
  • Severity of Illness Index
  • sex
  • Sex Factors
  • specializing in Medical
  • Statistics as Topic
  • Sweden - epidemiology
  • urologic
  • Usage
  • Vascular disease
  • Vein & artery diseases
ispartof: Age and Ageing, 2014-05, Vol.43 (3), p.411-417
description: Background/objectives: to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes. Design: a cross-sectional analysis of a healthy subset from the Good Aging in Skåne-cohort study representative of the Swedish general population. Subjects: 1252 participants without vascular disease and diabetes (43.9% men) of whom 203 were over 80 years old were included from the original cohort of 2931. Methods: plasma cystatin C and plasma creatinine were used as markers for GFR. Estimated GFR (eGFR) was calculated with three chronic kidney disease epidemiology collaboration (CKD-EPI) formulas involving cystatin C, creatinine or both. Results: the median for plasma cystatin C was 0.93 mg/l (60–69 years old), 1.04 (70–79 years old) and 1.24 (80+ years old). The difference in mg/l between the 5th and 95th percentile was 0.46, 0.62 and 0.90 for these age groups. Male sex increased the age effect on plasma cystatin C levels with 0.004 mg/l/year (P = 0.03), adjusted for vascular risk factors. Smoking, lower HDL and higher diastolic blood pressure were associated with higher cystatin C levels. 54.7% (CKD-EPI creatinine) to 73.9% (CKD-EPI cystatin C) of the 80+ had an eGFR < 60 ml/min/1.73 m2. Conclusion: non-diabetics without overt vascular disease exhibit an age related but heterogeneous decline in renal function. The ageing effect is more pronounced in men. At least half of healthy 80+ years old could be expected to have at least CKD Stage 3 with eGFR < 60 ml/min/1.73 m2.
language: eng
source:
identifier: ISSN: 0002-0729
fulltext: no_fulltext
issn:
  • 0002-0729
  • 1468-2834
  • 1468-2834
url: Link


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titleMale sex and vascular risk factors affect cystatin C-derived renal function in older people without diabetes or overt vascular disease
creatorWerner, Karin Birgitta ; Elmståhl, Sölve ; Christensson, Anders ; Pihlsgård, Mats
creatorcontribWerner, Karin Birgitta ; Elmståhl, Sölve ; Christensson, Anders ; Pihlsgård, Mats
descriptionBackground/objectives: to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes. Design: a cross-sectional analysis of a healthy subset from the Good Aging in Skåne-cohort study representative of the Swedish general population. Subjects: 1252 participants without vascular disease and diabetes (43.9% men) of whom 203 were over 80 years old were included from the original cohort of 2931. Methods: plasma cystatin C and plasma creatinine were used as markers for GFR. Estimated GFR (eGFR) was calculated with three chronic kidney disease epidemiology collaboration (CKD-EPI) formulas involving cystatin C, creatinine or both. Results: the median for plasma cystatin C was 0.93 mg/l (60–69 years old), 1.04 (70–79 years old) and 1.24 (80+ years old). The difference in mg/l between the 5th and 95th percentile was 0.46, 0.62 and 0.90 for these age groups. Male sex increased the age effect on plasma cystatin C levels with 0.004 mg/l/year (P = 0.03), adjusted for vascular risk factors. Smoking, lower HDL and higher diastolic blood pressure were associated with higher cystatin C levels. 54.7% (CKD-EPI creatinine) to 73.9% (CKD-EPI cystatin C) of the 80+ had an eGFR < 60 ml/min/1.73 m2. Conclusion: non-diabetics without overt vascular disease exhibit an age related but heterogeneous decline in renal function. The ageing effect is more pronounced in men. At least half of healthy 80+ years old could be expected to have at least CKD Stage 3 with eGFR < 60 ml/min/1.73 m2.
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languageeng
publisherEngland: Oxford University Press
subjectAdult ; Aged ; Aged, 80 and over ; Ageing ; Aging ; Aging - physiology ; Analysis ; Annan medicin och hälsovetenskap ; Biomarkers - blood ; Care and treatment ; Cohort Studies ; Creatinine - blood ; Cross-Sectional Studies ; cystatin C ; Cystatin C - blood ; Diabetes ; Diabetes in old age ; Diabetes mellitus ; Diagnosis ; Elderly ; Epidemiology ; female genital diseases ; Gerontologi, medicinsk/hälsovetenskaplig inriktning ; Gerontology ; Gerontology, specializing in Medical and Health Sciences ; Glomerular Filtration Rate ; Health Sciences ; Humans ; Kidney diseases ; kidney function ; Kidney Function Tests - methods ; Kidney Function Tests - statistics & numerical data ; Male ; male genital diseases ; Males ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Men ; Observational studies ; Older people ; Other Medical Sciences ; pregnancy complications ; Renal Insufficiency, Chronic - blood ; Renal Insufficiency, Chronic - diagnosis ; Renal Insufficiency, Chronic - epidemiology ; Renal Insufficiency, Chronic - physiopathology ; Research Papers ; Risk Factors ; Severity of Illness Index ; sex ; Sex Factors ; specializing in Medical ; Statistics as Topic ; Sweden - epidemiology ; urologic ; Usage ; Vascular disease ; Vein & artery diseases
ispartofAge and Ageing, 2014-05, Vol.43 (3), p.411-417
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1Elmståhl, Sölve
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0Male sex and vascular risk factors affect cystatin C-derived renal function in older people without diabetes or overt vascular disease
1Age and Ageing
addtitleAge Ageing
descriptionBackground/objectives: to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes. Design: a cross-sectional analysis of a healthy subset from the Good Aging in Skåne-cohort study representative of the Swedish general population. Subjects: 1252 participants without vascular disease and diabetes (43.9% men) of whom 203 were over 80 years old were included from the original cohort of 2931. Methods: plasma cystatin C and plasma creatinine were used as markers for GFR. Estimated GFR (eGFR) was calculated with three chronic kidney disease epidemiology collaboration (CKD-EPI) formulas involving cystatin C, creatinine or both. Results: the median for plasma cystatin C was 0.93 mg/l (60–69 years old), 1.04 (70–79 years old) and 1.24 (80+ years old). The difference in mg/l between the 5th and 95th percentile was 0.46, 0.62 and 0.90 for these age groups. Male sex increased the age effect on plasma cystatin C levels with 0.004 mg/l/year (P = 0.03), adjusted for vascular risk factors. Smoking, lower HDL and higher diastolic blood pressure were associated with higher cystatin C levels. 54.7% (CKD-EPI creatinine) to 73.9% (CKD-EPI cystatin C) of the 80+ had an eGFR < 60 ml/min/1.73 m2. Conclusion: non-diabetics without overt vascular disease exhibit an age related but heterogeneous decline in renal function. The ageing effect is more pronounced in men. At least half of healthy 80+ years old could be expected to have at least CKD Stage 3 with eGFR < 60 ml/min/1.73 m2.
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1Aged
2Aged, 80 and over
3Ageing
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5Aging - physiology
6Analysis
7Annan medicin och hälsovetenskap
8Biomarkers - blood
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10Cohort Studies
11Creatinine - blood
12Cross-Sectional Studies
13cystatin C
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15Diabetes
16Diabetes in old age
17Diabetes mellitus
18Diagnosis
19Elderly
20Epidemiology
21female genital diseases
22Gerontologi, medicinsk/hälsovetenskaplig inriktning
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24Gerontology, specializing in Medical and Health Sciences
25Glomerular Filtration Rate
26Health Sciences
27Humans
28Kidney diseases
29kidney function
30Kidney Function Tests - methods
31Kidney Function Tests - statistics & numerical data
32Male
33male genital diseases
34Males
35Medical and Health Sciences
36Medicin och hälsovetenskap
37Men
38Observational studies
39Older people
40Other Medical Sciences
41pregnancy complications
42Renal Insufficiency, Chronic - blood
43Renal Insufficiency, Chronic - diagnosis
44Renal Insufficiency, Chronic - epidemiology
45Renal Insufficiency, Chronic - physiopathology
46Research Papers
47Risk Factors
48Severity of Illness Index
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50Sex Factors
51specializing in Medical
52Statistics as Topic
53Sweden - epidemiology
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56Vascular disease
57Vein & artery diseases
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titleMale sex and vascular risk factors affect cystatin C-derived renal function in older people without diabetes or overt vascular disease
authorWerner, Karin Birgitta ; Elmståhl, Sölve ; Christensson, Anders ; Pihlsgård, Mats
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1Aged
2Aged, 80 and over
3Ageing
4Aging
5Aging - physiology
6Analysis
7Annan medicin och hälsovetenskap
8Biomarkers - blood
9Care and treatment
10Cohort Studies
11Creatinine - blood
12Cross-Sectional Studies
13cystatin C
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15Diabetes
16Diabetes in old age
17Diabetes mellitus
18Diagnosis
19Elderly
20Epidemiology
21female genital diseases
22Gerontologi, medicinsk/hälsovetenskaplig inriktning
23Gerontology
24Gerontology, specializing in Medical and Health Sciences
25Glomerular Filtration Rate
26Health Sciences
27Humans
28Kidney diseases
29kidney function
30Kidney Function Tests - methods
31Kidney Function Tests - statistics & numerical data
32Male
33male genital diseases
34Males
35Medical and Health Sciences
36Medicin och hälsovetenskap
37Men
38Observational studies
39Older people
40Other Medical Sciences
41pregnancy complications
42Renal Insufficiency, Chronic - blood
43Renal Insufficiency, Chronic - diagnosis
44Renal Insufficiency, Chronic - epidemiology
45Renal Insufficiency, Chronic - physiopathology
46Research Papers
47Risk Factors
48Severity of Illness Index
49sex
50Sex Factors
51specializing in Medical
52Statistics as Topic
53Sweden - epidemiology
54urologic
55Usage
56Vascular disease
57Vein & artery diseases
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atitleMale sex and vascular risk factors affect cystatin C-derived renal function in older people without diabetes or overt vascular disease
jtitleAge and Ageing
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abstractBackground/objectives: to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes. Design: a cross-sectional analysis of a healthy subset from the Good Aging in Skåne-cohort study representative of the Swedish general population. Subjects: 1252 participants without vascular disease and diabetes (43.9% men) of whom 203 were over 80 years old were included from the original cohort of 2931. Methods: plasma cystatin C and plasma creatinine were used as markers for GFR. Estimated GFR (eGFR) was calculated with three chronic kidney disease epidemiology collaboration (CKD-EPI) formulas involving cystatin C, creatinine or both. Results: the median for plasma cystatin C was 0.93 mg/l (60–69 years old), 1.04 (70–79 years old) and 1.24 (80+ years old). The difference in mg/l between the 5th and 95th percentile was 0.46, 0.62 and 0.90 for these age groups. Male sex increased the age effect on plasma cystatin C levels with 0.004 mg/l/year (P = 0.03), adjusted for vascular risk factors. Smoking, lower HDL and higher diastolic blood pressure were associated with higher cystatin C levels. 54.7% (CKD-EPI creatinine) to 73.9% (CKD-EPI cystatin C) of the 80+ had an eGFR < 60 ml/min/1.73 m2. Conclusion: non-diabetics without overt vascular disease exhibit an age related but heterogeneous decline in renal function. The ageing effect is more pronounced in men. At least half of healthy 80+ years old could be expected to have at least CKD Stage 3 with eGFR < 60 ml/min/1.73 m2.
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