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Probiotics in prevention of IgE-associated eczema: A double-blind, randomized, placebo-controlled trial

Background An altered microbial exposure may underlie the increase of allergic diseases in affluent societies. Probiotics may alleviate and even prevent eczema in infants. Objective To prevent eczema and sensitization in infants with a family history of allergic disease by oral supplementation with... Full description

Journal Title: Journal of allergy and clinical immunology 2007, Vol.119 (5), p.1174-1180
Main Author: Abrahamsson, Thomas R., MD
Other Authors: Jakobsson, Ted, MD , Böttcher, Malin Fagerås, PhD , Fredrikson, Mats, PhD , Jenmalm, Maria C., PhD , Björkstén, Bengt, MD, PhD , Oldaeus, Göran, MD, PhD
Format: Electronic Article Electronic Article
Language: English
Subjects:
Age
IgE
Quelle: Alma/SFX Local Collection
Publisher: New York, NY: Mosby, Inc
ID: ISSN: 0091-6749
Zum Text:
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title: Probiotics in prevention of IgE-associated eczema: A double-blind, randomized, placebo-controlled trial
format: Article
creator:
  • Abrahamsson, Thomas R., MD
  • Jakobsson, Ted, MD
  • Böttcher, Malin Fagerås, PhD
  • Fredrikson, Mats, PhD
  • Jenmalm, Maria C., PhD
  • Björkstén, Bengt, MD, PhD
  • Oldaeus, Göran, MD, PhD
subjects:
  • Abridged Index Medicus
  • Age
  • Allergic diseases
  • Allergies
  • Allergy and Immunology
  • Antibiotics
  • Asthma
  • Biological and medical sciences
  • Breastfeeding & lactation
  • Child, Preschool
  • Children
  • Clinical trials
  • Ear diseases
  • Eczema
  • Eczema - prevention & control
  • Families & family life
  • Family medical history
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Fundamental immunology
  • Humans
  • Hypersensitivity - prevention & control
  • IgE
  • Immunoglobulin E - blood
  • Immunopathology
  • Infant
  • Infant, Newborn
  • Infections
  • Lactobacillus
  • Lactobacillus reuteri
  • Lactobacillus reuteri - immunology
  • Male
  • Medical and Health Sciences
  • Medical sciences
  • MEDICIN
  • Medicin och hälsovetenskap
  • MEDICINE
  • Mothers
  • Pregnancy
  • Prevention
  • Probiotics
  • Probiotics - therapeutic use
  • sensitization
  • Skin allergic diseases. Stinging insect allergies
  • skin prick test
  • Skin Tests
  • Studies
ispartof: Journal of allergy and clinical immunology, 2007, Vol.119 (5), p.1174-1180
description: Background An altered microbial exposure may underlie the increase of allergic diseases in affluent societies. Probiotics may alleviate and even prevent eczema in infants. Objective To prevent eczema and sensitization in infants with a family history of allergic disease by oral supplementation with the probiotic Lactobacillus reuteri. Methods Double-blind, randomized, placebo-controlled trial, which comprised 232 families with allergic disease, of whom 188 completed the study. The mothers received L reuteri ATCC 55730 (1 × 108 colony forming units) daily from gestational week 36 until delivery. Their babies then continued with the same product from birth until 12 months of age and were followed up for another year. Primary outcome was allergic disease, with or without positive skin prick test or circulating IgE to food allergens. Results The cumulative incidence of eczema was similar, 36% in the treated versus 34% in the placebo group. The L reuteri group had less IgE-associated eczema during the second year, 8% versus 20% ( P = .02), however. Skin prick test reactivity was also less common in the treated than in the placebo group, significantly so for infants with mothers with allergies, 14% versus 31% ( P = .02). Wheeze and other potentially allergic diseases were not affected. Conclusion Although a preventive effect of probiotics on infant eczema was not confirmed, the treated infants had less IgE-associated eczema at 2 years of age and therefore possibly run a reduced risk to develop later respiratory allergic disease. Clinical implication Probiotics may reduce the incidence of IgE-associated eczema in infancy.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0091-6749
fulltext: fulltext
issn:
  • 0091-6749
  • 1097-6825
  • 1097-6825
url: Link


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titleProbiotics in prevention of IgE-associated eczema: A double-blind, randomized, placebo-controlled trial
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creatorAbrahamsson, Thomas R., MD ; Jakobsson, Ted, MD ; Böttcher, Malin Fagerås, PhD ; Fredrikson, Mats, PhD ; Jenmalm, Maria C., PhD ; Björkstén, Bengt, MD, PhD ; Oldaeus, Göran, MD, PhD
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descriptionBackground An altered microbial exposure may underlie the increase of allergic diseases in affluent societies. Probiotics may alleviate and even prevent eczema in infants. Objective To prevent eczema and sensitization in infants with a family history of allergic disease by oral supplementation with the probiotic Lactobacillus reuteri. Methods Double-blind, randomized, placebo-controlled trial, which comprised 232 families with allergic disease, of whom 188 completed the study. The mothers received L reuteri ATCC 55730 (1 × 108 colony forming units) daily from gestational week 36 until delivery. Their babies then continued with the same product from birth until 12 months of age and were followed up for another year. Primary outcome was allergic disease, with or without positive skin prick test or circulating IgE to food allergens. Results The cumulative incidence of eczema was similar, 36% in the treated versus 34% in the placebo group. The L reuteri group had less IgE-associated eczema during the second year, 8% versus 20% ( P = .02), however. Skin prick test reactivity was also less common in the treated than in the placebo group, significantly so for infants with mothers with allergies, 14% versus 31% ( P = .02). Wheeze and other potentially allergic diseases were not affected. Conclusion Although a preventive effect of probiotics on infant eczema was not confirmed, the treated infants had less IgE-associated eczema at 2 years of age and therefore possibly run a reduced risk to develop later respiratory allergic disease. Clinical implication Probiotics may reduce the incidence of IgE-associated eczema in infancy.
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languageeng
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subjectAbridged Index Medicus ; Age ; Allergic diseases ; Allergies ; Allergy and Immunology ; Antibiotics ; Asthma ; Biological and medical sciences ; Breastfeeding & lactation ; Child, Preschool ; Children ; Clinical trials ; Ear diseases ; Eczema ; Eczema - prevention & control ; Families & family life ; Family medical history ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Hypersensitivity - prevention & control ; IgE ; Immunoglobulin E - blood ; Immunopathology ; Infant ; Infant, Newborn ; Infections ; Lactobacillus ; Lactobacillus reuteri ; Lactobacillus reuteri - immunology ; Male ; Medical and Health Sciences ; Medical sciences ; MEDICIN ; Medicin och hälsovetenskap ; MEDICINE ; Mothers ; Pregnancy ; Prevention ; Probiotics ; Probiotics - therapeutic use ; sensitization ; Skin allergic diseases. Stinging insect allergies ; skin prick test ; Skin Tests ; Studies
ispartofJournal of allergy and clinical immunology, 2007, Vol.119 (5), p.1174-1180
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4Jenmalm, Maria C., PhD
5Björkstén, Bengt, MD, PhD
6Oldaeus, Göran, MD, PhD
title
0Probiotics in prevention of IgE-associated eczema: A double-blind, randomized, placebo-controlled trial
1Journal of allergy and clinical immunology
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descriptionBackground An altered microbial exposure may underlie the increase of allergic diseases in affluent societies. Probiotics may alleviate and even prevent eczema in infants. Objective To prevent eczema and sensitization in infants with a family history of allergic disease by oral supplementation with the probiotic Lactobacillus reuteri. Methods Double-blind, randomized, placebo-controlled trial, which comprised 232 families with allergic disease, of whom 188 completed the study. The mothers received L reuteri ATCC 55730 (1 × 108 colony forming units) daily from gestational week 36 until delivery. Their babies then continued with the same product from birth until 12 months of age and were followed up for another year. Primary outcome was allergic disease, with or without positive skin prick test or circulating IgE to food allergens. Results The cumulative incidence of eczema was similar, 36% in the treated versus 34% in the placebo group. The L reuteri group had less IgE-associated eczema during the second year, 8% versus 20% ( P = .02), however. Skin prick test reactivity was also less common in the treated than in the placebo group, significantly so for infants with mothers with allergies, 14% versus 31% ( P = .02). Wheeze and other potentially allergic diseases were not affected. Conclusion Although a preventive effect of probiotics on infant eczema was not confirmed, the treated infants had less IgE-associated eczema at 2 years of age and therefore possibly run a reduced risk to develop later respiratory allergic disease. Clinical implication Probiotics may reduce the incidence of IgE-associated eczema in infancy.
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37Mothers
38Pregnancy
39Prevention
40Probiotics
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titleProbiotics in prevention of IgE-associated eczema: A double-blind, randomized, placebo-controlled trial
authorAbrahamsson, Thomas R., MD ; Jakobsson, Ted, MD ; Böttcher, Malin Fagerås, PhD ; Fredrikson, Mats, PhD ; Jenmalm, Maria C., PhD ; Björkstén, Bengt, MD, PhD ; Oldaeus, Göran, MD, PhD
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1Age
2Allergic diseases
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4Allergy and Immunology
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6Asthma
7Biological and medical sciences
8Breastfeeding & lactation
9Child, Preschool
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abstractBackground An altered microbial exposure may underlie the increase of allergic diseases in affluent societies. Probiotics may alleviate and even prevent eczema in infants. Objective To prevent eczema and sensitization in infants with a family history of allergic disease by oral supplementation with the probiotic Lactobacillus reuteri. Methods Double-blind, randomized, placebo-controlled trial, which comprised 232 families with allergic disease, of whom 188 completed the study. The mothers received L reuteri ATCC 55730 (1 × 108 colony forming units) daily from gestational week 36 until delivery. Their babies then continued with the same product from birth until 12 months of age and were followed up for another year. Primary outcome was allergic disease, with or without positive skin prick test or circulating IgE to food allergens. Results The cumulative incidence of eczema was similar, 36% in the treated versus 34% in the placebo group. The L reuteri group had less IgE-associated eczema during the second year, 8% versus 20% ( P = .02), however. Skin prick test reactivity was also less common in the treated than in the placebo group, significantly so for infants with mothers with allergies, 14% versus 31% ( P = .02). Wheeze and other potentially allergic diseases were not affected. Conclusion Although a preventive effect of probiotics on infant eczema was not confirmed, the treated infants had less IgE-associated eczema at 2 years of age and therefore possibly run a reduced risk to develop later respiratory allergic disease. Clinical implication Probiotics may reduce the incidence of IgE-associated eczema in infancy.
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