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Serum high sensitivity C-reactive protein and cognitive function in elderly women

Background: inflammation has been linked to cognitive impairment. However, limited data are available on the association between inflammatory markers and cognitive function. Objectives: we tested the hypothesis that elevated serum concentration of high sensitivity C-reactive protein (hs-CRP), an est... Full description

Journal Title: Age and ageing 2007-07, Vol.36 (4), p.443-448
Main Author: Komulainen, Pirjo
Other Authors: Lakka, Timo A , Kivipelto, Miia , Hassinen, Maija , Penttilä, Ilkka M , Helkala, Eeva-Liisa , Gylling, Helena , Nissinen, Aulikki , Rauramaa, Rainer
Format: Electronic Article Electronic Article
Language: English
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Publisher: England: Oxford University Press
ID: ISSN: 0002-0729
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title: Serum high sensitivity C-reactive protein and cognitive function in elderly women
format: Article
creator:
  • Komulainen, Pirjo
  • Lakka, Timo A
  • Kivipelto, Miia
  • Hassinen, Maija
  • Penttilä, Ilkka M
  • Helkala, Eeva-Liisa
  • Gylling, Helena
  • Nissinen, Aulikki
  • Rauramaa, Rainer
subjects:
  • Aged
  • Aged women
  • Aged, 80 and over
  • Aging - metabolism
  • Aging - physiology
  • Biomarkers - blood
  • C-reactive protein
  • C-Reactive Protein - metabolism
  • Cognition
  • Cognition - physiology
  • Cognition Disorders - blood
  • Cognition Disorders - diagnosis
  • cognitive function
  • Elderly women
  • Evaluation
  • Female
  • Follow-Up Studies
  • Geriatric Assessment
  • high sensitivity CRP
  • Humans
  • Influence
  • Medicin och hälsovetenskap
  • Memory Disorders - blood
  • Memory Disorders - diagnosis
  • Memory Disorders - physiopathology
  • Middle Aged
  • Predictive Value of Tests
  • Psychological aspects
  • Risk Factors
  • Sensitivity and Specificity
ispartof: Age and ageing, 2007-07, Vol.36 (4), p.443-448
description: Background: inflammation has been linked to cognitive impairment. However, limited data are available on the association between inflammatory markers and cognitive function. Objectives: we tested the hypothesis that elevated serum concentration of high sensitivity C-reactive protein (hs-CRP), an established marker of low-grade inflammation, predicts cognitive impairment in elderly women. Design: a 12-year population-based follow-up study. Participants: a total of 97 women between 60 and 70 years of age at baseline. Methods: serum hs-CRP concentration was measured by a high sensitivity assay. Global cognitive function was measured with the Mini-Mental State Examination (MMSE), and memory and cognitive speed were measured with a detailed cognitive test battery. Results: higher baseline hs-CRP was associated with poorer memory at 12-year follow-up without adjustment and after adjustment for age, education and depression (standardised regression coefficient β −0.842, 95% confidence interval −1.602 to −0.083, P = 0.030), and further adjustment for the use of hormone replacement therapy, smoking, serum LDL cholesterol and body mass index (standardised regression coefficient β −0.817, 95% confidence interval −1.630 to −0.004, P = 0.049). Memory at 12-year follow-up worsened linearly with increasing hs-CRP at baseline (P = 0.048 for linear trend). There was no association between hs-CRP at baseline and cognitive speed or MMSE score at 12-year follow-up. Conclusions: high serum hs-CRP concentration predicts poorer memory 12 years later in elderly women. Hs-CRP may be a useful biomarker to identify individuals at an increased risk for cognitive decline.
language: eng
source:
identifier: ISSN: 0002-0729
fulltext: no_fulltext
issn:
  • 0002-0729
  • 1468-2834
url: Link


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titleSerum high sensitivity C-reactive protein and cognitive function in elderly women
creatorKomulainen, Pirjo ; Lakka, Timo A ; Kivipelto, Miia ; Hassinen, Maija ; Penttilä, Ilkka M ; Helkala, Eeva-Liisa ; Gylling, Helena ; Nissinen, Aulikki ; Rauramaa, Rainer
creatorcontribKomulainen, Pirjo ; Lakka, Timo A ; Kivipelto, Miia ; Hassinen, Maija ; Penttilä, Ilkka M ; Helkala, Eeva-Liisa ; Gylling, Helena ; Nissinen, Aulikki ; Rauramaa, Rainer
descriptionBackground: inflammation has been linked to cognitive impairment. However, limited data are available on the association between inflammatory markers and cognitive function. Objectives: we tested the hypothesis that elevated serum concentration of high sensitivity C-reactive protein (hs-CRP), an established marker of low-grade inflammation, predicts cognitive impairment in elderly women. Design: a 12-year population-based follow-up study. Participants: a total of 97 women between 60 and 70 years of age at baseline. Methods: serum hs-CRP concentration was measured by a high sensitivity assay. Global cognitive function was measured with the Mini-Mental State Examination (MMSE), and memory and cognitive speed were measured with a detailed cognitive test battery. Results: higher baseline hs-CRP was associated with poorer memory at 12-year follow-up without adjustment and after adjustment for age, education and depression (standardised regression coefficient β −0.842, 95% confidence interval −1.602 to −0.083, P = 0.030), and further adjustment for the use of hormone replacement therapy, smoking, serum LDL cholesterol and body mass index (standardised regression coefficient β −0.817, 95% confidence interval −1.630 to −0.004, P = 0.049). Memory at 12-year follow-up worsened linearly with increasing hs-CRP at baseline (P = 0.048 for linear trend). There was no association between hs-CRP at baseline and cognitive speed or MMSE score at 12-year follow-up. Conclusions: high serum hs-CRP concentration predicts poorer memory 12 years later in elderly women. Hs-CRP may be a useful biomarker to identify individuals at an increased risk for cognitive decline.
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subjectAged ; Aged women ; Aged, 80 and over ; Aging - metabolism ; Aging - physiology ; Biomarkers - blood ; C-reactive protein ; C-Reactive Protein - metabolism ; Cognition ; Cognition - physiology ; Cognition Disorders - blood ; Cognition Disorders - diagnosis ; cognitive function ; Elderly women ; Evaluation ; Female ; Follow-Up Studies ; Geriatric Assessment ; high sensitivity CRP ; Humans ; Influence ; Medicin och hälsovetenskap ; Memory Disorders - blood ; Memory Disorders - diagnosis ; Memory Disorders - physiopathology ; Middle Aged ; Predictive Value of Tests ; Psychological aspects ; Risk Factors ; Sensitivity and Specificity
ispartofAge and ageing, 2007-07, Vol.36 (4), p.443-448
rightsCopyright © The Author 2007. Published by Oxford University Press on behalf of the British Geriatrics Society. 2007
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3Hassinen, Maija
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descriptionBackground: inflammation has been linked to cognitive impairment. However, limited data are available on the association between inflammatory markers and cognitive function. Objectives: we tested the hypothesis that elevated serum concentration of high sensitivity C-reactive protein (hs-CRP), an established marker of low-grade inflammation, predicts cognitive impairment in elderly women. Design: a 12-year population-based follow-up study. Participants: a total of 97 women between 60 and 70 years of age at baseline. Methods: serum hs-CRP concentration was measured by a high sensitivity assay. Global cognitive function was measured with the Mini-Mental State Examination (MMSE), and memory and cognitive speed were measured with a detailed cognitive test battery. Results: higher baseline hs-CRP was associated with poorer memory at 12-year follow-up without adjustment and after adjustment for age, education and depression (standardised regression coefficient β −0.842, 95% confidence interval −1.602 to −0.083, P = 0.030), and further adjustment for the use of hormone replacement therapy, smoking, serum LDL cholesterol and body mass index (standardised regression coefficient β −0.817, 95% confidence interval −1.630 to −0.004, P = 0.049). Memory at 12-year follow-up worsened linearly with increasing hs-CRP at baseline (P = 0.048 for linear trend). There was no association between hs-CRP at baseline and cognitive speed or MMSE score at 12-year follow-up. Conclusions: high serum hs-CRP concentration predicts poorer memory 12 years later in elderly women. Hs-CRP may be a useful biomarker to identify individuals at an increased risk for cognitive decline.
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authorKomulainen, Pirjo ; Lakka, Timo A ; Kivipelto, Miia ; Hassinen, Maija ; Penttilä, Ilkka M ; Helkala, Eeva-Liisa ; Gylling, Helena ; Nissinen, Aulikki ; Rauramaa, Rainer
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26Predictive Value of Tests
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28Risk Factors
29Sensitivity and Specificity
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abstractBackground: inflammation has been linked to cognitive impairment. However, limited data are available on the association between inflammatory markers and cognitive function. Objectives: we tested the hypothesis that elevated serum concentration of high sensitivity C-reactive protein (hs-CRP), an established marker of low-grade inflammation, predicts cognitive impairment in elderly women. Design: a 12-year population-based follow-up study. Participants: a total of 97 women between 60 and 70 years of age at baseline. Methods: serum hs-CRP concentration was measured by a high sensitivity assay. Global cognitive function was measured with the Mini-Mental State Examination (MMSE), and memory and cognitive speed were measured with a detailed cognitive test battery. Results: higher baseline hs-CRP was associated with poorer memory at 12-year follow-up without adjustment and after adjustment for age, education and depression (standardised regression coefficient β −0.842, 95% confidence interval −1.602 to −0.083, P = 0.030), and further adjustment for the use of hormone replacement therapy, smoking, serum LDL cholesterol and body mass index (standardised regression coefficient β −0.817, 95% confidence interval −1.630 to −0.004, P = 0.049). Memory at 12-year follow-up worsened linearly with increasing hs-CRP at baseline (P = 0.048 for linear trend). There was no association between hs-CRP at baseline and cognitive speed or MMSE score at 12-year follow-up. Conclusions: high serum hs-CRP concentration predicts poorer memory 12 years later in elderly women. Hs-CRP may be a useful biomarker to identify individuals at an increased risk for cognitive decline.
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