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Serum high sensitivity C-reactive protein and cognitive function in elderly women

Background: inflammation has been linked to cognitive impairment. However, limited data are available on the association between inflammatory markers and cognitive function. Objectives: we tested the hypothesis that elevated serum concentration of high sensitivity C-reactive protein (hs-CRP), an est... Full description

Journal Title: Age and ageing 2007-07, Vol.36 (4), p.443-448
Main Author: Komulainen, Pirjo
Other Authors: Lakka, Timo A , Kivipelto, Miia , Hassinen, Maija , Penttilä, Ilkka M , Helkala, Eeva-Liisa , Gylling, Helena , Nissinen, Aulikki , Rauramaa, Rainer
Format: Electronic Article Electronic Article
Language: English
Subjects:
Aged
Aged women
Aged, 80 and over
Aging - metabolism
Aging - physiology
Biomarkers - blood
C-reactive protein
C-Reactive Protein - metabolism
Cognition
Cognition - physiology
Cognition Disorders - blood
Cognition Disorders - diagnosis
cognitive function
Cognitive functioning
Elderly women
Evaluation
Female
Follow-Up Studies
Geriatric Assessment
high sensitivity CRP
Humans
Inflammation
Influence
Medicin och hälsovetenskap
Memory Disorders - blood
Memory Disorders - diagnosis
Memory Disorders - physiopathology
Middle Aged
Predictive Value of Tests
Psychological aspects
Risk Factors
Sensitivity and Specificity
Publisher: England: Oxford University Press
ID: ISSN: 0002-0729
Zum Text:
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title: Serum high sensitivity C-reactive protein and cognitive function in elderly women
format: Article
creator:
  • Komulainen, Pirjo
  • Lakka, Timo A
  • Kivipelto, Miia
  • Hassinen, Maija
  • Penttilä, Ilkka M
  • Helkala, Eeva-Liisa
  • Gylling, Helena
  • Nissinen, Aulikki
  • Rauramaa, Rainer
subjects:
  • Aged
  • Aged women
  • Aged, 80 and over
  • Aging - metabolism
  • Aging - physiology
  • Biomarkers - blood
  • C-reactive protein
  • C-Reactive Protein - metabolism
  • Cognition
  • Cognition - physiology
  • Cognition Disorders - blood
  • Cognition Disorders - diagnosis
  • cognitive function
  • Cognitive functioning
  • Elderly women
  • Evaluation
  • Female
  • Follow-Up Studies
  • Geriatric Assessment
  • high sensitivity CRP
  • Humans
  • Inflammation
  • Influence
  • Medicin och hälsovetenskap
  • Memory Disorders - blood
  • Memory Disorders - diagnosis
  • Memory Disorders - physiopathology
  • Middle Aged
  • Predictive Value of Tests
  • Psychological aspects
  • Risk Factors
  • Sensitivity and Specificity
ispartof: Age and ageing, 2007-07, Vol.36 (4), p.443-448
description: Background: inflammation has been linked to cognitive impairment. However, limited data are available on the association between inflammatory markers and cognitive function. Objectives: we tested the hypothesis that elevated serum concentration of high sensitivity C-reactive protein (hs-CRP), an established marker of low-grade inflammation, predicts cognitive impairment in elderly women. Design: a 12-year population-based follow-up study. Participants: a total of 97 women between 60 and 70 years of age at baseline. Methods: serum hs-CRP concentration was measured by a high sensitivity assay. Global cognitive function was measured with the Mini-Mental State Examination (MMSE), and memory and cognitive speed were measured with a detailed cognitive test battery. Results: higher baseline hs-CRP was associated with poorer memory at 12-year follow-up without adjustment and after adjustment for age, education and depression (standardised regression coefficient β −0.842, 95% confidence interval −1.602 to −0.083, P = 0.030), and further adjustment for the use of hormone replacement therapy, smoking, serum LDL cholesterol and body mass index (standardised regression coefficient β −0.817, 95% confidence interval −1.630 to −0.004, P = 0.049). Memory at 12-year follow-up worsened linearly with increasing hs-CRP at baseline (P = 0.048 for linear trend). There was no association between hs-CRP at baseline and cognitive speed or MMSE score at 12-year follow-up. Conclusions: high serum hs-CRP concentration predicts poorer memory 12 years later in elderly women. Hs-CRP may be a useful biomarker to identify individuals at an increased risk for cognitive decline.
language: eng
source:
identifier: ISSN: 0002-0729
fulltext: no_fulltext
issn:
  • 0002-0729
  • 1468-2834
url: Link


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titleSerum high sensitivity C-reactive protein and cognitive function in elderly women
creatorKomulainen, Pirjo ; Lakka, Timo A ; Kivipelto, Miia ; Hassinen, Maija ; Penttilä, Ilkka M ; Helkala, Eeva-Liisa ; Gylling, Helena ; Nissinen, Aulikki ; Rauramaa, Rainer
creatorcontribKomulainen, Pirjo ; Lakka, Timo A ; Kivipelto, Miia ; Hassinen, Maija ; Penttilä, Ilkka M ; Helkala, Eeva-Liisa ; Gylling, Helena ; Nissinen, Aulikki ; Rauramaa, Rainer
descriptionBackground: inflammation has been linked to cognitive impairment. However, limited data are available on the association between inflammatory markers and cognitive function. Objectives: we tested the hypothesis that elevated serum concentration of high sensitivity C-reactive protein (hs-CRP), an established marker of low-grade inflammation, predicts cognitive impairment in elderly women. Design: a 12-year population-based follow-up study. Participants: a total of 97 women between 60 and 70 years of age at baseline. Methods: serum hs-CRP concentration was measured by a high sensitivity assay. Global cognitive function was measured with the Mini-Mental State Examination (MMSE), and memory and cognitive speed were measured with a detailed cognitive test battery. Results: higher baseline hs-CRP was associated with poorer memory at 12-year follow-up without adjustment and after adjustment for age, education and depression (standardised regression coefficient β −0.842, 95% confidence interval −1.602 to −0.083, P = 0.030), and further adjustment for the use of hormone replacement therapy, smoking, serum LDL cholesterol and body mass index (standardised regression coefficient β −0.817, 95% confidence interval −1.630 to −0.004, P = 0.049). Memory at 12-year follow-up worsened linearly with increasing hs-CRP at baseline (P = 0.048 for linear trend). There was no association between hs-CRP at baseline and cognitive speed or MMSE score at 12-year follow-up. Conclusions: high serum hs-CRP concentration predicts poorer memory 12 years later in elderly women. Hs-CRP may be a useful biomarker to identify individuals at an increased risk for cognitive decline.
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languageeng
publisherEngland: Oxford University Press
subjectAged ; Aged women ; Aged, 80 and over ; Aging - metabolism ; Aging - physiology ; Biomarkers - blood ; C-reactive protein ; C-Reactive Protein - metabolism ; Cognition ; Cognition - physiology ; Cognition Disorders - blood ; Cognition Disorders - diagnosis ; cognitive function ; Cognitive functioning ; Elderly women ; Evaluation ; Female ; Follow-Up Studies ; Geriatric Assessment ; high sensitivity CRP ; Humans ; Inflammation ; Influence ; Medicin och hälsovetenskap ; Memory Disorders - blood ; Memory Disorders - diagnosis ; Memory Disorders - physiopathology ; Middle Aged ; Predictive Value of Tests ; Psychological aspects ; Risk Factors ; Sensitivity and Specificity
ispartofAge and ageing, 2007-07, Vol.36 (4), p.443-448
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0Copyright © The Author 2007. Published by Oxford University Press on behalf of the British Geriatrics Society. 2007
1Copyright (c) The Author 2007. Published by Oxford University Press on behalf of the British Geriatrics Society.
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1Lakka, Timo A
2Kivipelto, Miia
3Hassinen, Maija
4Penttilä, Ilkka M
5Helkala, Eeva-Liisa
6Gylling, Helena
7Nissinen, Aulikki
8Rauramaa, Rainer
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0Serum high sensitivity C-reactive protein and cognitive function in elderly women
1Age and ageing
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descriptionBackground: inflammation has been linked to cognitive impairment. However, limited data are available on the association between inflammatory markers and cognitive function. Objectives: we tested the hypothesis that elevated serum concentration of high sensitivity C-reactive protein (hs-CRP), an established marker of low-grade inflammation, predicts cognitive impairment in elderly women. Design: a 12-year population-based follow-up study. Participants: a total of 97 women between 60 and 70 years of age at baseline. Methods: serum hs-CRP concentration was measured by a high sensitivity assay. Global cognitive function was measured with the Mini-Mental State Examination (MMSE), and memory and cognitive speed were measured with a detailed cognitive test battery. Results: higher baseline hs-CRP was associated with poorer memory at 12-year follow-up without adjustment and after adjustment for age, education and depression (standardised regression coefficient β −0.842, 95% confidence interval −1.602 to −0.083, P = 0.030), and further adjustment for the use of hormone replacement therapy, smoking, serum LDL cholesterol and body mass index (standardised regression coefficient β −0.817, 95% confidence interval −1.630 to −0.004, P = 0.049). Memory at 12-year follow-up worsened linearly with increasing hs-CRP at baseline (P = 0.048 for linear trend). There was no association between hs-CRP at baseline and cognitive speed or MMSE score at 12-year follow-up. Conclusions: high serum hs-CRP concentration predicts poorer memory 12 years later in elderly women. Hs-CRP may be a useful biomarker to identify individuals at an increased risk for cognitive decline.
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22Influence
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24Memory Disorders - blood
25Memory Disorders - diagnosis
26Memory Disorders - physiopathology
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29Psychological aspects
30Risk Factors
31Sensitivity and Specificity
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titleSerum high sensitivity C-reactive protein and cognitive function in elderly women
authorKomulainen, Pirjo ; Lakka, Timo A ; Kivipelto, Miia ; Hassinen, Maija ; Penttilä, Ilkka M ; Helkala, Eeva-Liisa ; Gylling, Helena ; Nissinen, Aulikki ; Rauramaa, Rainer
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8Cognition
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14Elderly women
15Evaluation
16Female
17Follow-Up Studies
18Geriatric Assessment
19high sensitivity CRP
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21Inflammation
22Influence
23Medicin och hälsovetenskap
24Memory Disorders - blood
25Memory Disorders - diagnosis
26Memory Disorders - physiopathology
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28Predictive Value of Tests
29Psychological aspects
30Risk Factors
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1Lakka, Timo A
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atitleSerum high sensitivity C-reactive protein and cognitive function in elderly women
jtitleAge and ageing
stitleAge Ageing
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date2007-07
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volume36
issue4
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abstractBackground: inflammation has been linked to cognitive impairment. However, limited data are available on the association between inflammatory markers and cognitive function. Objectives: we tested the hypothesis that elevated serum concentration of high sensitivity C-reactive protein (hs-CRP), an established marker of low-grade inflammation, predicts cognitive impairment in elderly women. Design: a 12-year population-based follow-up study. Participants: a total of 97 women between 60 and 70 years of age at baseline. Methods: serum hs-CRP concentration was measured by a high sensitivity assay. Global cognitive function was measured with the Mini-Mental State Examination (MMSE), and memory and cognitive speed were measured with a detailed cognitive test battery. Results: higher baseline hs-CRP was associated with poorer memory at 12-year follow-up without adjustment and after adjustment for age, education and depression (standardised regression coefficient β −0.842, 95% confidence interval −1.602 to −0.083, P = 0.030), and further adjustment for the use of hormone replacement therapy, smoking, serum LDL cholesterol and body mass index (standardised regression coefficient β −0.817, 95% confidence interval −1.630 to −0.004, P = 0.049). Memory at 12-year follow-up worsened linearly with increasing hs-CRP at baseline (P = 0.048 for linear trend). There was no association between hs-CRP at baseline and cognitive speed or MMSE score at 12-year follow-up. Conclusions: high serum hs-CRP concentration predicts poorer memory 12 years later in elderly women. Hs-CRP may be a useful biomarker to identify individuals at an increased risk for cognitive decline.
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pubOxford University Press
pmid17537742
doi10.1093/ageing/afm051
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