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The behaviour of satellite cells in response to exercise: What have we learned from human studies?

Understanding the complex role played by satellite cells in the adaptive response to exercise in human skeletal muscle has just begun. The development of reliable markers for the identification of satellite cell status (quiescence/activation/proliferation) is an important step towards the understand... Full description

Journal Title: Pflügers Archiv 2005-11, Vol.451 (2), p.319-327
Main Author: Kadi, Fawzi
Other Authors: Charifi, Nadia , Denis, Christian , Lexell, Jan , Andersen, Jesper L , Schjerling, Peter , Olsen, Steen , Kjaer, Michael
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Germany: Springer Nature B.V
ID: ISSN: 0031-6768
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title: The behaviour of satellite cells in response to exercise: What have we learned from human studies?
format: Article
creator:
  • Kadi, Fawzi
  • Charifi, Nadia
  • Denis, Christian
  • Lexell, Jan
  • Andersen, Jesper L
  • Schjerling, Peter
  • Olsen, Steen
  • Kjaer, Michael
subjects:
  • aging
  • Annan klinisk medicin
  • Annan samhällsvetenskap
  • Basic Medicine
  • Biological Markers/analysis
  • Biomarkers - analysis
  • Cell Differentiation - physiology
  • Cell Nucleus - physiology
  • Cell Proliferation
  • Clinical Medicine
  • Exercise - physiology
  • fibre type
  • Fysiologi
  • Fysiologi och farmakologi
  • Health Sciences
  • human
  • Humans
  • hypertrophy
  • Hälsovetenskaper
  • Idrott
  • Idrottsvetenskap
  • INTERDISCIPLINARY RESEARCH AREAS
  • Klinisk medicin
  • Medical and Health Sciences
  • MEDICIN
  • Medicin och hälsovetenskap
  • MEDICINE
  • Medicinska och farmaceutiska grundvetenskaper
  • Models, Biological
  • Muscle Fibers, Skeletal - chemistry
  • Muscle Fibers, Skeletal - cytology
  • Muscle Fibers, Skeletal - physiology
  • Muscle Fibers/chemistry/cytology/physiology
  • Muscle, Skeletal - cytology
  • Muscle, Skeletal - growth & development
  • Muscle
  • Skeletal/cytology/growth & development
  • Muscular system
  • myonuclei
  • Other Clinical Medicine
  • Other Social Sciences
  • Physiology
  • Physiology and pharmacology
  • Proteins
  • Samhällsvetenskap
  • satellite cell biology
  • Satellite Cells, Skeletal Muscle - chemistry
  • Satellite Cells, Skeletal Muscle - cytology
  • Satellite Cells, Skeletal Muscle - physiology
  • Satellite Cells
  • Skeletal Muscle/chemistry/cytology/physiology
  • skeletal muscle
  • Social Sciences
  • Social Sciences Interdisciplinary
  • Sport and Fitness Sciences
  • Sports
  • Sports Science
  • strength training
  • TVÄRVETENSKAPLIGA FORSKNINGSOMRÅDEN
  • Tvärvetenskapliga studier inom samhällsvetenskap
ispartof: Pflügers Archiv, 2005-11, Vol.451 (2), p.319-327
description: Understanding the complex role played by satellite cells in the adaptive response to exercise in human skeletal muscle has just begun. The development of reliable markers for the identification of satellite cell status (quiescence/activation/proliferation) is an important step towards the understanding of satellite cell behaviour in exercised human muscles. It is hypothesised currently that exercise in humans can induce (1) the activation of satellite cells without proliferation, (2) proliferation and withdrawal from differentiation, (3) proliferation and differentiation to provide myonuclei and (4) proliferation and differentiation to generate new muscle fibres or to repair segmental fibre injuries. In humans, the satellite cell pool can increase as early as 4 days following a single bout of exercise and is maintained at higher level following several weeks of training. Cessation of training is associated with a gradual reduction of the previously enhanced satellite cell pool. In the elderly, training counteracts the normal decline in satellite cell number seen with ageing. When the transcriptional activity of existing myonuclei reaches its maximum, daughter cells generated by satellite cell proliferation are involved in protein synthesis by enhancing the number of nuclear domains. Clearly, delineating the events and the mechanisms behind the activation of satellite cells both under physiological and pathological conditions in human skeletal muscles remains an important challenge.
language: eng
source:
identifier: ISSN: 0031-6768
fulltext: no_fulltext
issn:
  • 0031-6768
  • 1432-2013
  • 1432-2013
url: Link


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titleThe behaviour of satellite cells in response to exercise: What have we learned from human studies?
creatorKadi, Fawzi ; Charifi, Nadia ; Denis, Christian ; Lexell, Jan ; Andersen, Jesper L ; Schjerling, Peter ; Olsen, Steen ; Kjaer, Michael
creatorcontribKadi, Fawzi ; Charifi, Nadia ; Denis, Christian ; Lexell, Jan ; Andersen, Jesper L ; Schjerling, Peter ; Olsen, Steen ; Kjaer, Michael
descriptionUnderstanding the complex role played by satellite cells in the adaptive response to exercise in human skeletal muscle has just begun. The development of reliable markers for the identification of satellite cell status (quiescence/activation/proliferation) is an important step towards the understanding of satellite cell behaviour in exercised human muscles. It is hypothesised currently that exercise in humans can induce (1) the activation of satellite cells without proliferation, (2) proliferation and withdrawal from differentiation, (3) proliferation and differentiation to provide myonuclei and (4) proliferation and differentiation to generate new muscle fibres or to repair segmental fibre injuries. In humans, the satellite cell pool can increase as early as 4 days following a single bout of exercise and is maintained at higher level following several weeks of training. Cessation of training is associated with a gradual reduction of the previously enhanced satellite cell pool. In the elderly, training counteracts the normal decline in satellite cell number seen with ageing. When the transcriptional activity of existing myonuclei reaches its maximum, daughter cells generated by satellite cell proliferation are involved in protein synthesis by enhancing the number of nuclear domains. Clearly, delineating the events and the mechanisms behind the activation of satellite cells both under physiological and pathological conditions in human skeletal muscles remains an important challenge.
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subjectaging ; Annan klinisk medicin ; Annan samhällsvetenskap ; Basic Medicine ; Biological Markers/analysis ; Biomarkers - analysis ; Cell Differentiation - physiology ; Cell Nucleus - physiology ; Cell Proliferation ; Clinical Medicine ; Exercise - physiology ; fibre type ; Fysiologi ; Fysiologi och farmakologi ; Health Sciences ; human ; Humans ; hypertrophy ; Hälsovetenskaper ; Idrott ; Idrottsvetenskap ; INTERDISCIPLINARY RESEARCH AREAS ; Klinisk medicin ; Medical and Health Sciences ; MEDICIN ; Medicin och hälsovetenskap ; MEDICINE ; Medicinska och farmaceutiska grundvetenskaper ; Models, Biological ; Muscle Fibers, Skeletal - chemistry ; Muscle Fibers, Skeletal - cytology ; Muscle Fibers, Skeletal - physiology ; Muscle Fibers/chemistry/cytology/physiology ; Muscle, Skeletal - cytology ; Muscle, Skeletal - growth & development ; Muscle; Skeletal/cytology/growth & development ; Muscular system ; myonuclei ; Other Clinical Medicine ; Other Social Sciences ; Physiology ; Physiology and pharmacology ; Proteins ; Samhällsvetenskap ; satellite cell biology ; Satellite Cells, Skeletal Muscle - chemistry ; Satellite Cells, Skeletal Muscle - cytology ; Satellite Cells, Skeletal Muscle - physiology ; Satellite Cells; Skeletal Muscle/chemistry/cytology/physiology ; skeletal muscle ; Social Sciences ; Social Sciences Interdisciplinary ; Sport and Fitness Sciences ; Sports ; Sports Science ; strength training ; TVÄRVETENSKAPLIGA FORSKNINGSOMRÅDEN ; Tvärvetenskapliga studier inom samhällsvetenskap
ispartofPflügers Archiv, 2005-11, Vol.451 (2), p.319-327
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7Kjaer, Michael
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descriptionUnderstanding the complex role played by satellite cells in the adaptive response to exercise in human skeletal muscle has just begun. The development of reliable markers for the identification of satellite cell status (quiescence/activation/proliferation) is an important step towards the understanding of satellite cell behaviour in exercised human muscles. It is hypothesised currently that exercise in humans can induce (1) the activation of satellite cells without proliferation, (2) proliferation and withdrawal from differentiation, (3) proliferation and differentiation to provide myonuclei and (4) proliferation and differentiation to generate new muscle fibres or to repair segmental fibre injuries. In humans, the satellite cell pool can increase as early as 4 days following a single bout of exercise and is maintained at higher level following several weeks of training. Cessation of training is associated with a gradual reduction of the previously enhanced satellite cell pool. In the elderly, training counteracts the normal decline in satellite cell number seen with ageing. When the transcriptional activity of existing myonuclei reaches its maximum, daughter cells generated by satellite cell proliferation are involved in protein synthesis by enhancing the number of nuclear domains. Clearly, delineating the events and the mechanisms behind the activation of satellite cells both under physiological and pathological conditions in human skeletal muscles remains an important challenge.
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19Idrott
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23Medical and Health Sciences
24MEDICIN
25Medicin och hälsovetenskap
26MEDICINE
27Medicinska och farmaceutiska grundvetenskaper
28Models, Biological
29Muscle Fibers, Skeletal - chemistry
30Muscle Fibers, Skeletal - cytology
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33Muscle, Skeletal - cytology
34Muscle, Skeletal - growth & development
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36Muscular system
37myonuclei
38Other Clinical Medicine
39Other Social Sciences
40Physiology
41Physiology and pharmacology
42Proteins
43Samhällsvetenskap
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46Satellite Cells, Skeletal Muscle - cytology
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50Social Sciences
51Social Sciences Interdisciplinary
52Sport and Fitness Sciences
53Sports
54Sports Science
55strength training
56TVÄRVETENSKAPLIGA FORSKNINGSOMRÅDEN
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abstractUnderstanding the complex role played by satellite cells in the adaptive response to exercise in human skeletal muscle has just begun. The development of reliable markers for the identification of satellite cell status (quiescence/activation/proliferation) is an important step towards the understanding of satellite cell behaviour in exercised human muscles. It is hypothesised currently that exercise in humans can induce (1) the activation of satellite cells without proliferation, (2) proliferation and withdrawal from differentiation, (3) proliferation and differentiation to provide myonuclei and (4) proliferation and differentiation to generate new muscle fibres or to repair segmental fibre injuries. In humans, the satellite cell pool can increase as early as 4 days following a single bout of exercise and is maintained at higher level following several weeks of training. Cessation of training is associated with a gradual reduction of the previously enhanced satellite cell pool. In the elderly, training counteracts the normal decline in satellite cell number seen with ageing. When the transcriptional activity of existing myonuclei reaches its maximum, daughter cells generated by satellite cell proliferation are involved in protein synthesis by enhancing the number of nuclear domains. Clearly, delineating the events and the mechanisms behind the activation of satellite cells both under physiological and pathological conditions in human skeletal muscles remains an important challenge.
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