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Improving Outcome after Stroke: Overcoming the Translational Roadblock

Stroke poses a massive burden of disease, yet we have few effective therapies. The paucity of therapeutic options stands contrary to intensive research efforts. The failure of these past investments demands a thorough re-examination of the pathophysiology of ischaemic brain injury. Several critical... Full description

Journal Title: Cerebrovascular diseases (Basel Switzerland), 2008-03, Vol.25 (3), p.268-278
Main Author: Endres, Matthias
Other Authors: Engelhardt, Britta , Koistinaho, Jari , Lindvall, Olle , Meairs, Stephen , Mohr, Jay P , Planas, Anna , Rothwell, Nancy , Schwaninger, Markus , Schwab, Martin E , Vivien, Denis , Wieloch, Tadeusz , Dirnagl, Ulrich
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Basel, Switzerland: S. Karger AG
ID: ISSN: 1015-9770
Zum Text:
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title: Improving Outcome after Stroke: Overcoming the Translational Roadblock
format: Article
creator:
  • Endres, Matthias
  • Engelhardt, Britta
  • Koistinaho, Jari
  • Lindvall, Olle
  • Meairs, Stephen
  • Mohr, Jay P
  • Planas, Anna
  • Rothwell, Nancy
  • Schwaninger, Markus
  • Schwab, Martin E
  • Vivien, Denis
  • Wieloch, Tadeusz
  • Dirnagl, Ulrich
subjects:
  • 570 Life sciences
  • 610 Medicine & health
  • Animals
  • Anti-Inflammatory Agents - pharmacology
  • Anti-Inflammatory Agents - therapeutic use
  • biology
  • Biomedical Research
  • Brain - blood supply
  • Brain - drug effects
  • Brain - pathology
  • Brain - physiopathology
  • Brain ischaemia
  • Brain Ischemia - complications
  • Brain Ischemia - pathology
  • Brain Ischemia - physiopathology
  • Brain Ischemia - therapy
  • Brain Research Institute
  • Cardiac and Cardiovascular Systems
  • Cerebrovascular Circulation - drug effects
  • Clinical Medicine
  • Clinical Trials as Topic
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Humans
  • Immune System - drug effects
  • Immune System - physiopathology
  • Inflammation - drug therapy
  • Ischemic Preconditioning
  • Kardiologi
  • Klinisk medicin
  • Medical and Health Sciences
  • Medicin och hälsovetenskap
  • Nerve Regeneration - drug effects
  • Neurons - drug effects
  • Neuroprotection
  • Neuroprotective Agents - pharmacology
  • Neuroprotective Agents - therapeutic use
  • Research Design
  • Review
  • Stroke - etiology
  • Stroke - pathology
  • Stroke - physiopathology
  • Stroke - therapy
  • Stroke treatment
  • Thrombolytic Therapy - adverse effects
  • Treatment Outcome
ispartof: Cerebrovascular diseases (Basel, Switzerland), 2008-03, Vol.25 (3), p.268-278
description: Stroke poses a massive burden of disease, yet we have few effective therapies. The paucity of therapeutic options stands contrary to intensive research efforts. The failure of these past investments demands a thorough re-examination of the pathophysiology of ischaemic brain injury. Several critical areas hold the key to overcoming the translational roadblock: (1) vascular occlusion: current recanalization strategies have limited effectiveness and may have serious side effects; (2) complexity of stroke pathobiology: therapy must acknowledge the ‘Janus-faced’ nature of many stroke targets and must identify endogenous neuroprotective and repair mechanisms; (3) inflammation and brain-immune-system interaction: inflammation contributes to lesion expansion, but is also instrumental in lesion containment and repair; stroke outcome is modulated by the interaction of the injured brain with the immune system; (4) regeneration: the potential of the brain for reorganization, plasticity and repair after injury is much greater than previously thought; (5) confounding factors, long-term outcome and predictive modelling. These 5 areas are linked on all levels and therefore need to be tackled by an integrative approach and innovative therapeutic strategies.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1015-9770
fulltext: fulltext
issn:
  • 1015-9770
  • 1421-9786
  • 1421-9786
url: Link


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titleImproving Outcome after Stroke: Overcoming the Translational Roadblock
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creatorEndres, Matthias ; Engelhardt, Britta ; Koistinaho, Jari ; Lindvall, Olle ; Meairs, Stephen ; Mohr, Jay P ; Planas, Anna ; Rothwell, Nancy ; Schwaninger, Markus ; Schwab, Martin E ; Vivien, Denis ; Wieloch, Tadeusz ; Dirnagl, Ulrich
creatorcontribEndres, Matthias ; Engelhardt, Britta ; Koistinaho, Jari ; Lindvall, Olle ; Meairs, Stephen ; Mohr, Jay P ; Planas, Anna ; Rothwell, Nancy ; Schwaninger, Markus ; Schwab, Martin E ; Vivien, Denis ; Wieloch, Tadeusz ; Dirnagl, Ulrich
descriptionStroke poses a massive burden of disease, yet we have few effective therapies. The paucity of therapeutic options stands contrary to intensive research efforts. The failure of these past investments demands a thorough re-examination of the pathophysiology of ischaemic brain injury. Several critical areas hold the key to overcoming the translational roadblock: (1) vascular occlusion: current recanalization strategies have limited effectiveness and may have serious side effects; (2) complexity of stroke pathobiology: therapy must acknowledge the ‘Janus-faced’ nature of many stroke targets and must identify endogenous neuroprotective and repair mechanisms; (3) inflammation and brain-immune-system interaction: inflammation contributes to lesion expansion, but is also instrumental in lesion containment and repair; stroke outcome is modulated by the interaction of the injured brain with the immune system; (4) regeneration: the potential of the brain for reorganization, plasticity and repair after injury is much greater than previously thought; (5) confounding factors, long-term outcome and predictive modelling. These 5 areas are linked on all levels and therefore need to be tackled by an integrative approach and innovative therapeutic strategies.
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subject570 Life sciences ; 610 Medicine & health ; Animals ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; biology ; Biomedical Research ; Brain - blood supply ; Brain - drug effects ; Brain - pathology ; Brain - physiopathology ; Brain ischaemia ; Brain Ischemia - complications ; Brain Ischemia - pathology ; Brain Ischemia - physiopathology ; Brain Ischemia - therapy ; Brain Research Institute ; Cardiac and Cardiovascular Systems ; Cerebrovascular Circulation - drug effects ; Clinical Medicine ; Clinical Trials as Topic ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Humans ; Immune System - drug effects ; Immune System - physiopathology ; Inflammation - drug therapy ; Ischemic Preconditioning ; Kardiologi ; Klinisk medicin ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Nerve Regeneration - drug effects ; Neurons - drug effects ; Neuroprotection ; Neuroprotective Agents - pharmacology ; Neuroprotective Agents - therapeutic use ; Research Design ; Review ; Stroke - etiology ; Stroke - pathology ; Stroke - physiopathology ; Stroke - therapy ; Stroke treatment ; Thrombolytic Therapy - adverse effects ; Treatment Outcome
ispartofCerebrovascular diseases (Basel, Switzerland), 2008-03, Vol.25 (3), p.268-278
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6Planas, Anna
7Rothwell, Nancy
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9Schwab, Martin E
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11Wieloch, Tadeusz
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descriptionStroke poses a massive burden of disease, yet we have few effective therapies. The paucity of therapeutic options stands contrary to intensive research efforts. The failure of these past investments demands a thorough re-examination of the pathophysiology of ischaemic brain injury. Several critical areas hold the key to overcoming the translational roadblock: (1) vascular occlusion: current recanalization strategies have limited effectiveness and may have serious side effects; (2) complexity of stroke pathobiology: therapy must acknowledge the ‘Janus-faced’ nature of many stroke targets and must identify endogenous neuroprotective and repair mechanisms; (3) inflammation and brain-immune-system interaction: inflammation contributes to lesion expansion, but is also instrumental in lesion containment and repair; stroke outcome is modulated by the interaction of the injured brain with the immune system; (4) regeneration: the potential of the brain for reorganization, plasticity and repair after injury is much greater than previously thought; (5) confounding factors, long-term outcome and predictive modelling. These 5 areas are linked on all levels and therefore need to be tackled by an integrative approach and innovative therapeutic strategies.
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4Anti-Inflammatory Agents - therapeutic use
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32Nerve Regeneration - drug effects
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34Neuroprotection
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39Stroke - etiology
40Stroke - pathology
41Stroke - physiopathology
42Stroke - therapy
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45Treatment Outcome
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abstractStroke poses a massive burden of disease, yet we have few effective therapies. The paucity of therapeutic options stands contrary to intensive research efforts. The failure of these past investments demands a thorough re-examination of the pathophysiology of ischaemic brain injury. Several critical areas hold the key to overcoming the translational roadblock: (1) vascular occlusion: current recanalization strategies have limited effectiveness and may have serious side effects; (2) complexity of stroke pathobiology: therapy must acknowledge the ‘Janus-faced’ nature of many stroke targets and must identify endogenous neuroprotective and repair mechanisms; (3) inflammation and brain-immune-system interaction: inflammation contributes to lesion expansion, but is also instrumental in lesion containment and repair; stroke outcome is modulated by the interaction of the injured brain with the immune system; (4) regeneration: the potential of the brain for reorganization, plasticity and repair after injury is much greater than previously thought; (5) confounding factors, long-term outcome and predictive modelling. These 5 areas are linked on all levels and therefore need to be tackled by an integrative approach and innovative therapeutic strategies.
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