Male sex and vascular risk factors affect cystatin C-derived renal function in older people without diabetes or overt vascular disease
| Journal Title: | Age and Ageing 2014-05, Vol.43 (3), p.411-417 |
| Main Author: | Werner, Karin Birgitta |
| Other Authors: | Elmståhl, Sölve , Christensson, Anders , Pihlsgård, Mats |
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 Electronic Article
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| Language: |
English |
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| Publisher: | England: Oxford University Press |
| ID: | ISSN: 0002-0729 |
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| recordid: | cdi_swepub_primary_oai_lup_lub_lu_se_4b10d1c1_fddf_47ad_b1b7_235a6fd2a49c |
| title: | Male sex and vascular risk factors affect cystatin C-derived renal function in older people without diabetes or overt vascular disease |
| format: | Article |
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| ispartof: | Age and Ageing, 2014-05, Vol.43 (3), p.411-417 |
| description: | Background/objectives: to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes. Design: a cross-sectional analysis of a healthy subset from the Good Aging in Skåne-cohort study representative of the Swedish general population. Subjects: 1252 participants without vascular disease and diabetes (43.9% men) of whom 203 were over 80 years old were included from the original cohort of 2931. Methods: plasma cystatin C and plasma creatinine were used as markers for GFR. Estimated GFR (eGFR) was calculated with three chronic kidney disease epidemiology collaboration (CKD-EPI) formulas involving cystatin C, creatinine or both. Results: the median for plasma cystatin C was 0.93 mg/l (60–69 years old), 1.04 (70–79 years old) and 1.24 (80+ years old). The difference in mg/l between the 5th and 95th percentile was 0.46, 0.62 and 0.90 for these age groups. Male sex increased the age effect on plasma cystatin C levels with 0.004 mg/l/year (P = 0.03), adjusted for vascular risk factors. Smoking, lower HDL and higher diastolic blood pressure were associated with higher cystatin C levels. 54.7% (CKD-EPI creatinine) to 73.9% (CKD-EPI cystatin C) of the 80+ had an eGFR < 60 ml/min/1.73 m2. Conclusion: non-diabetics without overt vascular disease exhibit an age related but heterogeneous decline in renal function. The ageing effect is more pronounced in men. At least half of healthy 80+ years old could be expected to have at least CKD Stage 3 with eGFR < 60 ml/min/1.73 m2. |
| language: | eng |
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| identifier: | ISSN: 0002-0729 |
| fulltext: | no_fulltext |
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